medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2024-4-55-59medalphabet-3679Research ArticleСтатьиСезонные коронавирусы и SARS-CoV-2: структурно-функциональные, клинико- эпидемиологические характеристики и гуморальный перекрестный иммунитетSeasonal coronaviruses and SARS-CoV-2: Structural, functional, clinical and epidemiological characteristics and humoral cross-immunityШабалинаЮ. В.ShabalinaYu. V.

Шабалина Юлия Вадимовна, ст. преподаватель кафедры биологической химии, клинической лабораторной диагностики

г. Барнаул

Shabalina Yulia V., senior lecturer at Dept of Biological Chemistry, Clinical Laboratory Diagnostics

Barnaul

shabalinajv@gmail.comЕльчаниноваС. А.ElchaninovaS. A.

Ельчанинова Светлана Александровна, д. б. н., проф. кафедры биологической химии, клинической лабораторной диагностики

г. Барнаул

Elchaninova Svetlana A., DBio Sci (habil.), professor at Dept of Biological Chemistry, Clinical Laboratory Diagnostics

Barnaul

saelch@mail.ruФГБОУ ВО «Алтайский государственный медицинский университет» Минздрава РоссииРоссияAltai State Medical UniversityRussian Federation20240905202404Современная лаборатория (1)5559Copyright © Шабалина Ю.В., Ельчанинова С.А., 20242024Шабалина Ю.В., Ельчанинова С.А.Shabalina Y.V., Elchaninova S.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/3679

Предполагается, что формирование и поддержание иммунитета к SARS-CoV-2 может зависеть от иммунного статуса по другим инфекциям, возбудителями которых являются коронавирусы человека (HCoV), называемые сезонными: HCoV-OC 43, HCoV-HKU 1, HCoV-229E, HCoV-NL63. Эти вирусы распространены повсеместно и обычно вызывают легкие и умеренные респираторные заболевания сезонного характера, передающиеся преимущественно воздушно-капельным путем. В обзоре представлен сравнительный анализ основных структурно-функциональных, клинико-эпидемиологических характеристик сезонных HCoV и SARS-CoV-2. Систематизация такого рода информации в сочетании с данными о перекрестном иммунитете к разным HCoV может позволить выявить влияющие на иммунитет к SARS-CoV-2 факторы и учитывать их при совершенствовании стратегии санитарно-эпидемиологического контроля COVID-19.

It is assumed that the formation and persistence of immunity to SARS-CoV-2 may depend on the immune status of other infections caused by human coronaviruses (HCoV), called seasonal: HCoV-OC 43, HCoV-HKU 1, HCoV-229E, HCoV-NL63. These viruses are ubiquitous and typically cause mild to moderate seasonal respiratory illness. A comparative analysis of the main structural, functional, clinical and epidemiological characteristics of seasonal HCoV and SARS-CoV-2 is presented in the review. Systematization of this information in combination with data on cross-immunity to different HCoV may make it possible to identify factors of immunity to SARS-CoV-2 and take them into account when improving the strategy for sanitary and epidemiological control of COVID-19.

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The authors declare that there are no conflicts of interest present.