<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2024-1-77-82</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-3546</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Результаты применения дентальных имплантатов ИРИС с поверхностью, модифицированной методом плазменного электролитического оксидирования</article-title><trans-title-group xml:lang="en"><trans-title>Results of application of the IRIS dental implants with the surface modified by the method of plasma electrolytic oxidation</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мурзабеков</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Murzabekov</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мурзабеков Ахмед Исропилович - соискатель кафедры челюстно-лицевой хирургии и хирургической стоматологии, врач-стоматолог-хирург, начальник центра оказания медицинской помощи при стоматологических заболеваниях.</p><p>Москва</p></bio><bio xml:lang="en"><p>Akhmed I. Murzabekov - PhD student of the department of maxillofacial surgery and surgical dentistry; oral surgeon, head of the center of medical care for dental diseases.</p><p>Moscow</p></bio><email xlink:type="simple">ahmedckb@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3982-5512</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мураев</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Muraev</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мураев Александр Александрович - д.м.н., доцент; профессор кафедры челюстно-лицевой хирургии и хирургической стоматологии.</p><p>Москва</p></bio><bio xml:lang="en"><p>Alexandr A. Muraev - MD, associate professor; professor of the department of maxillofacial surgery and surgical dentistry.</p><p>Moscow</p></bio><email xlink:type="simple">muraev_aa@pfur.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6975-7018</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мухаметшин</surname><given-names>Р. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Mukhametshin</surname><given-names>R. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мухаметшин Роман Флоридович - к.м.н.; ассистент кафедры челюстнолицевой хирургии и хирургической стоматологии.</p><p>Москва</p></bio><bio xml:lang="en"><p>Roman F. Mukhametshin - PhD; assistant of the department of maxillofacial surgery and surgical dentistry.</p><p>Moscow</p></bio><email xlink:type="simple">doc.mukhametshin@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6909-8726</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ким</surname><given-names>Э. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kim</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ким Элеонора Владимировна - ассистент кафедры челюстно-лицевой хирургии и хирургической стоматологии.</p><p>Москва</p></bio><bio xml:lang="en"><p>Eleonora V. Kim - assistant of the department of maxillofacial surgery and surgical dentistry.</p><p>Moscow</p></bio><email xlink:type="simple">kim_ev@pfur.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5458-0192</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванов</surname><given-names>С. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanov</surname><given-names>S. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иванов Сергей Юрьевич - д.м.н., профессор, член-корреспондент РАН; заведующий кафедрой челюстно-лицевой хирургии и хирургической стоматологии.</p><p>Москва</p></bio><bio xml:lang="en"><p>Sergey Yu. Ivanov - MD, professor, corresponding Member of the Russian Academy of Sciences; head of the department of maxillofacial surgery and surgical dentistry; head of the department of maxillofacial surgery.