medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2024-5-23-26medalphabet-3645Research ArticleСтатьиКишечная микробиота и желчнокаменная болезнь – есть ли связь?Intestinal microbiota and gallstone disease – is there a connection?https://orcid.org/0000-0002-7603-8481АхмедовВ. А.AkhmedovV. A.

Ахмедов Вадим Адильевич - д.м.н., проф., зав. кафедрой медицинской реабилитации дополнительного профессионального образования.

Омск

Akhmedov Vadim A. - DM Sci (habil.) professor, head of Dept of Medical Rehabilitation of Additional Professional Education.

Omsk

v_akhmedov@mail.ruФГБОУ ВО «Омский государственный медицинский университет» Минздрава РоссииРоссияOmsk State Medical UniversityRussian Federation20240705202405Практическая гастроэнтерология (1)2326Copyright © Ахмедов В.А., 20242024Ахмедов В.А.Akhmedov V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/3645

Желчнокаменная болезнь представляет собой довольно распространенное заболевание органов пищеварения, поражающее от 10 % до 15 % взрослого населения. Несмотря на множество исследований, посвященных данной проблеме, механизмы формирования желчнокаменной болезни не до конца выяснены. В последнее время рассматриваются аспекты влияния кишечной микробиоты на механизмы формирования различных патологий желудочно-кишечного тракта как неалкогольная жировая болезнь печени, воспалительные заболевания кишечника, синдром раздраженной кишки, болезни поджелудочной железы, гастроэзофагеальная рефлюксная болезнь. В представленной обзорной статье рассмотрено возможное участие в патогенезе желчнокаменной болезни микробиома желудочно-кишечного тракта. В статье рассматриваются роль микроорганизмов и их метаболитов в формировании камней в желчном пузыре.

Cholelithiasis is a fairly common disease of the digestive system, affecting from 10 % to 15 % of the adult population. Despite many studies devoted to this problem, the mechanisms of formation of gallstone disease have not been fully elucidated. Recently, aspects of the influence of the intestinal microbiota on the mechanisms of formation of various pathologies of the gastrointestinal tract such as non-alcoholic fatty liver disease, inflammatory bowel diseases, irritable bowel syndrome, pancreatic diseases, gastroesophageal reflux disease have been considered. The presented review article examines the possible involvement of the gastrointestinal microbiome in the pathogenesis of gallstone disease. The article discusses the role of microorganisms and their metabolites in the formation of gallstones.

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The authors declare that there are no conflicts of interest present.