medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2023-27-55-60medalphabet-3425Research ArticleСтатьиХимиотерапия с включением доксорубицина, ифосфамида при распространенной злокачественной гломусной опухоли мягких тканей предплечья (клинический случай и обзор литературы)Chemotherapy with inclusion of doxorubicin, ifosfamide for common malignant glomus tumor of soft tissues of forearm (clinical case and literature review)https://orcid.org/0000-0002-8721-8437СавчинаВ. В.SavchinaV. V.

Савчина Виктория Владимировна, н.с. отдела лекарственного лечения опухолей

Москва.

Savchina Victoria V., researcher at Dept of Drug Treatment of Tumors

Moscow.

savchina_v.v@mail.ruhttps://orcid.org/0000-0001-5505-037XРатоваЕ. И.RatovaE. I.

Ратова Евгения Игоревна, врач-ординатор отделения химиотерапии отдела лекарственного лечения опухолей

Москва.

Ratova Evgeniya I., resident physician at Chemotherapy Unit of Dept of Drug Treatment of Tumors

Moscow.

jane_usacheva@mail.ruhttps://orcid.org/0000-0003-4879-2687БолотинаЛ. В.BolotinaL. V.

Болотина Лариса Владимировна, д.м.н., зав. отделением химиотерапии отдела лекарственного лечения опухолей, 

AuthorID: 594953

Москва.

Bolotina Larisa V., DM Sci (habil.), head of Chemotherapy Unit of Dept of Drug Treatment of Tumor,

AuthorID: 594953

Moscow.

lbolotina@yandex.ruhttps://orcid.org/0000-0003-3196-1368КарагодинаЮ. Б.KaragodinaYu. B.

Карагодина Юлия Борисовна, н.с. отдела лекарственного лечения опухолей

Москва.

Karagodina Yulia B., researcher at Dt of Drug Treatment of Tumors

Moscow.

yuliaborisovnakaragodina@gmail.comhttps://orcid.org/0000-0003-4927-5585ФеденкоА. А.FedenkoA. A.

Феденко Александр Александрович, д.м.н., проф., рук. отдела лекарственного лечения опухолей,

AuthorID: 823233

Москва.

Fedenko Alexander A., DM Sci (habil.), professor, head of Dept of Drug Treatment of Tumors,

AuthorID: 823233

Moscow.

fedenko@eesg.ruФГБУ «Национальный медицинский исследовательский центр радиологии» Минздрава РоссииРоссияNational Medical Research Centre of RadiologyRussian Federation202305122023027Диагностика и онкотерапия (3)5560Copyright © Савчина В.В., Ратова Е.И., Болотина Л.В., Карагодина Ю.Б., Феденко А.А., 20232023Савчина В.В., Ратова Е.И., Болотина Л.В., Карагодина Ю.Б., Феденко А.А.Savchina V.V., Ratova E.I., Bolotina L.V., Karagodina Y.B., Fedenko A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/3425

Злокачественная гломусная опухоль представляет собой крайне редкое и агрессивное новообразование, состоящие из модифицированных клеток гломусного тела. Постановка верного морфологического диагноза затруднительна и требует тщательной дифференциальной диагностики между нейроэндокринными опухолями, перицитарными опухолями, новообразованиями гладкой мускулатуры. В литературе описаны лишь единичные клинические наблюдения, серии случаев и результаты небольшого количества ретроспективных исследований. В связи с редкостью нозологии оптимальной стратегии лечения данного заболевания не выработано. В большинстве случаев при местнораспространенном процессе применяется хирургическое лечение. Случаи метастазирования злокачественной гломусной опухоли встречаются крайне редко. Единого консенсуса по тактике системного лечения на сегодняшний день не достигнуто. В данной статье мы представляем клинический случай достижения стабилизации опухолевого процесса после проведения пяти курсов химиотерапии доксорубицином, ифосфамидом у 49-летнего пациента со злокачественной гломусной опухолью мягких тканей левого предплечья с метастатическим поражением тканей передней стенки грудной клетки слева с распространением на левую малую грудную мышцу, третье ребро и плевральную полость, с метастатическим поражением паренхимы легких.

Malignant glomus tumor is an extremely rare, aggressive neoplasm, which is contain from modified glomus body’s cells. The correct morphological diagnosis is difficult, and requires careful differential diagnosis between neuroendocrine tumors, pericytic tumors, smooth muscle neoplasms. The literature describes only sporadic clinical observations, a series of cases and the results of a small number of retrospective studies. Due to the rarity of nosology, the optimal treatment strategy for this disease has not been developed. Most cases, surgical treatment is used in a locally common process. Cases of metastasis of a malignant glomus tumor are extremely rare. There is no consensus on the tactics of systemic treatment to date. In this article, we present a clinical case of achieving stabilization of the tumor process after 5 courses of chemotherapy with doxorubicin, ifosfamide in a 49-year-old patient with a malignant glomus tumor of the soft tissues of the left forearm with metastatic lesion of the tissues of the anterior chest wall on the left with spread to the left small pectoral muscle, 3rd rib and pleural cavity, with metastatic lesion lung parenchyma.

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The authors declare that there are no conflicts of interest present.