medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2023-19-7-15medalphabet-3295Research ArticleСтатьиРоль липотропных факторов в коррекции метаболических нарушений у женщин в перименопаузальный периодThe role of lipotropic factors in the correction of metabolic disorders in women during the perimenopausal periodhttps://orcid.org/0000-0002-4689-3591ОрловаС. В.OrlovaS. V.

Орлова Светлана Владимировна, д. м. н., проф., зав. кафедрой диетологиии клинической нутрициологии, главный научный сотрудник

Москва

Orlova Svetlana V., DM Sci (habil.), professor, head of Dept of Dietetics and Clinical Nutritiology, Chief Researcher

Moscow

orlova-sv@rudn.ruhttps://orcid.org/0000-0003-3220-0333НикитинаЕ. А.NikitinaE. A.

Никитина Елена Александровна, к. м. н., доцент кафедры диетологии и клинической нутрициологии, научный сотрудник

Москва

Nikitina Elena A., PhD Med, assistant professor of Dept of Dietetics and Clinical Nutritiology, Researcher

Moscow

nikitina-ea1@rudn.ruФГАОУ ВО «Российский университет дружбы народов имени Патриса Лумумбы»; ГБУЗ «Научно-практический центр детской психоневрологии Департамента здравоохранения г. Москвы»РоссияPeoples’ Friendship University of Russia named after Patrice Lumumba; Scientific and Practical Center for Child Psychoneurology, Moscow Department of HealthRussian Federation202305112023019Современная гинекология (2)715Copyright © Орлова С.В., Никитина Е.А., 20232023Орлова С.В., Никитина Е.А.Orlova S.V., Nikitina E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/3295

У женщин в период перименопаузы выявляются изменения метаболических параметров, такие как увеличение массы тела, запускающее каскад патологических реакций, которые приводят к формированию метаболических нарушений (липидного, углеводного обменов) и эндотелиальной дисфункции, в развитии которых определенную роль играет дефицит половых гормонов при наступлении климактерия. Имеется взаимосвязь гормональных сдвигов и увеличение количества абдоминального и/или висцерального жира, что сопровождается ослаблением процессов окисления в жировой ткани, снижением расхода энергии и предрасположенностью к развитию метаболического синдрома. В качестве нутритивной коррекции целесообразно введение в рацион липотропных веществ, способствующих катализации распада жиров и обеспечивающих процессы гидроксилирования и метилирования токсических веществ в печени, таких как метионин, инозитол и холин. Каждый из липотропных веществ влияет на мобилизацию жиров, а их комбинация может обеспечить синергетический эффект и увеличить естественную метаболическую функцию печени.

In women during perimenopause, changes in metabolic parameters are detected, such as weight gain, which triggers a cascade of pathological reactions leading to the formation of metabolic disorders (lipid, carbohydrate metabolism) and endothelial dysfunction, during the development of which a deficiency of sex hormones plays a certain role in the onset of menopause. There is a connection between hormonal changes and an increase in the amount of abdominal and/or visceral fat, which is accompanied by a weakening of oxidative processes in adipose tissue, a decrease in energy consumption and a predisposition to the development of metabolic syndrome. As a nutritional correction, it is advisable to introduce into the diet lipotropic substances that help catalyze the breakdown of fats and ensure the processes of hydroxylation and methylation of toxic substances in the liver, such as methionine, inositol and choline. Each of the lipotropic substances affects the mobilization of fats, and their combination can provide a synergistic effect and increase the natural metabolic function of the liver.

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The authors declare that there are no conflicts of interest present.