medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2024-9-7-11medalphabet-3762Research ArticleСтатьиВозможности коррекции раннего поседения и инволютивных изменений волосThe possibilities of correction of premature greying of hair and involutive hair changeshttps://orcid.org/0000-0002-0238-6563ШатохинаЕ. А.ShatokhinaE. A.

Шатохина Евгения Афанасьевна - д.м.н., профессор кафедры дерматовенерологии и косметологии.

Москва

Evgeniya A. Shatokhina - DM Sci (habil.), professor, at Dept of Dermatovenereology and Cosmetology.

Moscow

e.a.shatokhina@gmail.comhttps://orcid.org/0009-0000-6652-2045ТопскаяА. В.TopskayaA. V.

Ординатор кафедры дерматовенерологии и косметологии.

Москва

Medical resident at Dept of Dermatovenereology and Cosmetology.

Moscow

anna.topskaya@mail.ruhttps://orcid.org/0000-0002-5044-5265КругловаЛ. С.KruglovaL. S.

Круглова Лариса Сергеевна - д.м.н., профессор, зав. кафедрой дерматовенерологии и косметологии.

Москва

Larisa S. Kruglova - DM Sci (habil.), professor, head of Dept of Dermatovenereology and Cosmetology.

Moscow

kruglovals@mail.ruФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента Российской ФедерацииРоссияCentral State Medical Academy of the Administrative Department of the President of RussiaRussian Federation20242007202409Дерматология (1)711Copyright © Шатохина Е.А., Топская А.В., Круглова Л.С., 20242024Шатохина Е.А., Топская А.В., Круглова Л.С.Shatokhina E.A., Topskaya A.V., Kruglova L.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/3762

В обзоре освещены имеющиеся публикационные данные по этиопатогенезу раннего поседения, инволюции волос и методам восстановления. Раннее поседение волос определяется как поседение в возрасте до 20 лет у европеоидов, до 25 лет у азиатов и до 30 лет у африканцев. В этиопатогенезе как ведущий механизм рассматривается дисбаланс между окислительным стрессом и антиоксидантной системой, значительную роль играет генетическая предрасположенность, гормональные нарушения щитовидной железы, острый стресс; причинами также могут являться дефицит витамина В12, меди, железа. На данный момент для профилактики потери пигмента и его восстановления используется активная молекула пальмитоил тетрапептид-20. Также рассматривается эндоканнабиноидная система в волосяном фолликуле, как мишень для стимуляции при восстановлении роста волос.

The review highlights the available published data on the etiopathogenesis of early graying, hair involution and restoration methods. Early graying of hair is defined as settlement before the age of 20 in Caucasians, before the age of 25 in Asians and before the age of 30 in Africans. In etiopathogenesis, an imbalance between oxidative stress and the antioxidant system is considered as the leading mechanism, a significant role is played by genetic predisposition, hormonal disorders of the thyroid gland, acute stress; the causes may also be deficiency of vitamin B12, copper, iron. Currently, the active molecule palmitoyl tetrapeptide-20 is used to prevent pigment loss and restore it. The endocannabinoid system in the hair follicle is also considered as a target for stimulation during the restoration of hair growth.

