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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2024-29-20-24</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-4042</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Минеральная плотность костной ткани и уровень мочевой кислоты у женщин в постменопаузе</article-title><trans-title-group xml:lang="en"><trans-title>Bone mineral density and uric acid level in postmenopausal women</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4739-4302</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Торопцова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Toroptsova</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Наталья Владимировна Торопцова, д. м. н., зав. лабораторией</p><p>лаборатория остеопороза</p><p>Москва</p><p>Researcher ID: I-9030-2017. Scopus Author ID: 6507457856</p></bio><bio xml:lang="en"><p>Natalia V. Toroptsova, DM Sci (habil.), head of the Laboratory</p><p>Osteoporosis Laboratory</p><p>Moscow</p><p>Researcher ID: I-9030-2017. Scopus Author ID: 6507457856</p></bio><email xlink:type="simple">torop@irramn.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2809-0197</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Добровольская</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Dobrovolskaya</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ольга Валерьевна Добровольская,  к. м. н., н. с.</p><p>лаборатория остеопороза</p><p>Москва</p><p>Researcher ID: AAF-2921-2021. Scopus Author ID: 57197823569</p></bio><bio xml:lang="en"><p>Olga V. Dobrovolskaya, PhD Med, researcher</p><p>Osteoporosis Laboratory</p><p>Moscow</p><p>Researcher ID: AAF-2921-2021. Scopus Author ID: 57197823569</p></bio><email xlink:type="simple">olgavdobr@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0560-3495</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Козырева</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kozyreva</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мария Витальевна Козырева, м. н. с.</p><p>лаборатория остеопороза</p><p>Москва</p><p>Researcher ID: HHZ-3451-2022</p></bio><bio xml:lang="en"><p>Maria V. Kozyreva, junior researcher</p><p>Osteoporosis Laboratory</p><p>Moscow</p><p>Researcher ID: HHZ-3451-2022</p></bio><email xlink:type="simple">epid@irramn.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0961-9785</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Демин</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Demin</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Николай Викторович Демин, м. н. с.</p><p>лаборатория остеопороза</p><p>Москва</p><p>Researcher ID: AAF-3400-2021. Scopus Author ID: 7006802179</p></bio><bio xml:lang="en"><p>Nikolay V. Demin, junior researcher</p><p>Osteoporosis Laboratory</p><p>Moscow</p><p>Researcher ID: AAF-3400-2021. Scopus Author ID: 7006802179</p></bio><email xlink:type="simple">epid@irramn.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБНУ «Научно-исследовательский институт ревматологии им. В. А. Насоновой»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>V. A. Nasonova Research Institute of Rheumatology</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>11</day><month>12</month><year>2024</year></pub-date><volume>0</volume><issue>29</issue><issue-title>Ревматология в общей врачебной практике (2)</issue-title><fpage>20</fpage><lpage>24</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Торопцова Н.В., Добровольская О.В., Козырева М.В., Демин Н.В., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Торопцова Н.В., Добровольская О.В., Козырева М.В., Демин Н.В.</copyright-holder><copyright-holder xml:lang="en">Toroptsova N.V., Dobrovolskaya O.V., Kozyreva M.V., Demin N.