</p><p>Moscow</p></bio><email xlink:type="simple">syivanov@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Клименков</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Klimenkov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Клименков Владимир Алексеевич - врач-стоматолог-хирург, ассистент кафедры челюстно-лицевой хирургии и хирургической стоматологии.</p><p>Москва</p></bio><bio xml:lang="en"><p>Vladimir A. Klimenkov - dental surgeon, assistant of the Department of Maxillofacial Surgery and Surgical Dentistry.</p><p>Moscow</p></bio><email xlink:type="simple">1142220867@pfur.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО Российский университет дружбы народов им. Патриса Лумумбы; ФГБУ Центральная клиническая больница с поликлиникой Управления делами Президента Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Patrice Lumumba Peoples’ Friendship University of Russia; Central Clinical Hospital of the Administrative directorate of the President of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАОУ ВО Российский университет дружбы народов им. Патриса Лумумбы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Patrice Lumumba Peoples’ Friendship University of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГАОУ ВО Российский университет дружбы народов им. Патриса Лумумбы; ФГАОУ ВО Первый Московский государственный медицинский университет им. И. М. Сеченова (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Patrice Lumumba Peoples’ Friendship University of Russia; I.M. Sechenov First Moscow State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>04</day><month>03</month><year>2024</year></pub-date><volume>0</volume><issue>1</issue><issue-title>Стоматология (1)</issue-title><fpage>77</fpage><lpage>82</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Мурзабеков А.И., Мураев А.А., Мухаметшин Р.Ф., Ким Э.В., Иванов С.Ю., Клименков В.А., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Мурзабеков А.И., Мураев А.А., Мухаметшин Р.Ф., Ким Э.В., Иванов С.Ю., Клименков В.А.</copyright-holder><copyright-holder xml:lang="en">Murzabekov A.I., Muraev A.A., Mukhametshin R.F., Kim E.V., Ivanov S.Y., Klimenkov V.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/3546">https://www.med-alphabet.com/jour/article/view/3546</self-uri><abstract><p>Модификации поверхности дентальных имплантатов для обеспечения оптимальных условий остеоинтеграции остаётся актуальной задачей в современной дентальной имплантологии. Ряд публикаций демонстрируют, что поверхность дентальных имплантатов, модифицированных плазменным электролитическим оксидированием (ПЭО), обладают комбинацией нескольких важных признаков, способствующих остеоинтеграции: оптимальную микрошероховатость в пределах 1-7 мкм, высокую химическую чистоту и механическую прочность [8,20].</p><sec><title>Цель исследования</title><p>Цель исследования. Оценить клиническую эффективность имплантатов ИРИС с новой поверхностью, модифицированной методом ПЭО (далее ИРИС ПЭО).</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. На базе медицинского центра РУДН им. Патриса Лумумбы и центра оказания медицинской помощи при стоматологических заболеваниях, ФГБУ «ЦКБ с поликлиникой» Управления делами Президента Российской Федерации проведено обследование и лечение 60 пациентов в возрасте от 27 до 52 лет с частичной потерей зубов. Пациентам было установлено по 1 имплантату ИРИС-ПЭО на верхней или нижней челюсти. Все имплантаты устанавливали с усилием от 35 до 50 Н/см2, с формирователями десны. Протезирование проводили через 2 месяца на нижней челюсти и через 4 месяца на верхней челюсти. Перед получением оттисков измеряли стабильность имплантатов с использованием аппарата (Penguin RFA (Integration Diagnostic Sweden AB, Швеция). Через год после протезирования оценивали пришеечную резорбцию имплантатов.