medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2022-35-23-28medalphabet-2956Research ArticleСтатьиПрименение устекинумаба при вульвовагинальном поражении, ассоциированном с болезнью Крона (клинический случай)Use of ustekinumab in vulvovaginal lesions associated with Crohn's disease (clinical case)СегальА. М.SegalA. M.

Сегаль Анастасия Михайловна - врач-гастроэнтеролог, заведующая поликлиническим отделением для оказания медицинской помощи больным воспалительными заболеваниями кишечника.

Санкт-Петербург

Anastasia M. Segal - gastroenterologist, head of Outpatient Dept for Providing Medical Care to Patients with Inflammatory Bowel Diseases.

St. Petersburg

segalam@mail.ruЛозовскаяН. Л.LozovskayaN. L.

Лозовская Наталия Леонидовна - врач-гастроэнтеролог поликлинического отделения для оказания медицинской помощи больным воспалительными заболеваниями кишечника.

Санкт-Петербург

Natalia L. Lozovskaya - gastroenterologist of Outpatient Dept for Providing Medical Care to Patients with Inflammatory Bowel Diseases.

St. Petersburg

shinale@mail.ruМардамшинаЕ. А.MardamshinaE. A.

Мардамшина Екатерина Андреевна - врач-гастроэнтеролог поликлинического отделения для оказания медицинской помощи больным воспалительными заболеваниями кишечника.

Санкт-Петербург

Ekaterina A. Mardamshina - gastroenterologist of Outpatient Dept for Providing Medical Care to Patients with Inflammatory Bowel Diseases.

St. Petersburg

katerinka251986@mail.ruМарковаЕ. A.MarkovaE. A.

Маркова Елена Анатольевна - врач-эндоскопист, заведующая эндоскопическим отделением.

Санкт-Петербург

Elena A. Markova - endoscopist, head of Endoscopic Dept.

St. Petersburg

markova2408@mail.ruРатниковаО. А.RatnikovaO. A.

Ратникова Оксана Александровна - врач-гастроэнтеролог поликлинического отделения для оказания медицинской помощи больным воспалительными заболеваниями кишечника.

Санкт-Петербург

Oksana A. Ratnikova - gastroenterologist of Outpatient Dept for Providing Medical Care to Patients with Inflammatory Bowel Diseases.

St. Petersburg

edvard7713@mail.ruГородской центр диагностики и лечения воспалительных заболеваний кишечника Городской клинической больницы № 31РоссияCity Centre for Diagnosis and Treatment of Inflammatory Bowel Diseases of City Clinical Hospital No. 31Russian Federation202212012023035«Практическая гастроэнтерология» (4) Эпидемиология, инфекционные болезни, гигиена2328Copyright © Сегаль А.М., Лозовская Н.Л., Мардамшина Е.А., Маркова Е.A., Ратникова О.А., 20232023Сегаль А.М., Лозовская Н.Л., Мардамшина Е.А., Маркова Е.A., Ратникова О.А.Segal A.M., Lozovskaya N.L., Mardamshina E.A., Markova E.A., Ratnikova O.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/2956

Поражение вульвы и влагалища при болезни Крона (БК) является редким и плохо диагностируется, поскольку рассматривается множество других, более вероятных воспалительных процессов в этой зоне. Поздняя диагностика и неэффективность лечения приводят к развитию осложнений, снижению качества жизни женщин. Представлен клинический случай поражения вульвовагинальной зоны у молодой пациентки, расцененного как внекишечная (метастатическая) БК. В представленном клиническом случае показана эффективность лечения препаратом устекинумаб БК, плохо поддающейся контролю, и внекишечных проявлений данного заболевания, в частности продемонстрирована эффективность лечения хронического вульвовагинита.

Involvement of the vulva and vagina in Crohn's disease (CD) is rare and underdiagnosed because many other more likely inflammatory processes in this area are considered. Late diagnosis and ineffectiveness of treatment lead to the development of complications, a decrease in the quality of life of women. A clinical case of a lesion of the vulvovaginal zone in a young patient, regarded as extraintestinal (metastatic) CD, is presented. The presented clinical case shows the effectiveness of treatment with ustekinumab for poorly controlled CD and extraintestinal manifestations of this disease, in particular, the effectiveness of treatment of chronic vulvovaginitis has been demonstrated.

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The authors declare that there are no conflicts of interest present.