medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2024-11-7-13medalphabet-3697Research ArticleСтатьиОценка динамики патогенной микробиоты полости рта у пациентов с COVID-19 методом геномного секвенирования после применения пенки, обладающей антимикробным действиемEvaluation of the dynamics of oral pathogenic microbiota in COVID-19 patients by genomic sequencing after application of foam with antimicrobial actionhttps://orcid.org/0000-0002-4293-8465ЯнушевичО. О.YanushevichO. O.

Янушевич Олег Олегович - академик РАН, д.м.н., проф., ректор, зав. кафедрой пропедевтики терапевтической стоматологии НОИ стоматологии им. А.И. Евдокимова

Yanushevich Oleg O. - academician RAS, DM Sci, prof., rector, head of the Department Propaedeutics of Therapeutic Dentistry of Scientific Research Institute of Dentistry named after A.I. Yevdokimov.

Moscow

mail@msmsu.ruhttps://orcid.org/0000-0002-8035-0638КрихелиН. И.KrikheliN. I.

Крихели Нателла Ильинична - д.м.н., проф., зав. кафедрой клинической стоматологии НОИ стоматологии им. А.И. Евдокимова

Krikheli Natella I. - DM Sci, prof., vice-rector, head of the Department of Clinical Dentistry.

Moscow

nataly0088@mail.ruhttps://orcid.org/0000-0001-6114-564XМаевИ. В.MaevI. V.

Маев Игорь Вениаминович - академик РАН, д.м.н., проф., зав. кафедрой пропедевтики внутренних болезней и гастроэнтерологии лечебного факультета НОИ «Клинической медицины им. Н.А. Семашко»

Mayev Igor V. - academician RAS, DМ Sci, prof., head of the Department propaedeutics of internal diseases and gastroenterology Faculty of Medicine.

Moscow

ProRekt-02@msmsu.ruhttps://orcid.org/0000-0002-7923-9916ЗаборовскийА. В.ZaborovskyA. V.

Заборовский Андрей Владимирович - д.м.н., доцент, зав. кафедрой фармакологии лечебного факультета НОИ «Клинической медицины им. Н.А. Семашко»

Zaborovsky Andrey V. - DM Sci, prof., head of the Department pharmacology Faculty of Medicine.

Moscow

ZABOROVSKY_AV@msmsu.ruhttps://orcid.org/0000-0003-0857-9398ЛевченкоО. В.LevchenkoO. V.

Левченко Олег Валерьевич - д.м.н., проф., зав. кафедрой нейрохирургии и нейрореанимации лечебного факультета НОИ «Клинической медицины им. Н.А. Семашко»

Levchenko Oleg V. - DM Sci, prof., head of the Department Neurosurgery and Neuroreanimation Faculty of Medicine.

Moscow

LEVCHENKO-OV@msmsu.ruhttps://orcid.org/0000-0001-6304-4607ГалееваЮ. С.GaleevaYu. S.

Галеева Юлия Сергеевна - младший научный сотрудник

Galeeva Yulia S. - Jr. scientific co-workers.

Moscow

https://orcid.org/0000-0001-6582-210XСтариковаЕ. В.StarikovaE. V.

Старикова Елизавета Валентиновна - научный сотрудник

Starikova Elizaveta V. - scientific co-workers.

Moscow

АндреевД. Н.AndreevD. N.

Andreev Dmitry N. - Ph.D. of Medical Sciences, assistant professor, assistant professor of the Department propaedeutics of internal diseases and gastroenterology Faculty of Medicine.

Moscow

https://orcid.org/0000-0002-4007-7112БелыйП. А.BelyP. A.

Андреев Дмитрий Николаевич - к.м.н., доцент, доцент кафедры пропедевтики внутренних болезней и гастроэнтерологии лечебного факультета НОИ «Клинической медицины им. Н.А. Семашко»

Bely Petr A. - Ph.D. of Medical Sciences, assistant professor of the Department propaedeutics of internal diseases and gastroenterology Faculty of Medicine.

Moscow

dna-mit8@mail.ruhttps://orcid.org/0000-0003-2813-6498СоколовФ. С.SokolovF. S.

