medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»medalphabet-380Research ArticleСтатьиТранскраниальная магнитная стимуляция в педиатрииTranscranial magnetic stimulation in pediatricsВойтенковВ. Б.VoitenkovV. B.noemail@neicon.ruСкрипченкоН. В.SkripchenkoN. V.noemail@neicon.ruФГБУ Детский научно-клинический центр инфекционных болезней Федерального медикобиологического агентстваРоссияPediatric Research and Clinical Center for Infectious DiseasesRussian Federation201718122017339Современная функциональная диагностика4651Copyright © Войтенков В.Б., Скрипченко Н.В., 20172017Войтенков В.Б., Скрипченко Н.В.Voitenkov V.B., Skripchenko N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/380

Мы приводим обзор современных литературных данных и собственные сведения по применению диагностической транскраниальной магнитной стимуляции (ТМС) в педиатрии. ТМС может имплементироваться как в нормальных, так и в патологических условиях. Эта методика безопасна, разрешена к применению в педиатрической практике. ТМС свойственны возрастные ограничения, связанные в первую очередь с неполной миелинизацией моторных путей у детей; в связи с этим получаемые вызванные моторные ответы могут носить черты, во взрослой нейрофизиологии рассматриваемые как патологические. С учётом этих ограничений методика может и должна широко применяться в современных условиях.

N our review we present update on modern state of knowledge and implementation of diagnostic transcranial magnetic stimulation in pediatrics. We review both literature and our own data. TMS may be implemented in normal as well as pathological conditions; it s safe and permitted for use in pediatrics. There are certain limitations due to incomplete myelination of motor pathways in children. Due to that some motor evoked potentials in healthy children may possess properties which would be considered pathological if registered in adults. Taking into the consideration these limitations, diagnostic TMS may be and should be implemented more aggressively in pediatrics.

транскраниальная магнитная стимуляциявызванный моторный ответпедиатриядетиtranscranial magnetic stimulationmotor evoked potentialpediatricschildrenReferencesAminoff, M.J. Aminoff’s Electrodiagnosis in Clinical Neurology, Sixth Edition / M. J. Aminoff.- Philadelphia: Saunders, 2012. - 348 p.Aminoff, M.J. Aminoff’s Electrodiagnosis in Clinical Neurology, Sixth Edition / M. J. Aminoff.- Philadelphia: Saunders, 2012. - 348 p.Barker A. T., Jalinous R., Freeston I. L. Non-invasive magnetic stimulation of human motor cortex. Lancet. 1985; l: 1106-1107.Barker A. T., Jalinous R., Freeston I. L. Non-invasive magnetic stimulation of human motor cortex. Lancet. 1985; l: 1106-1107.Müller K, Hömberg V, Coppenrath P, Lenard HG. Maturation of lower extremity EMG responses to postural perturbations: relationship of response-latencies to development of fastest central and peripheral efferents. Exp Brain Res. 1991;84(2):444-52. PMID: 2065752Müller K, Hömberg V, Coppenrath P, Lenard HG. Maturation of lower extremity EMG responses to postural perturbations: relationship of response-latencies to development of fastest central and peripheral efferents. Exp Brain Res. 1991;84(2):444-52. PMID: 2065752Reutens DC, Puce A, Berkovic SF. Cortical hyper-excitability in progressive myoclonus epilepsy: a study with transcranial magnetic stimulation. Neurology. 1993;43(1):186-92. PMID: 8190300Reutens DC, Puce A, Berkovic SF. Cortical hyper-excitability in progressive myoclonus epilepsy: a study with transcranial magnetic stimulation. Neurology. 1993;43(1):186-92. PMID: 8190300Haug BA, Kukowski B. Latency and duration of the muscle silent period following transcranial magnetic stimulation in multiple sclerosis, cerebral ischemia, and other upper motoneuron lesions. Neurology. 