medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2023-29-62-66medalphabet-3420Research ArticleСтатьиАнтибактериальные, пробиотические и иммуномодулирующие свойства L. acidophilus La‑14Antibacterial, probiotic and immunomodulatory properties of L. acidophilus La‑14https://orcid.org/0000-0002-4689-3591ОрловаС. В.OrlovaS. V.

Орлова Светлана Владимировна, д.м.н., проф., зав. кафедрой диетологии и клинической нутрициологии

Москва

Orlova Svetlana V., DM Sci (habil.), professor, head of Dept of Dietetics and Clinical Nutritiology; Chief Researche

Moscow

orlova-sv@rudn.ruhttps://orcid.org/0000-0003-3220-0333НикитинаЕ. А.NikitinaЕ. А.

Никитина Елена Александровна, к.м.н., доцент кафедры диетологии и клинической нутрициологии; научный сотрудник

Москва

Nikitina Elena A., PhD Med, assistant professor of Dept of Dietetics and Clinical Nutritiology; Researcher

Moscow

nikitina-ea1@rudn.ruhttps://orcid.org/0000-0003-3309-4683ПопадюкВ. И.PopadyukV. I.

Попадюк Валентин Иванович, д.м.н., профессор, декан факультета ФНМО, зав. кафедрой оториноларингологии Медицинского института

Москва

Popadyuk Valentin I., DM Sci (habil.), professor, dean of FNMO Faculty, Head of the Department of Otorhinolaryngology of the Medical Institute

Moscow

lorval04@mail.ruhttps://orcid.org/0009-0007-5460-5178КузнецоваН. В.KuznetsovaN. V.

Кузнецова Надежда Владимировна, аспирант кафедрыоториноларингологии Медицинского института

Москва

Kuznetsova Nadezhda V., postgraduate student of the Dept ofOtorhinolaryngology of the Medical Institute

Moscow

1142230493@rudn.ruhttps://orcid.org/0000-0001-6966-8656КириенкоИ. М.KirichenkoI. M.

Кириченко Ирина Михайловна, д.м.н., профессор кафедрыоториноларингологии Медицинского института; главный оториноларинголог

Москва

Kirichenko Irina M., DM Sci (habil.), professor of the Dept of Otorhinolaryngology of the Medical Institute; head of the Dept of Otorhinolaryngology

Moscow

loririna@yandex.ruФГАОУ ВО «Российский университет дружбы народов» имени Патриса Лумумбы; ГБУЗ «Научно-практический центр детской психоневрологии Департамента здравоохранения г. Москвы»РоссияPeoples’ Friendship University of Russia named after Patrice Lumumba; Scientific and Practical Center for Pediatric Psychoneurology of the Moscow Department of HealthRussian FederationФГАОУ ВО «Российский университет дружбы народов» имени Патриса Лумумбы; Международный медицинский центр «Он Клиник»РоссияPeoples’ Friendship University of Russia named after Patrice LumumbaRussian FederationФГАОУ ВО «Российский университет дружбы народов» имени Патриса ЛумумбыРоссияPeoples’ Friendship University of Russia named after Patrice LumumbaRussian FederationФГАОУ ВО «Российский университет дружбы народов» имени Патриса Лумумбы; Международный медицинский центр «Он Клиник»РоссияPeoples’ Friendship University of Russia named after Patrice Lumumba; International Medical Center On ClinicsRussian Federation202304122023029«Диетология и нутрициология» (2)6266Copyright © Орлова С.В., Никитина Е.А., Попадюк В.И., Кузнецова Н.В., Кириенко И.М., 20232023Орлова С.В., Никитина Е.А., Попадюк В.И., Кузнецова Н.В., Кириенко И.М.Orlova S.V., Nikitina Е.А., Popadyuk V.I., Kuznetsova N.V., Kirichenko I.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/3420

Многие научные исследования показывают профилактическое и лечебное действие пробиотиков при различных заболеваниях. Штамм L. acidophilus La‑14 обладает доказанной антибактериальной, пробиотической и иммуномодулирующей эффективностью, имеет долгую историю применения и не вызывает развития антибиотикорезистентности. Необходимы дальнейшие исследования для определения оптимальной дозы и продолжительности приема пробиотика.