Соколов Филипп Сергеевич - преподаватель кафедры фармакологии лечебного факультета НОИ «Клинической медицины им. Н.А. Семашко»

Solodov Alexander A. - DM Sci., Director.

Moscow

phlppsokolov@gmail.comhttps://orcid.org/0000-0002-1794-7263ФоменкоА. К.FomenkoA. K.

Фоменко Алексей Константинович - преподаватель кафедры фармакологии лечебного факультета НОИ «Клинической медицины им. Н.А. Семашко»

Fomenko Alexey K. - teacher of the department pharmacology Faculty of Medicine.

Moscow

docfomenko@yandex.ruhttps://orcid.org/0000-0002-0254-0516ЦарегородцевС. В.TsaregorodtsevS. V.

Царегородцев Сергей Вадимович - преподаватель кафедры фармакологии лечебного факультета НОИ «Клинической медицины им. Н.А. Семашко»

Tsaregorodtsev Sergey V. - teacher of the department pharmacology Faculty of Medicine.

Moscow

sergiotsar@yandex.ruhttps://orcid.org/0000-0002-5136-0140АндреевН. Г.AndreevN. G.

Андреев Николай Германович - к.м.н., доцент, доцент кафедры пропедевтики внутренних болезней и гастроэнтерологии лечебного факультета НОИ «Клинической медицины им. Н.А. Семашко»

Andreev Nikolay G. - Ph.D. of Medical Sciences, assistant professor, assistant professor of the Department propaedeutics of internal diseases and gastroenterology Faculty of Medicine.

Moscow

https://orcid.org/0000-0001-9281-579XЕвдокимовВ. В.EvdokimovV. V.

Евдокимов Владимир Вячеславович - д.м.н., заведующий кафедрой госпитальной терапии №2 лечебного факультета НОИ «Клинической медицины им. Н.А. Семашко»

Evdokimov Vladimir V. - DM Sci, prof., head of the Department of Hospital Therapy №2 Faculty of Medicine.

Moscow

vvevdokimov@rambler.ruhttps://orcid.org/0000-0002-3736-4196ДевкотаМ. К.DevkotaM. K.

Девкота Михаил Кумарович1, преподаватель кафедры фармакологии лечебного факультета НОИ «Клинической медицины им. Н.А. Семашко»

Devkota Mikhail K. - teacher of the department pharmacology Faculty of Medicine.

Moscow

devkota@bk.ruhttps://orcid.org/0000-0002-7570-9650КебинаА. Л.KebinaA. L.

Кебина Анастасия Леонидовна - заместитель главного врача, ассистент кафедры терапии, клинической фармакологии и скорой медицинской помощи лечебного факультета НОИ «Клинической медицины им. Н.А. Семашко»

Kebina Anastasia L. - Deputy Chief Physician, assistant of the department of therapy, clinical pharmacology and emergency medical care of the medical faculty.

Moscow

https://orcid.org/0000-0003-0130-5079ИльинаЕ. Н.IlyinaE. N.

Ильина Елена Николаевна - член-корреспондент РАН, профессор РАН, д.б.н, главный научный сотрудник

Ilyina Elena N. - corresponding member RAS, prof. RAS, DB Sci, Ch. scientific co-workers.

Moscow

https://orcid.org/0000-0003-0837-8764ГоворунВ. М.GovorunV. M.

Говорун Вадим Маркович - академик РАН, д.б.н., профессор, директор

Govorun Vadim M. - academician RAS, DB Sci, prof., Director.

Moscow

https://orcid.org/0000-0003-0225-2773РудневаО. В.RudnevaO. V.

Руднева Ольга Витальевна - ассистент кафедры клинической стоматологии НОИ стоматологии им. А.И. Евдокимова

Rudneva Olga V. - Assistant of the Department of Clinical Dentistry.

