medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2023-25-67-72medalphabet-3392Research ArticleСтатьиСиндром кишечной недостаточности: стадии, роль в формировании и прогрессировании синдрома полиорганной недостаточности, основные этапы интенсивной терапии (обзор литературы)Acute gastrointestinal injury: Stages, role in formation and progression of multiple organ failure syndrome, main stages of intensive therapy (literature review)https://orcid.org/0000-0002-9466-7556МачулинаИ. А.MachulinaI. A.

Мачулина Ирина Александровна, зам. гл. врача по анестезиологии и реанимации

Москва

Machulina Irina A., deputy chief physician in anesthesiology and resuscitation

Moscow

ir0@yandex.ruhttps://orcid.org/0000-0002-5278-7058ШестопаловА. Е.ShestopalovA. E.

Шестопалов Александр Ефимович, научный консультант

РИНЦ ID: 703014. Scopus ID: 8295880000

Москва

Shestopalov Alexander E., scientific consultant.

Moscow

ashest@yandex.ruhttps://orcid.org/0000-0003-2693-0823ПоповаТ. С.PopovaT. S.

Попова Тамара Сергеевна, проф., г.н.с.

Москва

Popova Tamara S., professor, senior researcher.

Moscow

ГБУЗ «Городская клиническая больница № 70 имени Е.О. Мухина Департамента здравоохранения города г. Москвы»РоссияCity Clinical Hospital No. 70 n.a. E.O. MukhinaRussian FederationФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава России; ФГБУ «Главный военный клинический госпиталь имени академика Н.Н. Бурденко» Минобороны РоссииРоссияRussian Medical Academy of Continuous Professional Education; Main Military Clinical Hospital n.a. academician N.N. Burdenko of the Ministry of Defense of RussiaRussian FederationГБУЗ г. Москвы «Научно-исследовательский институт скорой помощи имени Н.В. Склифосовского Департамента здравоохранения Москвы»РоссияResearch Institute for Emergency Medicine n.a. N.V. SklifosovskyRussian Federation202311112023025Кардиология. Неотложная медицина (3)6772Copyright © Мачулина И.А., Шестопалов А.Е., Попова Т.С., 20232023Мачулина И.А., Шестопалов А.Е., Попова Т.С.Machulina I.A., Shestopalov A.E., Popova T.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/3392

Синдром кишечной недостаточности развивается более чем у половины всех пациентов отделения реанимации, независимо от основной патологии, и является одной из главных причин формирования и прогрессирования полиорганной недостаточности и синдрома системного воспаления. Тяжесть синдрома кишечной недостаточности коррелирует с риском летального исхода. Более глубокое понимание патогенетических механизмов развития дисфункции желудочно-кишечного тракта у пациентов в критическом состоянии необходимо для разработки и внедрения схемы интенсивной терапии, позволяющей в короткие сроки восстановить функцию желудочно-кишечного тракта и разорвать порочный круг патофизиологических изменений, в конечном итоге приведет к улучшению результатов лечения пациентов в критическом состоянии и снижению уровня летальности.

Acute gastrointestinal injury develops in more than half of all patients in the intensive care unit, regardless of the underlying pathology and it is one of the main reasons for the onset and progression of multiple organ failure and systemic inflammatory response syndrome. The severity of the acute gastrointestinal injury correlates with the risk of death. A deeper understanding of the pathogenetic mechanisms of dysfunction of the gastrointestinal tract in critically ill patients is necessary for the development and implementation of an intensive care regimen that allows to quickly restore the function of the gastrointestinal tract and break the vicious circle of pathophysiological changes, which will ultimately lead to improvement treatment outcomes for critically ill patients and reduced mortality.

 

 

 

 

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The authors declare that there are no conflicts of interest present.