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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2024-26-45-53</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-3965</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРАКТИЧЕСКАЯ ГАСТРОЭНТЕРОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PRACTICAL GASTROENTEROLOGY</subject></subj-group></article-categories><title-group><article-title>Принципы онконастороженности  для амбулаторного терапевта на примере  колоректального рака</article-title><trans-title-group xml:lang="en"><trans-title>Principles of oncological alertness for outpatient therapists  using the example of colorectal cancer</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8975-8608</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вёрткин</surname><given-names>А. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Vertkin</surname><given-names>A. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Вёрткин Аркадий Львович - д.м.н., проф., зав. кафедрой</p><p>Москва</p></bio><bio xml:lang="en"><p>Vertkin Arkady L. - DM Sci (habil.), professor, head of Dept</p><p>Moscow</p></bio><email xlink:type="simple">kafedrakf@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рудницкая</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rudnitskaya</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рудницкая Мария Андреевна - ассистент кафедры</p><p>Москва</p></bio><bio xml:lang="en"><p>Rudnitskaya Maria A. - assistant at Dept</p><p>Moscow</p></bio><email xlink:type="simple">bondar3011@rambler.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вахабова</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vakhabova</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Вахабова Юлия Вячеславовна - ассистент кафедры</p><p>Москва</p></bio><bio xml:lang="en"><p>Vakhabova Yulia V. - assistant at Dept</p><p>Moscow</p></bio><email xlink:type="simple">alt78@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4391-2889</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кнорринг</surname><given-names>Г. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Knorring</surname><given-names>G. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кнорринг Герман Юрьевич - к.м.н., доцент кафедры</p><p>Москва</p><p> </p></bio><bio xml:lang="en"><p>Knorring German Yu. - PhD Med, associate professor at Dept.</p><p>Moscow</p></bio><email xlink:type="simple">knorring@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Кафедра терапии, клинической фармакологии и скорой медицинской помощи лечебного факультета научно-образовательного института клинической медицины имени Н.А. Семашко ФГБОУ ВО «Российский университет медицины» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Dept of Therapy, Clinical Pharmacology and Emergency Medical Care at Faculty of Medicine, Scientific and Educational Institute of Clinical Medicine named after &#13;
N.A. Semashko at Russian University of Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Кафедра терапии, клинической фармакологии и скорой медицинской помощи лечебного факультета научно-образовательного института клинической медицины имени Н.А. Семашко ФГБОУ ВО "Российский университет медицины» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Dept of Therapy, Clinical Pharmacology and Emergency Medical Care at Faculty of Medicine, Scientific and Educational Institute of Clinical Medicine named after &#13;
N.A. Semashko at Russian University of Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>10</day><month>11</month><year>2024</year></pub-date><volume>0</volume><issue>26</issue><issue-title>«Практическая гастроэнтерология» (2)</issue-title><fpage>45</fpage><lpage>53</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Вёрткин А.Л., Рудницкая М.А., Вахабова Ю.В., Кнорринг Г.Ю., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Вёрткин А.Л., Рудницкая М.А., Вахабова Ю.В., Кнорринг Г.Ю.</copyright-holder><copyright-holder xml:lang="en">Vertkin A.L., Rudnitskaya M.A., Vakhabova Y.V., Knorring G.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/3965">https://www.med-alphabet.com/jour/article/view/3965</self-uri><abstract><p>Злокачественные заболевания остаются важной проблемой медицины, при этом решение ее зависит от эффективности выявления ранних стадий онкозаболеваний на амбулаторном этапе, включая терапевтическое звено оказания медицинской помощи. Формирование навыков онкологической настороженности у врача первичного амбулаторного звена необходимо для раннего выявления и снижения частоты продвинутых стадий опухолей и более раннего начала специализированного лечения. Выявление симптоматики, подозрительной на злокачественные новообразования, с помощью алгоритмизированных подходов и последующая консультация пациента специалистом-хирургом или онкологом должны улучшить результаты лечения. Статья рассматривает принципы онконастороженности, применимые на амбулаторном этапе терапевтами и врачами общей практики на примере колоректального рака. Предлагается набор специально разработанных печатных материалов, облегчающих выполнение принципов онкологической настороженности.