Many scientific studies show the preventive and therapeutic effects of probiotics in various diseases. The L. acidophilus La‑14 strain has proven antibacterial, probiotic and immunomodulatory effectiveness, has a long history of use and does not cause the development of antibiotic resistance. Further research is needed to determine the optimal dose and duration of probiotic intake.

Lactobacillus acidophilus La‑14лактобактериимикробиомпробиотикиинфекциииммунитетLactobacillus acidophilus La‑14Lactobacillimicrobiomeprobioticsinfectionsimmune functionReferencesFAO/WHO Food and Agriculture Organization of the United Nations/World Health Organization Guidelines for the Evaluation of Probiotics in Food. [(accessed on 21 November 2020)]; Report of a Joint FAO/WHO Working Group on Drafting Guidelines for the Evaluation of Probiotics in Food. 2002 Available online: https://www.who.int/foodsafety/fs_management/en/ probiotic_guidelines.pdf.FAO/WHO Food and Agriculture Organization of the United Nations/World Health Organization Guidelines for the Evaluation of Probiotics in Food. [(accessed on 21 November 2020)]; Report of a Joint FAO/WHO Working Group on Drafting Guidelines for the Evaluation of Probiotics in Food. 2002 Available online: https://www.who.int/foodsafety/fs_management/en/ probiotic_guidelines.pdf.Технический регламент Таможенного союза ТР ТС 033/2013 «О безопасности молока и молочной продукции». Принят Решением Совета Евразийской экономической комиссии от 9 октября 2013 г. N67. https://docs. cntd.ru/document/499050562Technical Regulations of the Customs Union TR CU 033/2013 “On the safety of milk and dairy products.” Adopted by the Decision of the Council of the Eurasian Economic Commission dated October 9, 2013 N 67. https://docs. cntd.ru/document/499050562Единые санитарно-эпидемиологические и гигиенические требования к продукции (товарам), подлежащей санитарно-эпидемиологическому надзору (контролю) (утв. Решением Комиссии Таможенного союза от 28 мая 2010 года № 299). https://eec.eaeunion.org/comission/ department/depsanmer/regulation/P2_299.phpUnified sanitary-epidemiological and hygienic requirements for products (goods) subject to sanitary-epidemiological supervision (control) (approved by the Decision of the Commission of the Customs Union dated May 28, 2010 No. 299). https://eec.eaeunion.org/commission/department/depsanmer/ regulation/P2_299.phpTechnical Memorandum Lactobacillus acidophilus La 14. Danisco. http://03a5bcb.netsolstores.com/images/research/Lacidophilus.pdfTechnical Memorandum Lactobacillus acidophilus La 14. Danisco. http://03a5bcb.netsolstores.com/images/research/Lacidophilus.pdfSchlievert PM, Gaitán AV, Kilgore SH, Roe AL, Maukonen J, Lehtoranta L, Leung DYM, Marsman DS. Inhibition of Toxic Shock Syndrome-Associated Staphylococcus aureus by Probiotic Lactobacilli. Microbiol. Spectr. 2023 Aug 17; 11 (4): e0173523. DOI: 10.1128/spectrum.01735–23Schlievert PM, Gaitán AV, Kilgore SH, Roe AL, Maukonen J, Lehtoranta L, Leung DYM, Marsman DS. Inhibition of Toxic Shock Syndrome-Associated Staphylococcus aureus by Probiotic Lactobacilli. Microbiol. Spectr. 