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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2025-1-67-70</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-4198</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Применение олигопептидов в стоматологии</article-title><trans-title-group xml:lang="en"><trans-title>Application of oligopeptides in dentistry</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3276-7615</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Болдырева</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Boldyreva</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Болдырева Юлия Викторовна, к.м.н., доцент, доцент кафедры биологической химии</p><p>г. Тюмень</p></bio><bio xml:lang="en"><p>Boldyreva Yulia V., MD, PhD, Associate Professor, Associate Professor of the Department of Biological Chemistry</p><p>Tyumen</p></bio><email xlink:type="simple">tgma.06@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5405-7182</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лебедев</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Lebedev</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лебедев Илья Аркадьевич, д.м.н., доцент, профессор кафедры остеопатии и традиционной медицины</p><p>г. Тюмень</p></bio><bio xml:lang="en"><p>Lebedev Ilya Arkadyevich, MD, Associate Professor, Professor of the Department of Osteopathy and Traditional Medicine</p><p>Tyumen</p></bio><email xlink:type="simple">lebedef@inbox.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2936-1374</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лебедев</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Lebedev</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лебедев Сергей Николаевич, к.м.н., доцент, доцент кафедры профилактической и детской стоматологии</p><p>г. Тюмень</p></bio><bio xml:lang="en"><p>Lebedev Sergey N., MD, PhD, Associate Professor, Associate Professor of the Department of Preventive and Pediatric Dentistry</p><p>Tyumen</p></bio><email xlink:type="simple">Ds-tyumen@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-2276-3337</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куман</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuman</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Куман Ольга Александровна, к.м.н., доцент кафедры профилактической и детской стоматологии</p><p>г. Тюмень</p></bio><bio xml:lang="en"><p>Kuman Olga A., MD, PhD, Associate Professor of the Department of Preventive and Pediatric Dentistry</p><p>Tyumen</p></bio><email xlink:type="simple">Olga_7a@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5390-1254</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Корнеева</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Korneeva</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Корнеева Мария Васильевна, к.м.н., доцент кафедры хирургической стоматологии</p><p>г. Тюмень</p></bio><bio xml:lang="en"><p>Korneeva Maria V., PhD, Associate Professor of the Department of Surgical Dentistry</p><p>Tyumen</p></bio><email xlink:type="simple">dok_kor@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0002-9158-8251</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фролкина</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Frolkina</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Фролкина Ольга Александровна, ассистент кафедры профилактической и детской стоматологии</p><p>г. Тюмень</p></bio><bio xml:lang="en"><p>Frolkina Olga Alexandrovna, Assistent at the Departament of Preventive and Pediatric Dentistry</p><p>Tyumen</p></bio><email xlink:type="simple">frolkinaja@tyumsmu.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-8308-3728</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шипицина</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shipitsina</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шипицина Ангелина Владимировна, студентка 5 курса Института стоматологии</p><p>г. Тюмень</p></bio><bio xml:lang="en"><p>Shipitsina Angelina V., 5th-year student of the Institute of Dentistry</p><p>Tyumen</p></bio><email xlink:type="simple">a_shipitsina@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0614-5433</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Литвинова</surname><given-names>Н. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Litvinova</surname><given-names>N. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Литвинова Наталья Сергеевна, старший преподаватель кафедры биологии Института фундаментальной медицины</p><p>г. Тюмень</p></bio><bio xml:lang="en"><p>Litvinova Natalia S., Senior Lecturer, Department of Biology, Institute of Fundamental Medicine</p><p>Tyumen</p></bio><email xlink:type="simple">nlitvinova512@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-8459-7226</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новоселова</surname><given-names>А. Я.