medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2023-10-18-24medalphabet-3155Research ArticleСтатьиВлияние гипофракционного режима адъювантной лучевой терапии на частоту осложнений у больных раком молочной железы с одномоментной реконструкцией синтетическими материаламиImpact of hypofractionated adjuvant radiotherapy on complication rate in breast cancer patients with implant-based immediate reconstructionhttps://orcid.org/0000-0002-2216-2807ТимошкинаЕ. В.TimoshkinaE. V.

Тимошкина Екатерина Валерьевна, к. м. н., врач-радиотерапевт 

Москва

 Timoshkina Ekaterina V., PhD Med., radiotherapist

 Moscow

doctoretim@gmail.comhttps://orcid.org/0000-0001-8965-8172ТкачевС. И.TkachevS. I.

Ткачев Сергей Иванович, д. м. н., проф., ведущий научный сотрудник

Москва

Tkachev Sergey I., DM Sci (habil.), professor, leading researcher

 Moscow

sitkachev@gmail.comhttps://orcid.org/0000-0002-8062-570XГлебовскаяВ. В.GlebovskayaV. V.

Глебовская Валерия Владимировна, д. м. н., старший научный сотрудник

Москва

 Glebovskaya Valeria V., DM Sci (habil.), senior researcher

Moscow

oncovalery@mail.ruhttps://orcid.org/0000-0002-7204-370XТрофимоваО. П.TrofiovaO. P.

Трофимова Оксана Петровна, д. м. н., проф., ведущий научный сотрудник

Москва

Trofiova Oksana P., DM Sci (habil.), professor, leading researcher

 Moscow

Dr.trofiova@mail.ruЧерныхМ. В.ChernykhM. V.

Черных Марина Васильевна, к. м. н., доцент, зам. директора по лечебной работе НИИ КиЭР , зав. отделением радиотерапии

Москва

Chernykh Marina V., PhD Med, associate professor, deputy director for Medical Work, Research Institute of Clinical and Experimental Radiology , head of the Deptof Radiotherapy

 Moscow

dr.chernich@mail.ruИвановС. М.IvanovS. M.

Иванов Станислав Михайлович, к. м. н., старший научный сотрудник

Москва

 Ivanov Stanislav M., PhD Med, senior researcher

Moscow

rad.ivanov@yahoo.comФГБУ «Национальный медицинский исследовательский центр онкологии имени Н. Н. Блохина» Минздрава РоссииРоссияNational Medical Research Centre of Oncology n.a. N. N. BlokhinRussian FederationФГБУ «Национальный медицинский исследовательский центр онкологии имени Н. Н. Блохина» Минздрава России; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияNational Medical Research Centre of Oncology n.a. N. N. Blokhin; Russian Medical Academy for Continuing Professional EducationRussian FederationФГБУ «Национальный медицинский исследовательский центр онкологии имени Н. Н. Блохина» Минздрава России; ФГАОУ ВО «Первый Московский государственный медицинский университет имени И. М. Сеченова» Минздрава России (Сеченовский университет)РоссияNational Medical Research Centre of Oncology n.a. N. N. Blokhin; First Moscow State Medical University n.a. I. M. SechenovRussian Federation202329062023010Диагностика и онкотерапия (1)1824Copyright © Тимошкина Е.В., Ткачев С.И., Глебовская В.В., Трофимова О.П., Черных М.В., Иванов С.М., 20232023Тимошкина Е.В., Ткачев С.И., Глебовская В.В., Трофимова О.П., Черных М.В., Иванов С.М.Timoshkina E.V., Tkachev S.I., Glebovskaya V.V., Trofiova O.P., Chernykh M.V., Ivanov S.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/3155

Гипофракционные режимы лучевой терапии при лечении больных раком молочной железы имеют значительное преимущество по сравнению с классическим фракционированием в силу меньшей длительности курса лучевого лечения при сохранении его противоопухолевой эффективности. Применение гипофракционных режимов у пациенток после одномоментной реконструктивно-пластической операции может быть ограничено риском большей частоты развития осложнений. Целью данной работы является оценка частоты возникновения осложнений со стороны реконструированной молочной железы после проведения гипофракционной лучевой терапии. В исследование были включены 100 больных раком молочной железы после выполненной одномоментно реконструктивно-пластической операции с применением синтетических материалов, которым был проведен адъювантный курс дистанционной лучевой терапии с разовой дозой 2,67 Гр до суммарной дозы 40,05 Гр. В рамках выполненного нами исследования частота развития капсулярной контрактуры составила 8 %, инфекционных осложнений – 2,3 %, возникновения протрузии – 4,6 %, Общая частота выявленных осложнений составила 15 %, что не превышает таковую при классическом режиме фракционирования.