ахромотрихияраннее поседение волоспальмитоил тетрапептид-20эндоканнабиноидная системаэкстракт семян коноплиachromotrichiapremature greying of hairpalmitoyl tetrapeptide-20endocannabinoid systemcannabis sativa seed extractReferencesKumar AB, Shamim H, Nagaraju U. Premature Graying of Hair: Review with Updates. Int J Trichology. 2018 Sep-Oct;10(5):198–203. doi: 10.4103/ijt.ijt_47_18. PMID: 30607038; PMCID: PMC6290285.Kumar AB, Shamim H, Nagaraju U. Premature Graying of Hair: Review with Updates. Int J Trichology. 2018 Sep-Oct;10(5):198–203. doi: 10.4103/ijt.ijt_47_18. PMID: 30607038; PMCID: PMC6290285.Trüeb RM. Pharmacologic interventions in aging hair. Clin Interv Aging. 2006;1(2):121–9. doi: 10.2147/ciia.2006.1.2.121. PMID: 18044109; PMCID: PMC 2695167.Trüeb RM. Pharmacologic interventions in aging hair. Clin Interv Aging. 2006;1(2):121–9. doi: 10.2147/ciia.2006.1.2.121. PMID: 18044109; PMCID: PMC 2695167.Hair Color Market Size and Growth Forecast by 2028, 2022 Jun; Report Code: TIPRE00029506.URL: https://www.theinsightpartners.com/reports/hair-color-marketHair Color Market Size and Growth Forecast by 2028, 2022 Jun; Report Code: TIPRE00029506.URL: https://www.theinsightpartners.com/reports/hair-color-marketАнализ рынка краски для волос в России (с базой импорта-экспорта), 2022. URL: https://drgroup.ru/2029-Analiz-rynka-sredstv-dlya-okraski-volos-v-Rossii.htmlAnalysis of the hair dye market in Russia (with import-export base), 2022. URL: https://drgroup.ru/2029-Analiz-rynka-sredstv-dlya-okraski-volos-v-Rossii.htmlTobin DJ, Paus R. Graying: gerontobiology of the hair follicle pigmentary unit. Exp Gerontol. 2001 Jan;36(1):29–54. doi: 10.1016/s0531–5565(00)00210–2. Erratum in: Exp Gerontol 2001 Mar;36(3):591–2. PMID: 11162910.Tobin DJ, Paus R. Graying: gerontobiology of the hair follicle pigmentary unit. Exp Gerontol. 2001 Jan;36(1):29–54. doi: 10.1016/s0531–5565(00)00210–2. Erratum in: Exp Gerontol 2001 Mar;36(3):591–2. PMID: 11162910.Panhard S, Lozano I, Loussouarn G. Greying of the human hair: a worldwide survey, revisiting the ‘50’ rule of thumb. Br J Dermatol. 2012 Oct;167(4):865–73. doi: 10.1111/j.1365–2133.2012.11095.x. PMID: 22716034.Panhard S, Lozano I, Loussouarn G. Greying of the human hair: a worldwide survey, revisiting the ‘50’ rule of thumb. Br J Dermatol. 2012 Oct;167(4):865–73. doi: 10.1111/j.1365–2133.2012.11095.x. PMID: 22716034.Choi HI, Choi GI, Kim EK, Choi YJ, Sohn KC, Lee Y, Kim CD, Yoon TJ, Sohn HJ, Han SH, Kim S, Lee JH, Lee YH. Hair greying is associated with active hair growth. Br J Dermatol. 2011 Dec;165(6):1183–9. doi: 10.1111/j.1365–2133.2011.10625.x. PMID: 21916889.Choi HI, Choi GI, Kim EK, Choi YJ, Sohn KC, Lee Y, Kim CD, Yoon TJ, Sohn HJ, Han SH, Kim S, Lee JH, Lee YH. Hair greying is associated with active hair growth. Br J Dermatol. 2011 Dec;165(6):1183–9. doi: 10.1111/j.1365–2133.2011.10625.x. PMID: 21916889.Daulatabad D, Singal A, Grover C, Chhillar N. Profile of Indian patients with premature canities. Indian J Dermatol Venereol Leprol. 2016 Mar-Apr;82(2):169–72. doi: 10.4103/0378–6323.168911. PMID: 26585843.Daulatabad D, Singal A, Grover C, Chhillar N. Profile of Indian patients with premature canities. Indian J Dermatol Venereol Leprol. 2016 Mar-Apr;82(2):169–72. doi: 10.4103/0378–6323.168911. PMID: 26585843.Arck PC, Overall R, Spatz K, Liezman C, Handjiski B, Klapp BF, Birch-Machin MA, Peters EM. Towards a «free radical theory of graying»: melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage. FASEB J. 2006 Jul;20(9):1567–9. doi: 10.1096/fj.05–4039fje. Epub 2006 May 24. PMID: 16723385.Arck PC, Overall R, Spatz K, Liezman C, Handjiski B, Klapp BF, Birch-Machin MA, Peters EM. Towards a «free radical theory of graying»: melanocyte apoptosis in the aging human hair follicle is an indicator of oxidative stress induced tissue damage. FASEB J. 2006 Jul;20(9):1567–9. doi: 10.1096/fj.05–4039fje. Epub 2006 May 24. PMID: 16723385.Trüeb RM. Oxidative stress in ageing of hair. Int J Trichology. 2009 Jan;1(1):6–14. doi: 10.4103/0974–7753.51923. PMID: 20805969; PMCID: PMC 2929555.Trüeb RM. Oxidative stress in ageing of hair. Int J Trichology. 2009 Jan;1(1):6–14. doi: 10.4103/0974–7753.51923. PMID: 20805969; PMCID: PMC 2929555.Shi Y, Luo LF, Liu XM, Zhou Q, Xu SZ, Lei TC. Premature graying as a consequence of compromised antioxidant activity in hair bulb melanocytes and their precursors. PLoS One. 2014 Apr 2;9(4): e93589. doi: 10.1371/journal.pone.0093589. PMID: 24695442; PMCID: PMC 3973559.Shi Y, Luo LF, Liu XM, Zhou Q, Xu SZ, Lei TC. Premature graying as a consequence of compromised antioxidant activity in hair bulb melanocytes and their precursors. PLoS One. 2014 Apr 2;9(4): e93589. doi: 10.1371/journal.pone.0093589. PMID: 24695442; PMCID: PMC 3973559.Zayed AA, Shahait AD, Ayoub MN, Yousef AM. Smokers’ hair: Does smoking cause premature hair graying? Indian Dermatol Online J. 2013 Apr;4(2):90–2. doi: 