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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2023-14-36-39</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-3248</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Церебральный венозный тромбоз в репродуктивном возрасте</article-title><trans-title-group xml:lang="en"><trans-title>Cerebral venous thrombosis in reproductive age</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1946-0424</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Манышева</surname><given-names>К. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Manysheva</surname><given-names>K. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Манышева Ксения Борисовна - ассистент кафедры нервных болезней, медицинской генетики и нейрохирургии.</p><p>Махачкала</p></bio><bio xml:lang="en"><p>Ksenia B. Manysheva - assistant at Dept of Nervous Diseases, Medical Genetics and Neurosurgery.</p><p>Makhachkala</p></bio><email xlink:type="simple">manyshevakb@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8493-9768</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абусуева</surname><given-names>Б. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Abusueva</surname><given-names>B. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Абусуева Бурлият Абусуевна - кандидат медицинских наук, доцент, заведующий кафедрой нервных болезней, медицинской генетики и нейрохирургии.</p><p>Махачкала</p></bio><bio xml:lang="en"><p>Burliyat A. Abusueva - PhD Med, associate professor, head of Dept of Nervous Diseases, Medical Genetics and Neurosurgery.</p><p>Makhachkala</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7729-1606</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абусуева</surname><given-names>З. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Abusueva</surname><given-names>Z. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Абусуева Зухра Абусуевна - доктор медицинских наук, профессор кафедры акушерства и гинекологии лечебного факультета.</p><p>Махачкала</p></bio><bio xml:lang="en"><p>Zukhra A. Abusueva - MD, professor at Dept of Obstetrics and Gynecology, Faculty of Medicine.</p><p>Makhachkala</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Багандов</surname><given-names>Б. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Bagandov</surname><given-names>B. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Багандов Багаутдин Русланович - студент лечебного факультета.</p><p>Махачкала</p></bio><bio xml:lang="en"><p>Bagautdin R. Bagandov - student of Faculty of Medicine.</p><p>Makhachkala</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Магомедова</surname><given-names>Ш. З.</given-names></name><name name-style="western" xml:lang="en"><surname>Magomedova</surname><given-names>Sh. Z.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Магомедова Шуайнат Загировна - студентка лечебного факультета.</p><p>Махачкала</p></bio><bio xml:lang="en"><p>Shuaynat Z. Magomedova - student of Faculty of Medicine.</p><p>Makhachkala</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Дагестанский государственный медицинский университет» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Dagestan State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>19</day><month>10</month><year>2023</year></pub-date><volume>0</volume><issue>14</issue><issue-title>«Неврология и психиатрия» (2)</issue-title><fpage>36</fpage><lpage>39</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Манышева К.Б., Абусуева Б.А., Абусуева З.А., Багандов Б.Р., Магомедова Ш.З., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Манышева К.Б., Абусуева Б.А., Абусуева З.А., Багандов Б.Р., Магомедова Ш.З.</copyright-holder><copyright-holder xml:lang="en">Manysheva K.B., Abusueva B.A., Abusueva Z.A., Bagandov B.R., Magomedova S.Z.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/3248">https://www.med-alphabet.com/jour/article/view/3248</self-uri><abstract><sec><title>Введение</title><p>Введение. Церебральный венозный тромбоз – относительно редко встречающееся патологическое состояние, которое часто приводит к развитию ишемического и (или) геморрагического инсульта.</p></sec><sec><title>Цель</title><p>Цель. Описать  клинический  случай  церебрального  венозного тромбоза,  сопровождавшийся  развитием  ишемического инсульта с геморрагической трансформацией, у женщины репродуктивного возраста на фоне приема комбинированного эстроген-гестагенного препарата из группы оральных контрацептивов.</p></sec><sec><title>Пациенты и методы</title><p>Пациенты и методы. Анализ проводили на основании данных анамнеза, клинического, лабораторного и инструментального обследования пациентки. Результаты. Представлен клинический случай пациентки 23 лет, у которой наблюдалось острое нарушение мозгового кровообращения по ишемическому типу с геморрагической трансформацией. С учетом данных анамнеза и дополнительных методов исследования установлено, что инсульт был обусловлен тромбозом церебральных синусов, который развился на фоне проведения гормональной контрацепции. Описание случая сопровождается изображениями МРТ головного мозга пациентки.</p></sec><sec><title>Выводы</title><p>Выводы. Риск развития церебрального венозного тромбоза у  женщин на  фоне приема гормональных контрацептивов почти    в восемь раз выше, чем у тех, кто не получает гормональной терапии. Возникновение неврологической симптоматики у женщин репродуктивного возраста требует тщательного изучения анамнеза жизни, акушерско-гинекологического и фармакологического анамнеза для установления факта приема эстроген-гестагенных препаратов с целью контрацепции или терапии гормональных расстройств. Описанный случай фокусирует внимание на  важности деликатного подхода к назначению гормональной терапии в лечении патологических состояний гинекологического и иного профиля, а также свидетельствует о необходимости рассмотрения    и рекомендации иных средств контрацепции пациенткам молодого возраста.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Relevance</title><p>Relevance. Cerebral venous thrombosis is a relatively rare pathological condition that often leads to the development of ischemic and/or hemorrhagic stroke.</p></sec><sec><title>Objective</title><p>Objective. Describe a clinical case of cerebral venous thrombosis, accompanied by the ischemic stroke with hemorrhagic transformation, in a reproductive age woman taking a combined estrogen-progestin drug from the group of oral contraceptives.</p></sec><sec><title>Patients and methods</title><p>Patients and methods. The analysis based on the anamnesis data, clinical, laboratory and instrumental examination of the patient.</p></sec><sec><title>Results</title><p>Results. A clinical case of a 23-year-old patient who had an acute ischemic stroke with hemorrhagic transformation is presented. According to the history data and instrumental methods, the stroke was caused by thrombosis of the cerebral sinuses, which developed on the background of hormonal contraception use. The clinical case is accompanied by MRI images of the patient's brain.</p></sec><sec><title>Conclusions</title><p>Conclusions. The risk of cerebral venous thrombosis in women with hormonal contraceptives use is almost 8 times higher than in those who do not receive hormone therapy. The occurrence of neurological symptoms in women of reproductive age requires a thorough study of the life history, obstetric/gynecological and pharmacological history to establish the fact of estrogen-progestin drugs use for contraception or treatment of hormonal disorders. The described case focuses on the importance of a delicate approach to prescribing hormonal therapy in the treatment of gynecological and other pathological conditions, and indicates the necessity to consider and recommend other contraceptives for young patients.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>женское здоровье</kwd><kwd>церебральный венозный тромбоз</kwd><kwd>ишемический инсульт</kwd><kwd>геморрагическая трансформация</kwd><kwd>комбинированные оральные контрацептивы</kwd><kwd>нежелательные эффекты гормональной терапии</kwd><kwd>репродуктивный возраст</kwd></kwd-group><kwd-group xml:lang="en"><kwd>women's health</kwd><kwd>cerebral venous thrombosis</kwd><kwd>ischemic stroke</kwd><kwd>hemorrhagic transformation</kwd><kwd>combined oral contraceptives</kwd><kwd>undesirable effects of hormone therapy</kwd><kwd>reproductive age</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Токова З. 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