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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2023-2-7-11</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-3012</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Головная и лицевая боль в специализированной клинике боли: распространенность и коморбидность</article-title><trans-title-group xml:lang="en"><trans-title>Headache diagnoses in patients with orofacial pain at a specialized pain center</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кислова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kislova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кислова Елена Александровна, врач-невролог</p><p>Москва</p></bio><bio xml:lang="en"><p>Kislova Elena A., neurologist</p><p>Moscow</p><p> </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9600-5540</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Латышева</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Latysheva</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Латышева Нина Владимировна, д. м. н., профессор кафедры нервных болезней ИПО</p><p>Москва</p></bio><bio xml:lang="en"><p>Latysheva Nina V., DM Sci (habil.), professor of Dept of Nervous Diseases, Institute for Postgraduate Education</p><p>Moscow</p></bio><email xlink:type="simple">ninalat@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9978-4180</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Филатова</surname><given-names>Е. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Filatova</surname><given-names>E. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Филатова Елена Глебовна, д. м. н., профессор кафедры нервных болезней ИПО</p><p>Москва</p></bio><bio xml:lang="en"><p>Filatova Elena G., DM Sci (habil.), professor of Dept of Nervous Diseases, Institute for Postgraduate Education</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Поликлиника № 2 сети клиник АО «Семейный доктор»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Family Doctor Clinic</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет имени И. М. Сеченова» Минздрава России (Сеченовский университет); 3ООО «Цефалголог» – Клиника головной боли и вегетативных расстройств имени академика Александра Вейна – клиническая база Первого Московского государственного медицинского университета имени И. М. Сеченова (Сеченовский университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I. M. Sechenov First Moscow State Medical University (Sechenov Unversity); Alexander Vein Headache Clinic</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>23</day><month>03</month><year>2023</year></pub-date><volume>0</volume><issue>2</issue><issue-title>Неврология и психиатрия (1)</issue-title><fpage>7</fpage><lpage>11</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кислова Е.А., Латышева Н.В., Филатова Е.Г., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Кислова Е.А., Латышева Н.В., Филатова Е.Г.</copyright-holder><copyright-holder xml:lang="en">Kislova E.A., Latysheva N.V., Filatova E.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/3012">https://www.med-alphabet.com/jour/article/view/3012</self-uri><abstract><p>Головная боль (ГБ) и лицевая боль широко распространены в практике специализированных центров боли. Однако надежных данных об их распространенности и коморбидности недостаточно.Цель исследования. Оценка представленности различных форм ГБ и орофациальной боли, а также их коморбидности.Методы. Диагноз ГБ и орофациальной боли ставился специалистом по боли на основе осмотра и интервью. Все пациенты заполняли шкалу депрессии Бека (BD I–II) и шкалу Бека для оценки тревоги. Наличие бруксизма оценивалось по самоотчетам пациентов. Результаты. В исследовании приняли участие 310 пациентов: 177 (57 %) пациентов с ГБ, 28 (9 %) пациентов с лицевой болью и 105 (34 %) пациентов с ГБ в сочетании с лицевой болью. Распространенность лицевой боли у пациентов с ГБ составила 37,2 %. Среди форм ГБ превалировала мигрень, среди форм лицевой боли – болевая форма дисфункции височно-нижнечелюстного сустава (ДВНЧС). У пациентов с лицевой болью отмечена высокая распространенность бруксизма сна и бодрствования.Обсуждение. Мигрень и болевая форма ДВНЧС являются наиболее частыми диагнозами у пациентов с ГБ и орофациальной болью в специализированном центре боли. В качестве препаратов первого выбора для терапии мигрени с коморбидной болевой формой ДВНЧС используются НПВС. Среди современных представителей этой группы можно отметить препараты ОКИ и ОКИ АКТ – это хорошо растворимые формы кетопрофена лизиновой соли, обеспечивающие быстрое действие по сравнению с таблетированными НПВП в сочетании с отличной переносимостью</p></abstract><trans-abstract xml:lang="en"><p>Background. Headache and orofacial pain (OFP) are widespread at specialized pain centers. However, reliable data on their prevalence and co-occurrence are lacking, and prevalence of OFP in headache patients seems to be underestimated. The aim of this study was to evaluate the types of headache in patients with OFP and types of OFP in patients with headache.Methods. We enrolled patients presenting with headache and/or OFP. Patients were examined by an experienced headache and pain specialist who questioned the patients about the presence of OFP. Depression was assessed with the Beck Depression Inventory (BDI-II), anxiety – with the Beck Anxiety Inventory (BAI). Bruxism was evaluated based on subject self-report.Results. We recruited 310 patients: 177 (57%) patients with headache, 28 (9%) patients with OFP and 105 (34%) patients presenting with both types of pain. The prevalence of OFP in headache patients was 37.2%. Migraine was the most prevalent type of headache, while painful temporomandibular disorder (TMD) – the most prevalent form of OFP. Patients with PFP presented with a high prevalence of sleep and awake bruxism.Conclusion. Migraine and pain-related TMD are the most prevalent diagnoses in a specialized pain center. OKI and OKI ACT are soluble forms of ketoprofen and reach peak concentration in 15 minutes. This enables faster onset of action compared to conventional NSAIDs and better tolerability. OKI and OKI ACT are recommended in the acute treatment of migraine with comorbid painful TMD.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>головная боль</kwd><kwd>мигрень</kwd><kwd>орофациальная боль</kwd><kwd>дисфункция височно-нижнечелюстного сустава</kwd><kwd>бруксизм</kwd></kwd-group><kwd-group xml:lang="en"><kwd>headache</kwd><kwd>migraine</kwd><kwd>orofacial pain</kwd><kwd>temporomandibular disorder</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Silva T. B., Ortiz F. R., Maracci L. M., Silva G. B., Salbego R. S., Liedke G. S., Marquezan</mixed-citation><mixed-citation xml:lang="en">Silva T. B., Ortiz F. R., Maracci L. M., Silva G. B., Salbego R. S., Liedke G. S., Marquezan</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">M. Association among headache, temporomandibular disorder, and awake bruxism:</mixed-citation><mixed-citation xml:lang="en">M. Association among headache, temporomandibular disorder, and awake bruxism:</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">A cross-sectional study. Headache. 2022; 62 (6): 748–754.</mixed-citation><mixed-citation xml:lang="en">A cross-sectional study. Headache. 2022; 62 (6): 748–754.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Е. В. Фомичев, Е. Н. Ярыгина. Диагностика и лечение синдрома болевой дис-</mixed-citation><mixed-citation xml:lang="en">Е. В. Фомичев, Е. Н. Ярыгина. Диагностика и лечение синдрома болевой дис-</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">функции височно-нижнечелюстного сустава. Вестник Волгоградского государ-</mixed-citation><mixed-citation xml:lang="en">функции височно-нижнечелюстного сустава. Вестник Волгоградского государ-</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">ственного медицинского университета. 2015. № 3 (55). С. 133–135.</mixed-citation><mixed-citation xml:lang="en">ственного медицинского университета. 2015. № 3 (55). С. 133–135.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">E. V. Fomichev, E. N. Yarygin. Diagnosis and treatment of temporomandibular joint</mixed-citation><mixed-citation xml:lang="en">E. V. Fomichev, E. N. Yarygin. Diagnosis and treatment of temporomandibular joint</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">pain dysfunction syndrome. Bulletin of the Volgograd State Medical University. 2015.</mixed-citation><mixed-citation xml:lang="en">pain dysfunction syndrome. Bulletin of the Volgograd State Medical University. 2015.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">No. 3 (55). Pp. 133–135.</mixed-citation><mixed-citation xml:lang="en">No. 3 (55). Pp. 133–135.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Kulkarni S., et al. Evaluating the effectiveness of nonsteroidal anti-inflammatory drug</mixed-citation><mixed-citation xml:lang="en">Kulkarni S., et al. Evaluating the effectiveness of nonsteroidal anti-inflammatory drug</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">for relief of pain associated with temporomandibular joint disorders: A systematic</mixed-citation><mixed-citation xml:lang="en">for relief of pain associated with temporomandibular joint disorders: A systematic</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">review. Clin Exp Dent Res. 2020; 6 (1): 134–146.</mixed-citation><mixed-citation xml:lang="en">review. Clin Exp Dent Res. 2020; 6 (1): 134–146.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Marmura M. J., Silberstein S. D., Schwedt T. J. The acute treatment of migraine in</mixed-citation><mixed-citation xml:lang="en">Marmura M. J., Silberstein S. D., Schwedt T. J. The acute treatment of migraine in</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">adults: the American headache society evidence assessment of migraine pharmacotherapies.</mixed-citation><mixed-citation xml:lang="en">adults: the American headache society evidence assessment of migraine pharmacotherapies.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Headache. 2015; 55 (1): 3–20.</mixed-citation><mixed-citation xml:lang="en">Headache. 2015; 55 (1): 3–20.