medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2023-20-19-29medalphabet-3313Research ArticleСтатьиПотенциальное использование мелатонина при заболеваниях пародонтаPotential Use of Melatonin in Periodontal Diseasehttps://orcid.org/0000-0002-4689-3591ОрловаС. В.OrlovaS. V.

Орлова Светлана Владимировна -  д.м.н., проф., зав. кафедрой диетологии и клинической нутрициологии, главный научный сотрудник

Orlova Svetlana Vladimirovna - Doctor of Medical Sciences, Professor, Head of the Department of Dietology and Clinical Nutrition

orlova-sv@rudn.ruhttps://orcid.org/0000-0002-6348-6867ЗыряновС. К.ZyryanovS. K.

Зырянов Сергей Кенсаринович - д.м.н., заведующий кафедрой общей и клинической фармакологи Медицинского института

Zyryanov Sergey Kensarinovich -  MD Head of the Department of General and Clinical Pharmacology of the Medical Institute

zyryanov-sk@rudn.ruhttps://orcid.org/0000-0003-3220-0333НикитинаЕ. А.NikitinaE. A.

Никитина Елена Александровна - к.м.н., доцент кафедры диетологии и клинической нутрициологии, научный сотрудник

Nikitina Elena Alexandrovna - Ph.D., assistant professor, Department of Dietology and Clinical Nutrition

nikitina-ea1@rudn.ruhttps://orcid.org/0000-0002-6500-9220ТигайЮ. О.TigayYu. O.

Тигай Юлия Олеговна-  ассистент кафедры патологической анатомии Медицинского института

Tigay Yuliya Olegovna - Assistant of the Department of Pathological Anatomy of the Medical Institute

chen_juliya@gmail.comОрловаА. А.OrlovaA. A.

Орлова Анастасия Алексеевна -  студентка Медицинского института

Orlova Anastasia Alekseevna - student of the Medical Institute

1032202909@rudn.ruhttps://orcid.org/0009-0000-2077-2233ГрабовскийГ. А.GrabovskyG. A.

Грабовский Григорий Андреевич -  студент лечебного факультета 

Grabovsky Grigory Andreevich -  student of the medical faculty

Gregorygrab@icloud.comФГАОУ ВО «Российский университет дружбы народов» имени Патриса Лумумбы; ГБУЗ Научно-практический центр детской психоневрологии департамента здравоохранения г. МосквыРоссияFederal State Autonomous Educational Institution of Higher Education «Peoples’ Friendship University of Russia» named after Patrice Lumumba; Scientific and Practical Center for Child Psychoneurology, Moscow Department of HealthRussian FederationФГАОУ ВО «Российский университет дружбы народов» имени Патриса ЛумумбыРоссияFederal State Autonomous Educational Institution of Higher Education «Peoples’ Friendship University of Russia» named after Patrice LumumbaRussian FederationФГАОУ ВО «Российский Национальный Исследовательский Медицинский Университет им. Н.И. Пирогова» Министерства здравоохранения Российской ФедерацииРоссияFederal State Autonomous Educational Institution of Higher Education «N.I. Pirogov Russian National Research Medical University» of the Ministry of HealthRussian Federation202306112023020«Стоматология» (3)1929Copyright © Орлова С.В., Зырянов С.К., Никитина Е.А., Тигай Ю.О., Орлова А.А., Грабовский Г.А., 20232023Орлова С.В., Зырянов С.К., Никитина Е.А., Тигай Ю.О., Орлова А.А., Грабовский Г.А.Orlova S.V., Zyryanov S.K., Nikitina E.A., Tigay Y.O., Orlova A.A., Grabovsky G.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/3313

Мелатонин представляет собой индоламин, который секретируется не только в эпифизе, но и других органах, в частности слюнных  железах. Многочисленные исследования показывают, что уровень мелатонина в слюне и сыворотке пациентов, страдающих заболеваниями пародонта, снижен, что позволяет предположить, что он может играть важную роль в защите тканей от повреждений, вызванных  оксидативным стрессом. Мелатонин помогает регулировать иммунный ответ и предотвращает повреждение тканей пародонта. Включение мелатонина в схему лечения заболеваний пародонта повышает ее эффективность. Необходимы дальнейшие исследования для  определения оптимальных форм и режимов дозирования мелатонина.

Melatonin is an indoleamine that is secreted not only in the pineal gland, but also in other organs, in particular the salivary glands. Numerous  studies show that melatonin levels in the saliva and serum of patients suffering from periodontal disease are reduced, suggesting that it may play  an important role in protecting tissues from damage caused by oxidative stress. Melatonin helps regulate the immune response and prevents  periodontal tissue damage. The inclusion of melatonin in the periodontal disease treatment regimen increases its effectiveness. Further research  is needed to determine the optimal forms and dosing regimens for melatonin.

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The authors declare that there are no conflicts of interest present.