2023 Aug 17; 11 (4): e0173523. DOI: 10.1128/spectrum.01735–23De Alberti D, Russo R, Terruzzi F, Nobile V, Ouwehand AC. Lactobacilli vaginal colonisation after oral consumption of Respecta(®) complex: a randomised controlled pilot study. Arch. Gynecol. Obstet. 2015 Oct; 292 (4): 861–7. DOI: 10.1007/s00404–015–3711–4De Alberti D, Russo R, Terruzzi F, Nobile V, Ouwehand AC. Lactobacilli vaginal colonisation after oral consumption of Respecta(®) complex: a randomised controlled pilot study. Arch. Gynecol. Obstet. 2015 Oct; 292 (4): 861–7. DOI: 10.1007/s00404–015–3711–4Russo R, Edu A, De Seta F. Study on the effects of an oral lactobacilli and lactoferrin complex in women with intermediate vaginal microbiota. Arch. Gynecol. Obstet. 2018 Jul; 298 (1): 139–145. DOI: 10.1007/s00404–018–4771-zRusso R, Edu A, De Seta F. Study on the effects of an oral lactobacilli and lactoferrin complex in women with intermediate vaginal microbiota. Arch. Gynecol. Obstet. 2018 Jul; 298 (1): 139–145. DOI: 10.1007/s00404–018–4771-zRusso R, Karadja E, De Seta F. Evidence-based mixture containing Lactobacillus strains and lactoferrin to prevent recurrent bacterial vaginosis: a double blind, placebo controlled, randomised clinical trial. Benef. Microbes. 2019 Feb 8; 10 (1): 19–26. DOI: 10.3920/BM2018.0075Russo R, Karadja E, De Seta F. Evidence-based mixture containing Lactobacillus strains and lactoferrin to prevent recurrent bacterial vaginosis: a double blind, placebo controlled, randomised clinical trial. Benef. Microbes. 2019 Feb 8; 10 (1): 19–26. DOI: 10.3920/BM2018.0075Russo R, Superti F, Karadja E, De Seta F. Randomised clinical trial in women with Recurrent Vulvovaginal Candidiasis: Efficacy of probiotics and lactoferrin as maintenance treatment. Mycoses. 2019 Apr; 62 (4): 328–335. DOI: 10.1111/myc.12883Russo R, Superti F, Karadja E, De Seta F. Randomised clinical trial in women with Recurrent Vulvovaginal Candidiasis: Efficacy of probiotics and lactoferrin as maintenance treatment. Mycoses. 2019 Apr; 62 (4): 328–335. DOI: 10.1111/myc.12883Del Popolo G, Nelli F. Recurrent bacterial symptomatic cystitis: A pilot study on a new natural option for treatment. Arch. Ital. Urol. Androl. 2018 Jun 30; 90 (2): 101–103.Del Popolo G, Nelli F. Recurrent bacterial symptomatic cystitis: A pilot study on a new natural option for treatment. Arch. Ital. Urol. Androl. 2018 Jun 30; 90 (2): 101–103.Luo, X.Y., Lun, Y.Z„ Gao, W„ Hu, H.B., Wang, Q., Liu, Y., Yin, J.S.& Jiang, S. J. Effects of spent culture supernatant of Lactobacillus acidophilus on intestinal flora in mice with antibiotic- associated diarrhoea. Shijie Huaren Xiaohua Zazhi. 2006; 14 (19): 1870–1873. DOI: 10.11569/wcjd.v14.i19.1870Luo, X.Y., Lun, Y.Z„ Gao, W„ Hu, H.B., Wang, Q., Liu, Y., Yin, J.S.& Jiang, S. J. Effects of spent culture supernatant of Lactobacillus acidophilus on intestinal flora in mice with antibiotic- associated diarrhoea. Shijie Huaren Xiaohua Zazhi. 2006; 14 (19): 1870–1873. DOI: 10.11569/wcjd.v14.i19.1870Guo Q, Goldenberg JZ, Humphrey C, El Dib R, Johnston BC. