medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2024-29-13-18medalphabet-4037Research ArticleСтатьиБиологически активные добавки при подагре: возможности и перспективыBiologically active additives in gout: opportunities and perspectiveshttps://orcid.org/0000-0002-5394-7869ЖелябинаО. В.ShelyabinaO. V.

Ольга Владимировна Желябина, м. н. с.

лаборатория микрокристаллических артритов

Москва

Olga V. Shelyabina, junior researcher

Laboratory of Micrcrystalline Arthritis

Moscow

olga-sheliabina@mail.ruhttps://orcid.org/0000-0003-1191-5831ЕлисеевМ. С.EliseevM. S.

Максим Сергеевич Елисеев, к. м. н., зав. лабораторией

лаборатория микрокристаллических артритов

Москва

Maxim S. Eliseev, PhD Med, head of the Laboratory

Laboratory of Micrcrystalline Arthritis

Moscow

elicmax@yandex.ruФГБНУ «Научно-исследовательский институт ревматологии им В. А. Насоновой»РоссияV. A. Nasonova Research Institute of RheumatologyRussian Federation202410122024029Ревматология в общей врачебной практике (2)1318Copyright © Желябина О.В., Елисеев М.С., 20242024Желябина О.В., Елисеев М.С.Shelyabina O.V., Eliseev M.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/4037

   В последние годы наблюдается растущий интерес к использованию биологически активных добавок (БАД) в комплексной терапии подагры, что открывает новые горизонты для пациентов и врачей. Подагра, будучи метаболическим заболеванием, требует не только традиционных методов лекарственной терапии, но и дополнительных стратегий для управления уровнем мочевой кислоты (МК) в крови. БАД могут служить важным дополнением к существующей лекарственной терапии, позволяя снизить уровень урикемии, частоту обострений артрита и улучшить качество жизни пациентов. Исследования показывают, что компоненты БАД могут модулировать воспалительные реакции и оказывать мочегонное действие, что особенно актуально для пациентов с уратной нефропатией. Однако, несмотря на обнадеживающие результаты, необходимы дальнейшие клинические испытания для подтверждения их безопасности и эффективности. Важно отметить, что интеграция БАД в стандартную терапию требует тщательного анализа взаимодействий с другими препаратами. Мы находимся на пороге новой эры в лечении подагры, и БАД могут занять достойное место в этой трансформации.

   In recent years, there has been a growing interest in the use of biologically active additives (BAA) in the comprehensive management of gout, thereby opening new avenues for both patients and healthcare providers. Gout, as a metabolic disorder, necessitates not only traditional pharmacological interventions but also additional strategies for managing serum uric acid (SUA) levels. BAAs may serve as an important adjunct to existing medical therapies, enabling the reduction of hyperuricemia, the frequency of arthritis flare-ups, and the improvement of patients' quality of life. Research indicates that components of BAAs can modulate inflammatory responses and exhibit diuretic effects, which is particularly relevant for patients with urate nephropathy. However, despite promising results, further clinical trials are required to confirm their safety and efficacy. It is important to note that the integration of BAAs into standard therapy necessitates a careful analysis of interactions with other medications. We are on the brink of a new era in gout treatment, and BAAs may occupy a significant position in this transformation.

