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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2023-33-34-36</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-3508</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Биохимические аспекты патогенеза мигрени</article-title><trans-title-group xml:lang="en"><trans-title>Biochemical aspects of migraine pathogenesis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3276-7615</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Болдырева</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Boldyreva</surname><given-names>Yu. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Болдырева Юлия Викторовна, к. м. н., доцент, доцент кафедры биологической химии Института фармации</p><p>г. Тюмень</p></bio><bio xml:lang="en"><p>Boldyreva Yulia V., PhD Med, associate professor, associate professor at Dept of Biological Chemistry of the Institute of Pharmac</p><p>Tyumen</p></bio><email xlink:type="simple">tgma.06@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5405-7182</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лебедев</surname><given-names>И. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Lebedev</surname><given-names>I. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лебедев Илья Аркадьевич, д. м. н., проф. кафедры топографической анатомии и оперативной хирургии с курсом остеопатии Института клинической медицины</p><p>г. Тюмень</p></bio><bio xml:lang="en"><p>Lebedev Ilya A., DM Sci (habil.), professor at Dept of Topographic Anatomy of the Institute of Clinical Medicine</p><p>Tyumen</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1736-4084</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Суплотов</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Suplotov</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Суплотов Сергей Николаевич, д. м. н., проф., зав. кафедрой клинической лабораторной диагностики Института клинической медицины</p><p>г. Тюмень</p></bio><bio xml:lang="en"><p>Suplotov Sergey N., DM Sci (habil.), professor, head of Dept of Clinical Laboratory Diagnostics of the Institute of Clinical Medicine</p><p>Tyumen</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-6760-9923</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бажина</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Bazhina</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бажина Мария Владимировна, ординатор I года обучения</p><p>г. Тюмень</p></bio><bio xml:lang="en"><p>Bazhina Maria V., first-year resident</p><p>Tyumen</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7534-9552</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гавриленко</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gavrilenko</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Гавриленко Елена Александровна, студентка IV курса Института материнства и детства</p><p>г. Тюмень</p></bio><bio xml:lang="en"><p>Gavrilenko Elena A., 4th year student of the Institute of Motherhood and Childhood</p><p>Tyumen</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7450-2888</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сенаторова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Senatorov</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сенаторова Ольга Владимировна, к. м. н., доцент кафедры детских болезней с курсом поликлинической педиатрии Института материнства и детства</p><p>г. Тюмень</p></bio><bio xml:lang="en"><p>Senatorova Olga V., PhD Med, associate professor at Dept of Childhood Diseases with a course in outpatient pediatrics at the Institute of Motherhood and Childhood</p><p>Tyumen</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Тюменский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Tyumen State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>19</day><month>01</month><year>2024</year></pub-date><volume>0</volume><issue>33</issue><issue-title>Неврология и психиатрия (4)</issue-title><fpage>34</fpage><lpage>36</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Болдырева Ю.В., Лебедев И.А., Суплотов С.Н., Бажина М.В., Гавриленко Е.А., Сенаторова О.В., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Болдырева Ю.В., Лебедев И.А., Суплотов С.Н., Бажина М.В., Гавриленко Е.А., Сенаторова О.В.</copyright-holder><copyright-holder xml:lang="en">Boldyreva Y.V., Lebedev I.A., Suplotov S.N., Bazhina M.V., Gavrilenko E.A., Senatorov O.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/3508">https://www.med-alphabet.com/jour/article/view/3508</self-uri><abstract><p>В статье приведен анализ современных источников литературы, посвященных биохимическим аспектам патогенеза мигрени. Описана роль тригеминоваскулярной системы и роль биологически активных веществ, вовлеченных в этот процесс. Понимание описанных механизмов позволит улучшить продолжительность и качество жизни пациентов.</p></abstract><trans-abstract xml:lang="en"><p>The article provides an analysis of modern literature sources devoted to the biochemical aspects of the pathogenesis of migraine. The role of the trigeminovascular system, etc. is described. biologically active substances involved in this process. Understanding the described processes makes it possible to increase the duration and quality of life of patients.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>мигрень</kwd><kwd>биохимия</kwd><kwd>патогенез</kwd><kwd>головная боль</kwd><kwd>тригеминоваскулярная система</kwd><kwd>нейротрансмиттеры</kwd><kwd>нейромедиаторы</kwd><kwd>нейропептиды</kwd></kwd-group><kwd-group xml:lang="en"><kwd>migraine</kwd><kwd>biochemistry</kwd><kwd>pathogenesis</kwd><kwd>headache</kwd><kwd>trigeminovascular system</kwd><kwd>neurotransmitters</kwd><kwd>neuropeptides</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ashina M., Migraine N., Engl J. Med. 2020 Nov 5; 383 (19): 1866–1876. https://doi.org/10.1056/nejmra1915327. PMID: 33211930.</mixed-citation><mixed-citation xml:lang="en">Ashina M., Migraine N., Engl J. 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