Hypofractionated radiotherapy in the treatment of breast cancer patients has a signifiant advantage over conventional fractionation due to the shorter duration of treatment course while maintaining its antitumor effiacy. Usage of hypofractionated regimens may be restricted in patients with immediate breast reconstruction because of higher rate of complications. The aim of this study is to evaluate the incidence of complications in the reconstructed breast after hypofractionated radiotherapy. The study involved 100 patients with breast cancer after immediate implant-based breast reconstruction who underwent an adjuvant course of external beam radiation therapy with a single dose of 2.67 Gy to a total dose of 40.05 Gy. In our study the incidence of capsular contracture is 8 %, infectious complications – 2.3 %, protrusion – 4.6 %. The total incidence of complications is 15 %, which does not exceed the incidence in conventional fractionation.

рак молочной железылучевая терапияреконструктивно-пластическая операциягипофракционированиеосложнениякапсулярная контрактураbreast cancerradiotherapyreconstructionhypofractionationcomplicationscapsular contracture.ReferencesJoanne S Haviland, J Roger Owen, John A Dewar et al. The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials. Lancet Oncol. 2013 Oct; 14 (11): 1086–1094. DOI: 10.1016/s1470–2045(13)70386–3.Joanne S Haviland, J Roger Owen, John A Dewar et al. The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials. Lancet Oncol. 2013 Oct; 14 (11): 1086–1094. DOI: 10.1016/s1470–2045(13)70386–3.Афонин Г. В., Рагулин Ю.А, Гулидов И. А. Ускоренные режимы адъювантной лучевой терапии в лечении рака молочной железы. Исследования и практика в медицине 2018, т. 4, № 3, с. 66–74. DOI: 10.17709/2409–2231–2017–4–3–6. Afonin G. V., Ragulin Yu.A., Gulidov I. A. Accelerated regimens of adjuvant radiotherapy in the treatment of breast cancer. Research and practice in medicine 2018, v.4, No. 3, p. 66–74. DOI: 10.17709/2409–2231–2017–4–3–6.Афонин Г. В., Рагулин Ю.А, Гулидов И. А. Ускоренные режимы адъювантной лучевой терапии в лечении рака молочной железы. Исследования и практика в медицине 2018, т. 4, № 3, с. 66–74. DOI: 10.17709/2409–2231–2017–4–3–6. Afonin G. V., Ragulin Yu.A., Gulidov I. A. Accelerated regimens of adjuvant radiotherapy in the treatment of breast cancer. Research and practice in medicine 2018, v.4, No. 3, p. 66–74. DOI: 10.17709/2409–2231–2017–4–3–6.NCCN Guideline for breast cancer. Version 02.2022. USA National Comprehensive Cancer Network Inc., 2022.NCCN Guideline for breast cancer. Version 02.2022. USA National Comprehensive Cancer Network Inc., 2022.Рак молочной железы. Клинические рекомендации. 2021. Ассоциация онкологов России. Mammary cancer. Clinical guidelines. 2021. Association of Oncologists of Russia.Рак молочной железы. Клинические рекомендации. 2021. Ассоциация онкологов России. Mammary cancer. Clinical guidelines. 2021. Association of Oncologists of Russia.Richard Simcock, Yoms Vengaloor Thomas, Christopher Estes Mercy et al. COVID-19: Global Radiation Oncology’s Targeted Response for Pandemic Preparedness. Clin Transl Radiat Oncol. 2020 Mar 24; 22: 55–68. DOI: 10.1016/j.ctro.2020.03.009.Richard Simcock, Yoms Vengaloor Thomas, Christopher Estes Mercy et al. COVID-19: Global Radiation Oncology’s Targeted Response for Pandemic Preparedness. Clin Transl Radiat Oncol. 