</p></sec><sec><title>Результаты</title><p>Результаты. В результате проведенного лечения все ортопедические конструкции отвечали функциональным и эстетическим требованиям. показатели стабильности имплантатов в единицах ISQ на верхней челюсти составили в среднем 75±3,4, на нижней челюсти 79±2,4. Резорбция костной ткани в пришеечной области имплантатов через 1 год после окончания лечения не отмечалась. Пилотное клиническое исследование имплантатов ИРИС-ПЭО позволило оптимизировать сроки реабилитации и получить высокий функциональный и эстетический результат при лечении пациентов с потерей зубов.</p></sec><sec><title>Выводы</title><p>Выводы. Пилотное клиническое внедрение имплантатов системы ИРИС с поверхностью, модифицированной плазменным электролитическим оксидированием, продемонстрировало возможность открытого ведения установленных имплантатов с формирователем десны, проводить протезирование через 2 месяца на нижней челюсти и 4 месяца на верхней челюсти. Пришеечной резорбции через год после протезирования не наблюдалось.</p></sec></abstract><trans-abstract xml:lang="en"><p>Surface modifications of dental implants to provide optimal conditions for osseointegration remains an urgent task in modern dental implantology. A few publications demonstrate that the surface of the dental implants modified by plasma electrolytic oxidation (PEO) possess a combination of several important features that promote osteointegration: optimal micro roughness within 1-7 microns, high chemical purity, and mechanical strength [8,20].</p><sec><title>The aim</title><p>The aim. To evaluate the clinical efficacy of IRIS implants with a new surface modified by the PEO method (hereinafter referred to as IRIS PEO).</p></sec><sec><title>Materials and methods</title><p>Materials and methods. Based on the Patrice Lumumba RUDN Medical Center and the Center of Medical Care for Dental Diseases, FGBU «Central Clinical Hospital with Polyclinic» of the Presidential Affairs Department of the Russian Federation, 60 patients aged 27 to 52 years with partial tooth loss were examined and treated. The patients received 1 IRIS-PEO implant each on the upper or lower jaw. All implants were placed with the force from 35 to 50 N/cm2, with gingiva shapers. Prosthetics were performed after 2 months on the lower jaw and after 4 months on the upper jaw. Before taking impressions, the stability of implants was measured using the Penguin RFA (Integration Diagnostic Sweden AB, Sweden). One year after prosthetics, the neck resorption of the implants was evaluated.</p></sec><sec><title>Results</title><p>Results. Because of the treatment, all prosthetic constructions met the functional and aesthetic requirements. The stability indices of implants in ISQ units on the upper jaw averaged 75±3.4, on the lower jaw 79±2.4. Bone resorption in the implants’ neck area 1 year after the end of the treatment was not observed. The pilot clinical study of the IRIS-PEO implants allowed to optimize the terms of rehabilitation and to obtain high functional and esthetic result in the treatment of patients with tooth loss.</p></sec><sec><title>Conclusions</title><p>Conclusions. Pilot clinical implementation of the implants of the IRIS system with the surface modified by plasma electrolytic oxidation demonstrated the possibility of open management of the implants with the gingiva shaper, to carry out prosthetics in 2 months on the lower jaw and 4 months on the upper jaw. No neck resorption was observed one year after prosthetics.