medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2023-35-7-11medalphabet-3484Research ArticleСтатьиИзменения микробиома при синдроме кишечной недостаточности в послеоперационном периоде: роль в развитии синдрома полиорганной недостаточностиMicrobiome changes in acute gastrointestinal injury in postoperative period: Role in development of multiorgan failure syndromehttps://orcid.org/0000-0002-9466-7556МачулинаИ. А.MachulinaI. A.

Мачулина Ирина Александровна, зам. гл. врача по анестезиологии и реанимации

Machulina Irina A., deputy chief physician in anesthesiology and resuscitation

Moscow

https://orcid.org/0000-0002-5278-7058ШестопаловА. Е.ShestopalovA. E.

Шестопалов Александр Ефимович, проф.; научный консультант

РИНЦ ID: 703014. Scopus ID: 8295880000

Москва

Shestopalov Alexander E., professor; scientific consultant

Moscow

https://orcid.org/0000-0003-2693-0823ПоповаТ. С.PopovaT. S.

Попова Тамара Сергеевна, проф., г.н.с.

Popova Tamara S., professor, senior researcher

Moscow

ГБУЗ «Городская клиническая больница № 70 имени Е. О. Мухина Департамента здравоохранения города г. Москвы»РоссияCity Clinical Hospital No. 70 n.a. E. O. MukhinaRussian FederationФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России; 3ФГБУ «Главный военный клинический госпиталь имени академика Н. Н. Бурденко» Минобороны РоссииРоссияRussian Medical Academy for Continuing Professional Education; Main Military Clinical Hospital n.a. academician N. N. BurdenkoRussian FederationГБУЗ г. Москвы «Научно-исследовательский институт скорой помощи имени Н. В. Склифосовского Департамента здравоохранения Москвы»РоссияResearch Institute for Emergency Medicine n.a. N. V. SklifosovskyRussian Federation202317012024035Кардиология. Неотложная медицина (4)711Copyright © Мачулина И.А., Шестопалов А.Е., Попова Т.С., 20242024Мачулина И.А., Шестопалов А.Е., Попова Т.С.Machulina I.A., Shestopalov A.E., Popova T.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/3484

Послеоперационная кишечная недостаточность остается одной из главных проблем пациентов хирургического профиля в отделении реанимации. Трансформация микробиома в патобиом, нарушение барьерной функции кишки, а также иммунной функции микробиоты приводит к развитию синдрома системного воспаления и полиорганной недостаточности. Понимание патофизиологических механизмов нарушения функции кишки, трансформации микробиома в патобиом необходимо для проведения адекватной интенсивной терапии и улучшения прогноза заболевания пациентов, перенесших оперативное вмешательство.

Postoperative ileus remains one of the main problems of surgical patients in the intensive care unit. Transformation of the microbiome into a pathobiome, failure of intestinal barrier function and immune function of microbiota leads to the development of systemic inflammation syndrome and multiple organ failure. Understanding the pathophysiological mechanisms of intestinal dysfunction and transformation of the microbiome into a pathobiome is necessary to conduct adequate intensive therapy and improve the prognosis of the disease in patients who have undergone surgical intervention.

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The authors declare that there are no conflicts of interest present.