10.4103/2229–5178.110586. PMID: 23741662; PMCID: PMC 3673399.Zayed AA, Shahait AD, Ayoub MN, Yousef AM. Smokers’ hair: Does smoking cause premature hair graying? Indian Dermatol Online J. 2013 Apr;4(2):90–2. doi: 10.4103/2229–5178.110586. PMID: 23741662; PMCID: PMC 3673399.Domínguez-Gerpe L, Araújo-Vilar D. Prematurely aged children: molecular alterations leading to Hutchinson-Gilford progeria and Werner syndromes. Curr Aging Sci. 2008 Dec;1(3):202–12. doi: 10.2174/1874609810801030202. PMID: 20021393.Domínguez-Gerpe L, Araújo-Vilar D. Prematurely aged children: molecular alterations leading to Hutchinson-Gilford progeria and Werner syndromes. Curr Aging Sci. 2008 Dec;1(3):202–12. doi: 10.2174/1874609810801030202. PMID: 20021393.Dawber RP. Integumentary associations of pernicious anaemia. Br J Dermatol. 1970 Mar;82(3):221–3. doi: 10.1111/j.1365–2133.1970.tb12428.x. PMID: 5441758.Dawber RP. Integumentary associations of pernicious anaemia. Br J Dermatol. 1970 Mar;82(3):221–3. doi: 10.1111/j.1365–2133.1970.tb12428.x. PMID: 5441758.Sonthalia S, Priya A, Tobin DJ. Demographic Characteristics and Association of Serum Vitamin B12, Ferritin and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases. Indian J Dermatol. 2017 May-Jun;62(3):304–308. doi: 10.4103/ijd.IJD_221_17. PMID: 28584374; PMCID: PMC 5448266.Sonthalia S, Priya A, Tobin DJ. Demographic Characteristics and Association of Serum Vitamin B12, Ferritin and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases. Indian J Dermatol. 2017 May-Jun;62(3):304–308. doi: 10.4103/ijd.IJD_221_17. PMID: 28584374; PMCID: PMC 5448266.van Beek N, Bodó E, Kromminga A, Gáspár E, Meyer K, Zmijewski MA, Slominski A, Wenzel BE, Paus R. Thyroid hormones directly alter human hair follicle functions: anagen prolongation and stimulation of both hair matrix keratinocyte proliferation and hair pigmentation. J Clin Endocrinol Metab. 2008 Nov;93(11):4381–8. doi: 10.1210/jc.2008–0283. Epub 2008 Aug 26. PMID: 18728176.van Beek N, Bodó E, Kromminga A, Gáspár E, Meyer K, Zmijewski MA, Slominski A, Wenzel BE, Paus R. Thyroid hormones directly alter human hair follicle functions: anagen prolongation and stimulation of both hair matrix keratinocyte proliferation and hair pigmentation. J Clin Endocrinol Metab. 2008 Nov;93(11):4381–8. doi: 10.1210/jc.2008–0283. Epub 2008 Aug 26. PMID: 18728176.El-Sheikh AM, Elfar NN, Mourad HA, Hewedy ES. Relationship between Trace Elements and Premature Hair Graying. Int J Trichology. 2018 Nov-Dec;10(6):278–283. doi: 10.4103/ijt.ijt_8_18. PMID: 30783336; PMCID: PMC 6369637.El-Sheikh AM, Elfar NN, Mourad HA, Hewedy ES. Relationship between Trace Elements and Premature Hair Graying. Int J Trichology. 2018 Nov-Dec;10(6):278–283. doi: 10.4103/ijt.ijt_8_18. PMID: 30783336; PMCID: PMC 6369637.Chandran S, Simon SA, George AE. A Clinical Study of Premature Canities and Its Association with Hemoglobin, Ferritin and Calcium Levels. Indian J Dermatol. 2022 May-Jun;67(3):216–221. doi: 10.4103/ijd.IJD_642_20. PMID: 36386090; PMCID: PMC 9644779.Chandran S, Simon SA, George AE. A Clinical Study of Premature Canities and Its Association with Hemoglobin, Ferritin and Calcium Levels. Indian J Dermatol. 2022 May-Jun;67(3):216–221. doi: 10.4103/ijd.IJD_642_20. PMID: 36386090; PMCID: PMC 9644779.Hartmann JT, Kanz L. Sunitinib and periodic hair depigmentation due to temporary c-KIT inhibition. Arch Dermatol. 2008 Nov;144(11):1525–6. doi: 10.1001/archderm.144.11.1525. PMID: 19015436.Hartmann JT, Kanz L. Sunitinib and periodic hair depigmentation due to temporary c-KIT inhibition. Arch Dermatol. 2008 Nov;144(11):1525–6. doi: 10.1001/archderm.144.11.1525. PMID: 19015436.Sideras K, Menefee ME, Burton JK, Erlichman C, Bible KC, Ivy SP. Profound hair and skin hypopigmentation in an African American woman treated with the multi-targeted tyrosine kinase inhibitor pazopanib. J Clin Oncol. 2010 Jul 1;28(19): e312–3. doi: 10.1200/JCO.2009.26.4432. Epub 2010 Jun 1. PMID: 20516434.Sideras K, Menefee ME, Burton JK, Erlichman C, Bible KC, Ivy SP. Profound hair and skin hypopigmentation in an African American woman treated with the multi-targeted tyrosine kinase inhibitor pazopanib. J Clin Oncol. 2010 Jul 1;28(19): e312–3. doi: 10.1200/JCO.2009.26.4432. Epub 2010 Jun 1. PMID: 20516434.Etienne G, Cony-Makhoul P, Mahon FX. Imatinib mesylate and gray hair. N Engl J Med. 2002 Aug 8;347(6):446. doi: 10.1056/NEJM200208083470614. PMID: 12167692.Etienne G, Cony-Makhoul P, Mahon FX. Imatinib mesylate and gray hair. N Engl J Med. 2002 Aug 8;347(6):446. doi: 10.1056/NEJM200208083470614. PMID: 12167692.Di Giacomo TB, Valente NY, Nico MM. Chloroquine -induced hair depigmentation. Lupus. 2009 Mar;18(3):264–6. doi: 10.1177/0961203308097473. PMID: 19213866.Di Giacomo TB, Valente NY, Nico MM. Chloroquine -induced hair depigmentation. Lupus. 