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>дентальные имплантаты</kwd><kwd>остеоинтеграция</kwd><kwd>плазменное электролитическое оксидирование</kwd><kwd>пришеечная резорбция</kwd></kwd-group><kwd-group xml:lang="en"><kwd>dental implants</kwd><kwd>osteointegration</kwd><kwd>plasma electrolytic oxidation</kwd><kwd>neck resorption</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bornstein MM, Hart CN, Halbritter SA, Morton D, Buser D. Early loading of non-submerged titanium implants with a chemically modified sand-blasted and acid-etched surface: 6-month results of a prospective case series study in the posterior mandible focusing on peri-implant crestal bone changes and implant stability quotient (ISQ) values. Clin Implant Dent Relat Res. 2009 Dec;11(4):338-47. https://doi.org/10.1111/j.1708-8208.2009.00148.</mixed-citation><mixed-citation xml:lang="en">Bornstein MM, Hart CN, Halbritter SA, Morton D, Buser D. Early loading of non-submerged titanium implants with a chemically modified sand-blasted and acid-etched surface: 6-month results of a prospective case series study in the posterior mandible focusing on peri-implant crestal bone changes and implant stability quotient (ISQ) values. Clin Implant Dent Relat Res. 2009 Dec;11(4):338-47. https://doi.org/10.1111/j.1708-8208.2009.00148.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Buser D, Broggini N, Wieland M, Schenk RK, Denzer AJ, Cochran DL et al. Enhanced bone apposition to a chemically modified SLA titanium surface. J Dent Res. 2004 Jul;83(7):529-33. https://doi.org/10.1177/154405910408300704.</mixed-citation><mixed-citation xml:lang="en">Buser D, Broggini N, Wieland M, Schenk RK, Denzer AJ, Cochran DL et al. Enhanced bone apposition to a chemically modified SLA titanium surface. J Dent Res. 2004 Jul;83(7):529-33. https://doi.org/10.1177/154405910408300704.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Carmo Filho LCD, Marcello-Machado RM, Castilhos ED, Del Bel Cury AA, Faot F. Can implant surfaces affect implant stability during osseointegration? A randomized clinical trial. Braz Oral Res. 2018 Oct 25;32:e110. https://doi.org/10.1590/1807-3107bor-2018.vol32.0110.</mixed-citation><mixed-citation xml:lang="en">Carmo Filho LCD, Marcello-Machado RM, Castilhos ED, Del Bel Cury AA, Faot F. Can implant surfaces affect implant stability during osseointegration? A randomized clinical trial. Braz Oral Res. 2018 Oct 25;32:e110. https://doi.org/10.1590/1807-3107bor-2018.vol32.0110.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Catanio Bortolan C, Paternoster C, Turgeon S, Paoletti C, Cabibbo M, Lecis N, Mantovani D. Plasma-immersion ion implantation surface oxidation on a cobalt-chromium alloy for biomedical applications. Biointerphases. 2020 Jul 20;15(4):041004. https://doi.org/10.1116/6.0000278.</mixed-citation><mixed-citation xml:lang="en">Catanio Bortolan C, Paternoster C, Turgeon S, Paoletti C, Cabibbo M, Lecis N, Mantovani D. Plasma-immersion ion implantation surface oxidation on a cobalt-chromium alloy for biomedical applications. Biointerphases. 2020 Jul 20;15(4):041004. https://doi.org/10.1116/6.0000278.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Ciosek Ż, Kot K, Kosik-Bogacka D, Łanocha-Arendarczyk N, Rotter I. The Effects of Calcium, Magnesium, Phosphorus, Fluoride, and Lead on Bone Tissue. Biomolecules. 2021 Mar 28; 11(4): 506. https://doi.org/10.3390/biom11040506.</mixed-citation><mixed-citation xml:lang="en">Ciosek Ż, Kot K, Kosik-Bogacka D, Łanocha-Arendarczyk N, Rotter I. The Effects of Calcium, Magnesium, Phosphorus, Fluoride, and Lead on Bone Tissue. Biomolecules. 2021 Mar 28; 11(4): 506. https://doi.org/10.3390/biom11040506.