medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»medalphabet-349Research ArticleСтатьиАффективные расстройства у больных болезнью Паркинсона на фоне хронической стимуляции субталамического ядра (обзор литературы)Affective disorders after deep brain stimulation of subthalamic nucleus in patients with Parkinson ’s disease (review of literature)ОмароваС. М.OmarovaS. M.noemail@neicon.ruФедороваН. В.FyodorovaN. V.noemail@neicon.ruТомскийА. А.TomskyA. A.noemail@neicon.ruБрияьЕ. В.BrilE. V.noemail@neicon.ruФГБОУ ДПО «Российская медицинская академия непрерывного последипломного образования» Минздрава РоссииРоссияRussian Medical Academy for Postgraduate Continuous EducationRussian FederationФГАУ «Национальный научно-практический центр нейрохирургии имени академика Н. Н. Бурденко» Минздрава РоссииРоссияNational Scientific and Practical Centre for Neurosurgery n.a. N. N. BurdenkoRussian FederationФГБОУ ДПО «Российская медицинская академия непрерывного последипломного образования» Минздрава России; Федеральный неврологический центр ФГБУ «Государственный научный центр Российской Федерации - Федеральный медицинский биофизический центр имени А. И. Бурназяна» ФМБА РоссииРоссияRussian Medical Academy for Postgraduate Continuous Education; State Scientific Centre of the Russian Federation - Federal Medical Biophysical Centre n.a. A. I. BurnazyanRussian Federation201716102017332Неврология и психиатрия5057Copyright © Омарова С.М., Федорова Н.В., Томский А.А., Брияь Е.В., 20172017Омарова С.М., Федорова Н.В., Томский А.А., Брияь Е.В.Omarova S.M., Fyodorova N.V., Tomsky A.A., Bril E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/349

Нейростимуляция субталамического ядра (НС STN) является эффективным методом симптоматической терапии болезни Паркинсона (БП) на развернутых стадиях заболевания, позволяющим уменьшить выраженность двигательных симптомов и улучшить качество жизни пациентов. Данные обзора литературы о частоте и выраженности различных аффективных нарушений у больных БП на фоне НС STN крайне противоречивы. В литературе описаны как улучшения, так и ухудшения, а также возникновение впервые этих расстройств в виде депрессии, тревоги, апатии, суицида после операции. В данном обзоре литературы рассмотрены различные влияния НС STN на аффективные расстройства у больных БП, а также патогенез этих нарушений и подходы к их коррекции. Необходимо проведение дальнейших исследований на большой группе пациентов БП с длительным катамнестическим наблюдением, желательно в сравнении с контрольной группой наблюдения, получающей только адекватную фармакотерапию.

Deep brain stimulation of the subthalamic nucleus (DBS STN) is very effective for the symptomatic treatment of Parkinson's disease (PD), improving both motor function and quality of life. There are various data about the effect of DBS STN on the frequency and severity of affective disorders in patient with DBS STN. The literature describes both improvements and worsening, as well as the appearance of these disorders for the first time in the form of depression, anxiety, apathy, suicide after surgery. In this review of the literature various effects of DBS STN on the affective disorders in patients with PD, as well as the pathogenesis of these disorders and approaches to their correction are considered. It is necessary to carry out further studies in a large group of patients with PD with prolonged follow-up, preferably in comparison with the control group of supervision receiving only adequate pharmacotherapy.

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The authors declare that there are no conflicts of interest present.