<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2024-9-31-37</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-3773</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Влияние экспозом-факторов на течение акне</article-title><trans-title-group xml:lang="en"><trans-title>The effect of exposure factors on acne</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3437-5233</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Грязева</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Gryazeva</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Грязева Наталья Владимировна - к.м.н., доцент кафедры дерматовенерологии и косметологии, проректор по учебной работе.</p><p>Москва</p></bio><bio xml:lang="en"><p>Natalia V. Gryazeva - PhD Med, associate professor at Depnt of Dermatovenerology and Cosmetology, vice-rector for Academic Affairs.</p><p>Moscow</p></bio><email xlink:type="simple">tynrik@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-6213-9496</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Безбородова</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bezborodova</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Безбородова Анна Владимировна - ординатор кафедры дерматовенерологии и косметологии.</p><p>Москва</p></bio><bio xml:lang="en"><p>Anna V. Bezborodova - resident at Dept of Dermatovenerology and Cosmetology.</p><p>Moscow</p></bio><email xlink:type="simple">bezborodova98@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-4278-193X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Казарян</surname><given-names>В. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Kazaryan</surname><given-names>V. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Казарян Валерия Эдуардовна - ординатор кафедры дерматовенерологии и косметологии.</p><p>Москва</p></bio><bio xml:lang="en"><p>Valeria E. Kazaryan - resident at Dept of Dermatovenerology and Cosmetology.</p><p>Moscow</p></bio><email xlink:type="simple">valeriya.kazaryan@biospher.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3190-7460</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Круглова</surname><given-names>М. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kruglova</surname><given-names>M. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Круглова Мария Сергеевна - студентка 3 курса лечебного факультета.</p><p>Москва</p></bio><bio xml:lang="en"><p>Maria S. Kruglova - 3rd year student of the Faculty of Medicine.</p><p>Moscow</p></bio><email xlink:type="simple">kruglovamashulka@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central State Medical Academy of the Administrative Department of the President of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Минздрава России (Сеченовский университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>20</day><month>07</month><year>2024</year></pub-date><volume>0</volume><issue>9</issue><issue-title>Дерматология (1)</issue-title><fpage>31</fpage><lpage>37</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Грязева Н.В., Безбородова А.В., Казарян В.Э., Круглова М.С., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Грязева Н.В., Безбородова А.В., Казарян В.Э., Круглова М.С.</copyright-holder><copyright-holder xml:lang="en">Gryazeva N.V., Bezborodova A.V., Kazaryan V.E., Kruglova M.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/3773">https://www.med-alphabet.com/jour/article/view/3773</self-uri><abstract><p>Кожа, представляя собой пограничный орган, который обеспечивает защитную функцию и постоянно подвергается воздействию окружающей среды. В научной литературе для описания экзогенных факторов применяется общепризнанный термин «экспозом- факторы». Воздействуя на кожный барьер и микробиоту кожи, они оказывают существенное влияние на течение акне, что подтверждается многочисленными исследованиями. Под термином «экспозом» понимают совокупную меру воздействия окружающей среды и связанных с ней биологических реакций на человека на протяжении всей жизни. Идентификация наиболее часто встречающихся факторов, повышающих риск развития акне, и уменьшение их воздействия на кожу является неотъемлемой частью в решении проблемы лечения акне. В статье приведены данные обзора литературы и собственных исследований по изучению влияния экспозом-факторов на течение акне.