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/4042">https://www.med-alphabet.com/jour/article/view/4042</self-uri><abstract><sec><title>   Цель исследования</title><p>   Цель исследования: изучить взаимосвязь между минеральной плотностью кости (МПК) и уровнем мочевой кислоты (МК) у женщин в постменопаузе.</p></sec><sec><title>   Материалы и методы</title><p>   Материалы и методы. Обследованы 263 женщины (медиана возраста 62 [56; 67] года). Проведено клиническое обследование, биохимический анализ крови для определения МК и двухэнергетическая рентгеновская денситометрия для оценки МПК в стандартных областях измерения (поясничный отдел позвоночника – L1-L4, шейка бедра – ШБ и проксимальный отдел бедра – ПОБ) и трабекулярного костного индекса (ТКИ).</p></sec><sec><title>   Результаты</title><p>   Результаты. Частота гиперурикемии у женщин в постменопаузе составила 12,5 %, а у лиц с остеопорозом (ОП) – 10,1 %. МК значимо коррелировала с МПК и Т-критерием в L1-L4 (r = 0,20 и r = 0,19 соответственно) и в ПОБ (r = 0,18 и r = 0,16 соответственно). Корреляция между МК и величиной ТКИ не выявлена (p &gt; 0,05). Линейный регрессионный анализ с поправкой на возраст показал значимую взаимосвязь между МК и МПК во всех областях измерения (b*L1-L4 = 0,21, р = 0,001; b*ШБ = 0,14, р = 0,024; b*ПОБ = 0,20, р = 0,002). У женщин с МК ≥200 мкмоль/л МПК и Т-критерий во всех областях измерения были значимо больше, а частота ОП – меньше по сравнению с лицами с уровнем МК &lt; 200 мкмоль/л (р &lt; 0,05 во всех случаях).</p></sec><sec><title>   Заключение</title><p>   Заключение. Гиперурикемия встречалась у 12,5 % женщин в постменопаузе, а у пациенток с ОП – в 10,1 % случаев. Выявлены значимые различия в величине МПК, Т-критерия и доли лиц с ОП во всех областях измерения в зависимости от уровня МК. Средняя величина ТКИ и частота выявления деградированной микроархитектоники трабекулярной кости не различались в зависимости от уровня МК.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>   Aim</title><p>   Aim: to study the association between bone mineral density (BMD) and uric acid (UA) level in postmenopausal women.</p></sec><sec><title>   Materials and methods</title><p>   Materials and methods. 263 women were examined (median age 62 [56; 67] years). A clinical examination and assessment of UA level were performed. Dual-energy X-ray absorptiometry was done to assess BMD in standard regions of interest (ROI): lumbar spine (L1-L4), femoral neck (FB) and total hip (TH) and trabecular bone score (TBS).</p></sec><sec><title>   Results</title><p>   Results. The frequency of hyperuricemia in postmenopausal women was 12.5 %, and in persons with osteoporosis (OP) – 10.1 %. UA correlated significantly with BMD and T-score in L1-L4 (r = 0.20 and r = 0.19, respectively) and TH (r = 0.18 and r = 0.16, respectively). No correlation was found between UA and TBS value (p &gt; 0.05). Linear regression analysis adjusted for age showed a significant association between UA and BMD in all ROI (b*L1-L4 = 0.21, p = 0.001; b*FN = 0.14, p = 0.024; b*TH = 0.20, p = 0.002). In women with UA level ≥ 200 mmol/l, the BMD and T-score in all ROI were significantly higher, and the frequency of OP was lower compared with women with UA &lt; 200 mmol/l (p &lt; 0.05 for all comparison).</p></sec><sec><title>   Conclusion</title><p>   Conclusion. Hyperuricemia was found in 12.5 % of postmenopausal women, and in 10.1 % of patients with OP. Significant differences in BMD, T-score, and OP frequency were found in all ROI, depending on the UA level. The mean value of TBS and the frequency of degraded bone microarchitecture did not differ depending on the UA level.