medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2022-31-46-49medalphabet-2941Research ArticleСтатьиБронхоальвеолярный лаваж в детской онкогематологииBronchoalveolar lavage in pediatric oncohematologyhttps://orcid.org/0000-0002-0868-3948КрыловецкаяМ. А.KrylovetskayaM. A.

Крыловецкая Мария Александровна, врач-эндоскопист эндоскопического отделения

Москва

Krylovetskaya Maria A., Endoscopist of Endoscopy Dept

Moscow

https://orcid.org/0000-0001-6179-1115ГусароваО. А.GusarovaO. A.

Гусарова Ольга Андреевна, врач-ординатор-эндоскопист эндоскопического отделения

Москва

Gusarova Olga A., resident endoscopist at Endoscopy Dept

Moscow

o.a.gusarova@mail.ruhttps://orcid.org/0000-0003-4246-0200СавосинР. С.SavosinR. S.

Савосин Руслан Сергеевич, врач-эндоскопист эндоскопического отделения

Москва

Savosin Ruslan S., endoscopist of Endoscopy Dept

Moscow

https://orcid.org/0000-0002-1469-2365ВалиевТ. Т.ValievT. T.

Валиев Тимур Теймуразович, д.м.н., в.н.с., врач – детский онколог, гематолог, зав. отделением детской онкологии и гематологии № 1

Москва

Valiev Timur T., DM Sci (habil.), leading researcher, pediatric oncologist, hematologist, head of Dept of Pediatric Oncology and Hematology No. 1

Moscow

КувшиновЮ. П.KuvshinovY. P.

Кувшинов Юрий Павлович, в.н.с., врач-эндоскопист, проф. эндоскопического отделения

Москва

Kuvshinov Yury P., leading researcher, endoscopist, professor at Endoscopy Dept

Moscow

https://orcid.org/0000-0003-4294-1995ГригорьевскаяЗ. В.GrigorievskayaZ. V.

Григорьевская Злата Валерьевна, д.м.н., врач-бактериолог, зав. микробиологической лабораторией

Москва

Grigorievskaya Zlata V., DM Sci (habil.), bacteriologist, head of Microbiological Laboratory

Moscow

https://orcid.org/0000-0003-0829-7809МалиховаО. А.MalikhovaO. A.

Малихова Ольга Александровна, д.м.н., врач-эндоскопист, зав. эндоскопическим отделением, проф. кафедры онкологии и паллиативной медицины

Москва

Malikhova Olga A., DM Sci (habil.), endoscopist, head of Endoscopic Dept, professor at Dept of Oncology and Palliative Medicine

Moscow

https://orcid.org/0000-0001-5863-5197ТуманянА. О.TumanyanA. O.

Туманян Армен Овикович, д.м.н., с.н.с. научно-консультативного отделения

Москва

Tumanyan Armen O., DM Sci (habil.), senior researcher Scientific Advisory Office

Moscow

ФГБУ «Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина» Минздрава РоссииРоссияNational Medical Research Centre of Oncology n.a. N.N. BlokhinRussian FederationФГБУ «Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина» Минздрава России; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» Минздрава РоссииРоссияNational Medical Research Centre of Oncology n.a. N.N. Blokhin; Russian Medical Academy for Continuing Professional EducationRussian Federation202211012023031Диагностика и онкотерапия (4)4649Copyright © Крыловецкая М.А., Гусарова О.А., Савосин Р.С., Валиев Т.Т., Кувшинов Ю.П., Григорьевская З.В., Малихова О.А., Туманян А.О., 20232023Крыловецкая М.А., Гусарова О.А., Савосин Р.С., Валиев Т.Т., Кувшинов Ю.П., Григорьевская З.В., Малихова О.А., Туманян А.О.Krylovetskaya M.A., Gusarova O.A., Savosin R.S., Valiev T.T., Kuvshinov Y.P., Grigorievskaya Z.V., Malikhova O.A., Tumanyan A.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/2941Актуальность

Актуальность. Поражение легочной ткани инфекционной этиологии у детей с онкогематологическими заболеваниями встречается часто и в некоторых случаях может сопровождаться летальным исходом. При поражении легочной ткани на фоне аплазии кроветворения в постхимиотерапевтическом периоде показано проведение бронхоскопии с целью определения генеза выявленных изменений.  

Цель

Цель. Определение диагностической ценности бронхоскопии с БАЛ у детей с онкогематологическими заболеваниями. Материалы и методы. На базе эндоскопического отделения НИИ детской онкологии и гематологии было выполнено 25 бронхоскопических исследования с проведением БАЛ.  

Результаты

Результаты. По результатам микробиологического исследования в 72 % случаев отмечен рост возбудителя. Наиболее частыми возбудителями, полученными по результатам посевов, оказались Haemophilus parainfluenzae, Streptococcus oralis, Neisseria macacae, Streptococcus peroris и Pseudomonas aeruginosa.  

Заключение

Заключение. Бронхоскопия с БАЛ у детей с опухолями системы крови является высокоинформативным методом обнаружения возбудителя и определения этиологической причины инфильтративно-воспалительных изменений в легких. 

Relevance

Relevance. Pulmonary lesions of infectious etiology in oncohematological children are common and, in some cases, may be accompanied by a lethal outcome. When pulmonary tissue lesions on the background of hematopoiesis aplasia in the post-chemotherapy period is shown bronchoscopy to determine the genesis of the identified changes.

Aim

Aim. To determine the diagnostic value of bronchoscopy with BAL in children with oncohematological diseases.

Materials and methods

Materials and methods. 25 bronchoscopies with BAL were performed on the basis of the endoscopic department of the Research Institute of Pediatric Oncology and Hematology.

Results

Results. According to the results of the study in 72% of cases a microbiologic agent was detected. The most frequent pathogens obtained by the results of cultures were Haemophilus parainfluenzae, Streptococcus oralis, Neisseria macacae, Streptococcus peroris and Pseudomonas aeruginosa.

Conclusions

Conclusions. Bronchoscopy with BAL in children with blood system tumors is a highly informative method of pathogen detection and determination of the etiological cause of infiltrative-inflammatory changes in the lungs.

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The authors declare that there are no conflicts of interest present.