medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2023-4-39-44medalphabet-3036Research ArticleСтатьиАртериальная жесткость как терапевтическая мишень для курильщиков с коморбидностьюArterial stiffness as therapeutic target for smokers with comorbidityhttps://orcid.org/0000-0001-6682-5644ГордеевА. И.GordeevA. I.

Гордеев Алексей Игоревич, студент VI курса лечебного факультета

Новосибирск

Gordeev Aleksey I., 6th year student of Faculty of Medicine

Novosibirsk

atirador99@mail.ruhttps://orcid.org/0000-0002-1250-8798ХидироваЛ. Д.KhidirovaL. D.

Хидирова Людмила Даудовна, д. м. н., проф. кафедры фармакологии, клинической фармакологии и доказательной медицины

Новосибирск

Khidirova Lyudmila D., DM Sci (habil.), professor at Dept of Pharmacology, Clinical Pharmacology and Evidence-Based Medicine

Novosibirsk

h_ludmila73@mail.ruhttps://orcid.org/0000-0001-7286-7461КаленоваС. А.KalenovaS. A.

Каленова Софья Александровна, студентка VI курса лечебного факультета

Новосибирск

Kalenova Sofya A., 6th year student of Faculty of Medicine

Novosibirsk

vanessa2000yutu@gmail.comhttps://orcid.org/0000-0002-4735-3861ОсмиеваЗ. М.OsmievaZ. M.

Осмиева Зурида Магомедовна, студентка VI курса

Новосибирск

Osmieva Zurida M., 5th year student

Novosibirsk

z.m.osmieva@mail.ruВасиленкоА. А.VasilenkoA. A.

Василенко Анна Анатольевна, ассистент кафедры фармакологии, клинической фармакологии и доказательной медицины фармацевтического факультета

Новосибирск

Vasilenko Anna A., assistant of Dept of Pharmacology, Clinical Pharmacology and Evidence-Based Medicine of Faculty of Pharmacy

Novosibirsk

vasilenko_anya@inbox.ruФГБОУ ВО «Новосибирский государственный медицинский университет» Минздрава РоссииРоссияNovosibirsk State Medical UniversityRussian Federation20233003202304Современная лаборатория (1)3944Copyright © Гордеев А.И., Хидирова Л.Д., Каленова С.А., Осмиева З.М., Василенко А.А., 20232023Гордеев А.И., Хидирова Л.Д., Каленова С.А., Осмиева З.М., Василенко А.А.Gordeev A.I., Khidirova L.D., Kalenova S.A., Osmieva Z.M., Vasilenko A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/3036

Курение сигарет уже давно считается фактором риска сердечно-сосудистых заболеваний и основной предотвратимой причиной смерти и инвалидности в развитых и развивающихся странах. Известно, что курение может вызывать эндотелиальную дисфункцию и гемодинамические дефекты, такие как артериальная жесткость. Среди различных суррогатных маркеров сердечно-сосудистого риска артериальная жесткость играет центральную роль и является сильным независимым предиктором сердечно-сосудистых событий, помимо классических сердечно-сосудистых факторов риска. В данном обзоре представлены основные механизмы, объясняющие развитие жесткости артерий при курении, представлены различные варианты лечения артериальной жесткости как терапевтической мишени для курильщиков с кардиореспираторной коморбидностью.

Cigarette smoking has long been considered a risk factor for cardiovascular disease and a major preventable cause of death and disability in developed and developing countries. It is known that smoking can cause endothelial dysfunction and hemodynamic defects such as arterial stiffness. Among various surrogate markers of cardiovascular risk, arterial stiffness plays a central role and is a strong independent predictor of cardiovascular events, in addition to classical cardiovascular risk factors. This review presents the main mechanisms that explain the development of arterial stiffness during smoking, presents various treatment options for arterial stiffness as a therapeutic target for smokers with cardiorespiratory comorbidity.

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The authors declare that there are no conflicts of interest present.