2020 Mar 24; 22: 55–68. DOI: 10.1016/j.ctro.2020.03.009.Bassim El-Sabawi, Joseph N. Carey, Thomas M. Hagopian et al. Radiation and breast reconstruction: Algorithmic approach and evidence-based outcomes. J Surg Oncol. 2016. V. 113 (8), P. 906–912. DOI: 10.1002/jso.24143.Bassim El-Sabawi, Joseph N. Carey, Thomas M. Hagopian et al. Radiation and breast reconstruction: Algorithmic approach and evidence-based outcomes. J Surg Oncol. 2016. V. 113 (8), P. 906–912. DOI: 10.1002/jso.24143.Christante D., Pommier S. J., Diggs B. S. et al. Using complications associated with postmastectomy radiation and immediate breast reconstruction to improve surgical decision-making Arch. Surg. 145: 873–878, 2010. DOI: 10.1001/archsurg.2010.170.Christante D., Pommier S. J., Diggs B. S. et al. Using complications associated with postmastectomy radiation and immediate breast reconstruction to improve surgical decision-making Arch. Surg. 145: 873–878, 2010. DOI: 10.1001/archsurg.2010.170.Benediktsson K, Perbeck L. Capsular contracture around saline-filed and textured subcutaneously placed implants in irradiated and non-irradiated breast cancer patients: fie years of monitoring of a prospective trial. J Plast Reconstr Aesthet Surg 2006; 59: 27–34. DOI: 10.1016/j.bjps.2005.08.005.Benediktsson K, Perbeck L. Capsular contracture around saline-filed and textured subcutaneously placed implants in irradiated and non-irradiated breast cancer patients: fie years of monitoring of a prospective trial. J Plast Reconstr Aesthet Surg 2006; 59: 27–34. DOI: 10.1016/j.bjps.2005.08.005.Seung Yeun Chung, Jee Suk Chang, Kyung Hwan Shin et al. Impact of radiation dose on complications among women with breast cancer who underwent breast reconstruction and post-mastectomy radiotherapy: A multi-institutional validation study. Breast. 2021 Apr; 56: 7–13. DOI: 10.1016/j.breast.2021.01.003.Seung Yeun Chung, Jee Suk Chang, Kyung Hwan Shin et al. Impact of radiation dose on complications among women with breast cancer who underwent breast reconstruction and post-mastectomy radiotherapy: A multi-institutional validation study. Breast. 2021 Apr; 56: 7–13. DOI: 10.1016/j.breast.2021.01.003.B. El-Sabawi, M. Sosin, J. N. Carey, M. Y. Nahabedian, K. M. Patel. Breast reconstruction and adjuvant therapy: A systematic review of surgical outcomes. J Surg Oncol., 2015, V. 112 (5), P. 458–464. DOI: 10.1002/jso.24028.B. El-Sabawi, M. Sosin, J. N. Carey, M. Y. Nahabedian, K. M. Patel. Breast reconstruction and adjuvant therapy: A systematic review of surgical outcomes. J Surg Oncol., 2015, V. 112 (5), P. 458–464. DOI: 10.1002/jso.24028.B. El-Sabawi, Joseph N. Carey, Thomas M. Hagopian et al. Radiation and breast reconstruction: Algorithmic approach and evidence-based outcomes. J Surg Oncol., 2016, V. 113 (8), P. 906–912. DOI: 10.1002/jso.24143.B. El-Sabawi, Joseph N. Carey, Thomas M. Hagopian et al. Radiation and breast reconstruction: Algorithmic approach and evidence-based outcomes. J Surg Oncol., 2016, V. 113 (8), P. 906–912. DOI: 10.1002/jso.24143.Reshma Jagsi, Adeyiza O. Momoh, Ji Qi et al. Impact of Radiotherapy on Complications and Patient-Reported Outcomes After Breast Reconstruction. J Natl Cancer Inst. 2018 Feb; 110 (2): 157–165. DOI: 10.1093/jnci/djx148.Reshma Jagsi, Adeyiza O. Momoh, Ji Qi et al. Impact of Radiotherapy on Complications and Patient-Reported Outcomes After Breast Reconstruction. J Natl Cancer Inst. 2018 Feb; 110 (2): 157–165. DOI: 