<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2023-35-55-62</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-3500</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Клинический случай лечения истинного утопления в пресной воде</article-title><trans-title-group xml:lang="en"><trans-title>Clinical case of treatment of true drowning in fresh water</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Капланов</surname><given-names>Р. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Kaplanov</surname><given-names>R. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Капланов Роман Петрович, врач реаниматолог-анестезиолог, зав. отделением общей реанимации</p><p>Москва</p></bio><bio xml:lang="en"><p>Kaplanov Roman P., resuscitator-anesthesiologist, head of the General Resuscitation Dept</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ивкина</surname><given-names>Е. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivkina</surname><given-names>Е. М.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ивкина Екатерина Михайловна, врач анестезиолог-реаниматолог</p><p>Москва</p></bio><bio xml:lang="en"><p>Ivkina Ekaterina M., anesthesiologist-reanimatologist</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9651-4759</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Суряхин</surname><given-names>В. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Suryakhin</surname><given-names>V. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Суряхин Виктор Станиславович, руководитель службы Анестезиологии и реаниматологии</p><p>Москва</p></bio><bio xml:lang="en"><p>Suryakhin Viktor S., head of the Anesthesiology and Reanimatology Service</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Давыдов</surname><given-names>П. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Davydov</surname><given-names>P. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Давыдов Петр Александрович, зам. главного врача по медицинской части</p><p> </p></bio><bio xml:lang="en"><p>Davydov Petr A., deputy chief Physician for Medical Affairs</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Плавунов</surname><given-names>Н. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Plavunov</surname><given-names>N. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Плавунов Николай Филиппович, главный врач</p></bio><bio xml:lang="en"><p>Plavunov Nikolay F., chief physician</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Саликов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Salikov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Саликов Александр Викторович, главный врач</p><p> Москва</p></bio><bio xml:lang="en"><p>Salikov Alexander V., chief physician</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ «Городская клиническая больница имени В. М. Буянова Департамента здравоохранения Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Clinical Hospital n.a. V. M. Buyanov</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ «Станция скорой и неотложной медицинской помощи имени А. С. Пучкова Департамента здравоохранения Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Ambulance and Medical Emergency Care Station n.a. A. S. Puchkov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>18</day><month>01</month><year>2024</year></pub-date><volume>0</volume><issue>35</issue><issue-title>Кардиология. Неотложная медицина (4)</issue-title><fpage>55</fpage><lpage>62</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Капланов Р.П., Ивкина Е.М., Суряхин В.С., Давыдов П.А., Плавунов Н.Ф., Саликов А.В., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Капланов Р.П., Ивкина Е.М., Суряхин В.С., Давыдов П.А., Плавунов Н.Ф., Саликов А.В.</copyright-holder><copyright-holder xml:lang="en">Kaplanov R.P., Ivkina Е.М., Suryakhin V.S., Davydov P.A., Plavunov N.F., Salikov A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/3500">https://www.med-alphabet.com/jour/article/view/3500</self-uri><abstract><p>Утопление занимает третье место в мире среди причин смерти от непреднамеренных травм. Наибольшее число пострадавших от утопления приходится на молодое трудоспособное население.Цель. В отсутствии современных протоколов интенсивной терапии утопления актуальной является возможность сформулировать основные принципы оказания медицинской помощи у пострадавших в результате утопления на госпитальном этапе.