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Dhingra K, Dinda AK, Kottarath SK, Chaudhari PK, Verma F. Mucoadhesive silver nanoparticle-based local drug delivery system for peri-implantitis management in COVID-19 era. Part 1: antimicrobial and safety in-vitro analysis. J Oral Biol Craniofac Res. 2022 Jan-Feb; 12(1): 177-181. https://doi.org/10.1016/j.jobcr.2021.11.007.</mixed-citation><mixed-citation xml:lang="en">Dhingra K, Dinda AK, Kottarath SK, Chaudhari PK, Verma F. Mucoadhesive silver nanoparticle-based local drug delivery system for peri-implantitis management in COVID-19 era. Part 1: antimicrobial and safety in-vitro analysis. J Oral Biol Craniofac Res. 2022 Jan-Feb; 12(1): 177-181. https://doi.org/10.1016/j.jobcr.2021.11.007.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Hadley KB, Newman SM, Hunt JR. Dietary zinc reduces osteoclast resorption activities and increases markers of osteoblast differentiation, matrix maturation, and mineralization in the long bones of growing rats. J Nutr Biochem. 2010 Apr;21(4):297-303. https://doi.org/10.1016/j.jnutbio.2009.01.002.</mixed-citation><mixed-citation xml:lang="en">Hadley KB, Newman SM, Hunt JR. Dietary zinc reduces osteoclast resorption activities and increases markers of osteoblast differentiation, matrix maturation, and mineralization in the long bones of growing rats. J Nutr Biochem. 2010 Apr;21(4):297-303. https://doi.org/10.1016/j.jnutbio.2009.01.002.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Hadzik J, Jurczyszyn K, Gębarowski T, Trytek A, Gedrange T, Kozakiewicz M, Dominiak M, Kubasiewicz-Ross P, Trzcionka-Szajna A, Szajna E, Simka W. An Experimental Anodized and Low-Pressure Oxygen Plasma-Treated Titanium Dental Implant Surface—Preliminary Report. International Journal of Molecular Sciences. 2023 Feb 10; 24(4): 3603. https://doi.org/10.3390/ijms24043603.</mixed-citation><mixed-citation xml:lang="en">Hadzik J, Jurczyszyn K, Gębarowski T, Trytek A, Gedrange T, Kozakiewicz M, Dominiak M, Kubasiewicz-Ross P, Trzcionka-Szajna A, Szajna E, Simka W. An Experimental Anodized and Low-Pressure Oxygen Plasma-Treated Titanium Dental Implant Surface—Preliminary Report. International Journal of Molecular Sciences. 2023 Feb 10; 24(4): 3603. https://doi.org/10.3390/ijms24043603.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">He W, Yin X, Xie L, Liu Z, Li J, Zou S, Chen J. Enhancing osseointegration of titanium implants through large-grit sandblasting combined with micro-arc oxidation surface modification. J Mater Sci Mater Med. 2019 Jun 11;30(6):73. https://doi.org/10.1007/s10856-019-6276-0.</mixed-citation><mixed-citation xml:lang="en">He W, Yin X, Xie L, Liu Z, Li J, Zou S, Chen J. Enhancing osseointegration of titanium implants through large-grit sandblasting combined with micro-arc oxidation surface modification. J Mater Sci Mater Med. 2019 Jun 11;30(6):73. https://doi.org/10.1007/s10856-019-6276-0.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Hiyari S, Wong RL, Yaghsezian A, Naghibi A, Tetradis S, Camargo PM, Pirih FQ. Ligature-induced peri-implantitis and periodontitis in mice. J Clin Periodontol. 2018 Jan; 45(1): 89-99. https://doi.org/10.1111/jcpe.12817.</mixed-citation><mixed-citation xml:lang="en">Hiyari S, Wong RL, Yaghsezian A, Naghibi A, Tetradis S, Camargo PM, Pirih FQ. Ligature-induced peri-implantitis and periodontitis in mice. J Clin Periodontol. 2018 Jan; 45(1): 89-99. https://doi.org/10.1111/jcpe.12817.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Hussain RA, Miloro M, Cohen JB. An Update on the Treatment of Periimplantitis. Dent Clin North Am. 2021 Jan; 65(1):43-56. https://doi.org/10.1016/j.cden.2020.09.003.