10.1093/jnci/djx148.Boon H Chua. Individualised target volume selection and dose prescription after conservative surgery, mastectomy and reconstruction. The Breast, 2019, 48, S 69–S 75. DOI: 10.1016/S 0960–9776(19)31128–2.Boon H Chua. Individualised target volume selection and dose prescription after conservative surgery, mastectomy and reconstruction. The Breast, 2019, 48, S 69–S 75. DOI: 10.1016/S 0960–9776(19)31128–2.Sriram Venigalla, David M. Guttmann, Varsha Jain et al. Trends and Patterns of Utilization of Hypofractionated Post-Mastectomy Radiotherapy: A National Cancer Database Analysis. Clin Breast Cancer. 2018 Oct; 18 (5): e899–e908. DOI: 10.1016/j.clbc.2018.02.009.Sriram Venigalla, David M. Guttmann, Varsha Jain et al. Trends and Patterns of Utilization of Hypofractionated Post-Mastectomy Radiotherapy: A National Cancer Database Analysis. Clin Breast Cancer. 2018 Oct; 18 (5): e899–e908. DOI: 10.1016/j.clbc.2018.02.009.Jee Suk Chang, Seung Yong Song, Joo Hyun Oh et al. Inflence of Radiation Dose to Reconstructed Breast Following Mastectomy on Complication in Breast Cancer Patients Undergoing Two-Stage Prosthetic Breast Reconstruction. Front Oncol. 2019; 9:243. DOI: 10.3389/fonc.2019.00243.Jee Suk Chang, Seung Yong Song, Joo Hyun Oh et al. Inflence of Radiation Dose to Reconstructed Breast Following Mastectomy on Complication in Breast Cancer Patients Undergoing Two-Stage Prosthetic Breast Reconstruction. Front Oncol. 2019; 9:243. DOI: 10.3389/fonc.2019.00243.Atif J. Khan, Matthew M. Poppe, Sharad Goyal et al. Hypofractionated Postmastectomy Radiation Therapy Is Safe and Effective: First Results from a Prospective Phase II Trial. Jiurnal of Clinical Oncology, 2017. V. 35 (18), P. 2037–2043. DOI: 10.1200/jco.2016.70.7158.Atif J. Khan, Matthew M. Poppe, Sharad Goyal et al. Hypofractionated Postmastectomy Radiation Therapy Is Safe and Effective: First Results from a Prospective Phase II Trial. Jiurnal of Clinical Oncology, 2017. V. 35 (18), P. 2037–2043. DOI: 10.1200/jco.2016.70.7158.Hypofractionated radiation therapy after mastectomy in preventing recurrence in patients with stage IIa-IIIa breast cancer. Available online: https://clinicaltrials.gov/ct2/show/nct03414970. NLM identifir: NCT03414970.Hypofractionated radiation therapy after mastectomy in preventing recurrence in patients with stage IIa-IIIa breast cancer. Available online: https://clinicaltrials.gov/ct2/show/nct03414970. NLM identifir: NCT03414970.Study of radiation Fractionation on patient outcomes After Breast REConstruction (FABREC) for invasive breast carcinoma. Available online: https://clinicaltrials.gov/ct2/show/nct03422003. NLM identifir: NCT03422003.Study of radiation Fractionation on patient outcomes After Breast REConstruction (FABREC) for invasive breast carcinoma. Available online: https://clinicaltrials.gov/ct2/show/nct03422003. NLM identifir: NCT03422003.Orecchia R., Rojas D. P., Cattani F., et al. Hypofractionated postmastectomy radiotherapy with helical tomotherapy in patients with immediate breast reconstruction: Dosimetric results and acute/intermediate toxicity evaluation. Medical Oncology, (2018), 35 (3). DOI: 10.1007/s12032–018–1095–6.Orecchia R., Rojas D. P., Cattani F., et al. Hypofractionated postmastectomy radiotherapy with helical tomotherapy in patients with immediate breast reconstruction: Dosimetric results and acute/intermediate toxicity evaluation. Medical