</p></abstract><trans-abstract xml:lang="en"><p>Malignant diseases remain an important medical problem, and its solution depends on the effectiveness of identifying the early stages of cancer at the outpatient stage, including the therapeutic level of medical care. Formation of oncological alertness skills in primary care physicians is necessary for early detection and reduction of the incidence of advanced tumor stages and earlier initiation of specialized treatment. Identification of symptoms suspicious for malignant neoplasms using algorithmic approaches and subsequent consultation of the patient by a specialist surgeon or oncologist should improve treatment outcomes. The article considers the principles of oncological alertness applicable at the outpatient stage by therapists and general practitioners using colorectal cancer as an example. A set of specially developed printed materials facilitating the implementation of the principles of oncological alertness is proposed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рак ободочной кишки</kwd><kwd>колоректальный рак</kwd><kwd>онконастороженность</kwd><kwd>онкологическая настороженность</kwd><kwd>амбулаторный прием</kwd></kwd-group><kwd-group xml:lang="en"><kwd>colon cancer</kwd><kwd>colorectal cancer</kwd><kwd>oncological diseases</kwd><kwd>oncological alertness</kwd><kwd>outpatient hospital</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Каприн А.Д., Старинский В.В., Шахзадова О.А. Состояние онкологической помощи населению России в 2020 году. М.: МНИОИ им. П.А. Герцена – филиал ФГБУ «НМИРЦ» Минздрава России, 2021.</mixed-citation><mixed-citation xml:lang="en">Kaprin A.D., Starinsky V.V., Shakhzadova O.A. The state of oncological care for the population of Russia in 2020. Moscow: P.A. Herzen Moscow State Medical Research Institute branch of the Federal State Budgetary Institution “NMIRC” of the Ministry of Health of Russia, 2021. (In Russ.). https://doi.org/10.1017/CBO9781107415324.004</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Marley AR, Nan H. Epidemiology of colorectal cancer. Int J. Mol. Epidemiol Genet. 2016; 7 (3): 105–114. https://doi.org/10.3109/9781420016307-2</mixed-citation><mixed-citation xml:lang="en">Marley AR, Nan H. Epidemiology of colorectal cancer. Int J. Mol. Epidemiol Genet. 2016; 7 (3): 105–114. https://doi.org/10.3109/9781420016307-2</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Хатьков И.Е., Каграманова А.В., Захаржевская Н.Б., Бабикова Е.А., Генерозов Э.В., Щербаков П.Л., Парфенов А.И. Современные принципы скрининга, диагностики и терапии колоректального рака. Терапевтический архив. 2016; 88 (2): 90–96. https://doi.org/10.17116/terarkh201688290–96</mixed-citation><mixed-citation xml:lang="en">Khatkov I. E., Kagramanova A. V., Zakharzhevskaya N. B., Babikova E. A., Generozov E.V., Shcherbakov P. L., Parfenov A.I. Current principles in the screening, diagnosis, and therapy of colorectal cancer. Ter. Archive. 2016; 88 (2): 90–96. https://doi.org/10.17116/terarkh201688290–96</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Сычёва А.С., Верткин А.Л., Кебина А.Л. Онкологическая настороженность у пациентов на амбулаторном терапевтическом этапе. Медицинский алфавит. 2021; (7): 41–45. https://doi.org/10.33667/2078-5631-2021-7-41-45</mixed-citation><mixed-citation xml:lang="en">Sycheva A. S., Vertkin A. L., Kebina A. L. Oncological alertness in patients at outpatient therapeutic stage. Medical alphabet. 2021; (7): 41–45. (In Russ.). https://doi.org/10.33667/2078-5631-2021-7-41-45</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Murata M, Thanan R, Ma N, Kawanishi S. Role of nitrative and oxidative DNA damage in inflammation-related carcinogenesis. J. Biomed Biotech. 2012; Article ID623019.</mixed-citation><mixed-citation xml:lang="en">Murata M, Thanan R, Ma N, Kawanishi S. Role of nitrative and oxidative DNA damage in inflammation-related carcinogenesis. J. Biomed Biotech. 2012; Article ID623019.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Липатов О.