</mixed-citation><mixed-citation xml:lang="en">Hussain RA, Miloro M, Cohen JB. An Update on the Treatment of Periimplantitis. Dent Clin North Am. 2021 Jan; 65(1):43-56. https://doi.org/10.1016/j.cden.2020.09.003.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Ito A, Kawamura H, Otsuka M, et al. Zinc-releasing calcium phosphate for stimulating bone formation. Mater Sci Eng C 2002;22:21–25. https://doi.org/10.1016/S0928-4931(02)00108-X.</mixed-citation><mixed-citation xml:lang="en">Ito A, Kawamura H, Otsuka M, et al. Zinc-releasing calcium phosphate for stimulating bone formation. Mater Sci Eng C 2002;22:21–25. https://doi.org/10.1016/S0928-4931(02)00108-X.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Ito A, Otsuka M, Kawamura H, et al. Zinc-containing tricalcium phosphate and related materials for promoting bone formation. Curr Appl Phys 2005; 5(5):402–406. https://doi.org/10.1016/j.cap.2004.10.006.</mixed-citation><mixed-citation xml:lang="en">Ito A, Otsuka M, Kawamura H, et al. Zinc-containing tricalcium phosphate and related materials for promoting bone formation. Curr Appl Phys 2005; 5(5):402–406. https://doi.org/10.1016/j.cap.2004.10.006.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Jinno Y, Stocchero M, Galli S, Toia M, Becktor JP. Impact of a Hydrophilic Dental Implant Surface on Osseointegration: Biomechanical Results in Rabbit. J Oral Implantol. 2021 Apr 1;47(2):163-168. https://doi.org/10.1563/aaid-joi-D-19-00217.</mixed-citation><mixed-citation xml:lang="en">Jinno Y, Stocchero M, Galli S, Toia M, Becktor JP. Impact of a Hydrophilic Dental Implant Surface on Osseointegration: Biomechanical Results in Rabbit. J Oral Implantol. 2021 Apr 1;47(2):163-168. https://doi.org/10.1563/aaid-joi-D-19-00217.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Kawamura H, Ito A, Miyakawa S, Layrolle P, Ojima K, Ichinose N, Tateishi T. Stimulatory effect of zinc-releasing calcium phosphate implant on bone formation in rabbit femora. J Biomed Mater Res. 2000 May;50(2):184-90. https://doi.org/10.1002/(sici)1097-4636(200005)50:2&lt;184::aid-jbm13&gt;3.0.co;2-3.</mixed-citation><mixed-citation xml:lang="en">Kawamura H, Ito A, Miyakawa S, Layrolle P, Ojima K, Ichinose N, Tateishi T. Stimulatory effect of zinc-releasing calcium phosphate implant on bone formation in rabbit femora. J Biomed Mater Res. 2000 May;50(2):184-90. https://doi.org/10.1002/(sici)1097-4636(200005)50:2&lt;184::aid-jbm13&gt;3.0.co;2-3.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Kawamura H, Ito A, Muramatsu T, Miyakawa S, Ochiai N, Tateishi T. Long-term implantation of zinc-releasing calcium phosphate ceramics in rabbit femora. J Biomed Mater Res A. 2003 Jun 15;65(4):468-74. https://doi.org/10.1002/jbm.a.10524.</mixed-citation><mixed-citation xml:lang="en">Kawamura H, Ito A, Muramatsu T, Miyakawa S, Ochiai N, Tateishi T. Long-term implantation of zinc-releasing calcium phosphate ceramics in rabbit femora. J Biomed Mater Res A. 2003 Jun 15;65(4):468-74. https://doi.org/10.1002/jbm.a.10524.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Li X, Sogo Y, Ito A, Mutsuzaki H, Ochiai N, Kobayashi T, Nakamura S, Yamashita K, Legeros RZ. The optimum zinc content in set calcium phosphate cement for promoting bone formation in vivo. Mater Sci Eng C Mater Biol Appl. 2009 Apr 30;29(3):969-975. https://doi.org/10.1016/j.msec.2008.08.021.</mixed-citation><mixed-citation xml:lang="en">Li X, Sogo Y, Ito A, Mutsuzaki H, Ochiai N, Kobayashi T, Nakamura S, Yamashita K, Legeros RZ. The optimum zinc content in set calcium phosphate cement for promoting bone formation in vivo. Mater Sci Eng C Mater Biol Appl. 2009 Apr 30;29(3):969-975. https://doi.org/10.1016/j.msec.2008.08.021.