Moscow

rudneva_ov@bk.ruФГБОУ ВО «Российский университет медицины» Минздрава РоссииРоссияFSBEI HE «ROSUNIMED» of MOH of RussiaRussian FederationФБУН НИИ СБМ РоспотребнадзораРоссияResearch Institute for Systems Biology and MedicineRussian Federation202411052024011Стоматология (2)713Copyright © Янушевич О.О., Крихели Н.И., Маев И.В., Заборовский А.В., Левченко О.В., Галеева Ю.С., Старикова Е.В., Андреев Д.Н., Белый П.А., Соколов Ф.С., Фоменко А.К., Царегородцев С.В., Андреев Н.Г., Евдокимов В.В., Девкота М.К., Кебина А.Л., Ильина Е.Н., Говорун В.М., Руднева О.В., 20242024Янушевич О.О., Крихели Н.И., Маев И.В., Заборовский А.В., Левченко О.В., Галеева Ю.С., Старикова Е.В., Андреев Д.Н., Белый П.А., Соколов Ф.С., Фоменко А.К., Царегородцев С.В., Андреев Н.Г., Евдокимов В.В., Девкота М.К., Кебина А.Л., Ильина Е.Н., Говорун В.М., Руднева О.В.Yanushevich O.O., Krikheli N.I., Maev I.V., Zaborovsky A.V., Levchenko O.V., Galeeva Y.S., Starikova E.V., Andreev D.N., Bely P.A., Sokolov F.S., Fomenko A.K., Tsaregorodtsev S.V., Andreev N.G., Evdokimov V.V., Devkota M.K., Kebina A.L., Ilyina E.N., Govorun V.M., Rudneva O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/3697Актуальность проблемы

Актуальность проблемы. Пандемия COVID-19, вызванная вирусом SARS-CoV-2, продемонстрировала критическую важность понимания механизмов передачи инфекции и поиска эффективных методов ее предотвращения. Особое внимание уделяется роли оральной гигиены, поскольку полость рта служит одним из основных путей передачи вируса. Исследования показывают, что состав микробиоты полости рта может влиять на течение и исход заболевания COVID-19. В связи с этим возникает необходимость в изучении воздействия антисептических средств для полости рта на микробиом, что может открыть новые возможности для профилактики и лечения данного заболевания.

Цель

Цель. Целью настоящего исследования является оценка эффективности применения очищающей пенки для полости рта «Пародонтол PROF» в снижении патогенной микрофлоры полости рта у пациентов с COVID-19 и оценка её влияния на риск развития вторичных инфекций.

Материалы и методы

Материалы и методы. Исследование проводилось на базе Клинического медицинского центра «Кусково» Российского университета медицины Минздрава РФ. В него было включено 450 пациентов с подтвержденным диагнозом COVID-19. Участники были разделены на две группы: испытуемая группа использовала очищающую пенку для полости рта, в то время как контрольная группа не применяла дополнительной гигиены полости рта. Были проведены сравнительные анализы таксономического состава микробиоты ротоглотки и зубного налета до и после использования очищающей пенки.

Результаты

Результаты. Исследование показало, что у пациентов, регулярно использующих очищающую пенку «Пародонтол PROF», наблюдается значительное снижение представленности патогенных микроорганизмов, включая Mycoplasma, и увеличение количества полезных комменсалов, таких как Lactococcus и Lactobacillus. Эти изменения свидетельствуют о потенциальной эффективности данного средства для улучшения оральной гигиены и снижения риска развития вторичных инфекций.

Relevance

Relevance. The COVID-19 pandemic caused by the SARS-CoV-2 virus has demonstrated the critical importance of understanding the mechanisms of transmission and finding effective methods of prevention. Particular attention has been paid to the role of oral hygiene, as the oral cavity serves as a major route of transmission. Studies show that the composition of the oral microbiota can influence the course and outcome of COVID-19 disease. Therefore, there is a need to study the effects of oral antiseptics on the microbiome, which may offer new opportunities for the prevention and treatment of this disease.

Objective

Objective. The aim of this study is to evaluate the effectiveness of the oral cleansing foam «Parodontol PROF» in reducing the pathogenic microflora of the oral cavity in patients with COVID-19 and to assess its effect on the risk of secondary infections.