подаграбиологически активные добавкиБАДмочевая кислотаgoutbiologically active additivesdietary supplementshyperuricemiauric acidСтатья подготовлена в рамках научного государственного задания по теме № 123041800013–3The article was prepared as part of the state scientific task under topic No. 123041800013–3ReferencesНасонова В. А., Барскова В. Г. Ранние диагностика и лечение подагры – научно обоснованное требование улучшения трудового и жизненного прогноза больных. Научно-практическая ревматология. 2004; 1: 5–7. doi: 10.14412/1995-4484-2004-1374Nasonova V. A., Barskova V. G. Early diagnostic and treatment of gout – is scientifically based reguirements for improvement of labour and living prognosis of patients. Nauchno-Prakticheskaya Revmatologiya. 2004; 42 (1): 5–7. (In Russ.). doi: 10.14412/1995-4484-2004-1374Singh J. A., Gaffo A. Gout epidemiology and comorbidities. Semin Arthritis Rheum. 2020; 50 (3S): S 11–S 16. doi: 10.1016/j.semarthrit.2020.04.008Singh J. A., Gaffo A. Gout epidemiology and comorbidities. Semin Arthritis Rheum. 2020; 50 (3S): S 11–S 16. doi: 10.1016/j.semarthrit.2020.04.008Елисеев М. С. Классификационные критерии подагры (рекомендации ACR/EULAR). Научно-практическая ревматология. 2015; 53 (6): 581–5. doi: 10.14412/1995-4484-2015-581-585Eliseev M. S. Gout classification criteria (ACR/EULAR guidelines). Nauchno-Prakticheskaya Revmatologiya. 2015; 53 (6): 581–5 (In Russ.). doi: 10.14412/1995-4484-2015-581-585Chandratre P., Roddy E., Clarson L. et al. Health-related quality of life in gout : a systematic review. Rheumatology (Oxford). 2013; 52 (11): 2031–2040. doi: 10.1093/rheumatology/ket265Chandratre P., Roddy E., Clarson L. et al. Health-related quality of life in gout : a systematic review. Rheumatology (Oxford). 2013; 52 (11): 2031–2040. doi: 10.1093/rheumatology/ket265Чикина М. Н., Желябина О. В., Елисеев М. С. Влияние уратснижающей терапии на показатели качества жизни у пациентов с подагрой. Современная ревматология. 2021; 15 (3): 62–68. doi: 10.14412/1996-7012-2021-3-62-68Chikina M. N., Zhelyabina O.V., Eliseev M.S. Impact of urate-lowering therapy on quality of life indicators in patients with gout. Sovremennaya Revmatologiya. 2021; 15 (3): 62–68. (In Russ.). doi: 10.14412/1996-7012-2021-3-62-68Елисеев М. С. Комментарии к обновленным рекомендациям Американской коллегии ревматологов по лечению подагры. Уратснижающие препараты (часть 1). Современная ревматология. 2020; 14 (3): 117–124. doi: 10.14412/1996-7012-2020-3-117-124Eliseev M. S. Commentaries on the updated American College of Rheumatology guidelines for the management of gout. Urate-lowering drugs (Part 1). Sovremennaya Revmatologiya. 2020; 14 (3): 117–124. (In Russ.). doi: 10.14412/1996-7012-2020-3-117-124Yokose C., McCormick N., Choi H. K. Dietary and Lifestyle-Centered Approach in Gout Care and Prevention. Curr Rheumatol Rep. 2021; 23 (7): 51. Published 2021 Jul 1. doi: 10.1007/s11926–021–01020-yYokose C., McCormick N., Choi H. K. Dietary and Lifestyle-Centered Approach in Gout Care and Prevention. Curr Rheumatol Rep. 2021; 23 (7): 51. Published 2021 Jul 1. doi: 10.1007/s11926–021–01020-yMahomoodally M. F., Coodian K., Hosenally M. et al. Herbal remedies in the management of hyperuricemia and gout: A review of in vitro, in vivo and clinical evidences. Phytother Res. 2024; 38 (7): 3370–3400. doi: 10.1002/ptr.8211Mahomoodally M. F., Coodian K., Hosenally M. et al. Herbal remedies in the management of hyperuricemia and gout: A review of in vitro, in vivo and clinical evidences. Phytother Res. 2024; 38 (7): 3370–3400. doi: 10.1002/ptr.8211Chai S. C., Davis K., Zhang Z. et al. Effects of Tart Cherry Juice on Biomarkers of Inflammation and Oxidative Stress in Older Adults. Nutrients. 2019; 11 (2): 228. Published 2019 Jan 22. doi: 10.3390/nu11020228Chai S. C., Davis K., Zhang Z. et al. Effects of Tart Cherry Juice on Biomarkers of Inflammation and Oxidative Stress in Older Adults. Nutrients. 2019; 11 (2): 228. Published 2019 Jan 22. doi: 10.3390/nu11020228Елисеев М. С., Желябина О. В. Влияние продуктов растительного происхождения на уровень мочевой кислоты : обзор литературы. Терапия. 2017; 4 (14): 52–58.Eliseev M. S., Zhelyabina O. V. The impact of plant-based products on uric acid levels : a literature review. Therapy. 