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Livne S, Marku-Cohen S, Harel N, Piek D, Ormianer Z. [The influence of dental implant surface on osseointegration: review]. Refuat Hapeh Vehashinayim (1993). 2012 Jan;29(1):41-6, 66. Hebrew. PMID: 22991876.</mixed-citation><mixed-citation xml:lang="en">Livne S, Marku-Cohen S, Harel N, Piek D, Ormianer Z. [The influence of dental implant surface on osseointegration: review]. Refuat Hapeh Vehashinayim (1993). 2012 Jan;29(1):41-6, 66. Hebrew. PMID: 22991876.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Mendhi J, Ramachandra SS, Prasadam I, Ivanovski S, Yang Y, Xiao Y. Endogenous nitric oxide-generating surfaces via polydopamine-copper coatings for preventing biofilm dispersal and promoting microbial killing. Mater Sci Eng C Mater Biol Appl. 2021 Sep; 128: 112297. https://doi.org/10.1016/j.msec.2021.112297.</mixed-citation><mixed-citation xml:lang="en">Mendhi J, Ramachandra SS, Prasadam I, Ivanovski S, Yang Y, Xiao Y. Endogenous nitric oxide-generating surfaces via polydopamine-copper coatings for preventing biofilm dispersal and promoting microbial killing. Mater Sci Eng C Mater Biol Appl. 2021 Sep; 128: 112297. https://doi.org/10.1016/j.msec.2021.112297.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Muraev A.A., Murzabekov A.I., Ivanov S.Yu., Tarasov Yu.V., Orlov E.A., Dolgalev A.A. Plasma Electrolytic Oxidation for Dental Implant Surface Treatment. Sovremennye tehnologii v medicine 2023; 15(3): 18, https://doi.org/10.17691/stm2023.15.3.02.</mixed-citation><mixed-citation xml:lang="en">Muraev A.A., Murzabekov A.I., Ivanov S.Yu., Tarasov Yu.V., Orlov E.A., Dolgalev A.A. Plasma Electrolytic Oxidation for Dental Implant Surface Treatment. Sovremennye tehnologii v medicine 2023; 15(3): 18, https://doi.org/10.17691/stm2023.15.3.02.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Nagata M, Lönnerdal B. Role of zinc in cellular zinc trafficking and mineralization in a murine osteoblast-like cell line. J Nutr Biochem. 2011 Feb;22(2):172-8. https://doi.org/10.1016/j.jnutbio.2010.01.003.</mixed-citation><mixed-citation xml:lang="en">Nagata M, Lönnerdal B. Role of zinc in cellular zinc trafficking and mineralization in a murine osteoblast-like cell line. J Nutr Biochem. 2011 Feb;22(2):172-8. https://doi.org/10.1016/j.jnutbio.2010.01.003.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Oikawa M, Masumoto H, Shiraishi N, Orii Y, Anada T, Suzuki O, Sasaki K. Effect of surface modification of Ti-6Al-4V alloy by electron cyclotron resonance plasma oxidation. Dent Mater J. 2021 Jan 31;40(1):228-234. https://doi.org/10.4012/dmj.2020-051.</mixed-citation><mixed-citation xml:lang="en">Oikawa M, Masumoto H, Shiraishi N, Orii Y, Anada T, Suzuki O, Sasaki K. Effect of surface modification of Ti-6Al-4V alloy by electron cyclotron resonance plasma oxidation. Dent Mater J. 2021 Jan 31;40(1):228-234. https://doi.org/10.4012/dmj.2020-051.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Porter AE. Nanoscale characterization of the interface between bone and hydroxyapatite implants and the effect of silicon on bone apposition. Micron. 2006; 37: 681–688. https://doi.org/10.1016/j.micron.2006.03.006.</mixed-citation><mixed-citation xml:lang="en">Porter AE. Nanoscale characterization of the interface between bone and hydroxyapatite implants and the effect of silicon on bone apposition. Micron. 2006; 37: 681–688. https://doi.org/10.1016/j.micron.2006.03.006.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Schwarz F, Jepsen S, Obreja K, Galarraga-Vinueza ME, Ramanauskaite A. Surgical therapy of peri-implantitis. Periodontol 2000. 2022 Feb; 88(1): 145-181. https://doi.org/10.1111/prd.12417.