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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2023-19-16-22</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-3296</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>«Алгологические узы эндометриоза». Особенности клинического менеджмента пациенток с типичными и нетипичными симптомами эндометриоза</article-title><trans-title-group xml:lang="en"><trans-title>‘Algological bonds of endometriosis’. Features of clinical management of patients with typical and atypical symptoms of endometriosis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5342-8129</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Оразов</surname><given-names>М. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Orazov</surname><given-names>M. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Оразов Мекан Рахимбердыевич, д. м. н., проф. кафедры акушерства и гинекологии с курсом перинатологии</p><p>Москва</p></bio><bio xml:lang="en"><p>Orazov Mekan R., DM Sci (habil.), professor of the Dept of Obstetrics and Gynecology with a Course in Perinatology</p><p>Moscow</p></bio><email xlink:type="simple">omekan@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7428-0469</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Радзинский</surname><given-names>В. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Radzinsky</surname><given-names>V. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Радзинский Виктор Евсеевич, заслуженный деятель науки РФ, член-корреспондент РАН, д. м. н., проф., зав. кафедрой акушерства и гинекологии с курсом перинатологии</p><p>Москва</p></bio><bio xml:lang="en"><p>Radzinsky Victor E., Honored Scientist of the Russian Federation, Corresponding Member of the Russian Academy of Sciences, DM Sci (habil.), professor, head of the Dept of Obstetrics and Gynecology with a Course in Perinatology</p><p>Moscow</p></bio><email xlink:type="simple">radzinsky@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6709-5209</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Долгов</surname><given-names>Е. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Dolgov</surname><given-names>E. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Долгов Евгений Денисович, клинический ординатор кафедры акушерства и гинекологии с курсом перинатологии</p><p>Москва</p></bio><bio xml:lang="en"><p>Dolgov Evgeny D., clinical resident of the Dept of Obstetrics and Gynecology with a Course in Perinatology</p><p>Moscow</p></bio><email xlink:type="simple">1586dolgde@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Российский университет дружбы народов»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Peoples’ Friendship University of Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>05</day><month>11</month><year>2023</year></pub-date><volume>0</volume><issue>19</issue><issue-title>Современная гинекология (2)</issue-title><fpage>16</fpage><lpage>22</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Оразов М.Р., Радзинский В.Е., Долгов Е.Д., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Оразов М.Р., Радзинский В.Е., Долгов Е.Д.</copyright-holder><copyright-holder xml:lang="en">Orazov M.R., Radzinsky V.E., Dolgov E.D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/3296">https://www.med-alphabet.com/jour/article/view/3296</self-uri><abstract><p>Эндометриоз по-прежнему остается одним из самых загадочных и контраверсионных заболеваний современной гинекологии. Современные статистические данные демонстрируют чрезвычайную актуальность активного внедрения эффективных терапевтических подходов в повседневную практику клинициста. Однако проблемой является ассоциированный с эндометриозом болевой синдром. Все чаще поднимается вопрос о т. н. атипичных алгологических проявлениях эндометриоза, которые, как казалось ранее, никак не соотносились с патогенезом основного заболевания. В этой связи целью данной статьи являлось предложение трехуровневой патогенетической концепции, способной связать основное проявление эндометриоза (тазовая боль) с другими нередко отдаленными алгологическими паттернами, а также составление алгоритма ведения данных пациенток, исходя из их патогенетического стадирования.