1994;44(5):936-40.PMID: 8423883Haug BA, Kukowski B. Latency and duration of the muscle silent period following transcranial magnetic stimulation in multiple sclerosis, cerebral ischemia, and other upper motoneuron lesions. Neurology. 1994;44(5):936-40.PMID: 8423883Rajapakse T., Kirton A. Non-invasive brain stimulation in children: applications and future directions // Transl. neurosci.- 2013.- Vol. 4, No. 2.- P. 128-137.Rajapakse T., Kirton A. Non-invasive brain stimulation in children: applications and future directions // Transl. neurosci.- 2013.- Vol. 4, No. 2.- P. 128-137.Frye RE, Rotenberg A., Ousley M., Pascual-Leone A. Transcranial magnetic stimulation in child neurology: current and future directions. J Child Neurol2008; 23(1): 9-96.Frye RE, Rotenberg A., Ousley M., Pascual-Leone A. Transcranial magnetic stimulation in child neurology: current and future directions. J Child Neurol2008; 23(1): 9-96.Lin K. L., Pascual-Leone A. Transcranial Magnetic Stimulation and Its Applications in Children // Chang Gung Med J. 2002. Vol. 25. No. 7. P. 424-436.Lin K. L., Pascual-Leone A. Transcranial Magnetic Stimulation and Its Applications in Children // Chang Gung Med J. 2002. Vol. 25. No. 7. P. 424-436.Wassermann E. M. Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation. Electroencephalogr. Clin. Neurophysiol. 1998.108: 1-16.Wassermann E. M. Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation. Electroencephalogr. Clin. Neurophysiol. 1998.108: 1-16.Allen CH, Kluger BM, Buard I. Safety of Transcranial Magnetic Stimulation in Children: A Systematic Review of the Literature. Pediatr Neurol. 2017;68:3-17. doi: 10.1016/j.pediatr-neurol.2016.12.009.Allen CH, Kluger BM, Buard I. Safety of Transcranial Magnetic Stimulation in Children: A Systematic Review of the Literature. Pediatr Neurol. 2017;68:3-17. doi: 10.1016/j.pediatr-neurol.2016.12.009.Benes F. M. Myelination of cortical-hippocampal relays during late adolescence. Schizophr Bull. 1989. Vol. 15. No. 4. P. 585-593.Benes F. M. Myelination of cortical-hippocampal relays during late adolescence. Schizophr Bull. 1989. Vol. 15. No. 4. P. 585-593.Garvey M. A., Mall V. Transcranial Magnetic Stimulation in Children. Clin Neurophysiol. 2008. 119(5): 973-984.Garvey M. A., Mall V. Transcranial Magnetic Stimulation in Children. Clin Neurophysiol. 2008. 119(5): 973-984.Määttä S, Könönen M, Kallioniemi E, Lakka T, Lintu N, Lindi V, Ferreri F, Ponzo D, Säisänen L. Development of cortical motor circuits between childhood and adulthood: A navigated TMS-HdEEG study. Hum Brain Mapp. 2017;38(5):2599-2615. doi: 10.1002/hbm.23545.Määttä S, Könönen M, Kallioniemi E, Lakka T, Lintu N, Lindi V, Ferreri F, Ponzo D, Säisänen L. Development of cortical motor circuits between childhood and adulthood: A navigated TMS-HdEEG study. Hum Brain Mapp. 2017;38(5):2599-2615. doi: 10.1002/hbm.23545.Ciechanski P, Zewdie E, Kirton A. Developmental profile of motor cortex transcallosal inhibition in children and adolescents. J Neurophysiol. 2017: jn.00076.2017. doi: 10.1152/jn.00076.2017.Ciechanski P, Zewdie E, Kirton A. Developmental profile of motor cortex transcallosal inhibition in children and adolescents. J Neurophysiol. 2017: jn.00076.2017. doi: 10.1152/jn.00076.2017.Koh T. H., Eyre J. A. Maturation of corticospinal tracts assessed by electromagnetic stimulation of the motor cortex. Arch Dis Child. 1988. 63: 1347-1352.Koh T. H., Eyre J. A. Maturation of corticospinal tracts assessed by electromagnetic stimulation of the motor cortex. Arch Dis Child. 1988. 