Materials and methods

Materials and methods. The study was conducted on the basis of the Clinical Medical Centre «Kuskovo» of Russian University of Medicine. It included 450 patients with a confirmed diagnosis of COVID-19. The participants were divided into two groups: the test group used oral cleansing foam, while the control group used no additional oral hygiene. Comparative analyses of the taxonomic composition of the oropharyngeal microbiota and dental plaque before and after the use of the cleansing foam were performed.

Results

Results. The study showed that patients who regularly used the cleansing foam «Parodontol PROF» had a significant decrease in the representation of pathogens, including Mycoplasma, and an increase in the number of beneficial commensals such as Lactococcus and Lactobacillus. These changes indicate the potential efficacy of this product to improve oral hygiene and reduce the risk of secondary infections.

Conclusion

Conclusion. The study supports the hypothesis that improving oral hygiene with specialised antiseptic agents, such as a cleansing foam, may help to reduce pathogenic microflora in the oral cavity in patients with COVID-19. This, in turn, may reduce the risk of pathogen migration into the lower respiratory tract and the development of secondary infections. The findings emphasise the importance of further research in this area and the development of comprehensive approaches to oral hygiene management in the context of infectious diseases.

COVID-19микробиомгеномное секвенированиегигиеническая пенка. КОНФЛИКТ ИНТЕРЕСОВ. Авторы заявляют об отсутствии конфликта интересовCOVID-19microbiomegenomic sequencinghygienic foamReferencesHoffmann D. The role of the oral cavity in SARS-CoV-2- and other viral infections / D. Hoffmann // Clinical Oral Investigations. – 2023. – Vol. 27. – № Suppl 1. – P. 15–22.Hoffmann D. The role of the oral cavity in SARS-CoV-2- and other viral infections / D. Hoffmann // Clinical Oral Investigations. – 2023. – Vol. 27. – № Suppl 1. – P. 15–22.Dysbiosis of Oral and Gut Microbiomes in SARS-CoV-2 Infected Patients in Bangladesh: Elucidating the Role of Opportunistic Gut Microbes / S.M.R. Islam, M.J. Foysal, M. N. Hoque [и др.]. – Текстs: электронный // Frontiers in Medicine. – 2022. – Т. 9. – Dysbiosis of Oral and Gut Microbiomes in SARS-CoV-2 Infected Patients in Bangladesh. – URL: https://www.frontiersin.org/articles/10.3389/fmed.2022.821777/full (дата обращения: 16.01.2024).Dysbiosis of Oral and Gut Microbiomes in SARS-CoV-2 Infected Patients in Bangladesh: Elucidating the Role of Opportunistic Gut Microbes / S.M.R. Islam, M.J. Foysal, M. N. Hoque [и др.]. – Текстs: электронный // Frontiers in Medicine. – 2022. – Т. 9. – Dysbiosis of Oral and Gut Microbiomes in SARS-CoV-2 Infected Patients in Bangladesh. – URL: https://www.frontiersin.org/articles/10.3389/fmed.2022.821777/full (дата обращения: 16.01.2024).Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection / L. Bao, C. Zhang, J. Dong [и др.]. – Текстs: электронный // Frontiers in Microbiology. – 2020. – Т. 11. – Oral Microbiome and SARS-CoV-2. – URL: https://www.frontiersin.org/articles/10.3389/fmicb.2020.01840/full (дата обращения: 16.01.2024).Oral Microbiome and SARS-CoV-2: Beware of Lung Co-infection / L. Bao, C. Zhang, J. Dong [и др.]. – Текстs: электронный // Frontiers in Microbiology. – 2020. – Т. 11. – Oral Microbiome and SARS-CoV-2. – URL: https://www.frontiersin.org/articles/10.3389/fmicb.2020.01840/full (дата обращения: 16.01.2024).104 Inflammation-Type Dysbiosis of the Oral Microbiome Associates With the Duration of Coronavirus Disease 2019 (COVID-19) and Long COVID Disease States / J. Haran, E. Bradley, A. Zeamer [и др.]