2017; 4 (14): 52–58. (In Russ.).Andrés M., Sivera F., Buchbinder R. et al. Dietary supplements for chronic gout. Cochrane Database Syst Rev. 2021; 11 (11): CD 010156. Published 2021 Nov 12. doi: 10.1002/14651858.CD010156.pub3Andrés M., Sivera F., Buchbinder R. et al. Dietary supplements for chronic gout. Cochrane Database Syst Rev. 2021; 11 (11): CD 010156. Published 2021 Nov 12. doi: 10.1002/14651858.CD010156.pub3Yang J., Li G., Xiong D., Chon T. Y., Bauer B. A. The Impact of Natural Product Dietary Supplements on Patients with Gout: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Evid Based Complement Alternat Med. 2020; 2020: 7976130. Published 2020 Jan 23. doi: 10.1155/2020/7976130Yang J., Li G., Xiong D., Chon T. Y., Bauer B. A. The Impact of Natural Product Dietary Supplements on Patients with Gout: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Evid Based Complement Alternat Med. 2020; 2020: 7976130. Published 2020 Jan 23. doi: 10.1155/2020/7976130Hertzler SR, Lieblein-Boff JC, Weiler M, Allgeier C. Plant Proteins: Assessing Their Nutritional Quality and Effects on Health and Physical Function. Nutrients. 2020;12(12):3704. Published 2020 Nov 30. doi: 10.3390/nu12123704Hertzler SR, Lieblein-Boff JC, Weiler M, Allgeier C. Plant Proteins: Assessing Their Nutritional Quality and Effects on Health and Physical Function. Nutrients. 2020;12(12):3704. Published 2020 Nov 30. doi: 10.3390/nu12123704Kumar A., Mosa K. A., Ji L. Y. et al. Metabolomics assisted biotechnological interventions for developing plant-based functional foods and nutraceuticals. Crit. Rev. Food. Sci. Nutr. 2018; 58: 1791–1807. doi: 10.1080/10408398.2017.1285752Kumar A., Mosa K. A., Ji L. Y. et al. Metabolomics assisted biotechnological interventions for developing plant-based functional foods and nutraceuticals. Crit. Rev. Food. Sci. Nutr. 2018; 58: 1791–1807. doi: 10.1080/10408398.2017.1285752Ji M. Y., Bo A., Yang M. et al. The pharmacological effects and health benefits of Platycodon grandiflorus – A medicine food homology species. Foods. 2020; 9: 142. doi: 10.3390/foods9020142Ji M. Y., Bo A., Yang M. et al. The pharmacological effects and health benefits of Platycodon grandiflorus – A medicine food homology species. Foods. 2020; 9: 142. doi: 10.3390/foods9020142Gong X., Ji M. Y., Xu J. P. et al. Hypoglycemic effects of bioactive ingredients from medicine food homology and medicinal health food species used in China. Crit. Rev. Food Sci. Nutr. 2019: 1–24. doi: 10.1080/10408398.2019.1634517Gong X., Ji M. Y., Xu J. P. et al. Hypoglycemic effects of bioactive ingredients from medicine food homology and medicinal health food species used in China. Crit. Rev. Food Sci. Nutr. 2019: 1–24. doi: 10.1080/10408398.2019.1634517Mehmood A., Zhao L., Wang C. T. et al. Management of hyperuricemia through dietary polyphenols as a natural medicament : A comprehensive review. Crit. Rev. Food Sci. 2019; 59: 1433–1455. doi: 10.1080/10408398.2017.1412939Mehmood A., Zhao L., Wang C. T. et al. Management of hyperuricemia through dietary polyphenols as a natural medicament : A comprehensive review. Crit. Rev. Food Sci. 2019; 59: 1433–1455. doi: 10.1080/10408398.2017.1412939Ji M. Y., Gong X., Li X. et al. Advanced research on the antioxidant activity and mechanism of polyphenols from Hippophae Species – A Review. Molecules. 2020; 25: 917. doi: 10.3390/molecules25040917Ji M. Y., Gong X., Li X. et al. Advanced research on the antioxidant activity and mechanism of polyphenols from Hippophae Species – A Review. Molecules. 2020; 25: 917. doi: 10.3390/molecules25040917Chen L., Li M., Wu J. L. et al. Effect of lemon water soluble extract on hyperuricemia in mouse model. Food Funct. 2019; 10: 6000–6008. doi: 10.1039/C9FO00509AChen L., Li M., Wu J. L. et al. Effect of lemon water soluble extract on hyperuricemia in mouse model. Food Funct. 2019; 10: 6000–6008. doi: 10.1039/C9FO00509AKapinova A., Stefanicka P., Kubatka P. et al. Are plant-based functional foods better choice against cancer than single phytochemicals? A critical review of current breast cancer research. Biomed. Pharmacother. 2017; 96: 1465–1477. doi: 10.1016/j.biopha.2017.11.134Kapinova A., Stefanicka P., Kubatka P. et al. Are plant-based functional foods better choice against cancer than single phytochemicals? A critical review of current breast cancer research. Biomed. Pharmacother. 