63: 1347-1352.Fietzek U.M., Heinen F., Berweck S. et al. Development of the corticospinal system and hand motor function: central conduction times and motor performance tests. Dev Med Child Neurol. 2000. 42: 220-227.Fietzek U.M., Heinen F., Berweck S. et al. Development of the corticospinal system and hand motor function: central conduction times and motor performance tests. Dev Med Child Neurol. 2000. 42: 220-227.Tamer SK Misra S, Jaiswal S. Central motor conduction time in malnourished children. Arch Dis Child.;77(4):323-5.PMID:9389236.Tamer SK Misra S, Jaiswal S. Central motor conduction time in malnourished children. Arch Dis Child.;77(4):323-5.PMID:9389236.Войтенков В. Б., Скрипченко Н. В., Климкин А. В., Аксенова А. И. Особенности вызванного моторного ответа у здоровых детей различного возраста. Российский педиатрический журнал. 2016. Т. 19. № 4. С. 228-231.Войтенков В. Б., Скрипченко Н. В., Климкин А. В., Аксенова А. И. Особенности вызванного моторного ответа у здоровых детей различного возраста. Российский педиатрический журнал. 2016. Т. 19. № 4. С. 228-231.Баранов А. А., Клочкова О. А., Куренков А.Л., Намазова-БарановаЛ.С., Никитин С. С., Артеменко А. Р., Мамедъяров А. М. Роль пластичности головного мозга в функциональной адаптации организма при детском церебральном параличе с поражением рук. Педиатрическая фармакология. 2012. Т. 9. № 6. С. 24-32.Баранов А. А., Клочкова О. А., Куренков А.Л., Намазова-БарановаЛ.С., Никитин С. С., Артеменко А. Р., Мамедъяров А. М. Роль пластичности головного мозга в функциональной адаптации организма при детском церебральном параличе с поражением рук. Педиатрическая фармакология. 2012. Т. 9. № 6. С. 24-32.Baranello G, Rossi Sebastiano D, Pagliano E, Visani E, Ciano C, Fumarola A, Arnoldi MT, Corlatti A, Foscan M, Marchi A, Erbetta A, Riva D. Hand function assessment in the first years of life in unilateral cerebral palsy: Correlation with neuroimaging and cortico-spinal reorganization. Eur J Paediatr Neurol. 2016; 20(1):114-24. doi: 10.1016/j.ejpn.2015.09.005.Baranello G, Rossi Sebastiano D, Pagliano E, Visani E, Ciano C, Fumarola A, Arnoldi MT, Corlatti A, Foscan M, Marchi A, Erbetta A, Riva D. Hand function assessment in the first years of life in unilateral cerebral palsy: Correlation with neuroimaging and cortico-spinal reorganization. Eur J Paediatr Neurol. 2016; 20(1):114-24. doi: 10.1016/j.ejpn.2015.09.005.Smorenburg AR, Gordon AM, Kuo HC, Ferre CL, Brandao M, Bleyenheuft Y, Carmel JB, Friel KM. Does Corticospinal Tract Connectivity Influence the Response to Intensive Bimanual Therapy in Children With Unilateral Cerebral Palsy? Neurorehabil Neural Repair. 2017 Mar;31(3):250-260. doi: 10.1177/1545968316675427.Smorenburg AR, Gordon AM, Kuo HC, Ferre CL, Brandao M, Bleyenheuft Y, Carmel JB, Friel KM. Does Corticospinal Tract Connectivity Influence the Response to Intensive Bimanual Therapy in Children With Unilateral Cerebral Palsy? Neurorehabil Neural Repair. 2017 Mar;31(3):250-260. doi: 10.1177/1545968316675427.Marzbani H, Parvin S, Amiri S, Lotfian M, Kharazi MR, Azizi S, Mirbagheri MM.The correlation between transcranial magnetic stimulation parameters and neuromuscular properties in children with cerebral palsy. Conf Proc IEEE Eng Med Biol Soc. 2016;2016:5473-5476. doi:10.1109/EMBC.2016.7591965.Marzbani H, Parvin S, Amiri S, Lotfian M, Kharazi MR, Azizi S, Mirbagheri MM.The correlation between transcranial magnetic stimulation parameters and neuromuscular properties in children with cerebral palsy. Conf Proc IEEE Eng Med Biol Soc. 2016;2016:5473-5476. doi:10.1109/EMBC.2016.7591965.Mackey A, Stinear C, Stott S, Byblow WD. Upper limb function and cortical organization in youth with unilateral cerebral palsy. Front Neurol. 