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Мигрень. Клинические рекомендации МЗРФ. 2021. https://cr.minzdrav.gov.ru/</mixed-citation><mixed-citation xml:lang="en">Мигрень. Клинические рекомендации МЗРФ. 2021. https://cr.minzdrav.gov.ru/</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">schema/295_2 (Доступ 01/02/23)</mixed-citation><mixed-citation xml:lang="en">schema/295_2 (Доступ 01/02/23)</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Migraine. Clinical recommendations of the MZRF. 2021. https://cr.minzdrav.gov.ru/</mixed-citation><mixed-citation xml:lang="en">Migraine. Clinical recommendations of the MZRF. 2021. https://cr.minzdrav.gov.ru/</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">schema/295_2 (Accessed 01/02/23)</mixed-citation><mixed-citation xml:lang="en">schema/295_2 (Accessed 01/02/23)</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Филатова Е. Г., Осипова В. В., Табеева Г. Р. и др. Диагностика и лечение мигрени:</mixed-citation><mixed-citation xml:lang="en">Филатова Е. Г., Осипова В. В., Табеева Г. Р. и др. Диагностика и лечение мигрени:</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">рекомендации российских экспертов. Неврология, нейропсихиатрия, психо-</mixed-citation><mixed-citation xml:lang="en">рекомендации российских экспертов. Неврология, нейропсихиатрия, психо-</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">соматика. 2020; 12 (4): 4–14.</mixed-citation><mixed-citation xml:lang="en">соматика. 2020; 12 (4): 4–14.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Filatova E. G., Osipova V. V., Tabeeva G. R. Diagnosis and treatment of migraine:</mixed-citation><mixed-citation xml:lang="en">Filatova E. G., Osipova V. V., Tabeeva G. R. Diagnosis and treatment of migraine:</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Recommendations of Russian experts. Neurology, neuropsychiatry, psychosomatics.</mixed-citation><mixed-citation xml:lang="en">Recommendations of Russian experts. Neurology, neuropsychiatry, psychosomatics.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">; 12 (4): 4–14.</mixed-citation><mixed-citation xml:lang="en">; 12 (4): 4–14.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Panerai A. E., Lanata L., Ferrari M., et al. A new ketoprofen lysine salt formulation:</mixed-citation><mixed-citation xml:lang="en">Panerai A. E., Lanata L., Ferrari M., et al. A new ketoprofen lysine salt formulation:</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">mg orodispersible granules. Trends Med 2012; 12 (4): 159–167.</mixed-citation><mixed-citation xml:lang="en">mg orodispersible granules. Trends Med 2012; 12 (4): 159–167.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Novelli R, Aramini A, Boccella S, Bagnasco M, Cattani F, Ferrari MP, Goisis G, Minnella</mixed-citation><mixed-citation xml:lang="en">Novelli R, Aramini A, Boccella S, Bagnasco M, Cattani F, Ferrari MP, Goisis G, Minnella</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">EM, Allegretti M, Pace V. Ketoprofen lysine salt has a better gastrointestinal</mixed-citation><mixed-citation xml:lang="en">EM, Allegretti M, Pace V. Ketoprofen lysine salt has a better gastrointestinal</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">and renal tolerability than ketoprofen acid: A comparative tolerability study in the</mixed-citation><mixed-citation xml:lang="en">and renal tolerability than ketoprofen acid: A comparative tolerability study in the</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Beagle dog. Biomed Pharmacother. 2022 Sep;153:113336.</mixed-citation><mixed-citation xml:lang="en">Beagle dog. Biomed Pharmacother. 2022 Sep;153:113336.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">OKI: Summary of Product Characteristics.</mixed-citation><mixed-citation xml:lang="en">OKI: Summary of Product Characteristics.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Natale F. Studio in soggetti volontari sani della biodisponibilità relativa e della farmacocinetica</mixed-citation><mixed-citation xml:lang="en">Natale F. Studio in soggetti volontari sani della biodisponibilità relativa e della farmacocinetica</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">di ketoprofen dopo somministrazione per via orale sotto forma di sale</mixed-citation><mixed-citation xml:lang="en">di ketoprofen dopo somministrazione per via orale sotto forma di sale</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">di lisina in formulazione bustine di granulato (dose singola e ripetuta) e in forma di</mixed-citation><mixed-citation xml:lang="en">di lisina in formulazione bustine di granulato (dose singola e ripetuta) e in forma di</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">ketoprofen acido formulato in capsule. Report Interno Dompè 1991.</mixed-citation><mixed-citation xml:lang="en">ketoprofen acido formulato in capsule. Report Interno Dompè 1991.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Пилипович А. А., Данилов А. Б., Симонов С. Г. Боль в шее: причины и подходы</mixed-citation><mixed-citation xml:lang="en">Пилипович А. А., Данилов А. Б., Симонов С. Г. Боль в шее: причины и подходы</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">к лечению. РМЖ. 2012. С. 18.</mixed-citation><mixed-citation xml:lang="en">к лечению. РМЖ. 2012. С. 18.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Pilipovich A. A., Danilov A. B., Simonov S. G. Neck pain: causes and treatment approaches.</mixed-citation><mixed-citation xml:lang="en">Pilipovich A. A., Danilov A. B., Simonov S. G. Neck pain: causes and treatment approaches.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">breast cancer. 2012. P. 18.</mixed-citation><mixed-citation xml:lang="en">breast cancer. 2012. P. 18.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
