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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2023-33-24-27</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-3512</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Анализ факторов риска и последствий гипоксически-ишемического поражения центральной нервной системы у новорожденных</article-title><trans-title-group xml:lang="en"><trans-title>Analysis of risk factors and hypoxic-ischemic damage consequences to central nervous system in newborns</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4213-5379</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Морозов</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Morozov</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Морозов Артем Михайлович, к. м. н., доцент кафедры общей хирургии</p><p>г. Тверь</p></bio><bio xml:lang="en"><p>Morozov Artyom M., PhD Med, associate professor at Dept of General Surgery</p><p>Tver </p></bio><email xlink:type="simple">ammorozovv@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9238-8270</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сороковикова</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sorokovikova</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сороковикова Татьяна Викторовна, к. м. н., доцент кафедры неврологии, реабилитации и нейрохирургии</p><p>г. Тверь</p></bio><bio xml:lang="en"><p>Sorokovikova Tatyana V., PhD Med, associate professor at Dept of Neurology, Rehabilitation and Neurosurgery </p><p>Tver </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6386-5093</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Алексанян</surname><given-names>К. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Aleksanyan</surname><given-names>K. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алексанян Кристина Артаковна, ординатор 1-го года </p><p>г. Тверь</p></bio><bio xml:lang="en"><p>Aleksanyan Kristina A., 1st year resident </p><p>Tver </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7514-711X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Салманова</surname><given-names>К. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Salmanova</surname><given-names>K. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Салманова Камила Гайнудиновна, ординатор 1-го года</p><p>г. Москва</p></bio><bio xml:lang="en"><p>Salmanova Kamila G., 1st year resident </p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8892-7086</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пичугова</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Pichugova</surname><given-names>A. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пичугова Анастасия Николаевна, ординатор 1-го года </p><p>г. Тверь</p></bio><bio xml:lang="en"><p>Pichugova Anastasiya N., 1st year resident </p><p>Tver </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Тверской государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Tver State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАОУ ВО «Российский университет дружбы народов имени Патриса Лумумбы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Peoples' Friendship University of Russia n. a. Patrice Lumumba</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>22</day><month>01</month><year>2024</year></pub-date><volume>0</volume><issue>33</issue><issue-title>Неврология и психиатрия (4)</issue-title><fpage>24</fpage><lpage>27</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Морозов А.М., Сороковикова Т.В., Алексанян К.А., Салманова К.Г., Пичугова А.Н., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Морозов А.М., Сороковикова Т.В., Алексанян К.А., Салманова К.Г., Пичугова А.Н.</copyright-holder><copyright-holder xml:lang="en">Morozov A.M., Sorokovikova T.V., Aleksanyan K.A., Salmanova K.G., Pichugova A.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/3512">https://www.med-alphabet.com/jour/article/view/3512</self-uri><abstract><p>Перинатальное поражение центральной нервной системы (ЦНС) представляет собой в настоящее время актуальную проблему в структуре неонатальной патологии и приводит к развитию различных неврологических осложнений, инвалидизации и смертности.</p><sec><title>Цель</title><p>Цель. Выявить факторы риска, способствующие перинатальному гипоксически-ишемическому поражению ЦНС III степени у новорожденных, изучить результаты клинических, лабораторных и инструментальных исследований.</p></sec><sec><title>Результаты</title><p>Результаты. В ходе настоящего исследования было выявлено, что у большинства детей из основной группы ведущими синдромами при рождении были синдром угнетения и синдром мышечной гипотонии. Из экстрагенитальных патологий наибольший удельный вес занимали перенесенные во время беременности и родов инфекционные заболевания различной этиологии. Среди осложнений беременности у матерей основной группы чаще всего были зарегистрированы анемии, патологии плодного пузыря и преждевременные разрывы плодных оболочек. При проведении нейросонографии наиболее часто визуализировались субэпиндимальные кисты, признаки церебральной ишемии и ветрикуломегалии.</p></sec><sec><title>Выводы</title><p>Выводы. В ходе исследования было установлено, что главными факторами риска развития гипоксически-ишемического поражения ЦНС являлись осложнения беременности и инфекционные заболевания различной этиологии, перенесенные во время беременности и родов.</p></sec></abstract><trans-abstract xml:lang="en"><p>Perinatal damage to the central nervous system (CNS) is currently a pressing issue within the structure of neonatal pathology, leading to the development of various neurological complications and causing disability and death.</p><sec><title>The purpose</title><p>The purpose. Identifying risk factors contributing to perinatal third-degree hypoxic-ischemic damage of the CNS in newborns and to examine the data of clinical, laboratory and instrumental studies.</p></sec><sec><title>Results</title><p>Results. In the course of this study, it was revealed that the leading syndromes at the birth of the majority of infants from the main group were the suppression syndrome and the syndrome of muscular hypotension. The highest proportion among extragenital pathologies was represented by infectious diseases of various etiologies, which the newborns’ mothers had suffered during pregnancy and childbirth. Most commonly reported pregnancy complications in mothers of the main group were anemia, fetal bladder abnormality and premature rupture of fetal membranes. Neurosonography revealed subependymal cysts, signs of cerebral ischemia and ventriculomegaly as most сommonly visualized abnormalities.</p></sec><sec><title>Conclusions</title><p>Conclusions. It was established during the study that the primary risk factors for the development of hypoxic-ischemic damage to the CNS were complications during pregnancy and infectious diseases of various etiologies, which the mothers had suffered during pregnancy and childbirth.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>гипоксически-ишемическое поражение</kwd><kwd>поражение ЦНС</kwd><kwd>неонатальная патология</kwd></kwd-group><kwd-group xml:lang="en"><kwd>hypoxic-ischemic damage</kwd><kwd>cns damage</kwd><kwd>neonatal pathology</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Redline RW. Placental pathology: Pathways leading to or associated with perinatal brain injury in experimental neurology, special issue: Placental mediated mechanisms of perinatal brain injury. Exp Neurol. 2022;347. 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