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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2023-24-79-83</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-3378</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Карцинома Меркеля – редкая злокачественная опухоль кожи (на примере двух клинических наблюдений)</article-title><trans-title-group xml:lang="en"><trans-title>Merkel cell carcinoma as rare malignant skin tumor (two clinical cases)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0737-0317</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Раводин</surname><given-names>Р. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ravodin</surname><given-names>R. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Раводин Роман Анатольевич, д. м. н., проф. кафедры кожных болезней и косметологии; зав. отделением</p><p>Москва</p></bio><bio xml:lang="en"><p>Ravodin Roman A., DM Sci (habil.), professor at Dept of Skin Diseases and Cosmetology; head of Dept</p><p>Moscow</p></bio><email xlink:type="simple">rracad@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5044-5265</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Круглова</surname><given-names>Л. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kruglova</surname><given-names>L. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Круглова Лариса Сергеевна, д. м. н., проф., зав. кафедрой дерматовенерологии и косметологии</p><p>Москва</p></bio><bio xml:lang="en"><p>Kruglova Larisa S., DM Sci (habil.), professor, head of Dept of Dermatovenereology and Cosmetology</p><p>Moscow</p></bio><email xlink:type="simple">kruglovals@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-1725-707X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никитина</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikitina</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Никитина Айыына Валерьевна, врач-онколог</p><p>Москва</p></bio><bio xml:lang="en"><p>Nikitina AyynaV., oncologist</p><p>Moscow</p><p> </p></bio><email xlink:type="simple">a.v.nikitinagkob1@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Российский Национальный Исследовательский Медицинский Университет имени&#13;
Н. И. Пирогова» Минздрава России; ГБУЗ «Городская клиническая онкологическая больница № 1 Департамента здравоохранения Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian National Research Medical University n. a. N. I. Pirogov; City Clinical Oncology Hospital No. 1</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБУ ДПО «Центральная государственная медицинская академия» Управления делами&#13;
Президента Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central State Medical Academy</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГБУЗ «Городская клиническая онкологическая больница № 1 Департамента здравоохранения Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Clinical Oncology Hospital No. 1</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>09</day><month>11</month><year>2023</year></pub-date><volume>0</volume><issue>24</issue><issue-title>Дерматология (2)</issue-title><fpage>79</fpage><lpage>83</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Раводин Р.А., Круглова Л.С., Никитина А.В., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Раводин Р.А., Круглова Л.С., Никитина А.В.</copyright-holder><copyright-holder xml:lang="en">Ravodin R.A., Kruglova L.S., Nikitina A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/3378">https://www.med-alphabet.com/jour/article/view/3378</self-uri><abstract><p>В данной статье представлен обзор литературы по распространенности карциномы Меркеля, особенностях ее клинической, дерматоскопической, патоморфологической диагностики и терапии. В свете представленных данных описаны два собственных клинических наблюдения карциномы Меркеля: даны клинико-дерматоскопическое описание, патоморфологическая и иммуногистохимическая картина, проведенное лечение и его отдаленные результаты. В представленных клинических наблюдениях карцинома Меркеля была выявлена у двух женщин 70 и 83 лет на I стадии, что определило благоприятный прогноз. Клинически опухоль была представлена в виде плотного неизъязвленного узла или узелка розово-красного цвета, все новообразования локализовались на голове. Дерматоскопическая картина была различна, в одном случае была представлена глобулами и точками красного цвета на фоне молочно-розовых и белых областей, отдельными линейными и извитыми сосудами, присутствовали белые структуры (по типу хризалидов), а в другом случае – бесструктурные области розового цвета с древовидными сосудами и белыми структурами в виде хризалидов. Гистологически преобладал мелкокруглоклеточный тип строения. При ИГХ-исследовании в обоих случаях выявлена выраженная экспрессия цитокератина 20 и хромогранина А, индекс Ki‑67 был выше 70 %.</p></abstract><trans-abstract xml:lang="en"><p>This article provides a review of the literature on the prevalence of Merkel carcinoma, the features of its clinical, dermoscopic, pathomorphological diagnosis and therapy. In the light of the presented data, two of our own clinical observations of Merkel carcinoma are described: a clinical and dermoscopic description, a pathomorphological and immunohistochemical picture, the treatment performed and its long-term results are given. In the presented clinical observations, Merkel carcinoma was detected in two women aged 70 and 83 years at stage I, which determined a favorable prognosis. Clinically, the tumor was presented in the form of a dense, non-ulcerated nodule or a pink-red nodule; all neoplasms were localized on the head. The dermoscopic picture was different, in one case it was represented by globules and dots of red color against a background of milky pink and white areas, individual linear and convoluted vessels, there were white structures (like chrysalids), and in another case – structureless areas of pink color with tree-like vessels and white structures in the form of chrysalids. Histologically, the small round cell type of structure predominated. An IHC study in both cases revealed a pronounced expression of cytokeratin 20 and chromogranin A, the Ki‑67 index was above 70 %.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>карцинома Меркеля</kwd><kwd>клиническая картина</kwd><kwd>дерматоскопическая диагностика</kwd><kwd>гистологическое исследование</kwd><kwd>иммуногистохимия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Merkel carcinoma</kwd><kwd>clinical picture</kwd><kwd>dermoscopic diagnosis</kwd><kwd>histological examination</kwd><kwd>immunohistochemistry</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Kohler S., Kerl H. Neural tumors. WHO Classification of tumours 2006 (6): 272.</mixed-citation><mixed-citation xml:lang="en">Kohler S., Kerl H. Neural tumors. 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