</p></abstract><trans-abstract xml:lang="en"><p>The skin, being a border organ that provides a protective function and is constantly exposed to the environment. In the scientific literature, the generally accepted term “exposome factors” is used to describe exogenous factors. By influencing the skin barrier and skin microbiota, they have a significant impact on the course of acne, which is confirmed by numerous studies. The term “exposure” is understood as the total measure of exposure to the environment and associated biological reactions on a person throughout life. Identification of the most common factors that increase the risk of developing acne and reducing their impact on the skin is an integral part in solving the problem of acne treatment. The article presents data from a literature review and our own research on the influence of exposure factors on the course of acne.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>акне</kwd><kwd>кожа</kwd><kwd>экспозом-факторы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acne</kwd><kwd>skin</kwd><kwd>exposome-factors</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Круглова Л. С. и др. Акне и розацеа.– 2021.</mixed-citation><mixed-citation xml:lang="en">Kruglova.L.S. et al. Acne and rosacea.– 2021.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Rappaport S. M. Genetic factors are not the major causes of chronic diseases // PloS one.– 2016.– V. 11.– № . 4.– P. e0154387. doi: 10.1371/journal.pone.0154387.</mixed-citation><mixed-citation xml:lang="en">Rappaport S. M. Genetic factors are not the major causes of chronic diseases // PloS one.– 2016.– V. 11.– № . 4.– P. e0154387. doi: 10.1371/journal.pone.0154387.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Miller G. W., Jones D. P. The nature of nurture: refining the definition of the exposome //Toxicological sciences.– 2014.– V. 137.– № . 1.– P. 1–2. doi: 10.1093/toxsci/kft251.</mixed-citation><mixed-citation xml:lang="en">Miller G. W., Jones D. P. The nature of nurture: refining the definition of the exposome //Toxicological sciences.– 2014.– V. 137.– № . 1.– P. 1–2. doi: 10.1093/toxsci/kft251.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Dréno B. et al. The influence of exposome on acne //Journal of the European Academy of Dermatology and Venereology.– 2018.– V. 32.– № . 5.– P. 812–819. doi: 10.1111/jdv.14820.</mixed-citation><mixed-citation xml:lang="en">Dréno B. et al. The influence of exposome on acne //Journal of the European Academy of Dermatology and Venereology.– 2018.– V. 32.– № . 5.– P. 812–819. doi: 10.1111/jdv.14820.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Aghasi M. et al. Dairy intake and acne development: a meta-analysis of observational studies //Clinical Nutrition.– 2019.– V. 38.– № . 3.– P. 1067–1075. doi: 10.1016/j.clnu.2018.04.015.</mixed-citation><mixed-citation xml:lang="en">Aghasi M. et al. Dairy intake and acne development: a meta-analysis of observational studies //Clinical Nutrition.– 2019.– V. 38.– № . 3.– P. 1067–1075. doi: 10.1016/j.clnu.2018.04.015.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Monfrecola G. et al. Mechanistic target of rapamycin (mTOR) expression is increased in acne patients’ skin //Experimental Dermatology.– 2016.– V. 25.– № . 2.– P. 153–155. doi: 10.1111/exd.12885.</mixed-citation><mixed-citation xml:lang="en">Monfrecola G. et al. Mechanistic target of rapamycin (mTOR) expression is increased in acne patients’ skin //Experimental Dermatology.– 2016.– V. 25.– № . 2.– P. 153–155. doi: 10.1111/exd.12885.