2009 Mar;18(3):264–6. doi: 10.1177/0961203308097473. PMID: 19213866.Zhang B, Ma S, Rachmin I, He M, Baral P, Choi S, Gonçalves WA, Shwartz Y, Fast EM, Su Y, Zon LI, Regev A, Buenrostro JD, Cunha TM, Chiu IM, Fisher DE, Hsu YC. Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature. 2020 Jan;577(7792):676–681. doi: 10.1038/s41586–020–1935–3. Epub 2020 Jan 22. PMID: 31969699; PMCID: PMC 7184936.Zhang B, Ma S, Rachmin I, He M, Baral P, Choi S, Gonçalves WA, Shwartz Y, Fast EM, Su Y, Zon LI, Regev A, Buenrostro JD, Cunha TM, Chiu IM, Fisher DE, Hsu YC. Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature. 2020 Jan;577(7792):676–681. doi: 10.1038/s41586–020–1935–3. Epub 2020 Jan 22. PMID: 31969699; PMCID: PMC 7184936.Han R, Beppu H, Lee YK, Georgopoulos K, Larue L, Li E, Weiner L, Brissette JL. A pair of transmembrane receptors essential for the retention and pigmentation of hair. Genesis. 2012 Nov;50(11):783–800. doi: 10.1002/dvg.22039. Epub 2012 Jun 19. PMID: 22611050; PMCID: PMC 3461250.Han R, Beppu H, Lee YK, Georgopoulos K, Larue L, Li E, Weiner L, Brissette JL. A pair of transmembrane receptors essential for the retention and pigmentation of hair. Genesis. 2012 Nov;50(11):783–800. doi: 10.1002/dvg.22039. Epub 2012 Jun 19. PMID: 22611050; PMCID: PMC 3461250.Schouwey K, Delmas V, Larue L, Zimber-Strobl U, Strobl LJ, Radtke F, Beermann F. Notch1 and Notch2 receptors influence progressive hair graying in a dose-dependent manner. Dev Dyn. 2007 Jan;236(1):282–9. doi: 10.1002/dvdy.21000. PMID: 17080428.Schouwey K, Delmas V, Larue L, Zimber-Strobl U, Strobl LJ, Radtke F, Beermann F. Notch1 and Notch2 receptors influence progressive hair graying in a dose-dependent manner. Dev Dyn. 2007 Jan;236(1):282–9. doi: 10.1002/dvdy.21000. PMID: 17080428.Hachiya A, Sriwiriyanont P, Kobayashi T, Nagasawa A, Yoshida H, Ohuchi A, Kitahara T, Visscher MO, Takema Y, Tsuboi R, Boissy RE. Stem cell factor-KIT signalling plays a pivotal role in regulating pigmentation in mammalian hair. J Pathol. 2009 May;218(1):30–9. doi: 10.1002/path.2503. PMID: 19214986.Hachiya A, Sriwiriyanont P, Kobayashi T, Nagasawa A, Yoshida H, Ohuchi A, Kitahara T, Visscher MO, Takema Y, Tsuboi R, Boissy RE. Stem cell factor-KIT signalling plays a pivotal role in regulating pigmentation in mammalian hair. J Pathol. 2009 May;218(1):30–9. doi: 10.1002/path.2503. PMID: 19214986.Pasricha JS. Effect of Grey Hair Evulsion on the Response to Calcium Pantothenate in Premature Grey Hairs. Indian J Dermatol Venereol Leprol. 1986 Mar-Apr;52(2):77–80. PMID: 28150658.Pasricha JS. Effect of Grey Hair Evulsion on the Response to Calcium Pantothenate in Premature Grey Hairs. Indian J Dermatol Venereol Leprol. 1986 Mar-Apr;52(2):77–80. PMID: 28150658.Sieve BF. CLINICAL ACHROMOTRICHIA. Science. 1941 Sep 12;94(2437):257–8. doi: 10.1126/science.94.2437.257. PMID: 17792884.Sieve BF. CLINICAL ACHROMOTRICHIA. Science. 1941 Sep 12;94(2437):257–8. doi: 10.1126/science.94.2437.257. PMID: 17792884.Rivera N, Boada A, Bielsa MI, Fernández-Figueras MT, Carcereny E, Moran MT, Ferrándiz C. Hair Repigmentation During Immunotherapy Treatment With an Anti-Programmed Cell Death 1 and Anti-Programmed Cell Death Ligand 1 Agent for Lung Cancer. JAMA Dermatol. 2017 Nov 1;153(11):1162–1165. doi: 10.1001/jamadermatol.2017.2106. PMID: 28700789; PMCID: PMC5817444.Rivera N, Boada A, Bielsa MI, Fernández-Figueras MT, Carcereny E, Moran MT, Ferrándiz C. Hair Repigmentation During Immunotherapy Treatment With an Anti-Programmed Cell Death 1 and Anti-Programmed Cell Death Ligand 1 Agent for Lung Cancer. JAMA Dermatol. 2017 Nov 1;153(11):1162–1165. doi: 10.1001/jamadermatol.2017.2106. PMID: 28700789; PMCID: PMC5817444.Sumitomo C, Akita H, Sugiura K. Unexpected side-effect of dupilumab: Reversal of hair graying. J Dermatol. 2020 Sep;47(9): e316-e317. doi: 10.1111/1346–8138.15472. Epub 2020 Jun 23. PMID: 32578240.Sumitomo C, Akita H, Sugiura K. Unexpected side-effect of dupilumab: Reversal of hair graying. J Dermatol. 2020 Sep;47(9): e316-e317. doi: 10.1111/1346–8138.15472. Epub 2020 Jun 23. PMID: 32578240.Tintle SJ, Dabade TS, Kalish RA, Rosmarin DM. Repigmentation of hair following adalimumab therapy. Dermatol Online J. 2015 Jun 16;21(6):13030/qt6fn0t1xz. PMID: 26158363.Tintle SJ, Dabade TS, Kalish RA, Rosmarin DM. Repigmentation of hair following adalimumab therapy. Dermatol Online J. 2015 Jun 16;21(6):13030/qt6fn0t1xz. PMID: 26158363.Rongioletti F, Mugheddu C, Murgia S. Repigmentation and new growth of hairs after anti-interleukin-17 therapy with secukinumab for psoriasis. JAAD Case Rep. 2018 May 7;4(5):486–488. doi: 10.1016/j.jdcr.2018.01.006. PMID: 29984292; PMCID: PMC 6031562.Rongioletti F, Mugheddu C, Murgia S. Repigmentation and new growth of hairs after anti-interleukin-17 therapy with secukinumab for psoriasis. JAAD Case Rep. 2018 May 7;4(5):486–488. doi: 10.1016/j.jdcr.2018.01.006. PMID: 29984292; PMCID: PMC 6031562.Park SJ, Ahn GR, Park JW, Seo SJ. The First Case of Ustekinumab-Associated Hair Repigmentation and a Proposed Mechanism of Action. Ann Dermatol. 