</p></abstract><trans-abstract xml:lang="en"><p>Endometriosis remains one of the most mysterious and controversial diseases in modern gynecology. Contemporary statistical data demonstrate the extreme relevance of actively implementing effective therapeutic approaches into the clinician’s everyday practice. However, a significant challenge associated with endometriosis is the pain syndrome. The question of so-called atypical algological manifestations of endometriosis, which previously seemed unrelated to the pathogenesis of the primary disease, is increasingly raised. In this regard, the aim of this article was to propose a three-level pathogenetic concept capable of linking the primary manifestation of endometriosis (pelvic pain) with other often distant algological patterns, as well as to create an algorithm for managing these patients based on their pathogenetic staging.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>эндометриоз</kwd><kwd>тазовая боль</kwd><kwd>эндометриоз-ассоциированная боль</kwd><kwd>диеногест</kwd></kwd-group><kwd-group xml:lang="en"><kwd>endometriosis</kwd><kwd>pelvic pain</kwd><kwd>endometriosis-associated pain</kwd><kwd>dienogest</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Yilmaz B. D., Bulun S. E. Endometriosis and nuclear receptors // Human reproduction update. 2019; 25 (4): 473–485.</mixed-citation><mixed-citation xml:lang="en">Yilmaz B. D., Bulun S. E. Endometriosis and nuclear receptors // Human reproduction update. 2019; 25 (4): 473–485.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Arnold MJ, Osgood AT, Aust A. Chronic Pelvic Pain in Women: ACOG Updates Recommendations. Am Fam Physician. 2021 Feb 1; 103 (3): 186–188. PMID: 33507045.</mixed-citation><mixed-citation xml:lang="en">Arnold MJ, Osgood AT, Aust A. Chronic Pelvic Pain in Women: ACOG Updates Recommendations. Am Fam Physician. 2021 Feb 1; 103 (3): 186–188. PMID: 33507045.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Bulun SE, Yilmaz BD, Sison C, Miyazaki K, Bernardi L, Liu S, Kohlmeier A, Yin P, Milad M, Wei J. Endometriosis. Endocr Rev. 2019 Aug 1; 40 (4): 1048–1079. DOI: 10.1210/er.2018–00242. PMID: 30994890; PMCID: PMC 6693056.</mixed-citation><mixed-citation xml:lang="en">Bulun SE, Yilmaz BD, Sison C, Miyazaki K, Bernardi L, Liu S, Kohlmeier A, Yin P, Milad M, Wei J. Endometriosis. Endocr Rev. 2019 Aug 1; 40 (4): 1048–1079. DOI: 10.1210/er.2018–00242. PMID: 30994890; PMCID: PMC 6693056.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Simopoulou M., Rapani A., Grigoriadis S., Pantou A., Tsioulou P., Maziotis E., Tzanakaki D., Triantafyllidou O., Kalampokas T., Siristatidis C., Bakas P., Vlahos N. Getting to Know Endometriosis-Related Infertility Better: A Review on How Endometriosis Affects Oocyte Quality and Embryo Development. Biomedicines. 2021; 9: 273. https://doi.org/10.3390/biomedicines9030273</mixed-citation><mixed-citation xml:lang="en">Simopoulou M., Rapani A., Grigoriadis S., Pantou A., Tsioulou P., Maziotis E., Tzanakaki D., Triantafyllidou O., Kalampokas T., Siristatidis C., Bakas P., Vlahos N. Getting to Know Endometriosis-Related Infertility Better: A Review on How Endometriosis Affects Oocyte Quality and Embryo Development. Biomedicines. 2021; 9: 273. https://doi.org/10.3390/biomedicines9030273</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Arnold MJ, Osgood AT, Aust A. Chronic Pelvic Pain in Women: ACOG Updates Recommendations. Am Fam Physician. 2021 Feb 1; 103 (3): 186–188. PMID: 33507045.</mixed-citation><mixed-citation xml:lang="en">Arnold MJ, Osgood AT, Aust A. Chronic Pelvic Pain in Women: ACOG Updates Recommendations. Am Fam Physician. 2021 Feb 1; 103 (3): 186–188. PMID: 33507045.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Chronic pelvic pain: ACOG Practice Bulletin, Number 218. Obstet Gynecol. 2020; 135: e98–e109. DOI: 10.1097/AOG.0000000000003716</mixed-citation><mixed-citation xml:lang="en">Chronic pelvic pain: ACOG Practice Bulletin, Number 218. Obstet Gynecol. 2020; 135: e98–e109. DOI: 10.1097/AOG.0000000000003716</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Радзинский В. Е., Оразов М. Р., Костин И. Н. Хроническая тазовая боль в гинекологической практике. Доктор.Ру. 2019; 7 (162): 30–35.