2017; 96: 1465–1477. doi: 10.1016/j.biopha.2017.11.134Han S., Wei R. H., Han D. et al. Hypouricemic effects of extracts from Urtica hyperborea Jacq. ex Wedd. in hyperuricemia mice through XOD, URAT1, and OAT1. BioMed Res. Int. 2020; 2020: 1–8. doi: 10.1155/2020/2968135Han S., Wei R. H., Han D. et al. Hypouricemic effects of extracts from Urtica hyperborea Jacq. ex Wedd. in hyperuricemia mice through XOD, URAT1, and OAT1. BioMed Res. Int. 2020; 2020: 1–8. doi: 10.1155/2020/2968135Liu X. R., Huang S. S., Xu W. D. et al. Association of dietary patterns and hyperuricemia: A cross-sectional study of the Yi ethnic group in China. Food Nutr. Res. 2018; 62: 1380. doi: 10.29219/fnr.v62.1380Liu X. R., Huang S. S., Xu W. D. et al. Association of dietary patterns and hyperuricemia: A cross-sectional study of the Yi ethnic group in China. Food Nutr. Res. 2018; 62: 1380. doi: 10.29219/fnr.v62.1380Li R. R., Yu K., Li C. W. Dietary factors and risk of gout and hyperuricemia : A meta-analysis and systematic review. Asia. Pac. J. Clin. Nutr. 2018; 27: 1344–1356. doi: 10.1007/s10067-013-2319-yLi R. R., Yu K., Li C. W. Dietary factors and risk of gout and hyperuricemia : A meta-analysis and systematic review. Asia. Pac. J. Clin. Nutr. 2018; 27: 1344–1356. doi: 10.1007/s10067-013-2319-yRistic B., Sikder M. O.F., Bhutia Y. D., Ganapathy V. Pharmacologic inducers of the uric acid exporter ABCG2 as potential drugs for treatment of gouty arthritis. Asian J. Pharm. Sci. 2020; 15: 173–180. doi: 10.1016/j.ajps.2019.10.002Ristic B., Sikder M. O.F., Bhutia Y. D., Ganapathy V. Pharmacologic inducers of the uric acid exporter ABCG2 as potential drugs for treatment of gouty arthritis. Asian J. Pharm. Sci. 2020; 15: 173–180. doi: 10.1016/j.ajps.2019.10.002Xu L. Q., Shi Y. F., Zhuang S. G., Liu N. Recent advances on uric acid transporters. Oncotarget. 2017; 8: 100852–100862. doi: 10.18632/oncotarget.20135Xu L. Q., Shi Y. F., Zhuang S. G., Liu N. Recent advances on uric acid transporters. Oncotarget. 2017; 8: 100852–100862. doi: 10.18632/oncotarget.20135Tan P. K., Liu S., Gunic E., Miner J. N. Discovery and characterization of verinurad, a potent and specific inhibitor of URAT1 for the treatment of hyperuricemia and gout. Sci. Rep. 2017; 7: 665. doi: 10.1038/s41598-017-00706-7Tan P. K., Liu S., Gunic E., Miner J. N. Discovery and characterization of verinurad, a potent and specific inhibitor of URAT1 for the treatment of hyperuricemia and gout. Sci. Rep. 2017; 7: 665. doi: 10.1038/s41598-017-00706-7Jiang L. L., Gong X., Ji M. Y. et al. Bioactive Compounds from Plant-Based Functional Foods: A Promising Choice for the Prevention and Management of Hyperuricemia. Foods. 2020; 9 (8): 973. Published 2020 Jul 23. doi: 10.3390/foods9080973Jiang L. L., Gong X., Ji M. Y. et al. Bioactive Compounds from Plant-Based Functional Foods: A Promising Choice for the Prevention and Management of Hyperuricemia. Foods. 2020; 9 (8): 973. Published 2020 Jul 23. doi: 10.3390/foods9080973Patra J. C., Chua B. H. Artificial neural network-based drug design for diabetes mellitus using flavonoids. J. Comput. Chem. 2011; 32: 555–567. doi: 10.1002/jcc.21641Patra J. C., Chua B. H. Artificial neural network-based drug design for diabetes mellitus using flavonoids. J. Comput. Chem. 2011; 32: 555–567. doi: 10.1002/jcc.21641Lin S. Y., Zhang G. W., Liao Y. J., Pan J. H. Dietary flavonoids as xanthine oxidase inhibitors: Structure-Affinity and Structure-Activity relationships. J. Agric. Food Chem. 2015; 63: 7784–7794. doi: 10.1021/acs.jafc.5b03386Lin S. Y., Zhang G. W., Liao Y. J., Pan J. H. Dietary flavonoids as xanthine oxidase inhibitors: Structure-Affinity and Structure-Activity relationships. J. Agric. Food Chem. 2015; 63: 7784–7794. doi: 10.1021/acs.jafc.5b03386Lin C. M., Chen C. S., Chen C. T. et al. Molecular modeling of flavonoids that inhibits xanthine oxidase. Biochem. Biophys. Res. Commun. 2002; 294: 167–172. doi: 10.1016/S0006-291X(02)00442-4Lin C. M., Chen C. S., Chen C. T. et al. Molecular modeling of flavonoids that inhibits xanthine oxidase. Biochem. Biophys. Res. Commun. 2002; 294: 167–172. doi: 10.1016/S0006-291X(02)00442-4Cheng L. C., Murugaiyah V., Chan K. L. Flavonoids and phenylethanoid glycosides from Lippia nodiflora as promising antihyperuricemic agents and elucidation of their mechanism of action. J. Ethnopharmacol. 