2021 Jun;33(3):300–301. doi: 10.5021/ad.2021.33.3.300. Epub 2021 May 4. PMID: 34079196; PMCID: PMC 8137327.Park SJ, Ahn GR, Park JW, Seo SJ. The First Case of Ustekinumab-Associated Hair Repigmentation and a Proposed Mechanism of Action. Ann Dermatol. 2021 Jun;33(3):300–301. doi: 10.5021/ad.2021.33.3.300. Epub 2021 May 4. PMID: 34079196; PMCID: PMC 8137327.Penzi LR, Manatis-Lornell A, Saavedra A, Fisher D, Senna MM. Hair repigmentation associated with the use of brentuximab. JAAD Case Rep. 2017 Nov 8;3(6):563–565. doi: 10.1016/j.jdcr.2017.09.027. PMID: 29159251; PMCID: PMC 5683745.Penzi LR, Manatis-Lornell A, Saavedra A, Fisher D, Senna MM. Hair repigmentation associated with the use of brentuximab. JAAD Case Rep. 2017 Nov 8;3(6):563–565. doi: 10.1016/j.jdcr.2017.09.027. PMID: 29159251; PMCID: PMC 5683745.Robert C, Spatz A, Faivre S, Armand JP, Raymond E. Tyrosine kinase inhibition and grey hair. Lancet. 2003 Mar 22;361(9362):1056. doi: 10.1016/S 0140–6736(03)12805-X. PMID: 12660081.Robert C, Spatz A, Faivre S, Armand JP, Raymond E. Tyrosine kinase inhibition and grey hair. Lancet. 2003 Mar 22;361(9362):1056. doi: 10.1016/S 0140–6736(03)12805-X. PMID: 12660081.Kockerols CCB, Westerweel PE. Hair Repigmentation Induced by Nilotinib. N Engl J Med. 2022 Aug 11;387(6): e12. doi: 10.1056/NEJMicm2119953. Epub 2022 Aug 6. PMID: 35929831.Kockerols CCB, Westerweel PE. Hair Repigmentation Induced by Nilotinib. N Engl J Med. 2022 Aug 11;387(6): e12. doi: 10.1056/NEJMicm2119953. Epub 2022 Aug 6. PMID: 35929831.Robert C, Mateus C, Spatz A, Wechsler J, Escudier B. Dermatologic symptoms associated with the multikinase inhibitor sorafenib. J Am Acad Dermatol. 2009 Feb;60(2):299–305. doi: 10.1016/j.jaad.2008.06.034. Epub 2008 Nov 25. PMID: 19028406.Robert C, Mateus C, Spatz A, Wechsler J, Escudier B. Dermatologic symptoms associated with the multikinase inhibitor sorafenib. J Am Acad Dermatol. 2009 Feb;60(2):299–305. doi: 10.1016/j.jaad.2008.06.034. Epub 2008 Nov 25. PMID: 19028406.Cheng YP, Chen HJ, Chiu HC. Erlotinib-induced hair repigmentation. Int J Dermatol. 2014 Jan;53(1): e55–7. doi: 10.1111/j.1365–4632.2011.05422.x. Epub 2013 Feb 22. PMID: 23432346.Cheng YP, Chen HJ, Chiu HC. Erlotinib-induced hair repigmentation. Int J Dermatol. 2014 Jan;53(1): e55–7. doi: 10.1111/j.1365–4632.2011.05422.x. Epub 2013 Feb 22. PMID: 23432346.Dasanu CA, Mitsis D, Alexandrescu DT. Hair repigmentation associated with the use of lenalidomide: graying may not be an irreversible process! J Oncol Pharm Pract. 2013 Jun;19(2):165–9. doi: 10.1177/1078155212442561. Epub 2012 Mar 22. PMID: 22440400.Dasanu CA, Mitsis D, Alexandrescu DT. Hair repigmentation associated with the use of lenalidomide: graying may not be an irreversible process! J Oncol Pharm Pract. 2013 Jun;19(2):165–9. doi: 10.1177/1078155212442561. Epub 2012 Mar 22. PMID: 22440400.Lovering S, Miao W, Bailie T, Amato D. Hair repigmentation associated with thalidomide use for the treatment of multiple myeloma. BMJ Case Rep. 2016 Jul 21;2016: bcr2016215521. doi: 10.1136/bcr-2016–215521. PMID: 27444138; PMCID: PMC 4964225.Lovering S, Miao W, Bailie T, Amato D. Hair repigmentation associated with thalidomide use for the treatment of multiple myeloma. BMJ Case Rep. 2016 Jul 21;2016: bcr2016215521. doi: 10.1136/bcr-2016–215521. PMID: 27444138; PMCID: PMC 4964225.Sadighha A, Zahed GM. Hair darkening after treatment with cyclosporin in a patient with psoriasis. J Eur Acad Dermatol Venereol. 2008 Nov;22(10):1239–41. doi: 10.1111/j.1468–3083.2008.02598.x. Epub 2008 Mar 7. PMID: 18331307.Sadighha A, Zahed GM. Hair darkening after treatment with cyclosporin in a patient with psoriasis. J Eur Acad Dermatol Venereol. 2008 Nov;22(10):1239–41. doi: 10.1111/j.1468–3083.2008.02598.x. Epub 2008 Mar 7. PMID: 18331307.Redondo P, Guzmán M, Marquina M, Pretel M, Aguado L, Lloret P, Gorrochategui A. Repigmentación del pelo canoso tras tratamiento con hormona tiroidea [Repigmentation of gray hair after thyroid hormone treatment]. Actas Dermosifiliogr. 2007 Nov;98(9):603–10. Spanish. PMID: 17961449.Redondo P, Guzmán M, Marquina M, Pretel M, Aguado L, Lloret P, Gorrochategui A. Repigmentación del pelo canoso tras tratamiento con hormona tiroidea [Repigmentation of gray hair after thyroid hormone treatment]. Actas Dermosifiliogr. 2007 Nov;98(9):603–10. Spanish. PMID: 17961449.Bellandi S, Amato L, Cipollini EM, Antiga E, Brandini L, Fabbri P. Repigmentation of hair after latanoprost therapy. J Eur Acad Dermatol Venereol. 2011 Dec;25(12):1485–7. doi: 10.1111/j.1468–3083.2010.03949.x. Epub 2010 Dec 29. PMID: 21198953.Bellandi S, Amato L, Cipollini EM, Antiga E, Brandini L, Fabbri P. Repigmentation of hair after latanoprost therapy. J Eur Acad Dermatol Venereol. 2011 Dec;25(12):1485–7. doi: 10.1111/j.1468–3083.2010.03949.x. Epub 2010 Dec 29. PMID: 21198953.Chan LKM, Braidy N, Ng W, Xu YH, Chen J, McDonald R, Chan DKY. Re-pigmentation of hair after prolonged cholinesterase inhibitor therapy in a Chinese population. Australas J Dermatol. 