. – Текстs: электронный // Annals of Emergency Medicine. – 2021. – Т. 78. – С. 47-47. – URL: https://www.sciencedirect.com/science/article/pii/S019606442100665X?via%3Dihub (дата обращения: 16.01.2024).104 Inflammation-Type Dysbiosis of the Oral Microbiome Associates With the Duration of Coronavirus Disease 2019 (COVID-19) and Long COVID Disease States / J. Haran, E. Bradley, A. Zeamer [и др.]. – Текстs: электронный // Annals of Emergency Medicine. – 2021. – Т. 78. – С. 47-47. – URL: https://www.sciencedirect.com/science/article/pii/S019606442100665X?via%3Dihub (дата обращения: 16.01.2024).Emerging role of bacteria in oral carcinogenesis: a review with special reference to perio-pathogenic bacteria / M. Perera, N. N. Al-Hebshi, D. J. Speicher [и др.] // Journal of Oral Microbiology. – 2016. – Т. 8. – Emerging role of bacteria in oral carcinogenesis. – С. 32762.Emerging role of bacteria in oral carcinogenesis: a review with special reference to perio-pathogenic bacteria / M. Perera, N. N. Al-Hebshi, D. J. Speicher [и др.] // Journal of Oral Microbiology. – 2016. – Т. 8. – Emerging role of bacteria in oral carcinogenesis. – С. 32762.Acquiring and maintaining a normal oral microbiome: current perspective / E. Zaura, E. A. Nicu, B. P. Krom, B. J. F. Keijser // Frontiers in Cellular and Infection Microbiology. – 2014. – Т. 4. – Acquiring and maintaining a normal oral microbiome. – С. 85.Acquiring and maintaining a normal oral microbiome: current perspective / E. Zaura, E. A. Nicu, B. P. Krom, B. J. F. Keijser // Frontiers in Cellular and Infection Microbiology. – 2014. – Т. 4. – Acquiring and maintaining a normal oral microbiome. – С. 85.Deo P. N. Oral microbiome: Unveiling the fundamentals / P. N. Deo, R. Deshmukh. – Texts: electronic // Journal of Oral and Maxillofacial Pathologys: JOMFP. – 2019. – Vol. 23. – Oral microbiome. – № 1. – P. 122–128. – URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503789/ (date accessed: 02.02.2024).Deo P. N. Oral microbiome: Unveiling the fundamentals / P. N. Deo, R. Deshmukh. – Texts: electronic // Journal of Oral and Maxillofacial Pathologys: JOMFP. – 2019. – Vol. 23. – Oral microbiome. – № 1. – P. 122–128. – URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503789/ (date accessed: 02.02.2024).COVID-19 and Its Effect on Dentistry / A. Sharma, R. Balpande, A. Shrivastava [и др.] // Journal of Advances in Medicine and Medical Research. – 2020. – С. 14–24.COVID-19 and Its Effect on Dentistry / A. Sharma, R. Balpande, A. Shrivastava [и др.] // Journal of Advances in Medicine and Medical Research. – 2020. – С. 14–24.Oral Microbiome Dysbiosis Is Associated With Symptoms Severity and Local Immune/Inflammatory Response in COVID-19 Patients: A Cross-Sectional Study / I. Soffritti, M. D’Accolti, C. Fabbri [и др.]. – Текстs: электронный // Frontiers in Microbiology. – 2021. – Т. 12. – Oral Microbiome Dysbiosis Is Associated With Symptoms Severity and Local Immune/Inflammatory Response in COVID-19 Patients. – URL: https://www.frontiersin.org/articles/10.3389/fmicb.2021.687513 (дата обращения: 11.11.2023).Oral Microbiome Dysbiosis Is Associated With Symptoms Severity and Local Immune/Inflammatory Response in COVID-19 Patients: A Cross-Sectional Study / I. Soffritti, M. D’Accolti, C. Fabbri [и др.]