Клиническое наблюдение. Больная 25 лет была доставлена бригадой скорой медицинской помощи в отделение реанимации и интенсивной терапии ГКБ имени В. М. Буянова с диагнозом «утопление в пресном водоеме» III степени тяжести. Больная была переведена на ИВЛ с закрытой аспирационной системой, проведена экстренная бронхоскопия с удалением 200 мл аспирированной в легкие жидкости. Проведение респираторной терапии осуществлялось пошаговым увеличением уровня PEEP и снижением уровня FiО2 с учетом респираторного индекса. Учитывая развитие провоспалительного медиаторного ответа, лактатацидоза, гемолиза, гипергидратации, высокий риск присоединения инфекционных осложнений, было принято решение о проведении в ранние сроки экстракорпоральной искусственной детоксикации методом вено-венозной гемодиафильтрации и деэскалационной антибактериальной терапии с применением меропенема методом его продленной инфузии. Проводимая терапия позволила к концу первых суток достичь целевых респираторных показателей, стабилизировать показатели центральной гемодинамики, предотвратить развитие почечного повреждения, провести коррекцию водно-электролитных и метаболических нарушений, снизить риск развития тяжелых септических осложнений. На 4-е сутки была прекращена вазопрессорная поддержка, на 5-е сутки больная была переведена на самостоятельное дыхание. Время пребывания в условиях реанимационного отделения составило 6 суток.Заключение. Проведение у пострадавших в результате утопления пошаговой респираторной терапии с использованием закрытых аспирационных систем и выполнение бронхоскопии в экстренном порядке предотвращает прямое повреждение альвеол и продолжающуюся транслокацию жидкости в сосудистое русло. Антибактериальная терапия препаратами широкого спектра у контаминированного больного с картиной шока позволяет снизить риск развития тяжелых септических осложнений с деструкцией легочной паренхимы. Раннее начало экстракорпоральной детоксикации в режиме СVVHDF позволяет провести коррекцию нарушений гомеостаза, устранить гиперволемию, снизить риск развития острого почечного повреждения в результате гемолиза.</p></abstract><trans-abstract xml:lang="en"><p>Drowning is the third leading cause of unintentional injury death worldwide. The largest number of victims of drowning falls on the young able- bodied population.Objective. There are no recent intensive care protocols for drowning, it is relevant to formulate guidelines for the treatment of drowning. Clinical observation. A 25-year-old female patient was taken by an ambulance team to the intensive care unit with a directional diagnosis ‘drowning in fresh water’ of three degree of severity. The patient had got on ventilator with closed aspiration system. Emergency bronchoscopy was performed during which 200 ml of fluid aspirated into the lungs was removed. Respiratory support was determined by stepwise increase of the PEEP level and decrease in FiO2 level taking into account respiratory index. Given the development of a pro-inflammatory mediator response, lactatacidosis, hemolysis, hyperhydration, a high risk of infectious complications, it was decided to start extracorporeal treatment early by continuous veno-venous hemodiafiltration and de-escalation of systemic antibacterial therapy with meropenem by prolonged infusion. Against the background of the ongoing treatment, we managed to achieve target respiratory parameters and stabilize central hemodynamic parameters by the end of the first day, prevent the development of renal damage, correct water-electrolyte and metabolic disorders, and avoid severe septic complications. Vasopressor support was discontinued on the 4th day, and on the 5th day the patient was switched to independent breathing. The patient`s stay in the intensive care unit was 6 days.Conclusions. Stepwise respiratory therapy using closed suction systems and urgent bronchoscopy prevent direct damage to the alveoli and ongoing translocation of fluid into the vascular bed. Prescribing broad-spectrum antibiotics prior to the growth of clinical and laboratory signs of infectious lung lesions allows to reduce the risk of severe septic complications with pulmonary destruction parenchyma. Early onset extracorporeal treatment by CVVHDF allows to correct homeostasis disorders, eliminate hypervolemia, prevent the development of acute renal damage as a result of hemolysis. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>утопление</kwd><kwd>респираторная терапия</kwd><kwd>бронхоскопия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>drowning</kwd><kwd>respiratory care</kwd><kwd>bronchoscopy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Интенсивная терапия. Национальное руководство. Том 1. Под ред.: Заболотских И. Б., Проценко Д. Н., М.: ГЭОТАР-Медиа. 2020; 498–499.</mixed-citation><mixed-citation xml:lang="en">Intensive therapy. National Guide. Volume 1. Edited by: Zabolotskikh I. B., Protsenko D. N., M.: GEOTAR-Media. 2020; 498–499.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Рахимаев Р. С., Ташснов Д. К., Седенко В. А., Хайрулин Р. З. Незавершенное утопление Вестник АГИУВ 2008; № 1–2 (6–7): 70–75.</mixed-citation><mixed-citation xml:lang="en">Rakhimaev R. S., Tashsnov D. K., Sedenko V. A., Khairulin R. Z. Incomplete drowning. Bulletin of the Almaty State Institute for Advanced Training of Physicians 2008; No. 1–2 (6–7): 70–75.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ярошецкий А. И., Грицан А. И. et al. Диагностика и интенсивная терапия острого респираторного дистресс-синдрома. Клинические рекомендации Федерации анестезиологов и реаниматологов. 2021.</mixed-citation><mixed-citation xml:lang="en">Yaroshetsky A. I., Gritsan A. I. et al. Diagnosis and intensive therapy of acute respiratory distress syndrome. Clinical recommendations of the Federation of Anesthesiologists and Resuscitators. 2021.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Кулабухов В. В., Чижов А. Г., Кудрявцев А. Н., Клеузович А. А., Чаус Н. И. Опыт внедрения концепции «Изолированный пациент» в отделении реанимации и интенсивной терапии. Медицинский Совет. 2013 (5–6): 53–58.</mixed-citation><mixed-citation xml:lang="en">Kulabukhov V. V., Chizhov A. G., Kudryavtsev A. N., Kleuzovich A. A., Chaus N. I. Experience in implementing the ‘Isolated patient’ concept in the intensive care unit. Medical Council. 2013 (5–6): 53–58.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">A. Joseph Layon, MD, Jerome H. Modell, MD, D. Sc. Drowing Anesthesiology 2009; 110: 1390–401.</mixed-citation><mixed-citation xml:lang="en">A. Joseph Layon, MD, Jerome H. Modell, MD, D. Sc. Drowing Anesthesiology 2009; 110: 1390–401.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">W. Hasibeder, B. Friesenecker, A. Mayr. Beinaheertrinken: Epidemiologie-Pathophysiologie-Therapie Anästhesiol Intensivmed Notfallmed Schmerzther 2003; 38: 333–340.</mixed-citation><mixed-citation xml:lang="en">W. Hasibeder, B. Friesenecker, A. Mayr. Beinaheertrinken: Epidemiologie-Pathophysiologie-Therapie Anästhesiol Intensivmed Notfallmed Schmerzther 2003; 38: 333–340.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Mark J. Rumbak, MD. The Etiology of Pulmonary Edema in Fresh Water Near-Drowing Am J Emerg Med 1996; 14: 176–179.‌</mixed-citation><mixed-citation xml:lang="en">Mark J. Rumbak, MD. The Etiology of Pulmonary Edema in Fresh Water Near-Drowing Am J Emerg Med 1996; 14: 176–179.‌</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ruben D. Restrepo, Joel M. Brown 2nd, John M. Hughes AARS Clinical Practice Guidelines. Endotracheal suctioning of mechanically ventilated patients with artificial airways 2010 Jun; 55 (6): 758–64.</mixed-citation><mixed-citation xml:lang="en">Ruben D. Restrepo, Joel M. Brown 2nd, John M. Hughes AARS Clinical Practice Guidelines. Endotracheal suctioning of mechanically ventilated patients with artificial airways 2010 Jun; 55 (6): 758–64.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Rodrigo Daminello Raimundo et al. Respir Care. 2021 May; 66 (5): 785–792.</mixed-citation><mixed-citation xml:lang="en">Rodrigo Daminello Raimundo et al. Respir Care. 2021 May; 66 (5): 785–792.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Jerome H. Modell, M. D. Joseph H. Davis, M. D. Electrolyte Changes in Human Drowing Victim Anesthesiology 1969; 30 (4): 414–420.</mixed-citation><mixed-citation xml:lang="en">Jerome H. Modell, M. D. Joseph H. Davis, M. D. Electrolyte Changes in Human Drowing Victim Anesthesiology 1969; 30 (4): 414–420.