2020 Nov;61(4): e417-e420. doi: 10.1111/ajd.13356. Epub 2020 Jun 29. PMID: 32597493.Chan LKM, Braidy N, Ng W, Xu YH, Chen J, McDonald R, Chan DKY. Re-pigmentation of hair after prolonged cholinesterase inhibitor therapy in a Chinese population. Australas J Dermatol. 2020 Nov;61(4): e417-e420. doi: 10.1111/ajd.13356. Epub 2020 Jun 29. PMID: 32597493.Hampson JP, Donnelly A, Lewis-Jones MS, Pye JK. Tamoxifen-induced hair colour change. Br J Dermatol. 1995 Mar;132(3):483–4. doi: 10.1111/j.1365–2133.1995.tb08690.x. PMID: 7718473.Hampson JP, Donnelly A, Lewis-Jones MS, Pye JK. Tamoxifen-induced hair colour change. Br J Dermatol. 1995 Mar;132(3):483–4. doi: 10.1111/j.1365–2133.1995.tb08690.x. PMID: 7718473.Komagamine T, Suzuki K, Hirata K. Darkening of white hair following levodopa therapy in a patient with Parkinson’s disease. Mov Disord. 2013 Oct;28(12):1643. doi: 10.1002/mds.25696. PMID: 24166898.Komagamine T, Suzuki K, Hirata K. Darkening of white hair following levodopa therapy in a patient with Parkinson’s disease. Mov Disord. 2013 Oct;28(12):1643. doi: 10.1002/mds.25696. PMID: 24166898.Villarreal-Reyna G, Garza-Morales R, Soto-Domínguez A, Montañez-Guerrero L, Saucedo-Cárdenas O, Gómez-Flores M, Ocampo-Garza JA, Pérez-Trujillo JJ, Montes-de-Oca-Luna R. Cerebrolysin induces hair repigmentation associated to MART-1/Melan-A reactivation. Eur J Med Res. 2022 Nov 21;27(1):257. doi: 10.1186/s40001–022–00889–4. PMID: 36411485; PMCID: PMC 9677656.Villarreal-Reyna G, Garza-Morales R, Soto-Domínguez A, Montañez-Guerrero L, Saucedo-Cárdenas O, Gómez-Flores M, Ocampo-Garza JA, Pérez-Trujillo JJ, Montes-de-Oca-Luna R. Cerebrolysin induces hair repigmentation associated to MART-1/Melan-A reactivation. Eur J Med Res. 2022 Nov 21;27(1):257. doi: 10.1186/s40001–022–00889–4. PMID: 36411485; PMCID: PMC 9677656.Ward PD, Miller HL, Shipman AR. A case of repigmentation and curling of hair on acitretin therapy. Clin Exp Dermatol. 2014 Jan;39(1):91–2. doi: 10.1111/ced.12212. Epub 2013 Nov 25. PMID: 24266744.Ward PD, Miller HL, Shipman AR. A case of repigmentation and curling of hair on acitretin therapy. Clin Exp Dermatol. 2014 Jan;39(1):91–2. doi: 10.1111/ced.12212. Epub 2013 Nov 25. PMID: 24266744.Nagase K, Inoue T, Narisawa Y. Manifest hair repigmentation associated with etretinate therapy. J Dermatol. 2017 Mar;44(3): e34-e35. doi: 10.1111/1346–8138.13514. Epub 2016 Jul 12. PMID: 27401844.Nagase K, Inoue T, Narisawa Y. Manifest hair repigmentation associated with etretinate therapy. J Dermatol. 2017 Mar;44(3): e34-e35. doi: 10.1111/1346–8138.13514. Epub 2016 Jul 12. PMID: 27401844.Khaled A, Trojjets S, Zeglaoui F, Fazaa B, Kamoun MR. Repigmentation of the white hair after systemic corticosteroids for bullous pemphigoid. J Eur Acad Dermatol Venereol. 2008 Aug;22(8):1018–20. doi: 10.1111/j.1468–3083.2007.02524.x. Epub 2007 Dec 13. PMID: 18081750.Khaled A, Trojjets S, Zeglaoui F, Fazaa B, Kamoun MR. Repigmentation of the white hair after systemic corticosteroids for bullous pemphigoid. J Eur Acad Dermatol Venereol. 2008 Aug;22(8):1018–20. doi: 10.1111/j.1468–3083.2007.02524.x. Epub 2007 Dec 13. PMID: 18081750.Pavithran K. Puvasol Therapy in Premature Greying of Hair. Indian J Dermatol Venereol Leprol. 1986 Mar-Apr;52(2):74–75. PMID: 28150657.Pavithran K. Puvasol Therapy in Premature Greying of Hair. Indian J Dermatol Venereol Leprol. 1986 Mar-Apr;52(2):74–75. PMID: 28150657.Philip M, Samson JF, Simi PS. Clofazimine-induced Hair Pigmentation. Int J Trichology. 2012 Jul;4(3):174–5. doi: 10.4103/0974–7753.100088. PMID: 23180930; PMCID: PMC 3500060.Philip M, Samson JF, Simi PS. Clofazimine-induced Hair Pigmentation. Int J Trichology. 2012 Jul;4(3):174–5. doi: 10.4103/0974–7753.100088. PMID: 23180930; PMCID: PMC 3500060.Read GM. Verapamil and hair colour change. Lancet. 1991 Dec 14;338(8781):1520. doi: 10.1016/0140–6736(91)92333-w. PMID: 1683935.Read GM. Verapamil and hair colour change. Lancet. 1991 Dec 14;338(8781):1520. doi: 10.1016/0140–6736(91)92333-w. PMID: 1683935.Chavez A, Tiger J. Hair Repigmentation After Mohs Micrographic Surgery and Secondary Intention Wound Healing on the Scalp of an 84-Year-Old Woman. Dermatol Surg. 2021 Sep 1;47(9):1281–1283. doi: 10.1097/DSS.0000000000003094. PMID: 34081046.Chavez A, Tiger J. Hair Repigmentation After Mohs Micrographic Surgery and Secondary Intention Wound Healing on the Scalp of an 84-Year-Old Woman. Dermatol Surg. 2021 Sep 1;47(9):1281–1283. doi: 10.1097/DSS.0000000000003094. PMID: 34081046.Yuriguchi M, Aoki H, Taguchi N, Kunisada T. Pigmentation of regenerated hairs after wounding. J Dermatol Sci. 2016 Oct;84(1):80–87. doi: 10.1016/j.jdermsci.2016.07.004. Epub 2016 Jul 6. PMID: 27435302.Yuriguchi M, Aoki H, Taguchi N, Kunisada T. Pigmentation of regenerated hairs after wounding. J Dermatol Sci. 2016 Oct;84(1):80–87. doi: 10.1016/j.jdermsci.2016.07.004. Epub 2016 Jul 6. PMID: 27435302.Li H, Fan L, Zhu S, Shin MK, Lu F, Qu J, Hou L. Epilation induces hair and skin pigmentation through an EDN 3/EDNRB-dependent regenerative response of melanocyte stem cells. Sci Rep. 2017 Aug 4;7(1):7272. doi: 10.1038/s41598–017–07683-x. PMID: 28779103; PMCID: PMC 5544680.Li H, Fan L, Zhu S, Shin MK, Lu F, Qu J, Hou L. Epilation induces hair and skin pigmentation through an EDN 3/EDNRB-dependent regenerative response of melanocyte stem cells. Sci Rep. 2017 Aug 4;7(1):7272. doi: 10.1038/s41598–017–07683-x. PMID: 28779103; PMCID: PMC 5544680.Messenger AG. Hair through the female life cycle. Br J Dermatol. 