. – Текстs: электронный // Frontiers in Microbiology. – 2021. – Т. 12. – Oral Microbiome Dysbiosis Is Associated With Symptoms Severity and Local Immune/Inflammatory Response in COVID-19 Patients. – URL: https://www.frontiersin.org/articles/10.3389/fmicb.2021.687513 (дата обращения: 11.11.2023).Use of an antiviral mouthwash as a barrier measure in the SARS-CoV-2 transmission in adults with asymptomatic to mild COVID-19: a multicentre, randomized, double-blind controlled trial / F. Carrouel, M. Valette, E. Gadea [et al.]. – Texts: electronic // Clinical Microbiology and Infection. – 2021. – Vol. 27. – Use of an antiviral mouthwash as a barrier measure in the SARS-CoV-2 transmission in adults with asymptomatic to mild COVID-19. – № 10. – P. 1494–1501. – URL: https://linkinghub.elsevier.com/retrieve/pii/S1198743X21002688 (date accessed: 26.09.2023).Use of an antiviral mouthwash as a barrier measure in the SARS-CoV-2 transmission in adults with asymptomatic to mild COVID-19: a multicentre, randomized, double-blind controlled trial / F. Carrouel, M. Valette, E. Gadea [et al.]. – Texts: electronic // Clinical Microbiology and Infection. – 2021. – Vol. 27. – Use of an antiviral mouthwash as a barrier measure in the SARS-CoV-2 transmission in adults with asymptomatic to mild COVID-19. – № 10. – P. 1494–1501. – URL: https://linkinghub.elsevier.com/retrieve/pii/S1198743X21002688 (date accessed: 26.09.2023).Efficacy of commercial mouth-rinses on SARS-CoV-2 viral load in saliva: randomized control trial in Singapore. / C.J. Seneviratne, P. Balan, K.K.K. Ko [и др.] // Infection. – 2020. – Т. 49. – № 2. – С. 305-311.Efficacy of commercial mouth-rinses on SARS-CoV-2 viral load in saliva: randomized control trial in Singapore. / C.J. Seneviratne, P. Balan, K.K.K. Ko [и др.] // Infection. – 2020. – Т. 49. – № 2. – С. 305-311.Antiviral Activity of Reagents in Mouth Rinses against SARS-CoV-2 / F. Carrouel, L.S. Gonçalves, M. P. Conte [и др.] // Journal of Dental Research. – 2021. – Т. 100. – № 2. – С. 124–132.Antiviral Activity of Reagents in Mouth Rinses against SARS-CoV-2 / F. Carrouel, L.S. Gonçalves, M. P. Conte [и др.] // Journal of Dental Research. – 2021. – Т. 100. – № 2. – С. 124–132.Evaluation of Current Evidence on the Use of Oral Antiseptics Against SARS-CoV-2: A Narrative Review / V. Chumpitaz-Cerrate, L. Chávez-Rimache, E. Ruiz-Ramirez [и др.] // Journal of International Society of Preventive and Community Dentistry. – 2022. – Т. 12. – Evaluation of Current Evidence on the Use of Oral Antiseptics Against SARS-CoV-2. – № 5. – С. 488–499.Evaluation of Current Evidence on the Use of Oral Antiseptics Against SARS-CoV-2: A Narrative Review / V. Chumpitaz-Cerrate, L. Chávez-Rimache, E. Ruiz-Ramirez [и др.] // Journal of International Society of Preventive and Community Dentistry. – 2022. – Т. 12. – Evaluation of Current Evidence on the Use of Oral Antiseptics Against SARS-CoV-2. – № 5. – С. 488–499.Oral antiseptics against coronavirus: in-vitro and clinical evidence / M.V. Mateos Moreno, A.M. Obrador, V.A. Márquez, M.D. Ferrer García // Journal of Hospital Infection. – 2021. – Т. 113. – Oral antiseptics against coronavirus. – С. 30–43.Oral antiseptics against coronavirus: in-vitro and clinical evidence / M.V. Mateos Moreno, A.M. Obrador, V.A. Márquez, M.D. Ferrer García // Journal of Hospital Infection. – 2021. – Т. 113. – Oral antiseptics against coronavirus. – С. 30–43.Antimicrobial mouthwashes (gargling) and nasal sprays administered to patients with suspected or confirmed COVID-19 infection to improve patient outcomes and to protect healthcare workers treating them / M.J. Burton, J.E. Clarkson, B. Goulao [et al.]