2014;5:117. doi: 10.3389/fneur.2014.00117.Mackey A, Stinear C, Stott S, Byblow WD. Upper limb function and cortical organization in youth with unilateral cerebral palsy. Front Neurol. 2014;5:117. doi: 10.3389/fneur.2014.00117.van der Aa NE, DeBode S, van Diessen E, Verhage CH, van Nieuwenhuizen O, Ramsey NF, de Vries LS. Cortical reorganisation in a preterm born child with unilateral watershed infarction. Eur J Paediatr Neurol. 2011;15(6):554-7. doi: 10.1016/j.ejpn.2011.04.008.van der Aa NE, DeBode S, van Diessen E, Verhage CH, van Nieuwenhuizen O, Ramsey NF, de Vries LS. Cortical reorganisation in a preterm born child with unilateral watershed infarction. Eur J Paediatr Neurol. 2011;15(6):554-7. doi: 10.1016/j.ejpn.2011.04.008.Kirton A, Deveber G, Gunraj C, Chen R. Cortical excitability and interhemispheric inhibition after subcortical pediatric stroke: plastic organization and effects of rTMS. Clin Neurophysiol. 2010;121(11):1922-9. doi: 10.1016/j. clinph.2010.04.021.Kirton A, Deveber G, Gunraj C, Chen R. Cortical excitability and interhemispheric inhibition after subcortical pediatric stroke: plastic organization and effects of rTMS. Clin Neurophysiol. 2010;121(11):1922-9. doi: 10.1016/j. clinph.2010.04.021.Zewdie E, Damji O, Ciechanski P, Seeger T, Kirton A. Contralesional Corticomotor Neurophysiology in Hemiparetic Children With Perinatal Stroke. Neurorehabil Neural Repair. 2017;31(3):261-271. doi: 10.1177/1545968316680485.Zewdie E, Damji O, Ciechanski P, Seeger T, Kirton A. Contralesional Corticomotor Neurophysiology in Hemiparetic Children With Perinatal Stroke. Neurorehabil Neural Repair. 2017;31(3):261-271. doi: 10.1177/1545968316680485.Ekusheva E. V., Damulin I. V. Post-stroke rehabilitation: importance of neuroplasticity and sensorimotor integration processes. Neuroscience and Behavioral Physiology. 2015.45(5): 594-599.Ekusheva E. V., Damulin I. V. Post-stroke rehabilitation: importance of neuroplasticity and sensorimotor integration processes. Neuroscience and Behavioral Physiology. 2015.45(5): 594-599.Куренков А. Л., Быкова О. В., Маслова О. И., Бойко А. Н., Соколов П. Л., Никитин С. С. Применение транскраниальной магнитной стимуляции для оценки состояния кортико -спинального тракта у детей с рассеянным склерозом. Альманах клинической медицины. 2001. 4: 148-151.Куренков А. Л., Быкова О. В., Маслова О. И., Бойко А. Н., Соколов П. Л., Никитин С. С. Применение транскраниальной магнитной стимуляции для оценки состояния кортико -спинального тракта у детей с рассеянным склерозом. Альманах клинической медицины. 2001. 4: 148-151.Екушева Е. В. Использование транскраниальных ответов для анализа степени вовлечения верхнего мотонейрона у больных рассеянным склерозом. Врач-аспирант. 2011. 44(1): 153-161.Екушева Е. В. Использование транскраниальных ответов для анализа степени вовлечения верхнего мотонейрона у больных рассеянным склерозом. Врач-аспирант. 2011. 44(1): 153-161.Войтенков В. Б., Команцев В. Н., Скрипченко Н. В., Иванова Г. П., Суровцева А. В., Климкин А. В. Состояние центральных моторных путей при рассеянном склерозе у детей. Вестник Российской академии медицинских наук. 2013. 11: 34-37.Войтенков В. Б., Команцев В. Н., Скрипченко Н. В., Иванова Г. П., Суровцева А. В., Климкин А. В. Состояние центральных моторных путей при рассеянном склерозе у детей. Вестник Российской академии медицинских наук. 2013. 11: 34-37.Wahl M, Hübers A, Lauterbach-Soon B, Hattingen E, Jung P, Cohen LG, Ziemann U. Motor callosal disconnection in early relapsing-remitting multiple sclerosis.Hum Brain Mapp. 2011;32(6):846-55. doi: 10.1002/hbm.21071.Wahl M, Hübers A, Lauterbach-Soon B, Hattingen E, Jung P, Cohen LG, Ziemann U. Motor callosal disconnection in early relapsing-remitting multiple sclerosis.Hum Brain Mapp. 2011;32(6):846-55. doi: 10.1002/hbm.21071.