medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»medalphabet-363Research ArticleСтатьиСравнительная оценка эффективности, безопасности и возможностей химиотерапии второй линии терапии метастатического рака желудкаComparative evaluation of efficacy, safety and possibilities of second-line chemotherapy of metastatic gastric cancerОрловаР. В.OrlovaR. V.noemail@neicon.ruБелякН. П.BelyakN. P.noemail@neicon.ruЭрдниевС. П.ErdnievS. P.noemail@neicon.ruКутуковаС. И.KutukovaS. I.noemail@neicon.ruЖуковаН. В.ZhukovaN. V.noemail@neicon.ruПоповаН. П.PopovaN. P.noemail@neicon.ruЗоринаЕ. Ю.ZorinaE. Yu.noemail@neicon.ruАвраменкоИ. В.AvramenkoI. V.noemail@neicon.ruИвановаА. К.IvanovaA. K.noemail@neicon.ruАнтимоникН. Ю.AntimonikN. Yu.noemail@neicon.ruГБОУ ВПО «Санкт-Петербургский государственный университет» Минздрава России; СПбГБУЗ «Городской клинический онкологический диспансер»РоссияCity Clinical Oncology Centre; Saint Petersburg State UniversityRussian FederationСПбГБУЗ «Городской клинический онкологический диспансер»РоссияCity Clinical Oncology CentreRussian FederationФГБОУ ВПО «Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова» Минздрава России; СПбГБУЗ «Городской клинический онкологический диспансер»РоссияCity Clinical Oncology Centre; First Saint Petersburg State Medical University n.a. I. P. PavlovRussian Federation201712112017335Диагностика и онкотерапия1722Copyright © Орлова Р.В., Беляк Н.П., Эрдниев С.П., Кутукова С.И., Жукова Н.В., Попова Н.П., Зорина Е.Ю., Авраменко И.В., Иванова А.К., Антимоник Н.Ю., 20172017Орлова Р.В., Беляк Н.П., Эрдниев С.П., Кутукова С.И., Жукова Н.В., Попова Н.П., Зорина Е.Ю., Авраменко И.В., Иванова А.К., Антимоник Н.Ю.Orlova R.V., Belyak N.P., Erdniev S.P., Kutukova S.I., Zhukova N.V., Popova N.P., Zorina E.Y., Avramenko I.V., Ivanova A.K., Antimonik N.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/363

Согласно данным опубликованных рандомизированных исследований терапии второй линии у пациентов с диагнозом «рак желудка» увеличение медианы выживаемости на фоне монотерапии химиопрепаратами (доцетакселом или иринотеканом) составляет приблизительно 1,5 месяца по сравнению с симптоматической терапиеий. Имеются данные сравнительных исследований по оценке эффективности других таргетных препаратов: применение эверолимуса в качестве препаратов второй линии не выявило значительного увеличения ОВ; исследования анти-EGFR-терапии (добавление панитумумаба или цетуксимаба к химиотерапии) в качестве терапии первой линии также не продемонстрировали значительного увеличения ОВ или ВВП соответственно. Увеличение ОВ у пациентов, получавших комбинацию рамуцирумаба и паклитаксела, по сравнению с группой плацебо и паклитаксела может быть признано клинически значимым для этой популяции пациентов и позволит рассматривать данный терапевтический режим как новый стандарт второй линии лечения у пациентов с данной нозологией

According to published randomized studies of second-line therapy in patients diagnosed with gastric cancer, an increase in the median survival with chemotherapeutic agents (docetaxel or irinotecan) is approximately 1.5 months compared with symptomatic therapy. There are data from comparative studies evaluating the effectiveness of other targeted drugs: the use of everolimus as second-line drugs did not reveal a significant increase in OS; studies of anti-EGFR therapy (the addition of panitumumab or cetuximab to chemotherapy) as first-line therapy also did not show a significant increase in OS or PFS, respectively. The increase in OS in patients treated with a combination of ramucirumab and paclitaxel, in comparison with the placebo group and paclitaxel, can be considered clinically significant for this patient population and will allow treating this therapeutic regimen as a new standard of second-line treatment in patients with this nosology.

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The authors declare that there are no conflicts of interest present.