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev. 2019 Apr 30; 4 (4): CD004827. DOI: 10.1002/14651858.CD004827.pub5Guo Q, Goldenberg JZ, Humphrey C, El Dib R, Johnston BC. Probiotics for the prevention of pediatric antibiotic-associated diarrhea. Cochrane Database Syst Rev. 2019 Apr 30; 4 (4): CD004827. DOI: 10.1002/14651858.CD004827.pub5Elawadli I, Brisbin JT, Mallard BA, Griffiths MW, Corredig M, Sharif S. Differential effects of lactobacilli on activation and maturation of mouse dendritic cells. Benef. Microbes. 2014 Sep; 5 (3): 323–34. DOI: 10.3920/BM2013.0066Elawadli I, Brisbin JT, Mallard BA, Griffiths MW, Corredig M, Sharif S. Differential effects of lactobacilli on activation and maturation of mouse dendritic cells. Benef. Microbes. 2014 Sep; 5 (3): 323–34. DOI: 10.3920/BM2013.0066Paineau D, Carcano D, Leyer G, Darquy S, Alyanakian MA, Simoneau G, Bergmann JF, Brassart D, Bornet F, Ouwehand AC. Effects of seven potential probiotic strains on specific immune responses in healthy adults: a double-blind, randomized, controlled trial. FEMS Immunol. Med. Microbiol. 2008 Jun; 53 (1): 107–13. DOI: 10.1111/j.1574–695X.2008.00413.xPaineau D, Carcano D, Leyer G, Darquy S, Alyanakian MA, Simoneau G, Bergmann JF, Brassart D, Bornet F, Ouwehand AC. Effects of seven potential probiotic strains on specific immune responses in healthy adults: a double-blind, randomized, controlled trial. FEMS Immunol. Med. Microbiol. 2008 Jun; 53 (1): 107–13. DOI: 10.1111/j.1574–695X.2008.00413.xGaldeano CM, Perdigón G. Role of viability of probiotic strains in their persistence in the gut and in mucosal immune stimulation. J. Appl. Microbiol. 2004; 97 (4): 673–81. DOI: 10.1111/j.1365–2672.2004.02353.xGaldeano CM, Perdigón G. Role of viability of probiotic strains in their persistence in the gut and in mucosal immune stimulation. J. Appl. Microbiol. 2004; 97 (4): 673–81. DOI: 10.1111/j.1365–2672.2004.02353.xPaineau D, Carcano D, Leyer G, Darquy S, Alyanakian MA, Simoneau G, Bergmann JF, Brassart D, Bornet F, Ouwehand AC. Effects of seven potential probiotic strains on specific immune responses in healthy adults: a double-blind, randomized, controlled trial. FEMS Immunol. Med. Microbiol. 2008 Jun; 53 (1): 107–13. DOI: 10.1111/j.1574–695X.2008.00413.xPaineau D, Carcano D, Leyer G, Darquy S, Alyanakian MA, Simoneau G, Bergmann JF, Brassart D, Bornet F, Ouwehand AC. Effects of seven potential probiotic strains on specific immune responses in healthy adults: a double-blind, randomized, controlled trial. FEMS Immunol. Med. Microbiol. 2008 Jun; 53 (1): 107–13. DOI: 10.1111/j.1574–695X.2008.00413.xForssten S, Ouwehand AC. Dose-Response Recovery of Probiotic Strains in Simulated Gastro-Intestinal Passage. Microorganisms. 2020 Jan 13; 8 (1): 112. DOI: 10.3390/microorganisms8010112Forssten S, Ouwehand AC. Dose-Response Recovery of Probiotic Strains in Simulated Gastro-Intestinal Passage. Microorganisms. 