Ремнёв А. Г. Клещевой энцефалит: особенности функционального состояния проводящих путей нервной системы. Волгоградский научно-медицинский журнал. 2006. 1: 3-4.Ремнёв А. Г. Клещевой энцефалит: особенности функционального состояния проводящих путей нервной системы. Волгоградский научно-медицинский журнал. 2006. 1: 3-4.Seeger TA, Kirton A, Esser MJ, Gallagher C, Dunn J, Zewdie E, Damji O, Ciechanski P, Barlow KM. Cortical excitability after pediatric mild traumatic brain injury. Brain Stimul. 2017;10(2):305-314. doi: 10.1016/j. brs.2016.11.011.Seeger TA, Kirton A, Esser MJ, Gallagher C, Dunn J, Zewdie E, Damji O, Ciechanski P, Barlow KM. Cortical excitability after pediatric mild traumatic brain injury. Brain Stimul. 2017;10(2):305-314. doi: 10.1016/j. brs.2016.11.011.Northoff G, Magioncalda P, Martino M, Lee HC, Tseng YC, Lane T. Too Fast or Too Slow? Time and Neuronal Variability in Bipolar Disorder-A Combined Theoretical and Empirical Investigation. Schizophr Bull. 2017. doi: 10.1093/schbul/sbx050.Northoff G, Magioncalda P, Martino M, Lee HC, Tseng YC, Lane T. Too Fast or Too Slow? Time and Neuronal Variability in Bipolar Disorder-A Combined Theoretical and Empirical Investigation. Schizophr Bull. 2017. doi: 10.1093/schbul/sbx050.Pedapati EV, Gilbert DL, Erickson CA, Horn PS, Shaffer RC, Wink LK, Laue CS, Wu SW. Abnormal Cortical Plasticity in Youth with Autism Spectrum Disorder: A Transcranial Magnetic Stimulation Case-Control Pilot Study. J Child Adolesc Psychopharmacol. 2016;26(7):625-31. doi: 10.1089/cap.2015.0183.Pedapati EV, Gilbert DL, Erickson CA, Horn PS, Shaffer RC, Wink LK, Laue CS, Wu SW. Abnormal Cortical Plasticity in Youth with Autism Spectrum Disorder: A Transcranial Magnetic Stimulation Case-Control Pilot Study. J Child Adolesc Psychopharmacol. 2016;26(7):625-31. doi: 10.1089/cap.2015.0183.Oberman LM, Ifert-Miller F, Najib U, Bashir S, Heydrich JG, Picker J, Rotenberg A, Pascual-Leone A. Abnormal Mechanisms of Plasticity and Metaplasticity in Autism Spectrum Disorders and Fragile X Syndrome. J Child Adolesc Psychopharmacol. 2016;26(7):617-24. doi:10.1089/cap.2015.0166.Oberman LM, Ifert-Miller F, Najib U, Bashir S, Heydrich JG, Picker J, Rotenberg A, Pascual-Leone A. Abnormal Mechanisms of Plasticity and Metaplasticity in Autism Spectrum Disorders and Fragile X Syndrome. J Child Adolesc Psychopharmacol. 2016;26(7):617-24. doi:10.1089/cap.2015.0166.Kirkovski M, Rogasch NC, Saeki T, Fitzgibbon BM, Enticott PG, Fitzgerald PB.Single Pulse Transcranial Magnetic Stimulation- Electroencephalogram Reveals No Electrophysiological Abnormality in Adults with High-Functioning Autism Spectrum Disorder. J Child Adolesc-Psychopharmacol. 2016; 26(7):606-16. doi: 10.1089/cap.2015.0181.Kirkovski M, Rogasch NC, Saeki T, Fitzgibbon BM, Enticott PG, Fitzgerald PB.Single Pulse Transcranial Magnetic Stimulation- Electroencephalogram Reveals No Electrophysiological Abnormality in Adults with High-Functioning Autism Spectrum Disorder. J Child Adolesc-Psychopharmacol. 2016; 26(7):606-16. doi: 10.1089/cap.2015.0181.Jarczok TA, Fritsch M, Kröger A, Schneider AL, Althen H, Siniatchkin M, Freitag CM, Bender S. Maturation of interhemispheric signal propagation in autism spectrum disorder and typically developing controls: a TMS-EEG study. J Neural Transm (Vienna). 2016;123(8):925-35. doi: 10.1007/s00702-016-1550-5.Jarczok TA, Fritsch M, Kröger A, Schneider AL, Althen H, Siniatchkin M, Freitag CM, Bender S. Maturation of interhemispheric signal propagation in autism spectrum disorder and typically developing controls: a TMS-EEG study. J Neural Transm (Vienna). 