medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2023-20-38-43medalphabet-3317Research ArticleСтатьиИспользование препаратов статинового ряда в медицинской практике. Обзор литературыThe use of statin drugs in medical practice. Literature reviewhttps://orcid.org/0000-0003-4415-766XСалехК. М.SalekhK. M.

Салех Карина Мустафаевна -  аспирант кафедры челюстно-лицевой хирургии и хирургической стоматологии

Москва

 

 

Salekh Karina. M. -  PhD student of the department of oral and maxillofacial surgery

 Moscow

ms.s.karina@mail.ruhttps://orcid.org/0000-0003-3982-5512МураевА. А.MuraevA. A.

Мураев Александр Александрович -  д.м.н., профессор кафедры челюстно-лицевой хирургии и хирургической стоматологии Author ID: 611838 

Москва

Muraev Alexandr. A. -  DDS, professor of the department of oral and maxillofacial surgery Author ID: 611838

Moscow

muraev_aa@pfur.ruhttps://orcid.org/0000-0001-5458-0192ИвановС. Ю.IvanovS. Y.

Иванов Сергей Юрьевич - д.м.н., профессор, член-корреспондент РАН, заведующий кафедрой челюстно-лицевой хирургии и хирургической стоматологии; заведующий кафедрой челюстно-лицевой хирургии Author ID: 615227

Москва

Ivanov Sergey Y - DDS, professor, corresponding Member of the Russian Academy of Sciences, the department of oral and maxillofacial surgery; the department of maxillofacial surgeryAuthor ID: 615227

Moscow

syivanov@yandex.ruhttps://orcid.org/0000-0002-6352-6750ДолгалевА. А.DolgalevA. A.

Долгалев Александр Александрович -  д.м.н., профессор кафедры стоматологии общей практики Author ID: 831419

Ставрополь

Dolgalev Alexandr. A. - MD, associate professor of the department of dentistry of general practice and pediatric dentistry

AuthorID: 831419

Stavropol

dolgalev@dolgalev.prohttps://orcid.org/0000-0001-5894-9524БонарцевА. П.BonartsevA. P.

Бонарцев Антон Павлович -д.б.н., доцент кафедры биоинженерии биологического факультета Author ID: 96555 

Москва

Bonartsev Anton. P. -  PhD, D.Sc., Assoc. Prof. Bioengineering department, Faculty of biology

Author ID: 96555

Moscow

ant_bonar@mail.ruФГАОУ ВО «Российский университет дружбы народов»Россия«Peoples’ Friendship University of Russia» (RUDN University)Russian FederationФГАОУ ВО «Российский университет дружбы народов»; ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский Университет)»Россия«Peoples’ Friendship University of Russia» (RUDN University); «I.M. Sechenov First Moscow State Medical University» (Sechenov University)Russian FederationФГБОУ ВО «Ставропольский государственный медицинский университет», Министерства здравоохранения РФРоссия«Stavropol State Medical University»Russian FederationФГБОУ ВО «Московский государственный университет имени М.В. Ломоносова»Россия«Lomonosov Moscow State University»Russian Federation202306112023020«Стоматология» (3)3843Copyright © Салех К.М., Мураев А.А., Иванов С.Ю., Долгалев А.А., Бонарцев А.П., 20232023Салех К.М., Мураев А.А., Иванов С.Ю., Долгалев А.А., Бонарцев А.П.Salekh K.M., Muraev A.A., Ivanov S.Y., Dolgalev A.A., Bonartsev A.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/3317Актуальность

Актуальность. Симвастатин – препарат из группы статинов, используемый для клинического контроля гиперхолестеринемии. За последние десятилетия неуклонно растет количество исследований о возможностях симвастатина, во многом превосходящих эффект снижения уровня холестерина в крови. Активно исследуется использование симвастатина в области регенерации костной ткани, а также его способность, связанная со снижением воспалительного ответа.

Цель обзора

Цель обзора: рассмотреть современные представления о симвастатине и изучить его плейотропные эффекты.

Материалы и методы

Материалы и методы. Произведен анализ научных публикаций в электронных базах данных eLIBRARY, PubMed и Google Scholar (статьи, метаанализы, систематические обзоры) за временной интервал с 2015 по 2022 г.г. Включены материалы, содержащие информацию о гипохолестеринемической активности симвастатина и его механизма действия, использование симвастатина в пародонтологической практике, а также остеоиндуктивное действие симвастатина и его использование в костной инженерии.

Результаты

Результаты. В ходе обзора было рассмотрено 83 статьи, из которых после анализа литературы было отобрано 53 статьи.

Заключение

Заключение. Исходя из проанализированных данных, можно сделать вывод о многогранности эффектов симвастатина. Доказана его противовоспалительная активность путем ингибирования интерлейкинов и медиаторов воспаления, участие в регенерации костной ткани посредством экспрессии генов и стимуляции дифференцировки остеобластных клеток

Relevance

Relevance. Simvastatin is a statin drug used for the clinical control of hypercholesterolemia. Over the past decades, there has been a steady increase in the number of studies on the possibilities of simvastatin, in many respects superior to the effect of lowering blood cholesterol levels. The use of simvastatin in the field of bone tissue regeneration, as well as its ability to reduce the inflammatory response, is being actively investigated.

The purpose of the review: to consider modern ideas about simvastatin and to study its pleiotropic effects.

Materials and methods

Materials and methods. The analysis of scientific publications in the electronic databases eLIBRARY, PubMed and Google Scholar (articles, meta-analyses, systematic reviews) for the time interval from 2015 to 2022 was carried out. Materials containing information on the hypocholes-terolemic activity of simvastatin and its mechanism of action, the use of simvastatin in periodontal practice, as well as the osteoinductive effect of simvastatin and its use in bone engineering are included.

Results

Results. The review reviewed 83 articles, from which 53 articles were selected after reviewing the literature.

Conclusion

Conclusion. Based on the analyzed data, it can be concluded that the effects of simvastatin are multifaceted. Its anti-inflammatory activity has been proven by inhibiting interleukins and inflammatory mediators, participation in bone tissue regeneration by gene expression and stimulation of osteoblast cell differentiation.

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The authors declare that there are no conflicts of interest present.