2020 Jan 13; 8 (1): 112. DOI: 10.3390/microorganisms8010112Hong Chau TT, Minh Chau NN, Hoang Le NT, Chung The H, Voong Vinh P, Nguyen To NT, Ngoc NM, Tuan HM, Chau Ngoc TL, Kolader ME, Farrar JJ, Wolbers M, Thwaites GE, Baker S; Oxford-Vietnam Probiotics Study Group. A Double-blind, Randomized, Placebo-controlled Trial of Lactobacillus acidophilus for the Treatment of Acute Watery Diarrhea in Vietnamese Children. Pediatr. Infect. Dis. J. 2018 Jan; 37 (1): 35–42. DOI: 10.1097/INF.0000000000001712Hong Chau TT, Minh Chau NN, Hoang Le NT, Chung The H, Voong Vinh P, Nguyen To NT, Ngoc NM, Tuan HM, Chau Ngoc TL, Kolader ME, Farrar JJ, Wolbers M, Thwaites GE, Baker S; Oxford-Vietnam Probiotics Study Group. A Double-blind, Randomized, Placebo-controlled Trial of Lactobacillus acidophilus for the Treatment of Acute Watery Diarrhea in Vietnamese Children. Pediatr. Infect. Dis. J. 2018 Jan; 37 (1): 35–42. DOI: 10.1097/INF.0000000000001712Todorov SD, Furtado DN, Saad SM, Gombossy de Melo Franco BD. Bacteriocin production and resistance to drugs are advantageous features for Lactobacillus acidophilus La 14, a potential probiotic strain. New Microbiol. 2011 Oct; 34 (4): 357–70. Epub 2011 Oct 31. PMID: 22143809Todorov SD, Furtado DN, Saad SM, Gombossy de Melo Franco BD. Bacteriocin production and resistance to drugs are advantageous features for Lactobacillus acidophilus La 14, a potential probiotic strain. New Microbiol. 2011 Oct; 34 (4): 357–70. Epub 2011 Oct 31. PMID: 22143809Лазебник Л. Б., Голованова Е. В., Туркина С. В., Райхельсон К. Л., Оковитый С. В., Драпкина О. М., Маев И. В., Мартынов А. И., Ройтберг Г. Е., Хлынова О. В., Абдулганиева Д. И., Алексеенко С. А., Ардатская М. Д., Бакулин И. Г., Бакулина Н. В., Буеверов А. О., Виницкая Е. В., Волынец Г. В., Еремина Е.Ю., Гриневич В. Б., Казюлин А.Н., Кашкина Е.И., Козлова И.В., Конев Ю. В., Корочанская Н. В., Кравчук Ю. А., Ли Е. Д., Лоранская И. Д., Махов В.М., Мехтиев С.Н., Новикова В.П., Остроумова О. Д., Павлов Ч. С., Радченко В. Г., Самсонов А. А., Сарсенбаева А. С., Сайфутдинов Р. Г., Селиверстов П. В., Ситкин С. И., Стефанюк О. В., Тарасова Л. В., Ткаченко Е. И., Успенский Ю. П., Фоминых Ю. А., Хавкин А. И., Цыганова Ю. В., Шархун О.О. Неалкогольная жировая болезнь печени у взрослых: клиника, диагностика, лечение. Рекомендации для терапевтов, третья версия. Экспериментальная и клиническая гастроэнтерология. 2021; 185 (1): 4–52. DOI: 10.31146/1682–8658-ecg 185–1–4–52. https://doi.org/10.31146/1682–8658-ecg 185–1–4–52Lazebnik L. B., Golovanova E. V., Turkina S. V., Raikhelson K. L., Okovityy S. V., Drapkina O.M., Maev I. V., Martynov A. I., Roitberg G. E., Khlynova O. V., Abdulganieva D.I., Alekseenko S.A., Ardatskaya M.D., Bakulin I.G., Bakulina N.V., Bueverov A.O., Vinitskaya E. V., Volynets G.V., Eremina E. Yu., Grinevich V.B., Dolgushina A. I., Kazyulin A. N., Kashkina E. I., Kozlova I. V., Konev Yu.V., Korochanskaya N. V., Kravchuk Yu.A., Li E. D., Loranskaya I. D., Makhov V. M., Mekhtiev S. N., Novikova V. P., Ostroumova O. D., Pavlov Ch.S., Radchenko V.G., Samsonov A.A., Sarsenbaeva A. S., Sayfutdinov R.G., Seliverstov P.V., Sitkin S. I., Stefanyuk O. V., Tarasova L. V., Tkachenko E. I., Uspensky Yu.P., Fominykh Yu.A., Khavkin A.I., Tsyganova Yu.V., Sharhun O.O. Non-alcoholic fatty liver disease in adults: clinic, diagnostics, treatment. Guidelines for therapists, third version. Experimental and Clinical Gastroenterology. 