medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2023-24-20-26medalphabet-3345Research ArticleСтатьиМикробиом кожи и возможности бактериотерапии (на примере старения кожи и атопического дерматита)Skin microbiome and possibilities of bacteriotherapy (on example of skin aging and atopic dermatitis)https://orcid.org/0000-0001-8584-615XСмирноваИ. О.SmirnovaI. O.

Смирнова Ирина Олеговна, д. м. н., проф., проф. кафедры инфекционных болезней, эпидемиологии и дерматовенерологии; врач-дерматовенеролог городского центра дерматологии и венерологии

Санкт-Петербург

Smirnova Irina O., DM Sci (habil.), professor, professor at Dept of Infectious Diseases, Epidemiology and Dermatovenereology; dermatovenerologist at theCity Centre of Dermatology and Venereology

Saint Petersburg

driosmirnova@yandex.ruhttps://orcid.org/0000-0002-2997-6109ХажомияК. Д.KhazhomiyaK. D.

Хажомия Кристина Девиевна, клинический ординатор кафедры инфекционных болезней, эпидемиологии и дерматовенерологии

Санкт-Петербург

Khazhomiya Kristina D., clinical resident of Dept of Infectious Diseases, Epidemiology and Dermatovenereology

Saint Petersburg

https://orcid.org/0000-0003-4699-1746ПташниковаП. Д.PtashnikovaP. D.

Пташникова Полина Дмитриевна, студент

Санкт-Петербург

Ptashnikova Polina D., student

Saint Petersburg

https://orcid.org/0000-0002-1045-9689СмирноваО. Н.SmirnovaO. N.

Смирнова Ольга Николаевна, к. м. н., доцент кафедры дерматовенерологии

Санкт-Петербург

Smirnova Olga N., PhD Med, associate professor at Dept of Dermatovenereology

Saint Petersburg

ФГБОУ ВО «Санкт-Петербургский государственный университет»; СПб ГБУЗ «Городской кожно-венерологический диспансер»РоссияSaint Petersburg State University; City Dermatovenerologic DispensaryRussian FederationФГБОУ ВО «Санкт-Петербургский государственный университет»РоссияSaint Petersburg State UniversityRussian FederationФГБОУ ВО «Северо-Западный государственный медицинский университет имени И. И. Мечникова» Минздрава РоссииРоссияNorth-Western State Medical University n. a. I. I. MechnikovRussian Federation202308112023024Дерматология (2)2026Copyright © Смирнова И.О., Хажомия К.Д., Пташникова П.Д., Смирнова О.Н., 20232023Смирнова И.О., Хажомия К.Д., Пташникова П.Д., Смирнова О.Н.Smirnova I.O., Khazhomiya K.D., Ptashnikova P.D., Smirnova O.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/3345

В настоящее время микробное сообщество кожи рассматривают как динамическую функциональную систему, которая синергетически развивается с организмом в целом и кожей в частности, участвует в регуляции и реализации ее функций, вносит вклад в старение кожи и патогенез хронических воспалительных дерматозов. Понимание вклада дисбиоза кожи в старение кожи и патогенез хронических дерматозов послужило основанием для разработки стратегий, направленных на коррекцию микробиоты кожи, или бактериотерапии.Последняя включает использование аллогенных или аутологичных живых бактерий, а также инактивированных микроорганизмов,компонентов их клеточной стенки, сигнальных молекул и метаболитов. Последние включают в состав средств для наружного применения,в том числе дерматокосметику. Среди бактерий, которые рассматриваются в качестве потенциальных источников активных компонентов для косметических средств, особого внимания заслуживают молочнокислые бактерии. Они не только являются представителя минормальной микробиоты кожи и желудочно-кишечного тракта и продуцируют антимикробные соединения, такие как органические кислоты и бактериоцины, но и широко используются как пробиотики. В статье рассмотрены вопросы значения микробиоты кожи дляосуществления ее функций в норме, в том числе в возрастном аспекте, а также перспективы применения методов бактериотерапиисредствами для наружного применения, содержащими инактивированную Lactobacillus, Lactococcus, Bifidobacterium и пребиотикиинулин и трегалозу, на примере атопического дерматита и возрастных изменений кожи.

Currently, the microbial community of the skin is considered as a dynamic functional system that develops synergistically with the body in general and the skin in particular, participates in the regulation and implementation of its functions, contributes to skin aging and the pathogenesis of chronic inflammatory dermatoses. Understanding the contribution of skin dysbiosis to skin aging and the pathogenesis of chronic dermatoses has provided the basis for the development of strategies aimed at correcting the skin microbiota, or bacteriotherapy. The latter includes the use of allogeneic or autologous living bacteria, as well as inactivated microorganisms, components of their cell wall, signaling molecules and metabolites. The latter are included in products for external use, including dermatocosmetics. Among the bacteria that are considered as potential sources of active ingredients for cosmetics, lactic acid bacteria deserve special attention. Not only are they members of the normal microbiota of the skin and gastrointestinal tract and produce antimicrobial compounds such as organic acids and bacteriocins, but they are also widely used as probiotics. The article discusses the importance of the skin microbiota for the implementation of its functions normally, including in the age aspect, as well as the prospects for using methods of bacteriotherapy with products for external use containing inactivated Lactobacillus, Lactococcus, Bifidobacterium and the prebiotics inulin and trehalose, using the example of atopic dermatitis and age-related skin changes.

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The authors declare that there are no conflicts of interest present.