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Fan W. Q. et al. Insulin-like growth factor 1/insulin signaling activates androgen signaling through direct interactions of Foxo1 with androgen receptor //Journal of Biological Chemistry.– 2007.– V. 282.– № . 10.– P. 7329–7338. doi: 10.1074/jbc.M610447200.</mixed-citation><mixed-citation xml:lang="en">Fan W. Q. et al. Insulin-like growth factor 1/insulin signaling activates androgen signaling through direct interactions of Foxo1 with androgen receptor //Journal of Biological Chemistry.– 2007.– V. 282.– № . 10.– P. 7329–7338. doi: 10.1074/jbc.M610447200.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Melnik B.C., Schmitz G. Role of insulin, insulin-like growth factor-1, hyperglycaemic food and milk consumption in the pathogenesis of acne vulgaris //Experimental dermatology.– 2009.– V. 18.– № . 10.– P. 833–841. doi: 10.1111/j.1600–0625.2009.00924.x.</mixed-citation><mixed-citation xml:lang="en">Melnik B.C., Schmitz G. Role of insulin, insulin-like growth factor-1, hyperglycaemic food and milk consumption in the pathogenesis of acne vulgaris //Experimental dermatology.– 2009.– V. 18.– № . 10.– P. 833–841. doi: 10.1111/j.1600–0625.2009.00924.x.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Kucharska A., Szmurło A., Sińska B. Significance of diet in treated and untreated acne vulgaris //Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii.– 2016.– V. 33.– № . 2.– P. 81–86. doi: 10.5114/ada.2016.59146.</mixed-citation><mixed-citation xml:lang="en">Kucharska A., Szmurło A., Sińska B. Significance of diet in treated and untreated acne vulgaris //Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii.– 2016.– V. 33.– № . 2.– P. 81–86. doi: 10.5114/ada.2016.59146.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Çerman A. A. et al. Dietary glycemic factors, insulin resistance, and adiponectin levels in acne vulgaris //Journal of the American Academy of Dermatology.– 2016.– V. 75.– № .1.– P. 155–162. doi: 10.1016/j.jaad.2016.02.1220.</mixed-citation><mixed-citation xml:lang="en">Çerman A. A. et al. Dietary glycemic factors, insulin resistance, and adiponectin levels in acne vulgaris //Journal of the American Academy of Dermatology.– 2016.– V. 75.– № .1.– P. 155–162. doi: 10.1016/j.jaad.2016.02.1220.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Baldwin H., Tan J. Effects of diet on acne and its response to treatment //American journal of clinical dermatology.– 2021.– V. 22.– P. 55–65. doi: 10.1007/s40257–020–00542-y.</mixed-citation><mixed-citation xml:lang="en">Baldwin H., Tan J. Effects of diet on acne and its response to treatment //American journal of clinical dermatology.– 2021.– V. 22.– P. 55–65. doi: 10.1007/s40257–020–00542-y.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Knaggs H. E. et al. Post-adolescent acne //International journal of cosmetic science.– 2004.– V. 26.– № . 3.– P. 129–138. doi.org/10.1111/j.1467–2494.2004.00210.x.</mixed-citation><mixed-citation xml:lang="en">Knaggs H. E. et al. Post-adolescent acne //International journal of cosmetic science.– 2004.– V. 26.– № . 3.– P. 129–138. doi.org/10.1111/j.1467–2494.2004.00210.x.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Bozdag G. et al. The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis //Human reproduction.– 2016.– V. 31.– № . 12.– P. 2841–2855. doi.org/10.1093/humrep/dew218.</mixed-citation><mixed-citation xml:lang="en">Bozdag G. et al. The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis //Human reproduction.– 2016.– V. 31.– № . 12.– P. 2841–2855. doi.org/10.1093/humrep/dew218.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Tyler K.H., Zirwas M.J. Contraception and the dermatologist //Journal of the American Academy of Dermatology.– 2013.– V. 68.– № . 6.– P. 1022–1029. doi: 10.1016/j.jaad.2012.11.018.</mixed-citation><mixed-citation xml:lang="en">Tyler K.H., Zirwas M.J. Contraception and the dermatologist //Journal of the American Academy of Dermatology.– 2013.