2015; 176: 485–493. doi: 10.1016/j.jep.2015.11.025Cheng L. C., Murugaiyah V., Chan K. L. Flavonoids and phenylethanoid glycosides from Lippia nodiflora as promising antihyperuricemic agents and elucidation of their mechanism of action. J. Ethnopharmacol. 2015; 176: 485–493. doi: 10.1016/j.jep.2015.11.025Montoro P., Braca A., Pizza C., De Tommasi N. Structure-antioxidant activity relationships of flavonoids isolated from different plant species. Food Chem. 2005; 92: 349–355. doi: 10.1016/j.foodchem.2004.07.028Montoro P., Braca A., Pizza C., De Tommasi N. Structure-antioxidant activity relationships of flavonoids isolated from different plant species. Food Chem. 2005; 92: 349–355. doi: 10.1016/j.foodchem.2004.07.028Wang C. P., Wang X., Zhang X. et al. Morin improves urate excretion and kidney function through regulation of renal organic ion transporters in hyperuricemic mice. J. Pharm. Pharm. Sci. 2010; 13: 411–427. doi: 10.18433/J3Q30HWang C. P., Wang X., Zhang X. et al. Morin improves urate excretion and kidney function through regulation of renal organic ion transporters in hyperuricemic mice. J. Pharm. Pharm. Sci. 2010; 13: 411–427. doi: 10.18433/J3Q30HSubawa I. W., Astawa P., Bakta I. M. et al. Purple sweet potato (Ipomoea batatas L.) extract effects on levels of inflammatory markers and chondrocyte count in gout arthritis Wistar rat model. Foot Ankle Surg. 2023; 29 (8): 611–615. doi: 10.1016/j.fas.2023.07.007Subawa I. W., Astawa P., Bakta I. M. et al. Purple sweet potato (Ipomoea batatas L.) extract effects on levels of inflammatory markers and chondrocyte count in gout arthritis Wistar rat model. Foot Ankle Surg. 2023; 29 (8): 611–615. doi: 10.1016/j.fas.2023.07.007Irondi E. A., Agboola S. O., Oboh G. et al. Guava leaves polyphenolics-rich extract inhibits vital enzymes implicated in gout and hypertension in vitro. J. Intercult. Ethnopharm. 2016; 5: 122–130. doi: 10.5455/jice.20160321115402Irondi E. A., Agboola S. O., Oboh G. et al. Guava leaves polyphenolics-rich extract inhibits vital enzymes implicated in gout and hypertension in vitro. J. Intercult. Ethnopharm. 2016; 5: 122–130. doi: 10.5455/jice.20160321115402González-Castejón M., Rodriguez-Casado A. Dietary phytochemicals and their potential effects on obesity : A review. Pharmacol. Res. 2011; 64: 438–455. doi: 10.1016/j.phrs.2011.07.004González-Castejón M., Rodriguez-Casado A. Dietary phytochemicals and their potential effects on obesity : A review. Pharmacol. Res. 2011; 64: 438–455. doi: 10.1016/j.phrs.2011.07.004Sang M. M., Du G. Y., Hao J. et al. Modeling and optimizing inhibitory activities of Nelumbinis folium extract on xanthine oxidase using response surface methodology. J. Pharm. Biomed. 2017; 139: 37–43. doi: 10.1016/j.jpba.2017.02.048Sang M. M., Du G. Y., Hao J. et al. Modeling and optimizing inhibitory activities of Nelumbinis folium extract on xanthine oxidase using response surface methodology. J. Pharm. Biomed. 2017; 139: 37–43. doi: 10.1016/j.jpba.2017.02.048Wang M. X., Liu Y. L., Yang Y. et al. Nuciferine restores potassium oxonate-induced hyperuricemia and kidney inflammation in mice. Eur. J. Pharmacol. 2015; 747: 59–70. doi: 10.1016/j.ejphar.2014.11.035Wang M. X., Liu Y. L., Yang Y. et al. Nuciferine restores potassium oxonate-induced hyperuricemia and kidney inflammation in mice. Eur. J. Pharmacol. 2015; 747: 59–70. doi: 10.1016/j.ejphar.2014.11.035Tao Z. Y., Cheng Y., Tang Y. et al. Effect of evodiamine on the animal model of Hyperuricemia. Pharm. Clin. Chin. Mater. Med. 2014; 5: 69–71.Tao Z. Y., Cheng Y., Tang Y. et al. Effect of evodiamine on the animal model of Hyperuricemia. Pharm. Clin. Chin. Mater. Med. 2014; 5: 69–71.Song Y., Li J., Cheng Y. et al. Lowering effect of evodiamine dispersible tablets on uric acid in chickens. Chin. J. New Drugs. 2015; 24: 1057–1060.Song Y., Li J., Cheng Y. et al. Lowering effect of evodiamine dispersible tablets on uric acid in chickens. Chin. J. New Drugs. 