medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2023-8-64-68medalphabet-3122Research ArticleСтатьиАнтивирусные свойства грудного молока: новая сфера исследованийAntiviral properties of breast milk: a new area of researchhttps://orcid.org/0000-0002-3738-3792ГрибакинС. Г.GribakinS. G.

Грибакин Сергей Германович, д. м. н., профессор кафедры диетологии и нутрициологии

Москва

Gribakin Sergey G., DM Sci (habil.), professor of the Dept of Dietology and Nutrition

Moscow

serg.gribakin2016@yandex.ruhttps://orcid.org/0000-0002-4689-3591ОрловаС. В.OrlovaS. V.

Орлова Светлана Владимировна, д. м. н., проф., зав. кафедрой диетологии и клинической нутрициологии

Москва

Orlova Svetlana V., D. M. Sci. (habil.), professor, head of Dept of Dietetics and Clinical Nutritiology

Moscow

orlova-sv@rudn.ruhttps://orcid.org/0000-0003-4099-2967ПодопригораИ. В.PodoprigoraI. V.

Подопригора Ирина Викторовна, к. м. н., доцент, зав. кафедрой микробиологии им. В. С. Киктенко медицинского факультета

Москва

Podoprigora Irina V., PhD Med, associate professor, head of Dept of Microbiology

Moscow

podoprigora-iv@rudn.ruФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияRussian Medical Academy of Continious Professional EducationRussian FederationФГАОУ ВО «Российский университет дружбы народов»РоссияPeoples, Friendship University of RussiaRussian Federation20231406202308«Диетология и нутрициология» (1)6468Copyright © Грибакин С.Г., Орлова С.В., Подопригора И.В., 20232023Грибакин С.Г., Орлова С.В., Подопригора И.В.Gribakin S.G., Orlova S.V., Podoprigora I.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/3122

Женское молоко уникальным образом сочетает в себе нутритивные, иммунологические, энзиматические и гормональные свойства. Уже более полувека изучаются свойства секреторного IgA (sIgA), более 30 лет –  роль олигосахаридов, более 10 лет обсуждается значение стволовых клеток грудного молока. Широкий интерес, в том числе в связи с SARS-CoV-2, ВИЧ, рота-, норо-, герпес- и другими вирусными инфекциями вызвали различные (более 10 видов) защитные факторы с противовирусной активностью, присутствующие в женском молоке. В данном обзоре рассмотрены свойства и значение иммуноглобулинов, лактоферрина, олигосахаридов, лизоцима, цитокинов в качестве противовирусных факторов, имеющих как научное, так и практическое значение.

Human milk uniquely combines nutritional, immunological, enzymatic and hormonal properties. The properties of secretory IgA (sIgA) have been studied for more than half a century, the role of oligosaccharides has been studied for more than 30 years, and the importance of breast milk stem cells has been discussed for more than 10 years. Wide interest, including in connection with SARS-CoV-2-, HIV-, rota-, norо-, herpes- and other viral infections, was caused by various (more than 10 types) protective factors with antiviral activity present in human milk. This review discusses the properties and significance of immunoglobulins, lactoferrin, oligosaccharides, lysozyme, cytokines as antiviral factors of both scientific and practical importance.

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The authors declare that there are no conflicts of interest present.