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>минеральная плотность кости</kwd><kwd>остеопороз</kwd><kwd>мочевая кислота</kwd><kwd>гиперурикемия</kwd><kwd>трабекулярный костный индекс</kwd></kwd-group><kwd-group xml:lang="en"><kwd>bone mineral density</kwd><kwd>osteoporosis</kwd><kwd>uric acid</kwd><kwd>hyperuricemia</kwd><kwd>trabecular bone score</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Исследование выполнено в рамках поисковой научной темы ФГБНУ «Научно-исследовательский институт ревматологии им. В. А. Насоновой» (регистрационный номер 123041800013-3)</funding-statement><funding-statement xml:lang="en">The study was carried out within the framework of the exploratory scientific topic of V. A. Nasonova Research Institute of Rheumatology (registration number 123041800013–3)</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kanis JA. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report. WHO Study Group. Osteoporos Int. 1994; 4 (6): 368–381. DOI: 10.1007/BF01622200</mixed-citation><mixed-citation xml:lang="en">Kanis JA. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report. WHO Study Group. Osteoporos Int. 1994; 4 (6): 368–381. DOI: 10.1007/BF01622200</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Eurasia Osteoporosis Audit – 2020. URL: https://www.osteoporosis.foundation/sites/iofbonehealth/files/2020–09/Audit_Osteop_Eurasia_2020.pdf (дата обращения: 11. 09. 2024).</mixed-citation><mixed-citation xml:lang="en">Eurasia Osteoporosis Audit – 2020. URL: https://www.osteoporosis.foundation/sites/iofbonehealth/files/2020–09/Audit_Osteop_Eurasia_2020.pdf (date of application: 11. 09. 2024).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Agidigbi TS, Kim C. Reactive Oxygen Species in Osteoclast Differentiation and Possible Pharmaceutical Targets of ROS-Mediated Osteoclast Diseases. Int J. Mol. Sci. 2019; 20 (14): 3576. doi: 10.3390/ijms20143576 (дата обращения: 11. 09. 2024). DOI: 10.3390/ijms20143576</mixed-citation><mixed-citation xml:lang="en">Agidigbi TS, Kim C. Reactive Oxygen Species in Osteoclast Differentiation and Possible Pharmaceutical Targets of ROS-Mediated Osteoclast Diseases. Int J. Mol. Sci. 2019; 20 (14): 3576. doi: 10.3390/ijms20143576 (date of application: 11. 09. 2024). DOI: 10.3390/ijms20143576</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Domazetovic V, Marcucci G, Iantomasi T, Brandi ML, Vincenzini MT. Oxidative stress in bone remodeling: role of antioxidants. Clin Cases Miner Bone Metab. 2017; 14 (2): 209–216. DOI: 10.11138/ccmbm/2017.14.1.209</mixed-citation><mixed-citation xml:lang="en">Domazetovic V, Marcucci G, Iantomasi T, Brandi ML, Vincenzini MT. Oxidative stress in bone remodeling: role of antioxidants. Clin Cases Miner Bone Metab. 2017; 14 (2): 209–216. DOI: 10.11138/ccmbm/2017.14.1.209</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Kaushal N, Vohora D, Jalali RK, Jha S. Review of the Literature Examining the Association of Serum Uric Acid with Osteoporosis and Mechanistic Insights into Its Effect on Bone Metabolism. Endocr Metab Immune Disord Drug Targets. 2019; 19 (3): 259–273. DOI: 10.2174/1871530318666181102115106</mixed-citation><mixed-citation xml:lang="en">Kaushal N, Vohora D, Jalali RK, Jha S. Review of the Literature Examining the Association of Serum Uric Acid with Osteoporosis and Mechanistic Insights into Its Effect on Bone Metabolism. Endocr Metab Immune Disord Drug Targets. 2019; 19 (3): 259–273. DOI: 10.2174/1871530318666181102115106</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Lin KM, Lu CL, Hung KC, Wu PC, Pan CF, Wu CJ, et al. The Paradoxical Role of Uric Acid in Osteoporosis. Nutrients. 