2015; 24: 1057–1060.Li P., Song Z. B., Chen M. M. et al. Research progress of therapeutic drug of hyperuricemia and its action target. China Mod. Med. 2018; 25: 16–19.Li P., Song Z. B., Chen M. M. et al. Research progress of therapeutic drug of hyperuricemia and its action target. China Mod. Med. 2018; 25: 16–19.Gong L. X., Chi J. W., Wang J. et al. Research progress on main functional component and action mechanism of Dioscorea opposita. Sci. Technol. Food Ind. 2019; 40: 312–319. doi: 10.13386/j.issn1002-0306.2019.16.052Gong L. X., Chi J. W., Wang J. et al. Research progress on main functional component and action mechanism of Dioscorea opposita. Sci. Technol. Food Ind. 2019; 40: 312–319. doi: 10.13386/j.issn1002-0306.2019.16.052Su J. X., Wei Y. H., Liu M. L. et al. Anti-hyperuricemic and nephroprotective effects of Rhizoma Dioscoreae septemlobae extracts and its main component dioscin via regulation of mOAT1, mURAT1 and mOCT2 in hypertensive mice. Arch. Pharm. Res. 2014; 37: 1336–1344. doi: 10.1007/s12272-014-0413-6Su J. X., Wei Y. H., Liu M. L. et al. Anti-hyperuricemic and nephroprotective effects of Rhizoma Dioscoreae septemlobae extracts and its main component dioscin via regulation of mOAT1, mURAT1 and mOCT2 in hypertensive mice. Arch. Pharm. Res. 2014; 37: 1336–1344. doi: 10.1007/s12272-014-0413-6Shi S., Wang N., Shang X. Y. et al. Effect of gypenoside on serum uric acid of hyperuricemic rats. Nat. Prod. Res. Dev. 2014; 26. doi: 10.16333/j.1001-6880.2014.08.028Shi S., Wang N., Shang X. Y. et al. Effect of gypenoside on serum uric acid of hyperuricemic rats. Nat. Prod. Res. Dev. 2014; 26. doi: 10.16333/j.1001-6880.2014.08.028Yang Q., Wang Q., Deng W. et al. Anti-hyperuricemic and anti-gouty arthritis activities of polysaccharide purified from Lonicera japonica in model rats. Int J. Biol. Macromol. 2019; 123: 801–809. doi: 10.1016/j.ijbiomac.2018.11.077/Yang Q., Wang Q., Deng W. et al. Anti-hyperuricemic and anti-gouty arthritis activities of polysaccharide purified from Lonicera japonica in model rats. Int J. Biol. Macromol. 2019; 123: 801–809. doi: 10.1016/j.ijbiomac.2018.11.077/Zhou J., Sun C., Li F. Research advances in mechanism of active components of traditional Chinese medicine for reducing uric acid. Chin. Pharmacol. Bull. 2018; 34: 19–22. doi: 10.3969/j.issn.1001-1978.2018.01.006Zhou J., Sun C., Li F. Research advances in mechanism of active components of traditional Chinese medicine for reducing uric acid. Chin. Pharmacol. Bull. 2018; 34: 19–22. doi: 10.3969/j.issn.1001-1978.2018.01.006Zeng J. X., Xu B. B., Wang J. et al. Hypouricemic effects of acteoside and isoacteoside from Plantaginis Semen on mice with acute hyperuricemia and their possible mechanisms. Chin. Tradit. Pat. Med. 2016; 38: 1449–1454. doi: 10.3969/j.issn.1001-1528.2016.07.003Zeng J. X., Xu B. B., Wang J. et al. Hypouricemic effects of acteoside and isoacteoside from Plantaginis Semen on mice with acute hyperuricemia and their possible mechanisms. Chin. Tradit. Pat. Med. 2016; 38: 1449–1454. doi: 10.3969/j.issn.1001-1528.2016.07.003Brzezińska O., Styrzyński F., Makowska J., Walczak K. Role of Vitamin C in Prophylaxis and Treatment of Gout-A Literature Review. Nutrients. 2021; 13 (2): 701. Published 2021 Feb 22. doi: 10.3390/nu13020701Brzezińska O., Styrzyński F., Makowska J., Walczak K. Role of Vitamin C in Prophylaxis and Treatment of Gout-A Literature Review. Nutrients. 2021; 13 (2): 701. Published 2021 Feb 22. doi: 10.3390/nu13020701Juraschek S. P., Gaziano J. M., Glynn R. J. et al. Effects of vitamin C supplementation on gout risk: results from the Physicians' Health Study II trial. Am. J. Clin. Nutr. 2022; 116 (3): 812–819. doi: 10.1093/ajcn/nqac140Juraschek S. P., Gaziano J. M., Glynn R. J. et al. Effects of vitamin C supplementation on gout risk: results from the Physicians' Health Study II trial. Am. J. Clin. Nutr. 2022; 116 (3): 812–819. doi: 10.1093/ajcn/nqac140Xie K. L., Li Z. H., Dong X. Z., Gong M. X. Research progress of quercetin on inhibiting the activity of xanthine oxidase. Lishizhen Med. Mater. Med. Res. 2019; 30: 2223-2225. doi: 10.3969/j.issn.1008-0805.2019.09.060Xie K. L., Li Z. H., Dong X. Z., Gong M. X. Research progress of quercetin on inhibiting the activity of xanthine oxidase. Lishizhen Med. Mater. Med. Res. 2019; 30: 2223-2225. doi: 10.3969/j.issn.1008-0805.2019.09.060Shi Y. L., Williamson G. Quercetin lowers plasma uric acid in pre-hyperuricaemic males: A randomised, double-blinded, placebo-controlled, cross-over trial. Brit. J. Nutr. 2016; 115: 800–806. doi: 10.1017/S0007114515005310Shi Y. L., Williamson G. Quercetin lowers plasma uric acid in pre-hyperuricaemic males: A randomised, double-blinded, placebo-controlled, cross-over trial. Brit. J. Nutr. 2016; 115: 800–806. doi: 10.1017/S0007114515005310Feng W., Zhong X. Q., Zheng X. X. et al. Study on the effect and mechanism of quercetin in treating gout arthritis. Int Immunopharmacol. 