2016;123(8):925-35. doi: 10.1007/s00702-016-1550-5.Lewis CP, Nakonezny PA, Ameis SH, Vande Voort JL, Husain MM, Emslie GJ, Daskalakis ZJ, Croarkin PE. Cortical inhibitory and excitatory correlates of depression severity in children and adolescents. J Affect Disord. 2016;190:566-75. doi: 10.1016/j.jad.2015.10.020.Lewis CP, Nakonezny PA, Ameis SH, Vande Voort JL, Husain MM, Emslie GJ, Daskalakis ZJ, Croarkin PE. Cortical inhibitory and excitatory correlates of depression severity in children and adolescents. J Affect Disord. 2016;190:566-75. doi: 10.1016/j.jad.2015.10.020.Croarkin PE, Wall CA, Lee J. Applications of transcranial magnetic stimulation (TMS) in child and adolescent psychiatry. Int Rev Psychiatry. 2011; 23(5):445-53. doi: 10.3109/09540261.2011.623688.Croarkin PE, Wall CA, Lee J. Applications of transcranial magnetic stimulation (TMS) in child and adolescent psychiatry. Int Rev Psychiatry. 2011; 23(5):445-53. doi: 10.3109/09540261.2011.623688.Voitenkov VB, Klimkin AV, Skripchenko NV, Pulman NF, Ivanova MV. Diagnostic transcranial magnetic stimulation as a prognostic tool in children with acute transverse myelitis. Spinal Cord. 2016;54(3):226-8. doi: 10.1038/ sc.2015.129. PMID:26238314Voitenkov VB, Klimkin AV, Skripchenko NV, Pulman NF, Ivanova MV. Diagnostic transcranial magnetic stimulation as a prognostic tool in children with acute transverse myelitis. Spinal Cord. 2016;54(3):226-8. doi: 10.1038/ sc.2015.129. PMID:26238314Nardone R, Höller Y, Brigo F, Orioli A, Tezzon F, Schwenker K, Christova M, Golaszewski S, Trinka E. Descending motor pathways and cortical physiology after spinal cord injury assessed by transcranial magnetic stimulation: a systematic review.Brain Res. 2015;1619:139-54. doi: 10.1016/j.brainres.2014.09.036.Nardone R, Höller Y, Brigo F, Orioli A, Tezzon F, Schwenker K, Christova M, Golaszewski S, Trinka E. Descending motor pathways and cortical physiology after spinal cord injury assessed by transcranial magnetic stimulation: a systematic review.Brain Res. 2015;1619:139-54. doi: 10.1016/j.brainres.2014.09.036.Lee KH, Kim UJ, Park SW, Park YG, Lee BH. Optical Imaging of the Motor Cortex Following Antidromic Activation of the Corticospinal Tract after Spinal Cord Injury. Front Neurosci. 2017;11:166. doi: 10.3389/fnins.2017.00166.Lee KH, Kim UJ, Park SW, Park YG, Lee BH. Optical Imaging of the Motor Cortex Following Antidromic Activation of the Corticospinal Tract after Spinal Cord Injury. Front Neurosci. 2017;11:166. doi: 10.3389/fnins.2017.00166.Lupu VD, Danielian L, Johnsen JA, Vasconcelos OM, Prokhorenko OA, Jabbari B, Campbell WW, Floeter MK. Physiology of the motor cortex in polio survivors. Muscle Nerve. 2008;37(2):177-82.Lupu VD, Danielian L, Johnsen JA, Vasconcelos OM, Prokhorenko OA, Jabbari B, Campbell WW, Floeter MK. Physiology of the motor cortex in polio survivors. Muscle Nerve. 2008;37(2):177-82.Oliveri M, Brighina F, La Bua V, Buffa D, Aloisio A, Fierro B. Reorganization of cortical motor area in prior polio patients. Clin Neurophysiol. 1999;110(5):806-12.Oliveri M, Brighina F, La Bua V, Buffa D, Aloisio A, Fierro B. Reorganization of cortical motor area in prior polio patients. Clin Neurophysiol. 1999;110(5):806-12.Дамулин И. В., Екушева Е. В. Клиническое значение феномена нейропластичности при ишемическом инсульте. Анналы клинической и экспериментальной неврологии. 2016. 10(1): 57-64.Дамулин И. В., Екушева Е. В. Клиническое значение феномена нейропластичности при ишемическом инсульте. Анналы клинической и экспериментальной неврологии. 2016. 10(1): 57-64.

The authors declare that there are no conflicts of interest present.