</mixed-citation><mixed-citation xml:lang="en">Schwarz F, Jepsen S, Obreja K, Galarraga-Vinueza ME, Ramanauskaite A. Surgical therapy of peri-implantitis. Periodontol 2000. 2022 Feb; 88(1): 145-181. https://doi.org/10.1111/prd.12417.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Sennerby L, Meredith N. Resonance frequency analysis: measuring implant stability and osseointegration. Compend Contin Educ Dent. 1998 May;19(5):493-8, 500, 502; quiz 504. PMID: 9693511.</mixed-citation><mixed-citation xml:lang="en">Sennerby L, Meredith N. Resonance frequency analysis: measuring implant stability and osseointegration. Compend Contin Educ Dent. 1998 May;19(5):493-8, 500, 502; quiz 504. PMID: 9693511.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Shinde SV, Chansoria S, Limaye M, Vijay M, Bansal S, Dhakne VM. Wound Healing in Dental Implant Surgery in Patients with or without Antibiotic Prophylaxis. J Contemp Dent Pract. 2018 Sep 1;19(9):1111-1116. https://doi.org/10.5005/jp-journals-10024-2390.</mixed-citation><mixed-citation xml:lang="en">Shinde SV, Chansoria S, Limaye M, Vijay M, Bansal S, Dhakne VM. Wound Healing in Dental Implant Surgery in Patients with or without Antibiotic Prophylaxis. J Contemp Dent Pract. 2018 Sep 1;19(9):1111-1116. https://doi.org/10.5005/jp-journals-10024-2390.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Souza JCM, Sordi MB, Kanazawa M, Ravindran S, Henriques B, Silva FS, Aparicio C, Cooper LF. Nano-scale modification of titanium implant surfaces to enhance osseointegration. Acta Biomater. 2019 Aug;94:112-131. https://doi.org/10.1016/j.actbio.2019.05.045.</mixed-citation><mixed-citation xml:lang="en">Souza JCM, Sordi MB, Kanazawa M, Ravindran S, Henriques B, Silva FS, Aparicio C, Cooper LF. Nano-scale modification of titanium implant surfaces to enhance osseointegration. Acta Biomater. 2019 Aug;94:112-131. https://doi.org/10.1016/j.actbio.2019.05.045.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Wang T, Bai J, Lu M, Huang C, Geng D, Chen G, Wang L, Qi J, Cui W, Deng L. Engineering immunomodulatory and osteoinductive implant surfaces via mussel adhesion-mediated ion coordination and molecular clicking. Nat Commun. 2022 Jan 10;13(1):160. https://doi.org/10.1038/s41467-021-27816-1.</mixed-citation><mixed-citation xml:lang="en">Wang T, Bai J, Lu M, Huang C, Geng D, Chen G, Wang L, Qi J, Cui W, Deng L. Engineering immunomodulatory and osteoinductive implant surfaces via mussel adhesion-mediated ion coordination and molecular clicking. Nat Commun. 2022 Jan 10;13(1):160. https://doi.org/10.1038/s41467-021-27816-1.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Zhao B, Zhang W, Wang D, et al. Effect of Zn content on cytoactivity and bacteriostasis of micro-arc oxidation coatings on pure titanium. Surf Coat Technol 2013;228(suppl): s428–s432. https://doi.org/10.1016/j.surfcoat.2012.05.037.</mixed-citation><mixed-citation xml:lang="en">Zhao B, Zhang W, Wang D, et al. Effect of Zn content on cytoactivity and bacteriostasis of micro-arc oxidation coatings on pure titanium. Surf Coat Technol 2013;228(suppl): s428–s432. https://doi.org/10.1016/j.surfcoat.2012.05.037.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Клинические рекомендации (протоколы лечения): издание официальное. Стоматологическая ассоциация России, Москва: СТАР, 2014. 7:1-122. https://e-stomatology.ru/director/protokols/protokols_30-09-2014/2_full_absent.doc.</mixed-citation><mixed-citation xml:lang="en">Clinical recommendations (treatment protocols): official publication. Stomatological Association of Russia, Moscow: STAR, 2014. 7:1-122. https://e-stomatology.ru/director/protokols/protokols_30-09-2014/2_full_absent.doc.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