2022; 111: 109112. doi: 10.1016/j.intimp.2022.109112Feng W., Zhong X. Q., Zheng X. X. et al. Study on the effect and mechanism of quercetin in treating gout arthritis. Int Immunopharmacol. 2022; 111: 109112. doi: 10.1016/j.intimp.2022.109112Ruiz-Miyazawa K.W., Staurengo-Ferrari L., Mizokami S. S. et al. Quercetin inhibits gout arthritis in mice: induction of an opioid-dependent regulation of inflammasome. Inflammopharmacology. Published online May 15, 2017. doi: 10.1007/s10787-017-0356-xRuiz-Miyazawa K.W., Staurengo-Ferrari L., Mizokami S. S. et al. Quercetin inhibits gout arthritis in mice: induction of an opioid-dependent regulation of inflammasome. Inflammopharmacology. Published online May 15, 2017. doi: 10.1007/s10787-017-0356-xJafari-Nozad A.M., Jafari A., Yousefi S. et al. Anti-gout and Urate-lowering Potentials of Curcumin : A Review from Bench to Beside. Curr Med Chem. 2024; 31 (24): 3715–3732. doi: 10.2174/0929867331666230721154653Jafari-Nozad A.M., Jafari A., Yousefi S. et al. Anti-gout and Urate-lowering Potentials of Curcumin : A Review from Bench to Beside. Curr Med Chem. 2024; 31 (24): 3715–3732. doi: 10.2174/0929867331666230721154653McMullen M. K. Curcumin/Turmeric: Their Effect on Serum Uric Acid Remains Unknown. J. Diet. Suppl. 2021; 18 (6): 714–715. doi: 10.1080/19390211.2020.1811827McMullen M. K. Curcumin/Turmeric: Their Effect on Serum Uric Acid Remains Unknown. J. Diet. Suppl. 2021; 18 (6): 714–715. doi: 10.1080/19390211.2020.1811827Wang C., Sun W., Dalbeth N. et al. Efficacy and safety of tart cherry supplementary citrate mixture on gout patients: a prospective, randomized, controlled study. Arthritis Res Ther. 2023; 25 (1): 164. Published 2023 Sep 7. doi: 10.1186/s13075-023-03152-1Wang C., Sun W., Dalbeth N. et al. Efficacy and safety of tart cherry supplementary citrate mixture on gout patients: a prospective, randomized, controlled study. Arthritis Res Ther. 2023; 25 (1): 164. Published 2023 Sep 7. doi: 10.1186/s13075-023-03152-1Evidence reviews for diet and lifestyle modifications for managing gout: Gout: diagnosis and management. London: National Institute for Health and Care Excellence (NICE); June 2022.Evidence reviews for diet and lifestyle modifications for managing gout: Gout: diagnosis and management. London: National Institute for Health and Care Excellence (NICE); June 2022.Zhang M., Zhang Y., Terkeltaub R. et al. Effect of Dietary and Supplemental Omega-3 Polyunsaturated Fatty Acids on Risk of Recurrent Gout Flares. Arthritis Rheumatol. 2019; 71 (9): 1580–1586. doi: 10.1002/art.40896Zhang M., Zhang Y., Terkeltaub R. et al. Effect of Dietary and Supplemental Omega-3 Polyunsaturated Fatty Acids on Risk of Recurrent Gout Flares. Arthritis Rheumatol. 2019; 71 (9): 1580–1586. doi: 10.1002/art.40896Mason R. P., Sherratt S. C.R., Eckel R. H. Omega-3-fatty acids: Do they prevent cardiovascular disease? Best Pract Res Clin Endocrinol Metab. 2023; 37 (3): 101681. doi: 10.1016/j.beem.2022.101681Mason R. P., Sherratt S. C.R., Eckel R. H. Omega-3-fatty acids: Do they prevent cardiovascular disease? Best Pract Res Clin Endocrinol Metab. 2023; 37 (3): 101681. doi: 10.1016/j.beem.2022.101681Чабан Н. Г., Степанов А. Е., Рапопорт Л. М. и др. Фитохимические основы создания препаратов для литолиза оксалатных камней. Тонкие химические технологии. 2014; 9 (2): 37–45.Chaban N. G., Stepanov A. E., Rapoport L. M. et al. Phytochemical basics of development medications for the litholysis of oxalate stones. Tonkie khimicheskie tekhnologii. 