medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2024-16-83-87medalphabet-3847Research ArticleСтатьиЛекарственное повреждение печени, вызванное приемом «биологически активной добавки» Ашваганды: систематический обзор отчетов о случаяхDrug-induced liver injury caused by Ashwagandha “supplementation”: a systematic review of case reportshttps://orcid.org/0000-0002-4030-0302МирошниковА. Б.MiroshnikovA. B.

Мирошников Александр Борисович, д. б. н., доцент, проф. кафедры спортивной медицины, декан факультета адаптивной физической культуры, рекреации и туризма

Москва

Miroshnikov Alexander B., Dr Bio Sci, associate professor, professor of Dept of Sports Medicine, dean of the Faculty of Adaptive Physical Culture, Recreation and Tourism

Moscow

benedikt116@mail.ruhttps://orcid.org/0000-0003-1165-6518РыбаковаП. Д.RybakovaP. D.

Рыбакова Полина Денисовна, аналитик отдела спортивной нутрициологии

Москва

Rybakova Polina D., analyst at the Sports Nutrition Dept

Moscow

rybakova.poly@yandex.ruhttps://orcid.org/0000-0002-3409-4485АнтоновА. Г.AntonovA. G.

Антонов Алексей Геннадьевич, аналитик отдела спортивной нутрициологии

Москва

Antonov Alexey G., analyst at the Sports Nutrition Dept

Moscow

alexantonovk@gmail.comФГБОУ ВО «Российский университет спорта “ГЦОЛИФК”»РоссияRussian University of Sports “GTSOLIFK”Russian FederationГКУ города Москвы «Центр спортивных инновационных технологий и подготовки сборных команд» Департамента спорта города МосквыРоссияCenter for Sports Innovative Technologies and training of National TeamsRussian Federation202405092024016Диетология и нутрициология8387Copyright © Мирошников А.Б., Рыбакова П.Д., Антонов А.Г., 20242024Мирошников А.Б., Рыбакова П.Д., Антонов А.Г.Miroshnikov A.B., Rybakova P.D., Antonov A.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/3847

Биологически активная добавка «Ашваганды» стала популярна среди россиян. Информация о побочных эффектах, связанных с приемом Ашваганды, присутствует в отчетах о случаях и сериях случаев, хотя она может быть недоступна.Цель. Проведение систематического обзора клинических случаев и серий случаев о предполагаемом повреждении печени, вызванным Ашвагандой.Методы. Исследование было проведено в соответствии с заявлением о предпочтительных отчетных показателях для систематических обзоров и метаанализов. В данном обзоре рассматривались статьи, опубликованные с декабря 2018 г. по декабрь 2023 г. Для проведения систематического поиска было использовано несколько научных баз: PubMed, Science Direct и Google Scholar. Уровень доказательности включенных исследований был классифицирован с использованием уровня доказательности Оксфордского центра доказательной медицины.Результаты. Всего в базах данных было выявлено 76 упоминаний, в ходе процедуры скрининга в обзор было включено 11 исследований.Выводы. Таким образом, мы представляем 23 случая лекарственного поражения печени, вызванных Ашвагандой, с аналогичными паттернами поражения печени и исходами.

Ashwagandha dietary supplement has become popular among Russians. Information about side effects associated with Ashwagandha supplementation is available in case reports and case series, although none may be available.Objective. To conduct a systematic review of clinical case reports and case series on suspected liver damage caused by Ashwagandha.Methods. The study was conducted in accordance with the statement of preferred reporting rates for systematic reviews and meta-analyses. This review considered articles published between December 2018 and December 2023.Several scientific databases were used for the systematic search: PubMed, Science Direct and Google Scholar. The level of evidence of included studies was classified using the Oxford Centre for Evidencebased Medicine level of evidence.Results. A total of 76 references were identified in the databases, 11 studies were included in the review during the screening procedure.Conclusions. We thus present 23 cases of drug-induced liver injury caused by Ashwagandha, with similar liver injury patterns and outcomes.

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The authors declare that there are no conflicts of interest present.