– V. 68.– № . 6.– P. 1022–1029. doi: 10.1016/j.jaad.2012.11.018.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Sanam M., Ziba O. Desogestrel+ ethinylestradiol versus levonorgestrel+ ethinylestradiol //Saudi Med J.– 2011.– V. 32.– № . 1.– P. 23–26.</mixed-citation><mixed-citation xml:lang="en">Sanam M., Ziba O. Desogestrel+ ethinylestradiol versus levonorgestrel+ ethinylestradiol //Saudi Med J.– 2011.– V. 32.– № . 1.– P. 23–26.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Barbieri J. S. et al. Influence of contraception class on incidence and severity of acne vulgaris //Obstetrics and gynecology.– 2020.– V. 135.– № . 6.– P. 1306. doi: 10.1097/AOG.0000000000003880.</mixed-citation><mixed-citation xml:lang="en">Barbieri J. S. et al. Influence of contraception class on incidence and severity of acne vulgaris //Obstetrics and gynecology.– 2020.– V. 135.– № . 6.– P. 1306. doi: 10.1097/AOG.0000000000003880.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Perez M. et al. When strength turns into disease: acne fulminans in a bodybuilder //Anais Brasileiros de Dermatologia.– 2016.– V. 91.– P. 706–706. doi: 10.1590/abd1806–4841.20165345.</mixed-citation><mixed-citation xml:lang="en">Perez M. et al. When strength turns into disease: acne fulminans in a bodybuilder //Anais Brasileiros de Dermatologia.– 2016.– V. 91.– P. 706–706. doi: 10.1590/abd1806–4841.20165345.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Kang D. et al. Vitamin B 12 modulates the transcriptome of the skin microbiota in acne pathogenesis //Science translational medicine.– 2015.– V. 7.– № . 293.– P. 293ra103–293ra103. doi: 10.1126/scitranslmed.aab2009.</mixed-citation><mixed-citation xml:lang="en">Kang D. et al. Vitamin B 12 modulates the transcriptome of the skin microbiota in acne pathogenesis //Science translational medicine.– 2015.– V. 7.– № . 293.– P. 293ra103–293ra103. doi: 10.1126/scitranslmed.aab2009.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Kazandjieva J., Tsankov N. Drug-induced acne //Clinics in dermatology.– 2017.– V. 35.– № . 2.– P. 156–162. doi: 10.1016/j.clindermatol.2016.10.007.</mixed-citation><mixed-citation xml:lang="en">Kazandjieva J., Tsankov N. Drug-induced acne //Clinics in dermatology.– 2017.– V. 35.– № . 2.– P. 156–162. doi: 10.1016/j.clindermatol.2016.10.007.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Nguyen S. H., Dang T. P., Maibach H. I. Comedogenicity in rabbit: some cosmetic ingredients/vehicles //Cutaneous and ocular toxicology.– 2007.– V. 26.– № . 4.– P. 287–292. doi: 10.1080/15569520701555383.</mixed-citation><mixed-citation xml:lang="en">Nguyen S. H., Dang T. P., Maibach H. I. Comedogenicity in rabbit: some cosmetic ingredients/vehicles //Cutaneous and ocular toxicology.– 2007.– V. 26.– № . 4.– P. 287–292. doi: 10.1080/15569520701555383.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Dréno B. et al. The skin microbiome: a new actor in inflammatory acne //American journal of clinical dermatology.– 2020.– V. 21.– № . Suppl 1.– P. 18–24. doi: 10.1007/s40257–020–00531–1.</mixed-citation><mixed-citation xml:lang="en">Dréno B. et al. The skin microbiome: a new actor in inflammatory acne //American journal of clinical dermatology.– 2020.– V. 21.– № . Suppl 1.– P. 18–24. doi: 10.1007/s40257–020–00531–1.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Lambers H. et al. Natural skin surface pH is on average below 5, which is beneficial for its resident flora //International journal of cosmetic science.– 2006.– V. 28.– № . 5.– P. 359–370. doi: 10.1111/j.1467–2494.2006.00344.x.</mixed-citation><mixed-citation xml:lang="en">Lambers H. et al. Natural skin surface pH is on average below 5, which is beneficial for its resident flora //International journal of cosmetic science.– 2006.– V. 28.– № . 5.– P. 359–370. doi: 10.1111/j.1467–2494.2006.00344.x.