2021; 1 (1): 4–52. (In Russ.) https://doi.org/10.31146/1682–8658-ecg 185–1–4–52World Gastroenterology Organisation Global Guidelines ‘Probiotics and Prebiotics’. 2017 Feb. Available at: https://www.worldgastroenterology.org/ UserFiles/file/guidelines/probiotics-and-prebiotics-english 2017.pdfWorld Gastroenterology Organisation Global Guidelines ‘Probiotics and Prebiotics’. 2017 Feb. Available at: https://www.worldgastroenterology.org/ UserFiles/file/guidelines/probiotics-and-prebiotics-english 2017.pdfPerna S, Ilyas Z, Giacosa A, Gasparri C, Peroni G, Faliva MA, Rigon C, Naso M, Riva A, Petrangolini G, A Redha A, Rondanelli M. Is Probiotic Supplementation Useful for the Management of Body Weight and Other Anthropometric Measures in Adults Affected by Overweight and Obesity with Metabolic Related Diseases? A Systematic Review and Meta-Analysis. Nutrients. 2021 Feb 19; 13 (2): 666. DOI: 10.3390/nu13020666Perna S, Ilyas Z, Giacosa A, Gasparri C, Peroni G, Faliva MA, Rigon C, Naso M, Riva A, Petrangolini G, A Redha A, Rondanelli M. Is Probiotic Supplementation Useful for the Management of Body Weight and Other Anthropometric Measures in Adults Affected by Overweight and Obesity with Metabolic Related Diseases? A Systematic Review and Meta-Analysis. Nutrients. 2021 Feb 19; 13 (2): 666. DOI: 10.3390/nu13020666Никитина Е. А., Орлова С. В., Орлова А. А. Пробиотики: настоящее и будущее. Медицинский алфавит. 2021; 21: 101–114. https://doi. Org/10.33667/2078–5.631–2021–21–101–114.Nikitina E.A., Orlova S.V., Orlova A.A. Probiotics: present and future. Medical alphabet. 2021; 21: 101–114. https://dloi.org/10.3366772078–5631–2021–21– 101–114Bendazzoli C, Turroni S, Gotti R, Olmo S, Brigidi P, Cavrini V. Determination of oxalyl-coenzyme A decarboxylase activity in Oxalobacter formigenes and Lactobacillus acidophilus by capillary electrophoresis. J. Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jul 1; 854 (1–2): 350–6. DOI: 10.1016/j. jchromb.2007.04.027Bendazzoli C, Turroni S, Gotti R, Olmo S, Brigidi P, Cavrini V. Determination of oxalyl-coenzyme A decarboxylase activity in Oxalobacter formigenes and Lactobacillus acidophilus by capillary electrophoresis. J. Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jul 1; 854 (1–2): 350–6. DOI: 10.1016/j. jchromb.2007.04.027Turroni S, Vitali B, Bendazzoli C, Candela M, Gotti R, Federici F, Pirovano F, Brigidi P. Oxalate consumption by lactobacilli: evaluation of oxalyl-CoA decarboxylase and formyl-CoA transferase activity in Lactobacillus acidophilus. J. Appl. Microbiol. 2007 Nov; 103 (5): 1600–9. DOI: 10.1111/j.1365– 2672.2007.03388.xTurroni S, Vitali B, Bendazzoli C, Candela M, Gotti R, Federici F, Pirovano F, Brigidi P. Oxalate consumption by lactobacilli: evaluation of oxalyl-CoA decarboxylase and formyl-CoA transferase activity in Lactobacillus acidophilus. J. Appl. Microbiol. 2007 Nov; 103 (5): 1600–9. DOI: 10.1111/j.1365– 2672.2007.03388.x

The authors declare that there are no conflicts of interest present.