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Olshaker JS. Neardrowning. Environmental Emergencies 1992; 10: 339–350.</mixed-citation><mixed-citation xml:lang="en">Olshaker JS. Neardrowning. Environmental Emergencies 1992; 10: 339–350.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Jerome H. Modell. The Pathophysiology and Treatment of Drowning and Near Drowning Springfield, IL, Charles C. Thomas, 1971; 3–119.</mixed-citation><mixed-citation xml:lang="en">Jerome H. Modell. The Pathophysiology and Treatment of Drowning and Near Drowning Springfield, IL, Charles C. Thomas, 1971; 3–119.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Idris A, Bert R, Bierens J, Bossaert L, Branche C, Gabrielli A, Graves S, Handley A, Hoelle R, Morley P, Papa L, Pepe P, Quan L, Szpilman D, Wiggington J, Modell J. Recommended guidelines for uniform reporting of data from drowning: The Utstein Style, Handbook on Drowning. Edited by Bierens J. Heidelberg, Springer-Verlag. 2006; 377–85.</mixed-citation><mixed-citation xml:lang="en">Idris A, Bert R, Bierens J, Bossaert L, Branche C, Gabrielli A, Graves S, Handley A, Hoelle R, Morley P, Papa L, Pepe P, Quan L, Szpilman D, Wiggington J, Modell J. Recommended guidelines for uniform reporting of data from drowning: The Utstein Style, Handbook on Drowning. Edited by Bierens J. Heidelberg, Springer-Verlag. 2006; 377–85.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Jerome H. Modell, Moya F. Effects of volume of aspirated fluid during chlorinated freshwater drowning. Anesthesiology 1966; 27: 662–72.</mixed-citation><mixed-citation xml:lang="en">Jerome H. Modell, Moya F. Effects of volume of aspirated fluid during chlorinated freshwater drowning. Anesthesiology 1966; 27: 662–72.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Jerome H. Modell, Moya F, Newby EJ, Ruiz BC, Showers AV. The effects of fluid volume in seawater drowning. Ann Intern Med 1967; 67: 68–80.</mixed-citation><mixed-citation xml:lang="en">Jerome H. Modell, Moya F, Newby EJ, Ruiz BC, Showers AV. The effects of fluid volume in seawater drowning. Ann Intern Med 1967; 67: 68–80.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Jerome H. Modell, Graves SA, Kuck EJ. Near-drowning: Correlation of level of consciousness and survival. Can Anaesth Soc J 1980; 27: 211–5.</mixed-citation><mixed-citation xml:lang="en">Jerome H. Modell, Graves SA, Kuck EJ. Near-drowning: Correlation of level of consciousness and survival. Can Anaesth Soc J 1980; 27: 211–5.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Jerome H. Modell, Pellis T, Weil MH: Hospital treatment: Cardiovascular changes, Handbook on Drowning. Edited by Bierens J. Heidelberg, Springer-Verlag. 2006; 423–7.</mixed-citation><mixed-citation xml:lang="en">Jerome H. Modell, Pellis T, Weil MH: Hospital treatment: Cardiovascular changes, Handbook on Drowning. Edited by Bierens J. Heidelberg, Springer-Verlag. 2006; 423–7.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Jerome H. Modell, Moya F, Williams HD, et al: Changes in the blood gas and A-a O2 during near-drowning. Anesthesiology 1968; 29: 456–465.</mixed-citation><mixed-citation xml:lang="en">Jerome H. Modell, Moya F, Williams HD, et al: Changes in the blood gas and A-a O2 during near-drowning. Anesthesiology 1968; 29: 456–465.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Giamonna ST, Modell JH: Drowning by total immersion: Effects on pulmonary surfactant of distilled water, isotonic saline and sea water. Am J Dis Child 1967; 114: 612–616.</mixed-citation><mixed-citation xml:lang="en">Giamonna ST, Modell JH: Drowning by total immersion: Effects on pulmonary surfactant of distilled water, isotonic saline and sea water. Am J Dis Child 1967; 114: 612–616.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Fuller RH: The clinical pathology of human near-drowning. Proc R Soc Med 1963; 56: 33–8.</mixed-citation><mixed-citation xml:lang="en">Fuller RH: The clinical pathology of human near-drowning. Proc R Soc Med 1963; 56: 33–8.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Tipton MJ: The initial response to cold-water immersion in man. Clin Sci (Lond) 1989; 77: 581–8.</mixed-citation><mixed-citation xml:lang="en">Tipton MJ: The initial response to cold-water immersion in man. Clin Sci (Lond) 1989; 77: 581–8.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