2011 Dec;165 Suppl 3:2–6. doi: 10.1111/j.1365–2133.2011.10628.x. PMID: 22171678.Messenger AG. Hair through the female life cycle. Br J Dermatol. 2011 Dec;165 Suppl 3:2–6. doi: 10.1111/j.1365–2133.2011.10628.x. PMID: 22171678.Tajima M, Hamada C, Arai T, Miyazawa M, Shibata R, Ishino A. Characteristic features of Japanese women’s hair with aging and with progressing hair loss. J Dermatol Sci. 2007 Feb;45(2):93–103. doi: 10.1016/j.jdermsci.2006.10.011. Epub 2006 Dec 11. PMID: 17161939.Tajima M, Hamada C, Arai T, Miyazawa M, Shibata R, Ishino A. Characteristic features of Japanese women’s hair with aging and with progressing hair loss. J Dermatol Sci. 2007 Feb;45(2):93–103. doi: 10.1016/j.jdermsci.2006.10.011. Epub 2006 Dec 11. PMID: 17161939.Matsumura H, Mohri Y, Binh NT, Morinaga H, Fukuda M, Ito M, Kurata S, Hoeijmakers J, Nishimura EK. Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis. Science. 2016 Feb 5;351(6273): aad 4395. doi: 10.1126/science.aad4395. Epub 2016 Feb 4. PMID: 26912707.Matsumura H, Mohri Y, Binh NT, Morinaga H, Fukuda M, Ito M, Kurata S, Hoeijmakers J, Nishimura EK. Hair follicle aging is driven by transepidermal elimination of stem cells via COL17A1 proteolysis. Science. 2016 Feb 5;351(6273): aad 4395. doi: 10.1126/science.aad4395. Epub 2016 Feb 4. PMID: 26912707.Robbins C, Mirmirani P, Messenger AG, Birch MP, Youngquist RS, Tamura M, Filloon T, Luo F, Dawson TL Jr. What women want – quantifying the perception of hair amount: an analysis of hair diameter and density changes with age in caucasian women. Br J Dermatol. 2012 Aug;167(2):324–32. doi: 10.1111/j.1365–2133.2012.11010.x. PMID: 22524482.Robbins C, Mirmirani P, Messenger AG, Birch MP, Youngquist RS, Tamura M, Filloon T, Luo F, Dawson TL Jr. What women want – quantifying the perception of hair amount: an analysis of hair diameter and density changes with age in caucasian women. Br J Dermatol. 2012 Aug;167(2):324–32. doi: 10.1111/j.1365–2133.2012.11010.x. PMID: 22524482.Jeong KH, Kim KS, Lee GJ, Choi SJ, Jeong TJ, Shin MK, Park HK, Sim WY, Lee MH. Investigation of aging effects in human hair using atomic force microscopy. Skin Res Technol. 2011 Feb;17(1):63–8. doi: 10.1111/j.1600–0846.2010.00466.x. PMID: 20923464.Jeong KH, Kim KS, Lee GJ, Choi SJ, Jeong TJ, Shin MK, Park HK, Sim WY, Lee MH. Investigation of aging effects in human hair using atomic force microscopy. Skin Res Technol. 2011 Feb;17(1):63–8. doi: 10.1111/j.1600–0846.2010.00466.x. PMID: 20923464.Erik B, Havitcioglu H, Aktan S, Karakus N. Biomechanical properties of human hair with different parameters. Skin Res Technol. 2008 May;14(2):147–51. doi: 10.1111/j.1600–0846.2007.00268.x. PMID: 18412556.Erik B, Havitcioglu H, Aktan S, Karakus N. Biomechanical properties of human hair with different parameters. Skin Res Technol. 2008 May;14(2):147–51. doi: 10.1111/j.1600–0846.2007.00268.x. PMID: 18412556.Turner GA, Bhogal RK. Hair and Aging. Skinmed. 2016 Oct 1;14(5):338–343. PMID: 27871344.Turner GA, Bhogal RK. Hair and Aging. Skinmed. 2016 Oct 1;14(5):338–343. PMID: 27871344.Giesen M, Gruedl S, Holtkoetter O, Fuhrmann G, Koerner A, Petersohn D. Ageing processes influence keratin and KAP expression in human hair follicles. Exp Dermatol. 2011 Sep;20(9):759–61. doi: 10.1111/j.1600–0625.2011.01301.x. Epub 2011 May 16. PMID: 21569108.Giesen M, Gruedl S, Holtkoetter O, Fuhrmann G, Koerner A, Petersohn D. Ageing processes influence keratin and KAP expression in human hair follicles. Exp Dermatol. 2011 Sep;20(9):759–61. doi: 10.1111/j.1600–0625.2011.01301.x. Epub 2011 May 16. PMID: 21569108.Kishimoto J, Burgeson RE, Morgan BA. Wnt signaling maintains the hair-inducing activity of the dermal papilla. Genes Dev. 2000 May 15;14(10):1181–5. PMID: 10817753; PMCID: PMC 316619.Kishimoto J, Burgeson RE, Morgan BA. Wnt signaling maintains the hair-inducing activity of the dermal papilla. Genes Dev. 2000 May 15;14(10):1181–5. PMID: 10817753; PMCID: PMC 316619.Голдсмит Лоуэлл А., Кац Стивен И., Паллер Эми С., Леффель Дэвид Дж., Вольф Клаус, пер. с англ. Миченко А. В., Вороненко В.