Н., Ахметгареева К. Т. Роль генетических мутаций в профилактике злокачественных новообразований у здорового населения (обзор литературы). Креативная хирургия и онкология. 2020; 10 (4): 330–338. https://doi.org/10.24060/2076-3093-2020-10-4-330-338</mixed-citation><mixed-citation xml:lang="en">Lipatov O.N., Akhmetgareeva K. T. The Role of Genetic Mutations in the Prevention of Malignant Tumours in a Healthy Population (A Review). Creative Surgery and Oncology. 2020; 10 (4): 330–338. (In Russ.). https://doi.org/10.24060/2076-3093-2020-10-4-330-338</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Shelton A.A. et al. Retrospective review of colorectal cancer in ulcerative colitis at a tertiary center. Arch Surg. 1996 Aug; 131 (8): 801–806. https://doi.org/10.1001/archsurg.1996.01430200016003</mixed-citation><mixed-citation xml:lang="en">Shelton A.A. et al. Retrospective review of colorectal cancer in ulcerative colitis at a tertiary center. Arch Surg. 1996 Aug; 131 (8): 801–806. https://doi.org/10.1001/archsurg.1996.01430200016003</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ханевич М.Д., Хазов А.В., Хрыков Г.Н., Меджидов О.А. Факторы риска и профилактика колоректального рака. Профилактическая медицина. 2019; 22 (3): 107–111. https://doi.org/10.17116/profmed201922031107</mixed-citation><mixed-citation xml:lang="en">Khanevich M.D., Khazov A.V., Khrykov G.N., Medghidov O.A. Risk factors and prevention of colorectal cancer. The Russian Journal of Preventive Medicine. 2019; 22 (3): 107–111. (In Russ.). https://doi.org/10.17116/profmed201922031107</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Дехисси Е.И., Станоевич У.С., Гребенкин Е.Н., Чхиквадзе В.Д. Патогенетические особенности колоректального рака на фоне нарушений жирового и углеводного обмена. Вестник РНЦРР. 2013; 13: 1–14.</mixed-citation><mixed-citation xml:lang="en">Dekhissi E.I., Stanoevich U.S., Grebenkin E.N., Chkhikvadze V.D. Pathogenetic features of colorectal cancer on the background of disorders of fat and carbohydrate metabolism. VRCRR Bulletin. 2013: 13: 1–14. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Norat T. et al. Meat, fish, and colorectal cancer risk: The European prospective investigation into cancer and nutrition. J. Natl. Cancer. Inst. 2005; 97 (12): 906–916. https://doi.org/10.1093/jnci/dji409</mixed-citation><mixed-citation xml:lang="en">Norat T. et al. Meat, fish, and colorectal cancer risk: The European prospective investigation into cancer and nutrition. J. Natl. Cancer. Inst. 2005; 97 (12): 906–916. https://doi.org/10.1093/jnci/dji409</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Приказ Министерства здравоохранения Российской Федерации № 404н «Об утверждении Порядка проведения профилактического медицинского осмотра и диспансеризации определенных групп взрослого населения» от 27.04.2021.</mixed-citation><mixed-citation xml:lang="en">Order of the Ministry of Health of the Russian Federation No. 404n «»On approval of the Procedure for preventive medical examination and medical examination of certain groups of the adult population»” from 04/27/2021. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Клинические рекомендации Минздрава РФ «Злокачественное новообразование ободочной кишки», 2022.</mixed-citation><mixed-citation xml:lang="en">Сlinical recommendations of the Ministry of Health of the Russian Federation “Malignant neoplasm of the colon”, 2022. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). URL: https://www.nccn.org/guidelines</mixed-citation><mixed-citation xml:lang="en">The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines). URL: https://www.nccn.org/guidelines</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">ESMO Clinical Practice Guidelines: Gastrointestinal Cancers, 2023. URL: https://www.esmo.org/guidelines/guidelines-by-topic/esmo-clinical-practice-guidelines-gastrointestinal-cancers</mixed-citation><mixed-citation xml:lang="en">ESMO Clinical Practice Guidelines: Gastrointestinal Cancers, 2023. URL: https://www.esmo.org/guidelines/guidelines-by-topic/esmo-clinical-practice-guidelines-gastrointestinal-cancers</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Приказ Министерства здравоохранения Российской Федерации № 116н «Об утверждении Порядка оказания медицинской помощи взрослому населению при онкологических заболеваниях» от 19.02.2021.</mixed-citation><mixed-citation xml:lang="en">Order of the Ministry of Health of the Russian Federation No. 116n “On approval of the Procedure for providing medical care to adults with oncological diseases” dated 02/19/2021. (In Russ.).</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