. – Texts: electronic // Cochrane Database of Systematic Reviews. – 2020. – № 9. – URL: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013627.pub2/full/ru (date accessed: 31.01.2024).Antimicrobial mouthwashes (gargling) and nasal sprays administered to patients with suspected or confirmed COVID-19 infection to improve patient outcomes and to protect healthcare workers treating them / M.J. Burton, J.E. Clarkson, B. Goulao [et al.]. – Texts: electronic // Cochrane Database of Systematic Reviews. – 2020. – № 9. – URL: https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD013627.pub2/full/ru (date accessed: 31.01.2024).Sampson V. Oral hygiene risk factor / V. Sampson. – Texts: electronic // British Dental Journal. – 2020. – Vol. 228. – № 8. – P. 569-569. – URL: https://www.nature.com/articles/s41415-020-1545-3 (date accessed: 31.01.2024).Sampson V. Oral hygiene risk factor / V. Sampson. – Texts: electronic // British Dental Journal. – 2020. – Vol. 228. – № 8. – P. 569-569. – URL: https://www.nature.com/articles/s41415-020-1545-3 (date accessed: 31.01.2024).Mani K. Role of oral health during COVID-19 / K. Mani, J. Karini. – Texts: electronic // International Journal of Research in Medical Sciences. – 2021. – Vol. 9. – № 1. – P. 324–324. – URL: https://www.msjonline.org/index.php/ijrms/article/view/9024 (date accessed: 31.01.2024).Mani K. Role of oral health during COVID-19 / K. Mani, J. Karini. – Texts: electronic // International Journal of Research in Medical Sciences. – 2021. – Vol. 9. – № 1. – P. 324–324. – URL: https://www.msjonline.org/index.php/ijrms/article/view/9024 (date accessed: 31.01.2024).Effects of xylitol-containing chewing gum on the oral microbiota / K. Takeuchi, M. Asakawa, T. Hashiba [и др.] // Journal of Oral Science. – 2018. – Т. 60. – № 4. – С. 588–594.Effects of xylitol-containing chewing gum on the oral microbiota / K. Takeuchi, M. Asakawa, T. Hashiba [и др.] // Journal of Oral Science. – 2018. – Т. 60. – № 4. – С. 588–594.Exploration of singular and synergistic effect of xylitol and erythritol on causative agents of dental caries / S. Kõljalg, I. Smidt, A. Chakrabarti [и др.] // Scientific Reports. – 2020. – Т. 10. – № 1. – С. 6297.Exploration of singular and synergistic effect of xylitol and erythritol on causative agents of dental caries / S. Kõljalg, I. Smidt, A. Chakrabarti [и др.] // Scientific Reports. – 2020. – Т. 10. – № 1. – С. 6297.Xylitol, a Promising Allied for Oral Heath / E.G D. Siqueira Fraga, F. M. Teófilo Campos, M.P.D. Silva Cavalcante [и др.]. – Текстs: электронный // Journal of Young Pharmacists. – 2020. – Т. 12. – № 3. – С. 197-200. – URL: http://www.jyoungpharm.org/article/1499 (дата обращения: 31.01.2024).Xylitol, a Promising Allied for Oral Heath / E.G D. Siqueira Fraga, F. M. Teófilo Campos, M.P.D. Silva Cavalcante [и др.]. – Текстs: электронный // Journal of Young Pharmacists. – 2020. – Т. 12. – № 3. – С. 197-200. – URL: http://www.jyoungpharm.org/article/1499 (дата обращения: 31.01.2024).Marquis R. E. Antimicrobial actions of fluoride for oral bacteria / R.E. Marquis // Canadian Journal of Microbiology. – 1995. – Т. 41. – № 11. – С. 955–964.Marquis R. E. Antimicrobial actions of fluoride for oral bacteria / R.E. Marquis // Canadian Journal of Microbiology. – 1995. – Т. 41. – № 11. – С. 955–964.Bacterial viability in oral biofilm after tooth brushing with amine fluoride or sodium fluoride / E.A. Naumova, L. Weber, V. Pankratz [и др.]