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Warshaw E. M. et al. Patch test reactions associated with sunscreen products and the importance of testing to an expanded series: retrospective analysis of North American Contact Dermatitis Group data, 2001 to 2010 //Dermatitis.– 2013.– V. 24.– № . 4.– P. 176–182. doi: 10.1097/DER.0b013e3182983845.</mixed-citation><mixed-citation xml:lang="en">Warshaw E. M. et al. Patch test reactions associated with sunscreen products and the importance of testing to an expanded series: retrospective analysis of North American Contact Dermatitis Group data, 2001 to 2010 //Dermatitis.– 2013.– V. 24.– № . 4.– P. 176–182. doi: 10.1097/DER.0b013e3182983845.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Yano S. et al. Mechanical stretching in vitro regulates signal transduction pathways and cellular proliferation in human epidermal keratinocytes //Journal of investigative dermatology.– 2004.– V. 122.– № . 3.– P. 783–790. doi: 10.1111/j.0022–202X.2004.22328.x.</mixed-citation><mixed-citation xml:lang="en">Yano S. et al. Mechanical stretching in vitro regulates signal transduction pathways and cellular proliferation in human epidermal keratinocytes //Journal of investigative dermatology.– 2004.– V. 122.– № . 3.– P. 783–790. doi: 10.1111/j.0022–202X.2004.22328.x.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Yano S. et al. Activation of Akt by mechanical stretching in human epidermal keratinocytes //Experimental dermatology.– 2006.– V. 15.– № . 5.– P. 356–361. doi: 10.1111/j.0906–6705.2006.00425.x.</mixed-citation><mixed-citation xml:lang="en">Yano S. et al. Activation of Akt by mechanical stretching in human epidermal keratinocytes //Experimental dermatology.– 2006.– V. 15.– № . 5.– P. 356–361. doi: 10.1111/j.0906–6705.2006.00425.x.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Krutmann J. et al. Pollution and acne: is there a link? //Clinical, cosmetic and investigational dermatology.– 2017.– P. 199–204. doi: 10.2147/CCID.S131323.</mixed-citation><mixed-citation xml:lang="en">Krutmann J. et al. Pollution and acne: is there a link? //Clinical, cosmetic and investigational dermatology.– 2017.– P. 199–204. doi: 10.2147/CCID.S131323.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Afaq F. et al. Aryl hydrocarbon receptor is an ozone sensor in human skin //Journal of investigative dermatology.– 2009.– V. 129.– № . 10.– P. 2396–2403. doi: 10.1038/jid.2009.85.</mixed-citation><mixed-citation xml:lang="en">Afaq F. et al. Aryl hydrocarbon receptor is an ozone sensor in human skin //Journal of investigative dermatology.– 2009.– V. 129.– № . 10.– P. 2396–2403. doi: 10.1038/jid.2009.85.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Puri P. et al. Effects of air pollution on the skin: A review //Indian journal of dermatology, venereology and leprology.– 2017.– V. 83.– P. 415. doi: 10.4103/0378–6323.199579.</mixed-citation><mixed-citation xml:lang="en">Puri P. et al. Effects of air pollution on the skin: A review //Indian journal of dermatology, venereology and leprology.– 2017.– V. 83.– P. 415. doi: 10.4103/0378–6323.199579.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Belushkin M., Jaccard G., Kondylis A. Considerations for comparative tobacco product assessments based on smoke constituent yields //Regulatory Toxicology and Pharmacology.– 2015.– V. 73.– № . 1.– P. 105–113. doi: 10.1016/j.yrtph.2015.06.017.</mixed-citation><mixed-citation xml:lang="en">Belushkin M., Jaccard G., Kondylis A. Considerations for comparative tobacco product assessments based on smoke constituent yields //Regulatory Toxicology and Pharmacology.– 2015.– V. 73.– № . 1.– P. 105–113. doi: 10.1016/j.yrtph.2015.06.017.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Calafat A. M. et al. Determination of tar, nicotine, and carbon monoxide yields in the mainstream smoke of selected international cigarettes //Tobacco Control.– 2004.– V. 13.– № . 1.