2019; 11 (9): 2111. Published 2019 Sep 5. DOI: 10.3390/nu11092111</mixed-citation><mixed-citation xml:lang="en">Lin KM, Lu CL, Hung KC, Wu PC, Pan CF, Wu CJ, et al. The Paradoxical Role of Uric Acid in Osteoporosis. Nutrients. 2019; 11 (9): 2111. Published 2019 Sep 5. DOI: 10.3390/nu11092111</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Chen F, Wang Y, Guo Y, Wang J, Yang A, Lv Q. et al. Specific higher levels of serum uric acid might have a protective effect on bone mineral density within a Chinese population over 60 years old: a cross-sectional study from northeast China. Clin Interv Aging. 2019; 14: 1065–1073. DOI: 10.2147/CIA.S186500</mixed-citation><mixed-citation xml:lang="en">Chen F, Wang Y, Guo Y, Wang J, Yang A, Lv Q. et al. Specific higher levels of serum uric acid might have a protective effect on bone mineral density within a Chinese population over 60 years old: a cross-sectional study from northeast China. Clin Interv Aging. 2019; 14: 1065–1073. DOI: 10.2147/CIA.S186500</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Chung PT, Ma HC, Huang SY, Lien HN, Ho KH, Hsu HY, et al. Association between Serum Uric Acid Levels and Bone Mineral Density in Taiwanese Elderly Population. Int J Environ Res Public Health. 2023; 20 (4): 3448. Published 2023 Feb 16. DOI: 10.3390/ijerph20043448</mixed-citation><mixed-citation xml:lang="en">Chung PT, Ma HC, Huang SY, Lien HN, Ho KH, Hsu HY, et al. Association between Serum Uric Acid Levels and Bone Mineral Density in Taiwanese Elderly Population. Int J Environ Res Public Health. 2023; 20 (4): 3448. Published 2023 Feb 16. DOI: 10.3390/ijerph20043448</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Li X, Li L, Yang L, Yang J, Lu H. No association between serum uric acid and lumbar spine bone mineral density in US adult males: a cross sectional study. Sci Rep. 2021; 11 (1): 15588. URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC 8329127 (дата обращения: 11. 09. 2024). DOI: 10.1038/s41598-021-95207-z</mixed-citation><mixed-citation xml:lang="en">Li X, Li L, Yang L, Yang J, Lu H. No association between serum uric acid and lumbar spine bone mineral density in US adult males: a cross sectional study. Sci Rep. 2021; 11 (1): 15588. URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC 8329127 (дата обращения: 11. 09. 2024). DOI: 10.1038/s41598-021-95207-z</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Han W, Bai X, Wang N, Han L, Sun X, Chen X. Association between lumbar bone mineral density and serum uric acid in postmenopausal women: a cross-sectional study of healthy Chinese population. Arch Osteoporos. 2017; 12 (1): 50. DOI: 10.1007/s11657-017-0345-0</mixed-citation><mixed-citation xml:lang="en">Han W, Bai X, Wang N, Han L, Sun X, Chen X. Association between lumbar bone mineral density and serum uric acid in postmenopausal women: a cross-sectional study of healthy Chinese population. Arch Osteoporos. 2017; 12 (1): 50. DOI: 10.1007/s11657-017-0345-0</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Bonaccorsi G, Trentini A, Greco P, Tisato V, Gemmati D, Bianchi N. et al. Changes in Adipose Tissue Distribution and Association between Uric Acid and Bone Health during Menopause Transition. Int J. Mol. Sci. 2019; 20 (24): 6321. URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC 6941025 (дата обращения: 11. 09. 2024). DOI: 10.3390/ijms20246321</mixed-citation><mixed-citation xml:lang="en">Bonaccorsi G, Trentini A, Greco P, Tisato V, Gemmati D, Bianchi N. et al. Changes in Adipose Tissue Distribution and Association between Uric Acid and Bone Health during Menopause Transition. Int J. Mol. Sci. 2019; 20 (24): 6321. URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC 6941025 (дата обращения: 11. 