Oncology, (2018), 35 (3). DOI: 10.1007/s12032–018–1095–6.Yara Bachour. Capsular Contracture in Breast Implant Surgery: Where Are We Now and Where Are We Going? Aesthetic Plast Surg 2021 Jun; 45 (3): 1328–1337. DOI: 10.1007/s00266–021–02141–6.Yara Bachour. Capsular Contracture in Breast Implant Surgery: Where Are We Now and Where Are We Going? Aesthetic Plast Surg 2021 Jun; 45 (3): 1328–1337. DOI: 10.1007/s00266–021–02141–6.Whitfild G. A., Horan G., Irwin M. S., Malata C. M., Wishart G. C., & Wilson C. B. Incidence of severe capsular contracture following implant-based immediate breast reconstruction with or without postoperative chest wall radiotherapy using 40 Gray in 15 fractions. Radiotherapy and Oncology, 2009, 90 (1), 141–147. DOI: 10.1016/j.radonc.2008.09.023.Whitfild G. A., Horan G., Irwin M. S., Malata C. M., Wishart G. C., & Wilson C. B. Incidence of severe capsular contracture following implant-based immediate breast reconstruction with or without postoperative chest wall radiotherapy using 40 Gray in 15 fractions. Radiotherapy and Oncology, 2009, 90 (1), 141–147. DOI: 10.1016/j.radonc.2008.09.023.Е. В. Тимошкина, С. И. Ткачев, А. В. Назаренко и соавт. Результаты комплексного лечения больных раком молочной железы, включающего реконструктивно-пластическую операцию с применением синтетических материалов, химиотерапию и конформную лучевую терапию. Медицинская радиология и радиационная безопасность. 2018, N 5 (63) C. 19–25. DOI: 0.12737/article_5bc8965ecf7302.64445070. E. V. Timoshkina, S. I. Tkachev, A. V. Nazarenko et al. The results of complex treatment of patients with breast cancer, including reconstructive plastic surgery using synthetic materials, chemotherapy and conformal radiation therapy. Medical radiology and radiation safety. 2018, No. 5 (63) C. 19–25. DOI: 0.12737/article_5bc8965ecf7302.64445070.Е. В. Тимошкина, С. И. Ткачев, А. В. Назаренко и соавт. Результаты комплексного лечения больных раком молочной железы, включающего реконструктивно-пластическую операцию с применением синтетических материалов, химиотерапию и конформную лучевую терапию. Медицинская радиология и радиационная безопасность. 2018, N 5 (63) C. 19–25. DOI: 0.12737/article_5bc8965ecf7302.64445070. E. V. Timoshkina, S. I. Tkachev, A. V. Nazarenko et al. The results of complex treatment of patients with breast cancer, including reconstructive plastic surgery using synthetic materials, chemotherapy and conformal radiation therapy. Medical radiology and radiation safety. 2018, No. 5 (63) C. 19–25. DOI: 0.12737/article_5bc8965ecf7302.64445070.Paul J. Chuba, William A. Stefani, Carrie Dul et al. Radiation and depression associated with complications of tissue expander reconstruction. Breast Cancer Res Treat. 2017 Aug; 164 (3): 641–647. DOI: 10.1007/s10549–017–4277–6.Paul J. Chuba, William A. Stefani, Carrie Dul et al. Radiation and depression associated with complications of tissue expander reconstruction. Breast Cancer Res Treat. 