А, Галкина Л. А., Германова К. Н., Петелин Д. С. Дерматология Фицпатрика в клинической практике, 1 том, второе издание. Издательство Панфилова, 2015 год, Москва. С. 1076–1079.Goldsmith Lowell A., Katz Steven I., Paller Amy S., Leffel David J., Wolf Klaus, trans. from English Michenko A.V., Voronenko V.A., Galkina L.A., Germanova K.N., Petelin D.S. Fitzpatrick’s Dermatology in Clinical Practice, 1st volume, second edition. Panfilov Publishing House, 2015, Moscow. pp. 1076–1079.Zhang X, Zhu J, Zhang J, Zhao H. Melanocyte stem cells and hair graying. J Cosmet Dermatol. 2023 Jun;22(6):1720–1723. doi: 10.1111/jocd.15652. Epub 2023 Feb 28. PMID: 36853923.Zhang X, Zhu J, Zhang J, Zhao H. Melanocyte stem cells and hair graying. J Cosmet Dermatol. 2023 Jun;22(6):1720–1723. doi: 10.1111/jocd.15652. Epub 2023 Feb 28. PMID: 36853923.Smith GL, Satino J. Hair Regrowth with Cannabidiol-rich Hemp Extract – A Case Series. Cannabis. 2021 Apr 22;4(1):53–59. doi: 10.26828/cannabis/2021.01.003. PMID: 37287996; PMCID: PMC10212262.Smith GL, Satino J. Hair Regrowth with Cannabidiol-rich Hemp Extract – A Case Series. Cannabis. 2021 Apr 22;4(1):53–59. doi: 10.26828/cannabis/2021.01.003. PMID: 37287996; PMCID: PMC10212262.Almeida Scalvino S, Chapelle A, Hajem N, Lati E, Gasser P, Choulot JC, Michel L, Hocquaux M, Loing E, Attia J, Wdzieczak-Bakala J. Efficacy of an agonist of α-MSH, the palmitoyl tetrapeptide-20, in hair pigmentation. Int J Cosmet Sci. 2018 Oct;40(5):516–524. doi: 10.1111/ics.12494. Epub 2018 Oct 8. PMID: 30222197.Almeida Scalvino S, Chapelle A, Hajem N, Lati E, Gasser P, Choulot JC, Michel L, Hocquaux M, Loing E, Attia J, Wdzieczak-Bakala J. Efficacy of an agonist of α-MSH, the palmitoyl tetrapeptide-20, in hair pigmentation. Int J Cosmet Sci. 2018 Oct;40(5):516–524. doi: 10.1111/ics.12494. Epub 2018 Oct 8. PMID: 30222197.Chavan D. Reversal of Premature Hair Graying Treated with a Topical Formulation Containing α-Melanocyte-Stimulating Hormone Agonist (Greyverse Solution 2 %). Int J Trichology. 2022 Nov-Dec;14(6):207–209. doi: 10.4103/ijt.ijt_85_22. Epub 2023 Jan 31. PMID: 37034550; PMCID: PMC 10075347.Chavan D. Reversal of Premature Hair Graying Treated with a Topical Formulation Containing α-Melanocyte-Stimulating Hormone Agonist (Greyverse Solution 2 %). Int J Trichology. 2022 Nov-Dec;14(6):207–209. doi: 10.4103/ijt.ijt_85_22. Epub 2023 Jan 31. PMID: 37034550; PMCID: PMC 10075347.Zha S, Zhao Q, Chen J, Wang L, Zhang G, Zhang H, Zhao B. Extraction, purification and antioxidant activities of the polysaccharides from maca (Lepidium meyenii). Carbohydr Polym. 2014 Oct 13; 111: 584–7. doi: 10.1016/j.carbpol.2014.05.017. Epub 2014 May 21. PMID: 25037390.Zha S, Zhao Q, Chen J, Wang L, Zhang G, Zhang H, Zhao B. Extraction, purification and antioxidant activities of the polysaccharides from maca (Lepidium meyenii). Carbohydr Polym. 2014 Oct 13; 111: 584–7. doi: 10.1016/j.carbpol.2014.05.017. Epub 2014 May 21. PMID: 25037390.Sun Y, Dai C, Shi S, Zheng Y, Wei W, Cai D. Composition analysis and antioxidant activity of essential oils, lipids and polysaccharides in different phenotypes of Lepidium meyenii. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Nov 1; 1099:25–33. doi: 10.1016/j.jchromb.2018.09.010. Epub 2018 Sep 10. PMID: 30241071.Sun Y, Dai C, Shi S, Zheng Y, Wei W, Cai D. Composition analysis and antioxidant activity of essential oils, lipids and polysaccharides in different phenotypes of Lepidium meyenii. J Chromatogr B Analyt Technol Biomed Life Sci. 2018 Nov 1; 1099:25–33. doi: 10.1016/j.jchromb.2018.09.010. Epub 2018 Sep 10. PMID: 30241071.Zhang L, Ravipati AS, Koyyalamudi SR, Jeong SC, Reddy N, Smith PT, Bartlett J, Shanmugam K, Münch G, Wu MJ. Antioxidant and anti-inflammatory activities of selected medicinal plants containing phenolic and flavonoid compounds. J Agric Food Chem. 2011 Dec 14;59(23):12361–7. doi: 10.1021/jf203146e. Epub 2011 Nov 10. PMID: 22023309.Zhang L, Ravipati AS, Koyyalamudi SR, Jeong SC, Reddy N, Smith PT, Bartlett J, Shanmugam K, Münch G, Wu MJ. Antioxidant and anti-inflammatory activities of selected medicinal plants containing phenolic and flavonoid compounds. J Agric Food Chem. 2011 Dec 14;59(23):12361–7. doi: 10.1021/jf203146e. Epub 2011 Nov 10. PMID: 22023309.Aly SH, Elissawy AM, Mahmoud AMA, El-Tokhy FS, Mageed SSA, Almahli H, Al-Rashood ST, Binjubair FA, Hassab MAE, Eldehna WM, Singab AEB. Synergistic Effect of Sophora japonica and Glycyrrhiza glabra Flavonoid-Rich Fractions on Wound Healing: In Vivo and Molecular Docking Studies. Molecules. 2023 Mar 27;28(7):2994. doi: 10.3390/molecules28072994. PMID: 37049756; PMCID: PMC 10096052.Aly SH, Elissawy AM, Mahmoud AMA, El-Tokhy FS, Mageed SSA, Almahli H, Al-Rashood ST, Binjubair FA, Hassab MAE, Eldehna WM, Singab AEB. Synergistic Effect of Sophora japonica and Glycyrrhiza glabra Flavonoid-Rich Fractions on Wound Healing: In Vivo and Molecular Docking Studies. Molecules. 2023 Mar 27;28(7):2994. doi: 10.3390/molecules28072994. PMID: 37049756; PMCID: PMC 10096052.

The authors declare that there are no conflicts of interest present.