– P. 45–51. doi: 10.1136/tc.2003.003673</mixed-citation><mixed-citation xml:lang="en">Calafat A. M. et al. Determination of tar, nicotine, and carbon monoxide yields in the mainstream smoke of selected international cigarettes //Tobacco Control.– 2004.– V. 13.– № . 1.– P. 45–51. doi: 10.1136/tc.2003.003673</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Pappas A. et al. Sebum analysis of individuals with and without acne //Dermato-endocrinology.– 2009.– V. 1.– № . 3.– P. 157–161. doi: 10.4161/derm.1.3.8473.</mixed-citation><mixed-citation xml:lang="en">Pappas A. et al. Sebum analysis of individuals with and without acne //Dermato-endocrinology.– 2009.– V. 1.– № . 3.– P. 157–161. doi: 10.4161/derm.1.3.8473.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Capitanio B. et al. Modulation of sebum oxidation and interleukin-1α levels associates with clinical improvement of mild comedonal acne //Journal of the European Academy of Dermatology and Venereology.– 2014.– V. 28.– № . 12.– P. 1792–1797. doi: 10.1111/jdv.12431.</mixed-citation><mixed-citation xml:lang="en">Capitanio B. et al. Modulation of sebum oxidation and interleukin-1α levels associates with clinical improvement of mild comedonal acne //Journal of the European Academy of Dermatology and Venereology.– 2014.– V. 28.– № . 12.– P. 1792–1797. doi: 10.1111/jdv.12431.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Deliaert A. E. K. et al. Smoking and its effect on scar healing //European journal of plastic surgery.– 2012.– V. 35.– P. 421–424. doi: 10.1007/s00238–011–0661–3.</mixed-citation><mixed-citation xml:lang="en">Deliaert A. E. K. et al. Smoking and its effect on scar healing //European journal of plastic surgery.– 2012.– V. 35.– P. 421–424. doi: 10.1007/s00238–011–0661–3.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Meyer K. et al. Evaluation of Seasonal Changes in Facial Skin With and Without Acne //Journal of Drugs in Dermatology: JDD.– 2015.– V. 14.– № . 6.– P. 593–601.</mixed-citation><mixed-citation xml:lang="en">Meyer K. et al. Evaluation of Seasonal Changes in Facial Skin With and Without Acne //Journal of Drugs in Dermatology: JDD.– 2015.– V. 14.– № . 6.– P. 593–601.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Piquero-Casals J. et al. Sun exposure, a relevant exposome factor in acne patients and how photoprotection can improve outcomes //Journal of Cosmetic Dermatology.– 2023.– V. 22.– № . 6.– P. 1919–1928. doi: 10.1111/jocd.15726.</mixed-citation><mixed-citation xml:lang="en">Piquero-Casals J. et al. Sun exposure, a relevant exposome factor in acne patients and how photoprotection can improve outcomes //Journal of Cosmetic Dermatology.– 2023.– V. 22.– № . 6.– P. 1919–1928. doi: 10.1111/jocd.15726.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Sardana K., Sharma R. C., Sarkar R. Seasonal variation in acne vulgaris – myth or reality //The Journal of dermatology.– 2002.– V. 29.– № . 8.– P. 484–488. doi: 10.1111/j.1346–8138.2002.tb00313.x.</mixed-citation><mixed-citation xml:lang="en">Sardana K., Sharma R. C., Sarkar R. Seasonal variation in acne vulgaris – myth or reality //The Journal of dermatology.– 2002.– V. 29.– № . 8.– P. 484–488. doi: 10.1111/j.1346–8138.2002.tb00313.x.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Narang I. et al. Seasonal aggravation of acne in summers and the effect of temperature and humidity in a study in a tropical setting //Journal of cosmetic dermatology.– 2019.– V. 18.– № . 4.– P. 1098–1104. doi: 10.1111/jocd.12777.</mixed-citation><mixed-citation xml:lang="en">Narang I. et al. Seasonal aggravation of acne in summers and the effect of temperature and humidity in a study in a tropical setting //Journal of cosmetic dermatology.– 2019.– V. 18.– № . 4.– P. 1098–1104. doi: 10.1111/jocd.12777.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Albuquerque R.G. R. et al. Could adult female acne be associated with modern life? //Archives of dermatological research.– 2014.– V. 306.– P. 683–688. doi: 10.1007/s00403–014–1482–6.