09. 2024). DOI: 10.3390/ijms20246321</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">McCloskey EV, Odén A, Harvey NC, Leslie WD, Hans D, Johansson H, et al. A Meta-Analysis of Trabecular Bone Score in Fracture Risk Prediction and Its Relationship to FRAX. J. Bone Miner Res. 2016; 31 (5): 940–948. DOI: 10.1002/jbmr.2734</mixed-citation><mixed-citation xml:lang="en">McCloskey EV, Odén A, Harvey NC, Leslie WD, Hans D, Johansson H, et al. A Meta-Analysis of Trabecular Bone Score in Fracture Risk Prediction and Its Relationship to FRAX. J. Bone Miner Res. 2016; 31 (5): 940–948. DOI: 10.1002/jbmr.2734</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Kang S, Kwon D, Lee J, Chung YJ, Kim MR. et al. Association between Serum Uric Acid Levels and Bone Mineral Density in Postmenopausal Women: A Cross-Sectional and Longitudinal Study. Healthcare (Basel). 2021; 9 (12): 1681. DOI: 10.3390/healthcare9121681</mixed-citation><mixed-citation xml:lang="en">Kang S, Kwon D, Lee J, Chung YJ, Kim MR. et al. Association between Serum Uric Acid Levels and Bone Mineral Density in Postmenopausal Women: A Cross-Sectional and Longitudinal Study. Healthcare (Basel). 2021; 9 (12): 1681. DOI: 10.3390/healthcare9121681</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Zhao X, Yu X, Zhang X. Association between Uric Acid and Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes Mellitus in China: A Cross-Sectional Inpatient Study. J. Diabetes Res. 2020; 2020: 3982831. DOI: 10.1155/2020/3982831</mixed-citation><mixed-citation xml:lang="en">Zhao X, Yu X, Zhang X. Association between Uric Acid and Bone Mineral Density in Postmenopausal Women with Type 2 Diabetes Mellitus in China: A Cross-Sectional Inpatient Study. J. Diabetes Res. 2020; 2020: 3982831. DOI: 10.1155/2020/3982831</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Ibrahim WN, Younes N, Shi Z, Abu-Madi MA. Serum Uric Acid Level is Positively Associated with Higher Bone Mineral Density at Multiple Skeletal Sites Among Healthy Qataris. Front Endocrinol (Lausanne). 2021; 12: 653685. DOI: 10.3389/fendo.2021.653685</mixed-citation><mixed-citation xml:lang="en">Ibrahim WN, Younes N, Shi Z, Abu-Madi MA. Serum Uric Acid Level is Positively Associated with Higher Bone Mineral Density at Multiple Skeletal Sites Among Healthy Qataris. Front Endocrinol (Lausanne). 2021; 12: 653685. DOI: 10.3389/fendo.2021.653685</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Muka T, de Jonge EA, Kiefte-de Jong JC, Uitterlinden AG, Hofman A, et al. The Influence of Serum Uric Acid on Bone Mineral Density, Hip Geometry, and Fracture Risk: The Rotterdam Study. J. Clin. Endocrinol Metab. 2016; 101 (3): 1113–1122. DOI: 10.1210/jc.2015–2446</mixed-citation><mixed-citation xml:lang="en">Muka T, de Jonge EA, Kiefte-de Jong JC, Uitterlinden AG, Hofman A, et al. The Influence of Serum Uric Acid on Bone Mineral Density, Hip Geometry, and Fracture Risk: The Rotterdam Study. J. Clin. Endocrinol Metab. 2016; 101 (3): 1113–1122. DOI: 10.1210/jc.2015–2446</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Veronese N, Carraro S, Bano G, Trevisan C, Solmi M. et al. Hyperuricemia protects against low bone mineral density, osteoporosis and fractures : a systematic review and meta-analysis. Eur. J. Clin. Invest. 2016; 46 (11): 920–930. DOI: 10.1111/eci.12677</mixed-citation><mixed-citation xml:lang="en">Veronese N, Carraro S, Bano G, Trevisan C, Solmi M. et al. Hyperuricemia protects against low bone mineral density, osteoporosis and fractures : a systematic review and meta-analysis. Eur. J. Clin. Invest. 2016; 46 (11): 920–930. DOI: 10.1111/eci.12677</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
