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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medalphabet-290</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Ведение пациента с рефрактерным течением гастроэзофагеальной рефлюксной болезни</article-title><trans-title-group xml:lang="en"><trans-title>Clinical management of patient with refractory gastroesophageal reflux disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чукаева</surname><given-names>И. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Chukaeva</surname><given-names>I. I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Орлова</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Orlova</surname><given-names>N. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Российский национальный исследовательский медицинский университет имени Н. И. Пирогова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian National Research Medical University n.a. N. I. Pirogov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>03</day><month>11</month><year>2017</year></pub-date><volume>2</volume><issue>34</issue><issue-title>Современная поликлиника</issue-title><fpage>22</fpage><lpage>27</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Чукаева И.И., Орлова Н.В., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Чукаева И.И., Орлова Н.В.</copyright-holder><copyright-holder xml:lang="en">Chukaeva I.I., Orlova N.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/290">https://www.med-alphabet.com/jour/article/view/290</self-uri><abstract><p>Гастроэзофагеальная рефлюксная болезнь - широко распространенная патология среди населения. Ведением больных ГЭРБ занимаются не только гастроэнтерологи, но также врачи общей практики и терапевты. Для эффективного лечения важно знание медикаментозных и немедикаментозных методов лечения. Немедикаментозное лечение включает модификацию факторов риска, провоцирующих обострение: ожирение, курение, наклоны туловища тела. Важным методом лечения является соблюдение диеты. Лечение включает назначение ингибиторов протонной помпы, антацидов, прокинетиков, при выявлении Helicobacter pylori проводится эрадикационная терапия. Одной из частых причин рефрактерности к стандартной терапии является наличие гастродуоденального рефлюкса. Эффективность терапии повышается при добавлении к лечению препаратов урсодезоксихолевой кислоты.</p></abstract><trans-abstract xml:lang="en"><p>Gastroesophageal reiflux disease is a widespread pathology. The management of patients with GERD is not limited to gastroenterologists, but also to general practitioners and therapists. For effective treatment, it is important to know the drug and non-drug methods of treatment. Non-drug treatment includes modification of risk factors that trigger an exacerbation: obesity, smoking, body torso. The diet is an important method of treatment. Treatment includes the prescription of inhibitors of the proton pump, antacids, prokinetic. If Helicobacter pylori is detected, eradication therapy should be carried out. One of the frequent reasons for refractory to standard therapy is gastroduodenal reflux. The addition of ursodeoxycholic acid to treatment increases the effectiveness of therapy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>гастроэзофагеальная рефлюксная болезнь</kwd><kwd>пищевод</kwd><kwd>гастродуоденальный рефлюкс</kwd><kwd>урсодезоксихолевая кислота</kwd></kwd-group><kwd-group xml:lang="en"><kwd>gastroesophageal reflux disease</kwd><kwd>esophagus</kwd><kwd>gastroduodenal reflux</kwd><kwd>ursodeoxycholic acid</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Nandurkar S., et al. Rates of Endoscopy and Endoscopic Findings Among People With Frequent Symptoms of Gastroesophageal Reflux in the Community. Am J Gastroenterol. 2005; J00 (7): J459-J465.</mixed-citation><mixed-citation xml:lang="en">Nandurkar S., et al. Rates of Endoscopy and Endoscopic Findings Among People With Frequent Symptoms of Gastroesophageal Reflux in the Community. 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