2014; 9(2): 37–45. (In Russ.).Teixeira C. C., Cabral T. P., de Sousa J. P. et al. Study of Quality Assurance for Peumus Boldus M Products By Botanic Profiling, Extraction Optimization, HPLC Quantification And Antioxidant Assay. Pharmacognosy Journal 8 (3): 264–272. doi: 10.5530/pj.2016.3.16Teixeira C. C., Cabral T. P., de Sousa J. P. et al. Study of Quality Assurance for Peumus Boldus M Products By Botanic Profiling, Extraction Optimization, HPLC Quantification And Antioxidant Assay. Pharmacognosy Journal 8 (3): 264–272. doi: 10.5530/pj.2016.3.16Vinholes J., Grosso C., Andrade P. B. et al. In vitro studies to assess the antidiabetic, anti-cholinesterase and antioxidant potential of Spergularia rubra. Food Chem. 2011; 129 (2): 454–462. doi: 10.1016/j.foodchem.2011.04.098Vinholes J., Grosso C., Andrade P. B. et al. In vitro studies to assess the antidiabetic, anti-cholinesterase and antioxidant potential of Spergularia rubra. Food Chem. 2011; 129 (2): 454–462. doi: 10.1016/j.foodchem.2011.04.098Liu Z., Kong H., Zhang B. Narrative literature review of antidiabetic drugs' effect on hyperuricemia: elaborating actual data and mechanisms. Endocr Connect. 2024; 13 (6): e240070. doi: 10.1530/EC-24–0070Liu Z., Kong H., Zhang B. Narrative literature review of antidiabetic drugs' effect on hyperuricemia: elaborating actual data and mechanisms. Endocr Connect. 2024; 13 (6): e240070. doi: 10.1530/EC-24–0070Wolfram R. M., Kritz H., Efthimiou Y., Stomatopoulos J., Sinzinger H. Effect of prickly pear (Opuntia robusta) on glucose- and lipid-metabolism in non-diabetics with hyperlipidemia-a pilot study. Wien Klin Wochenschr. 2002; 114 (19–20): 840–846.Wolfram R. M., Kritz H., Efthimiou Y., Stomatopoulos J., Sinzinger H. Effect of prickly pear (Opuntia robusta) on glucose- and lipid-metabolism in non-diabetics with hyperlipidemia-a pilot study. Wien Klin Wochenschr. 2002; 114 (19–20): 840–846.Villar A., Recio M. C., Ríos J. L., Zafra-Polo M. C. Antimicrobial activity of essential oils from Sideritis species. Pharmazie. 1986; 41 (4): 298–299.Villar A., Recio M. C., Ríos J. L., Zafra-Polo M. C. Antimicrobial activity of essential oils from Sideritis species. Pharmazie. 1986; 41 (4): 298–299.Ruiz-Navajas Y., Viuda-Martos M., Sendra E., Perez-Alvarez J.A., Fernández-López J. In vitro antioxidant and antifungal properties of essential oils obtained from aromatic herbs endemic to the southeast of Spain. J. Food Prot. 2013; 76 (7): 1218–1225. doi: 10.4315/0362–028X.JFP-12–554Ruiz-Navajas Y., Viuda-Martos M., Sendra E., Perez-Alvarez J.A., Fernández-López J. In vitro antioxidant and antifungal properties of essential oils obtained from aromatic herbs endemic to the southeast of Spain. J. Food Prot. 2013; 76 (7): 1218–1225. doi: 10.4315/0362–028X.JFP-12–554Fareed S. A., Yousef E. M., Abd El-Moneam S. M. Assessment of Effects of Rosemary Essential Oil on the Kidney Pathology of Diabetic Adult Male Albino Rats. Cureus. 2023; 15 (3): e35736. doi: 10.7759/cureus.35736Fareed S. A., Yousef E. M., Abd El-Moneam S. M. Assessment of Effects of Rosemary Essential Oil on the Kidney Pathology of Diabetic Adult Male Albino Rats. Cureus. 2023; 15 (3): e35736. doi: 10.7759/cureus.35736Кароматов И. Д., Музаффаров Х. А. Мелисса лекарственная – химический состав, применение в древней, современной народной и научной медицине. Биология и интегративная медицина. 2021; 50 (3): 203–236.Karomatov I. D., Muzaffarov H. A. Lemon balm (melissa officinalis l.) – chemical composition, application in ancient, modern folk and scientific medicine. Biology and Integrative Medicine. 2021; 50 (3): 203–236. (In Russ.).Manjiri M. A., Asadpour A. A., Yousefi M. et al. The effects of Cynodon dactylon (Poaceae family) and Dolichos biflorus (Fabaceae family) extracts on decreasing size and excretion of kidney and urinary tract stones: a randomized, double-blind controlled trial. J. Complement Integr Med. 2022; 20 (1): 214–222. doi: 10.1515/jcim-2022-0166Manjiri M. A., Asadpour A. A., Yousefi M. et al. The effects of Cynodon dactylon (Poaceae family) and Dolichos biflorus (Fabaceae family) extracts on decreasing size and excretion of kidney and urinary tract stones: a randomized, double-blind controlled trial. J. Complement Integr Med. 2022; 20 (1): 214–222. doi: 10.1515/jcim-2022-0166Желябина О. В., Елисеев М. С., Кузьмина Я. И. Диета при подагре и гиперурикемии: несколько важных вопросов. Современная ревматология. 2024; 18 (1): 117–121. doi: 10.14412/1996-7012-2024-1-117-121Zhelyabina O. V., Eliseev M. S., Kuzmina Ya. I. Diet for gout and hyperuricaemia: some important questions. Sovremennaya Revmatologiya. 2024; 18 (1): 117–121. (In Russ). doi: 10.14412/1996-7012-2024-1-117-121

The authors declare that there are no conflicts of interest present.