medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2023-28-13-18medalphabet-3368Research ArticleСтатьиПатофизиология анемического синдрома при целиакии и его терапевтическое лечениеPathophysiology of anemic syndrome in celiac disease and its therapeutic treatmenthttps://orcid.org/0000-0002-2726-9996ОрешкоЛ. С.OreshkoL. S.

Орешко Людмила Саварбековна, д. м. н., проф., доцент 2-й кафедры (терапии усовершенствования врачей)

Санкт-Петербург

Oreshko Lyudmila S., DM Sci (habil.), professor, associate professor at 2nd Dept (Therapy for Advanced Training of Physicians)

Saint Petersburg

oreshkol@yandex.ruhttps://orcid.org/0000-0001-9897-5989ЛеденцоваС. С.LedentsovaS. S.

Леденцова Светлана Сергеевна, врач-дерматолог консультативно-диагностического центра

Санкт-Петербург

Ledentsova Svetlana S., dermatologist of Consultative and Diagnostic Centre

Saint Petersburg

https://orcid.org/0000-0001-5623-4226СеливерстовП. В.SeliverstovP. V.

Селиверстов Павел Васильевич, к. м. н., доцент 2-й кафедры (терапии усовершенствования врачей)

Санкт-Петербург

Seliverstov Pavel V., PhD Med, associate professor at 2nd Dept (Therapy for Advanced Training of Physicians)

Saint Petersburg

https://orcid.org/0000-0003-4839-9578СаликоваС. П.SalikovaS. P.

Саликова Светлана Петровна, д. м. н., доцент 2-й кафедры (терапии усовершенствования врачей)

Санкт-Петербург

Salikova Svetlana P., DM Sci (habil.), associate professor at 2nd Dept (Therapy for Advanced Training of Physicians)

Saint Petersburg

https://orcid.org/0000-0002-2785-6699ИванюкЕ. С.IvanyukE. S.

Иванюк Елена Сергеевна, к. м. н., врач-гастроэнтеролог, доцент 2-й кафедры (терапии усовершенствования врачей)

Санкт-Петербург

Ivanyuk Elena S., PhD Med, gastroenterologist, associate professor at 2nd Dept (Therapy for Advanced Training of Physicians)

Saint Petersburg

ФГБВОУ ВО «Военно-медицинская академия имени С. М. Кирова» Минобороны РоссииРоссияMilitary Medical Academy n. a. S. M. KirovRussian FederationФГБОУ ВО «Санкт-Петербургский государственный педиатрический медицинский университет» Минздрава РоссииРоссияSaint Petersburg State Pediatric Medical UniversityRussian Federation202309112023028Практическая гастроэнтерология (3)1318Copyright © Орешко Л.С., Леденцова С.С., Селиверстов П.В., Саликова С.П., Иванюк Е.С., 20232023Орешко Л.С., Леденцова С.С., Селиверстов П.В., Саликова С.П., Иванюк Е.С.Oreshko L.S., Ledentsova S.S., Seliverstov P.V., Salikova S.P., Ivanyuk E.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/3368

В обзоре изложены современные представления о патофизиологии анемического синдрома, ассоциированного с целиакией. Приводится краткая информация об основных белках, участвующих в метаболизме железа, и их роли в поддержании гомеостаза. Внимание уделяется многофакторности патогенетических механизмов анемии при целиакии, состоянию слизистой оболочки двенадцатиперстной кишки и ультраструктурным изменениям ворсинок энтероцитов с признаками атрофии, играющих ключевую роль в регуляции всасывания железа. Также приводится информация о механизмах развития функционального дефицита железа и его роли в патогенезе анемии хронических заболеваний.

The review presents modern ideas about the pathophysiology of the anemia syndrome associated with celiac disease. Brief information is provided about the main proteins involved in iron metabolism and their role in maintaining homeostasis. Attention is paid to the multifactorial pathogenetic mechanisms of anemia in celiac disease, the state of the duodenal mucosa and ultrastructural changes in the villi of enterocytes with signs of atrophy, which play a key role in the regulation of iron absorption, and also provides information on the mechanisms of the development of functional iron deficiency and its role in the pathogenesis of anemia of chronic diseases.

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The authors declare that there are no conflicts of interest present.