</mixed-citation><mixed-citation xml:lang="en">Radzinsky V. E., Orazov M. R., Kostin I. N. Chronic Pelvic Pain in Gynecological Practice. Doctor.Ru. 2019; 7 (162): 30–35.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Bourdel N., Matsusakï S., Roman H., Lenglet Y., Botchorischvili R., Mage G., Canis M. Endometriosis in teenagers. Gynecol. Obstet. Fertil. 2006; 34: 727–734.</mixed-citation><mixed-citation xml:lang="en">Bourdel N., Matsusakï S., Roman H., Lenglet Y., Botchorischvili R., Mage G., Canis M. Endometriosis in teenagers. Gynecol. Obstet. Fertil. 2006; 34: 727–734.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Briceag I, Costache A, Purcarea VL, Cergan R, Dumitru M, Briceag I, Sajin M, Ispas AT. Fallopian tubes – literature review of anatomy and etiology in female infertility. J. Med Life. 2015; 8 (2): 129–31.</mixed-citation><mixed-citation xml:lang="en">Briceag I, Costache A, Purcarea VL, Cergan R, Dumitru M, Briceag I, Sajin M, Ispas AT. Fallopian tubes – literature review of anatomy and etiology in female infertility. J. Med Life. 2015; 8 (2): 129–31.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Ballweg M. L. Impact of endometriosis on women’s health: Comparative historical data show that the earlier the onset, the more severe the disease. Best Pract. Res. Clin. Obstet. Gynaecol. 2004; 18: 201–218.</mixed-citation><mixed-citation xml:lang="en">Ballweg M. L. Impact of endometriosis on women’s health: Comparative historical data show that the earlier the onset, the more severe the disease. Best Pract. Res. Clin. Obstet. Gynaecol. 2004; 18: 201–218.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Greene R., Stratton P., Cleary S. D., Ballweg M. L., Sinaii N. Diagnostic experience among 4334 women reporting surgically diagnosed endometriosis. Fertil. Steril. 2009; 91: 32–39.</mixed-citation><mixed-citation xml:lang="en">Greene R., Stratton P., Cleary S. D., Ballweg M. L., Sinaii N. Diagnostic experience among 4334 women reporting surgically diagnosed endometriosis. Fertil. Steril. 2009; 91: 32–39.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Оразов М. Р., Радзинский В. Е., Долгов Е. Д. Современные возможности терапевтического менеджмента пациенток с эндометриозом в различные возрастные периоды. Women’s Clinic. 2023; 2: 10–18.</mixed-citation><mixed-citation xml:lang="en">Orazov M. R., Radzinsky V. E., Dolgov E. D. Modern Therapeutic Management Options for Patients with Endometriosis in Different Age Groups. Women’s Clinic. 2023; 2: 10–18.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Zeitoun K., Takayama K., Sasano H., Suzuki T., Moghrabi N., Andersson S., Johns A., Meng L., Putman M., Carr B. Deficient 17β-hydroxysteroid dehydrogenase type 2 expression in endometriosis: Failure to metabolize 17β-estradiol. J. Clin. Endocrinol. Metab. 1998; 83: 4474–4480.</mixed-citation><mixed-citation xml:lang="en">Zeitoun K., Takayama K., Sasano H., Suzuki T., Moghrabi N., Andersson S., Johns A., Meng L., Putman M., Carr B. Deficient 17β-hydroxysteroid dehydrogenase type 2 expression in endometriosis: Failure to metabolize 17β-estradiol. J. Clin. Endocrinol. Metab. 1998; 83: 4474–4480.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Noble L. S., Takayama K., Zeitoun K. M., Putman J. M., Johns D. A., Hinshelwood M. M., Agarwal V. R., Zhao Y., Carr B. R., Bulun S. E. Prostaglandin E 2 stimulates aromatase expression in endometriosis-derived stromal cells. J. Clin. Endocrinol. Metab. 1997; 82: 600–606.</mixed-citation><mixed-citation xml:lang="en">Noble L. S., Takayama K., Zeitoun K. M., Putman J. M., Johns D. A., Hinshelwood M. M., Agarwal V. R., Zhao Y., Carr B. R., Bulun S. E. Prostaglandin E 2 stimulates aromatase expression in endometriosis-derived stromal cells. J. Clin. Endocrinol. Metab. 1997; 82: 600–606.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Bulun S. E., Yang S., Fang Z., Gurates B., Tamura M., Zhou J., Sebastian S. Role of aromatase in endometrial disease. J. Steroid Biochem. Mol. Biol. 2001; 79: 19–25.</mixed-citation><mixed-citation xml:lang="en">Bulun S. E., Yang S., Fang Z., Gurates B., Tamura M., Zhou J., Sebastian S. Role of aromatase in endometrial disease. J. Steroid Biochem. Mol. Biol. 2001; 79: 19–25.