. – Текст: электронный // Archives of Oral Biology. – 2019. – Т. 97. – С. 91–96. – URL: https://www.sciencedirect.com/science/article/pii/S0003996918303042 (дата обращения: 31.01.2024).Bacterial viability in oral biofilm after tooth brushing with amine fluoride or sodium fluoride / E.A. Naumova, L. Weber, V. Pankratz [и др.]. – Текст: электронный // Archives of Oral Biology. – 2019. – Т. 97. – С. 91–96. – URL: https://www.sciencedirect.com/science/article/pii/S0003996918303042 (дата обращения: 31.01.2024).Killing of Gram-positive cocci by fatty acids and monoglycerides / G. Bergsson, J. Arnfinnsson, O. Steingrímsson, H. Thormar // APMIS: acta pathologica, microbiologica, et immunologica Scandinavica. – 2001. – Т. 109. – № 10. – С. 670–678.Killing of Gram-positive cocci by fatty acids and monoglycerides / G. Bergsson, J. Arnfinnsson, O. Steingrímsson, H. Thormar // APMIS: acta pathologica, microbiologica, et immunologica Scandinavica. – 2001. – Т. 109. – № 10. – С. 670–678.Vergara-Buenaventura A. Use of mouthwashes against COVID-19 in dentistry / A. Vergara-Buenaventura, C. Castro-Ruiz. – Текстs: электронный // British Journal of Oral and Maxillofacial Surgery. – 2020. – Т. 58. – № 8. – С. 924–927. URL: https://www.bjoms.com/article/S0266-4356(20)30403-4/fulltext (дата обращения: 02.02.2024).Vergara-Buenaventura A. Use of mouthwashes against COVID-19 in dentistry / A. Vergara-Buenaventura, C. Castro-Ruiz. – Текстs: электронный // British Journal of Oral and Maxillofacial Surgery. – 2020. – Т. 58. – № 8. – С. 924–927. URL: https://www.bjoms.com/article/S0266-4356(20)30403-4/fulltext (дата обращения: 02.02.2024).Shklair I. L. The Inhibitory Effect of Sodium N-Lauroyl Sarcosinate On Oral Lactobacilli When Grown On Various Media / I.L. Shklair, K.C. Hoerman, H.R. Englander. – Texts: electronic // Journal of Dental Research. – 1957. – Vol. 36. – № 1. – P. 129–131. – URL: https://doi.org/10.1177/00220345570360010701 (date accessed: 31.01.2024).Shklair I. L. The Inhibitory Effect of Sodium N-Lauroyl Sarcosinate On Oral Lactobacilli When Grown On Various Media / I.L. Shklair, K.C. Hoerman, H.R. Englander. – Texts: electronic // Journal of Dental Research. – 1957. – Vol. 36. – № 1. – P. 129–131. – URL: https://doi.org/10.1177/00220345570360010701 (date accessed: 31.01.2024).Mouthrinses against SARS-CoV-2: anti-inflammatory effectivity and a clinical pilot study / M. Schürmann, M. Aljubeh, C. Tiemann, H. Sudhoff // European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. – 2021. – Vol. 278. – Mouthrinses against SARS-CoV-2. – № 12. – P. 5059–5067.Mouthrinses against SARS-CoV-2: anti-inflammatory effectivity and a clinical pilot study / M. Schürmann, M. Aljubeh, C. Tiemann, H. Sudhoff // European archives of oto-rhino-laryngology: official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS): affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. – 2021. – Vol. 278. – Mouthrinses against SARS-CoV-2. – № 12. – P. 5059–5067.Emerging technologies and potential applications of algae in dentistry – A critical review / A. Balasubramaniam, M. Arumugham I, S. Nathan P [и др.]. – Текстs: электронный // Journal of Biotechnology. – 2022. – Т. 360. – С. 1–10. – URL: https://www.sciencedirect.com/science/article/pii/S0168165622002309 (дата обращения: 31.01.2024).Emerging technologies and potential applications of algae in dentistry – A critical review / A. Balasubramaniam, M. Arumugham I, S. Nathan P [и др.]. – Текстs: электронный // Journal of Biotechnology. – 2022. – Т. 360. – С. 1–10. – URL: https://www.sciencedirect.com/science/article/pii/S0168165622002309 (дата обращения: 31.01.2024).

The authors declare that there are no conflicts of interest present.