medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2023-28-29-32medalphabet-3371Research ArticleСтатьиПерспективы бариатрической хирургии в ведении пациентов с неалкогольной жировой болезнью печениProspects of bariatric surgery in management of patients with non-alcoholic fatty liver diseasehttps://orcid.org/0000-0002-7603-8481АхмедовВ. А.AkhmedovV. A.

Ахмедов Вадим Адильевич, д. м. н., проф., зав. кафедрой медицинской реабилитации дополнительного профессионального образования

Scopus: 6603891660; Web of Science: AAU-3847–2020

г. Омск

Akhmedov Vadim A., DM Sci (habil.), professor, head of Dept of Medical Rehabilitation of Additional Professional Education

Scopus: 6603891660; Web of Science: AAU-3847–2020

Omsk

v_akhmedov@mail.ruФГБОУ ВО «Омский государственный медицинский университет» Минздрава РоссииРоссияOmsk State Medical UniversityRussian Federation202309112023028Практическая гастроэнтерология (3)2932Copyright © Ахмедов В.А., 20232023Ахмедов В.А.Akhmedov V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/3371

Эпидемия ожирения в мире сопровождается значительным увеличением числа случаев неалкогольной жировой болезни печени (НАЖБП). Одним из направлений является бариатрическая хирургия. В представленной обзорной статье приводится анализ краткосрочной и долгосрочной эффективности применения методов бариатрической хирургии у пациентов с НАЖБП. Отмечены аспекты влияния бариатрической хирургии на биохимические и гистологические показатели фиброза печени, изменения инсулинорезистентности и липидного профиля, кишечный микробиом, участвующий в гомеостазе оси «кишечник – печень». Представлена роль полиморфизмов генов в прогрессировании НАЖБП, а также защите от фиброзных изменений у пациентов в послеоперационном периоде.

The obesity epidemic in the world is accompanied by a significant increase in the number of cases of non-alcoholic fatty liver disease (NAFLD). One of the directions is bariatric surgery. The review article presents an analysis of the short-term and long-term effectiveness of the use of bariatric surgery methods in patients with NAFLD. Aspects of the influence of bariatric surgery on biochemical and histological parameters of liver fibrosis, changes in insulin resistance and lipid profile, intestinal microbiome involved in the homeostasis of the intestine-liver axis are noted. The role of gene polymorphisms in the progression of NAFLD, as well as protection from fibrotic changes in patients with postoperative period is presented.

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The authors declare that there are no conflicts of interest present.