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Laganà A. S. et al. The pathogenesis of endometriosis: molecular and cell biology insights // International journal of molecular sciences. 2019; 20 (22): 5615.</mixed-citation><mixed-citation xml:lang="en">Laganà A. S. et al. The pathogenesis of endometriosis: molecular and cell biology insights // International journal of molecular sciences. 2019; 20 (22): 5615.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Оразов М. Р., Токтар Л. Р. Боль по кругу. StatusPraesens. Гинекология, акушерство, бесплодный брак. 2020; 4: 42–47.</mixed-citation><mixed-citation xml:lang="en">Orazov M. R., Toktar L. R. Pain in a Circle. Status Praesens. Gynecology, Obstetrics, Infertility. 2020; 4: 42–47.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Smolarz B., Szyłło K., Romanowicz H. Endometriosis: epidemiology, classification, pathogenesis, treatment and genetics (review of literature) //International journal of molecular sciences. 2021; 22 (19): 10554.</mixed-citation><mixed-citation xml:lang="en">Smolarz B., Szyłło K., Romanowicz H. Endometriosis: epidemiology, classification, pathogenesis, treatment and genetics (review of literature) //International journal of molecular sciences. 2021; 22 (19): 10554.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Яковлева Э. Б., Бабенко О. М., Бугаев А. Б. Современный взгляд на проблему лечения хронической тазовой боли. Медицина неотложных состояний. 2014; 2 (57): 134–139.</mixed-citation><mixed-citation xml:lang="en">Yakovleva E. B., Babenko O. M., Bugaev A. B. Modern Perspective on the Treatment of Chronic Pelvic Pain. Emergency Medicine. 2014; 2 (57): 134–139.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Русина Е. И., Ярмолинская М. И., Пьянкова В. О. Глубокий инфильтративный эндометриоз. Спорные вопросы: за и против. Гинекология. 2020; 5.</mixed-citation><mixed-citation xml:lang="en">Rusina E. I., Yarmolinskaya M. I., Pyankova V. O. Deep Infiltrating Endometriosis. Controversial Issues: Pros and Cons. Gynecology. 2020; 5.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Quintana R. L. Endometriosis infiltrativa profunda en la vejiga, resección quirúrgica por laparoscopia. Reporte de un caso y revisión de la bibliografía. REVISTA MEXICANA DE MEDICINA DE LA REPRODUCCIÓN. 2022; 13. – № . d.</mixed-citation><mixed-citation xml:lang="en">Quintana R. L. Endometriosis infiltrativa profunda en la vejiga, resección quirúrgica por laparoscopia. Reporte de un caso y revisión de la bibliografía. REVISTA MEXICANA DE MEDICINA DE LA REPRODUCCIÓN. 2022; 13. – № . d.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Kor E. et al. Relationship between the severity of endometriosis symptoms (dyspareunia, dysmenorrhea and chronic pelvic pain) and the spread of the disease on ultrasound //BMC Research Notes. 2020; 13: 1–8.</mixed-citation><mixed-citation xml:lang="en">Kor E. et al. Relationship between the severity of endometriosis symptoms (dyspareunia, dysmenorrhea and chronic pelvic pain) and the spread of the disease on ultrasound //BMC Research Notes. 2020; 13: 1–8.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Gutman G., Nunez A. T., Fisher M. Dysmenorrhea in adolescents //Current Problems in Pediatric and Adolescent Health Care. 2022; 101186.</mixed-citation><mixed-citation xml:lang="en">Gutman G., Nunez A. T., Fisher M. Dysmenorrhea in adolescents //Current Problems in Pediatric and Adolescent Health Care. 2022; 101186.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Gete D. G., Doust J., Mortlock S., Montgomery G., Mishra G. D. 2023. Associations between endometriosis and common symptoms: findings from the Australian Longitudinal Study on Women’s Health. American Journal of Obstetrics and Gynecology.</mixed-citation><mixed-citation xml:lang="en">Gete D. G., Doust J., Mortlock S., Montgomery G., Mishra G. D. 2023. Associations between endometriosis and common symptoms: findings from the Australian Longitudinal Study on Women’s Health. American Journal of Obstetrics and Gynecology.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Mechsner S. 2022. Endometriosis, an Ongoing Pain–Step-by-Step Treatment. Journal of Clinical Medicine. 2022; 11 (2): 467.</mixed-citation><mixed-citation xml:lang="en">Mechsner S. 2022. Endometriosis, an Ongoing Pain–Step-by-Step Treatment. Journal of Clinical Medicine. 