2017 Aug; 164 (3): 641–647. DOI: 10.1007/s10549–017–4277–6.C. Yan, J. P. Fischer, G. M. Freedman, M. N. Basta, S. J. Kovach, J. M. Serletti, L. Lin, L. C. Wu. The Timing of Breast Irradiation in Two-Stage Expander/Implant Breast Reconstruction. Breast J. 2016. V. 22 (3), P. 322–329. DOI: 10.1111/tbj.12572.C. Yan, J. P. Fischer, G. M. Freedman, M. N. Basta, S. J. Kovach, J. M. Serletti, L. Lin, L. C. Wu. The Timing of Breast Irradiation in Two-Stage Expander/Implant Breast Reconstruction. Breast J. 2016. V. 22 (3), P. 322–329. DOI: 10.1111/tbj.12572.Banuelos J., Abu-Ghname A., Asaad M., Vyas K., Rizwan M. S., & Sharaf B. (2019). Microbiology of Implant-Based Breast Reconstruction Infections. Annals of Plastic Surgery, 1. DOI: 10.1097/sap.0000000000001974.Banuelos J., Abu-Ghname A., Asaad M., Vyas K., Rizwan M. S., & Sharaf B. (2019). Microbiology of Implant-Based Breast Reconstruction Infections. Annals of Plastic Surgery, 1. DOI: 10.1097/sap.0000000000001974.Ogita M., Nagura N., Kawamori J., In R., Yoshida A., Yamauchi H., … Sekiguchi K. (2017). Risk factors for complications among breast cancer patients treated with post-mastectomy radiotherapy and immediate tissue-expander/permanent implant reconstruction: A retrospective cohort study. Breast Cancer, 25 (2), 167–175. DOI: 10.1007/s12282–017–0808–6.Ogita M., Nagura N., Kawamori J., In R., Yoshida A., Yamauchi H., … Sekiguchi K. (2017). Risk factors for complications among breast cancer patients treated with post-mastectomy radiotherapy and immediate tissue-expander/permanent implant reconstruction: A retrospective cohort study. Breast Cancer, 25 (2), 167–175. DOI: 10.1007/s12282–017–0808–6.Nahabedian MY, Tsangaris T, Momen B, Manson PN. Infectious complications following breast reconstruction with expanders and implants. Plast Reconstr Surg. 2003; 112 (2): 467–476. DOI: 10.1097/01.PRS.0000070727.02992.54.Nahabedian MY, Tsangaris T, Momen B, Manson PN. Infectious complications following breast reconstruction with expanders and implants. Plast Reconstr Surg. 2003; 112 (2): 467–476. DOI: 10.1097/01.PRS.0000070727.02992.54.Krueger E. A., Wilkins E. G., Strawderman M., Cederna P., Goldfarb S., Vicini F. A., Pierce L. J. Complications and patient satisfaction following expander/implant breast reconstruction with and without radiotherapy. International Journal of Radiation Oncology* Biology* Physics, 2001, 49 (3), 713–721. DOI: 10.1016/s0360–3016(00)01402–4.Krueger E. A., Wilkins E. G., Strawderman M., Cederna P., Goldfarb S., Vicini F. A., Pierce L. J. Complications and patient satisfaction following expander/implant breast reconstruction with and without radiotherapy. International Journal of Radiation Oncology* Biology* Physics, 2001, 49 (3), 713–721. DOI: 10.1016/s0360–3016(00)01402–4.Elswick S. M., Harless C. A., Bishop et al. (2018). Prepectoral Implant-Based Breast Reconstruction with Postmastectomy Radiation Therapy. Plastic and Reconstructive Surgery, 142 (1), 1–12. DOI: 10.1097/prs.0000000000004453.Elswick S. M., Harless C. A., Bishop et al. (2018). Prepectoral Implant-Based Breast Reconstruction with Postmastectomy Radiation Therapy. Plastic and Reconstructive Surgery, 142 (1), 1–12. DOI: 10.1097/prs.0000000000004453.Sbitany H. et al. Immediate Implant-Based Breast Reconstruction following Total Skin-Sparing Mastectomy. Plastic and Reconstructive Surgery, 2014, 134 (3), 396–404. DOI: 10.1097/prs.0000000000000466.Sbitany H. et al. Immediate Implant-Based Breast Reconstruction following Total Skin-Sparing Mastectomy. Plastic and Reconstructive Surgery, 2014, 134 (3), 396–404. DOI: 10.1097/prs.0000000000000466.Dragana Ajdic et al. The Relationship of Bacterial Biofims and Capsular Contracture in Breast Implants. Aesthet Surg J. 2016 Mar; 36 (3): 297–309. DOI: 10.1093/asj/sjv177.Dragana Ajdic et al. The Relationship of Bacterial Biofims and