</mixed-citation><mixed-citation xml:lang="en">Albuquerque R.G. R. et al. Could adult female acne be associated with modern life? //Archives of dermatological research.– 2014.– V. 306.– P. 683–688. doi: 10.1007/s00403–014–1482–6.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Taheri M. et al. Exposure to visible light emitted from smartphones and tablets increases the proliferation of Staphylococcus aureus: can this be linked to acne? //Journal of biomedical physics &amp; engineering.– 2017.– V. 7.– № . 2.– P. 163.</mixed-citation><mixed-citation xml:lang="en">Taheri M. et al. Exposure to visible light emitted from smartphones and tablets increases the proliferation of Staphylococcus aureus: can this be linked to acne? //Journal of biomedical physics &amp; engineering.– 2017.– V. 7.– № . 2.– P. 163.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Toyoda M., Nakamura M., Morohashi M. Neuropeptides and sebaceous glands //European Journal of Dermatology.– 2002.– V. 12.– № . 5.– P. 422–7.</mixed-citation><mixed-citation xml:lang="en">Toyoda M., Nakamura M., Morohashi M. Neuropeptides and sebaceous glands //European Journal of Dermatology.– 2002.– V. 12.– № . 5.– P. 422–7.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Chiu A., Chon S. Y., Kimball A. B. The response of skin disease to stress: changes in the severity of acne vulgaris as affected by examination stress //Archives of dermatology.– 2003.– V. 139.– № . 7.– P. 897–900. doi: 10.1001/archderm.139.7.897.</mixed-citation><mixed-citation xml:lang="en">Chiu A., Chon S. Y., Kimball A. B. The response of skin disease to stress: changes in the severity of acne vulgaris as affected by examination stress //Archives of dermatology.– 2003.– V. 139.– № . 7.– P. 897–900. doi: 10.1001/archderm.139.7.897.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Toyoda M. et al. Sebaceous glands in acne patients express high levels of neutral endopeptidase //Experimental dermatology.– 2002.– V. 11.– № . 3.– P. 241–247. doi: 10.1034/j.1600–0625.2002.110307.x.</mixed-citation><mixed-citation xml:lang="en">Toyoda M. et al. Sebaceous glands in acne patients express high levels of neutral endopeptidase //Experimental dermatology.– 2002.– V. 11.– № . 3.– P. 241–247. doi: 10.1034/j.1600–0625.2002.110307.x.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Lotti T., Bianchi B., Panconesi E. Neuropeptides and skin disorders. The new frontiers of neuro–endocrine–cutaneous immunology //International journal of dermatology.– 1999.– V. 38.– № . 9.– P. 673–675. doi: 10.1046/j.1365–4362.1999.00767.x.</mixed-citation><mixed-citation xml:lang="en">Lotti T., Bianchi B., Panconesi E. Neuropeptides and skin disorders. The new frontiers of neuro–endocrine–cutaneous immunology //International journal of dermatology.– 1999.– V. 38.– № . 9.– P. 673–675. doi: 10.1046/j.1365–4362.1999.00767.x.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Ganceviciene R. et al. Involvement of the corticotropin-releasing hormone system in the pathogenesis of acne vulgaris //British Journal of Dermatology.– 2009.– V. 160.– № . 2.– P. 345–352. doi: 10.1111/j.1365–2133.2008.08959.x.</mixed-citation><mixed-citation xml:lang="en">Ganceviciene R. et al. Involvement of the corticotropin-releasing hormone system in the pathogenesis of acne vulgaris //British Journal of Dermatology.– 2009.– V. 160.– № . 2.– P. 345–352. doi: 10.1111/j.1365–2133.2008.08959.x.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">He H. et al. Association of brain-derived neurotrophic factor levels and depressive symptoms in young adults with acne vulgaris //BMC psychiatry.– 2019.– V. 19.– № . 1.– P. 1–8. doi: 10.1186/s12888–019–2182–8.</mixed-citation><mixed-citation xml:lang="en">He H. et al. Association of brain-derived neurotrophic factor levels and depressive symptoms in young adults with acne vulgaris //BMC psychiatry.– 2019.– V. 19.– № . 1.– P. 1–8. doi: 10.1186/s12888–019–2182–8.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