2022; 11 (2): 467.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Lai ZZ, Yang HL, Ha SY, Chang KK, Mei J, Zhou WJ, Qiu XM, Wang XQ, Zhu R, Li DJ, Li MQ. Cyclooxygenase‑2 in Endometriosis. Int J. Biol. Sci. 2019 Oct 23; 15 (13): 2783–2797. DOI: 10.7150/ijbs.35128. PMID: 31853218; PMCID: PMC 6909960</mixed-citation><mixed-citation xml:lang="en">Lai ZZ, Yang HL, Ha SY, Chang KK, Mei J, Zhou WJ, Qiu XM, Wang XQ, Zhu R, Li DJ, Li MQ. Cyclooxygenase‑2 in Endometriosis. Int J. Biol. Sci. 2019 Oct 23; 15 (13): 2783–2797. DOI: 10.7150/ijbs.35128. PMID: 31853218; PMCID: PMC 6909960</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Kim H. J. et al. Dienogest May Reduce Estradiol-and Inflammatory Cytokine-Induced Cell Viability and Proliferation and Inhibit the Pathogenesis of Endometriosis: A Cell Culture-and Mouse Model-Based Study. Biomedicines. 2022; 10 (11): 2992.</mixed-citation><mixed-citation xml:lang="en">Kim H. J. et al. Dienogest May Reduce Estradiol-and Inflammatory Cytokine-Induced Cell Viability and Proliferation and Inhibit the Pathogenesis of Endometriosis: A Cell Culture-and Mouse Model-Based Study. Biomedicines. 2022; 10 (11): 2992.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Оразов М. Р., Радзинский В. Е., Долгов Е. Д., Абрамашвили Ю. Г. Патогенез и патогенетические опции в менеджменте эндометриоза. Вопросы гинекологии, акушерства и перинатологии. 2023; 22(1): 92–104. DOI: 10.20953/1726–1678–2023–1–92–104</mixed-citation><mixed-citation xml:lang="en">Orazov M. R., Radzinsky V. E., Dolgov E. D., Abramashvili Yu. G. Pathogenesis and Pathogenetic Options in the Management of Endometriosis. Issues in Gynecology, Obstetrics, and Perinatology. 2023; 22 (1): 92–104. DOI: 10.20953/1726–1678–2023–1–92–104</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Оразов М. Р., Радзинский В. Е., Орехов Р. Е., Таирова М. Б. Эффективность профилактики рецидивов после хирургического лечения эндометриоза яичников. Вопросы гинекологии, акушерства и перинатологии. 2022; 21 (3): 53.</mixed-citation><mixed-citation xml:lang="en">Orazov M. R., Radzinsky V. E., Orekhov R. E., Tairova M. B. The Effectiveness of Preventing Recurrences after Surgical Treatment of Ovarian Endometriosis. Issues in Gynecology, Obstetrics, and Perinatology. 2022; 21 (3): 53.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Uludag S. Z., Demirtas E., Sahin Y., Aygen E. M. Dienogest reduces endometrioma volume and endometriosis-related pain symptoms. Journal of Obstetrics and Gynaecology. 2021; 41 (8): 1246–1251.</mixed-citation><mixed-citation xml:lang="en">Uludag S. Z., Demirtas E., Sahin Y., Aygen E. M. Dienogest reduces endometrioma volume and endometriosis-related pain symptoms. Journal of Obstetrics and Gynaecology. 2021; 41 (8): 1246–1251.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Vignali M., Belloni G. M., Pietropaolo G., Barbasetti Di Prun A., Barbera V., Angioni S., Pino I. Effect of Dienogest therapy on the size of the endometrioma. Gynecological Endocrinology. 2020; 36 (8): 723–727.</mixed-citation><mixed-citation xml:lang="en">Vignali M., Belloni G. M., Pietropaolo G., Barbasetti Di Prun A., Barbera V., Angioni S., Pino I. Effect of Dienogest therapy on the size of the endometrioma. Gynecological Endocrinology. 2020; 36 (8): 723–727.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Bono Y., Kyo S., Kiyono T., Mizumoto Y., Nakamura M., Maida Y., Takakura M., Fujiwara H. Concurrent estrogen action was essential for maximal progestin effect in oral contraceptives. Fertility and Sterility. 2014; 101: 5.</mixed-citation><mixed-citation xml:lang="en">Bono Y., Kyo S., Kiyono T., Mizumoto Y., Nakamura M., Maida Y., Takakura M., Fujiwara H. Concurrent estrogen action was essential for maximal progestin effect in oral contraceptives. Fertility and Sterility. 2014; 101: 5.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Mueck A. O., Sitruk-Ware R. Nomegestrol acetate, a novel progestogen for oral contraception. Steroids. 2011; 76 (6): 531–539.</mixed-citation><mixed-citation xml:lang="en">Mueck A. O., Sitruk-Ware R. Nomegestrol acetate, a novel progestogen for oral contraception. Steroids. 2011; 76 (6): 531–539.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