Capsular Contracture in Breast Implants. Aesthet Surg J. 2016 Mar; 36 (3): 297–309. DOI: 10.1093/asj/sjv177.Constantine R. S. et al. The Ever-Changing Role of Biofims in Plastic Surgery. Plastic and Reconstructive Surgery, 2014, 133 (6), 865e-872e. DOI: 10.1097/prs.0000000000000213.Constantine R. S. et al. The Ever-Changing Role of Biofims in Plastic Surgery. Plastic and Reconstructive Surgery, 2014, 133 (6), 865e-872e. DOI: 10.1097/prs.0000000000000213.Tamboto H, Vickery K, Deva AK. Subclinical (biofim) infection causes capsular contracture in a porcine model following augmentation mammaplasty. Plast Reconstr Surg. 2010; 1263: 835–842. DOI: 10.1097/prs.0b013e3181e3b456.Tamboto H, Vickery K, Deva AK. Subclinical (biofim) infection causes capsular contracture in a porcine model following augmentation mammaplasty. Plast Reconstr Surg. 2010; 1263: 835–842. DOI: 10.1097/prs.0b013e3181e3b456.Kossovsky N, Heggers JP, Parsons RW, Robson MC. Acceleration of capsule formation around silicone implants by infection in a guinea pig model. Plast Reconstr Surg. 1984; 731: 91–98. DOI: 10.1097/00006534–198401000–00021.Kossovsky N, Heggers JP, Parsons RW, Robson MC. Acceleration of capsule formation around silicone implants by infection in a guinea pig model. Plast Reconstr Surg. 1984; 731: 91–98. DOI: 10.1097/00006534–198401000–00021.Fodor L., Ramon Y., Ullmann Y., Eldor L., & Peled I. J. (2003). Fate of Exposed Breast Implants in Augmentation Mammoplasty. Annals of Plastic Surgery, 50 (5), 447–449. DOI: 10.1097/01.sap.0000044251.40733.2b.Fodor L., Ramon Y., Ullmann Y., Eldor L., & Peled I. J. (2003). Fate of Exposed Breast Implants in Augmentation Mammoplasty. Annals of Plastic Surgery, 50 (5), 447–449. DOI: 10.1097/01.sap.0000044251.40733.2b.Власова М. Ю., Зикиряходжаев А. Д., Решетов И. В. и др. Осложнения после одномоментной препекторальной реконструкции имплантатами с полиуретановым покрытием при раке молочной железы. Опухоли женской репродуктивной системы 2020; 16 (4): 12–20. DOI: 10.17650/1994–4098–2020–16–4–12–20. Vlasova M. Yu., Zikiryakhodzhaev A. D., Reshetov I. V. Complications after one-stage prepectoral reconstruction with polyurethane-coated implants in breast cancer. Tumors of the female reproductive system 2020; 16 (4): 12–20. DOI: 10.17650/1994–4098–2020–16–4–12–20.Власова М. Ю., Зикиряходжаев А. Д., Решетов И. В. и др. Осложнения после одномоментной препекторальной реконструкции имплантатами с полиуретановым покрытием при раке молочной железы. Опухоли женской репродуктивной системы 2020; 16 (4): 12–20. DOI: 10.17650/1994–4098–2020–16–4–12–20. Vlasova M. Yu., Zikiryakhodzhaev A. D., Reshetov I. V. Complications after one-stage prepectoral reconstruction with polyurethane-coated implants in breast cancer. Tumors of the female reproductive system 2020; 16 (4): 12–20. DOI: 10.17650/1994–4098–2020–16–4–12–20.Ascherman J. A., Hanasono M. M., Newman M. I., & Hughes D. B. (2006). Implant Reconstruction in Breast Cancer Patients Treated with Radiation Therapy. Plastic and Reconstructive Surgery, 117 (2), 359–365. DOI: 10.1097/01.prs.0000201478.64877.87.Ascherman J. A., Hanasono M. M., Newman M. I., & Hughes D. B. (2006). Implant Reconstruction in Breast Cancer Patients Treated with Radiation Therapy. Plastic and Reconstructive Surgery, 117 (2), 359–365. DOI: 10.1097/01.prs.0000201478.64877.87.

The authors declare that there are no conflicts of interest present.