</given-names></name><name name-style="western" xml:lang="en"><surname>Novoselova</surname><given-names>A. Ya.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Новоселова Анна Яновна, ассистент кафедры медицинской деонтологии с сетевой секцией биоэтики ЮНЕСКО</p><p>г. Тюмень</p></bio><bio xml:lang="en"><p>Novoselova Anna Y., Assistant, Department of Medical Deontology with UNESCO Bioethics Network Section</p><p>Tyumen</p></bio><email xlink:type="simple">brandtanna@bk.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1736-4084</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Суплотов</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Suplotov</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Суплотов Сергей Николаевич, д.м.н., профессор, заведующий кафедрой клинической лабораторной диагностики</p><p>г. Тюмень</p></bio><bio xml:lang="en"><p>Suplotov Sergey Nikolaevich, MD, Professor, Head of the Department of Clinical Laboratory Diagnostics</p><p>Tyumen</p></bio><email xlink:type="simple">suplotov@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Тюменский государственный медицинский университет Минздрава России»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Tyumen State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2025</year></pub-date><pub-date pub-type="epub"><day>03</day><month>03</month><year>2025</year></pub-date><volume>0</volume><issue>1</issue><issue-title>Стоматология (1)</issue-title><fpage>67</fpage><lpage>70</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Болдырева Ю.В., Лебедев И.А., Лебедев С.Н., Куман О.А., Корнеева М.В., Фролкина О.А., Шипицина А.В., Литвинова Н.С., Новоселова А.Я., Суплотов С.Н., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Болдырева Ю.В., Лебедев И.А., Лебедев С.Н., Куман О.А., Корнеева М.В., Фролкина О.А., Шипицина А.В., Литвинова Н.С., Новоселова А.Я., Суплотов С.Н.</copyright-holder><copyright-holder xml:lang="en">Boldyreva Y.V., Lebedev I.A., Lebedev S.N., Kuman O.A., Korneeva M.V., Frolkina O.A., Shipitsina A.V., Litvinova N.S., Novoselova A.Y., Suplotov S.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/4198">https://www.med-alphabet.com/jour/article/view/4198</self-uri><abstract><p>Кариес является наиболее распространенным заболеванием во всем мире (95%), несмотря на пропаганду и комплексной профилактике стоматологических заболеваний, введение фтора в различных формах и высокую степень информированности населения. Новой перспективой для остановки разрушения эмали являются средства, содержащие олигопептиды (ОП). ОП – это органические молекулы, состоящие из небольшого числа остатков аминокислот, соединенных пептидными связями, которые нашли широкое применение в медицинской практике. Одним из представителей является синтетический, рН контролируемый, самоорганизующийся пептид P11-4 (INCI name Oligopeptide 104), используемый для биомиметической минерализации, в том числе, для регенерации эмали. Поскольку P11-4 способствует образованию кристаллов гидроксиапатита de novo глубоко внутри и по всей площади очага кариозного поражения, то применение данного средства в стоматологии можно рассматривать, как новый, эффективный и неинвазивный вариант лечения кариеса эмали при отсутствии кариозной полости.</p></abstract><trans-abstract xml:lang="en"><p>Caries is the most common disease worldwide (95%), despite the promotion and comprehensive prevention of dental diseases, the introduction of ﬂuoride in various forms and a high level of public awareness. A new prospect for stopping the destruction of enamel are products containing oligopeptides (OP). OP are organic molecules consisting of a small number of amino acid residues connected by peptide bonds, which have found wide application in medical practice. One of the representatives is the synthetic, pH-controlled, self-organizing peptide P11-4 (INCI name Oligopeptide 104), used for biomimetic mineralization, including enamel regeneration. Since P11-4 promotes the formation of hydroxyapatite crystals de novo deep within and throughout the entire area of the carious lesion, the use of this agent in dentistry can be considered as a new, effective and non-invasive option for the treatment of enamel caries in the absence of a carious cavity.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>олигопептиды</kwd><kwd>кариес</kwd><kwd>самоорганизующийся пептид P11-4</kwd><kwd>реминерализация</kwd><kwd>слюна</kwd><kwd>эмаль</kwd><kwd>разрушение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>oligopeptides</kwd><kwd>caries</kwd><kwd>self-organizing peptide P11-4</kwd><kwd>remineralization</kwd><kwd>saliva</kwd><kwd>enamel</kwd><kwd>destruction</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Сабитова Р.И., Буляков Р.Т., Шакиров Д.Ф., Камилов Ф.Х. 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