medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2022-28-23-27medalphabet-2890Research ArticleСтатьиСовременные аспекты патогенетически обоснованной фитотерапии хронического атрофического гастритаModern aspects of pathogenetically based phytotherapy of chronic atrophic gastritishttps://orcid.org/0000-0002-7603-8481АхмедовВ. А.AkhmedovV. A.

Ахмедов Вадим Адильевич, д.м.н., проф., зав. кафедрой медицинской реабилитации ДПО

г. Омск

Akhmedov Vadim A., DM Sci (habil), professor, head of Dept of Medical Rehabilitation of Additional Professional Education 

Omsk

v_akhmedov@mail.ruФГБОУ ВО «Омский государственный медицинский университет» Минздрава РоссииРоссияOmsk State Medical UniversityRussian Federation202212122022128Практическая гастроэнтерология (3)2327Copyright © Ахмедов В.А., 20222022Ахмедов В.А.Akhmedov V.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/2890

Хронический атрофический гастрит является наиболее распространенной причиной смерти от онкологических заболеваний и занимает второе место среди других причин смерти, связанных с раком, во всем мире. В представленной обзорной статье проводится анализ новых патогенетически обоснованных методов терапии хронического атрофического гастрита на основе экспериментальных и клинических исследований, представленных в современной литературе, включая анализ рандомизированных клинических исследований, систематических обзоров и метаанализов. На основе проведенного анализа намечены перспективы применения новых методов фитотерапии хронического атрофического гастрита.

Chronic atrophic gastritis is the most common cause of death from cancer and ranks second among other cancer-related causes of death worldwide. The presented review article analyzes new pathogenetically justified methods of therapy for chronic atrophic gastritis based on experimental and clinical studies presented in the modern literature, including the analysis of randomized clinical trials, systematic reviews and meta-analyses. Based on the analysis, the prospects for the use of new methods of phytotherapy in chronic atrophic gastritis are outlined.

хронический атрофический гастриттерапияобзорchronic atrophic gastritisphytotherapyreviewReferencesRugge M, Genta RM, Graham DY et al. Chronicles of a cancer foretold: 35 years of gastric cancer risk assessment. Gut. 2016; 65 (5): 721–725. DOI: 10.1136/gutjnl-2015–310846.Rugge M, Genta RM, Graham DY et al. Chronicles of a cancer foretold: 35 years of gastric cancer risk assessment. Gut. 2016; 65 (5): 721–725. DOI: 10.1136/gutjnl-2015–310846.Torre LA, Bray F, Siegel RL et al. Global cancer statistics, 2012. CA Cancer J Clin. 2015; 65 (2): 87–108. DOI: 10.3322/caac.21262.Torre LA, Bray F, Siegel RL et al. Global cancer statistics, 2012. CA Cancer J Clin. 2015; 65 (2): 87–108. DOI: 10.3322/caac.21262.Park YH, Kim N. Review of atrophic gastritis and intestinal metaplasia as a premalignant lesion of gastric cancer. J Cancer Prev. 2015; 20 (1): 25–40. DOI: 10.15430/JCP.2015.20.1.25.Park YH, Kim N. Review of atrophic gastritis and intestinal metaplasia as a premalignant lesion of gastric cancer. J Cancer Prev. 2015; 20 (1): 25–40. DOI: 10.15430/JCP.2015.20.1.25.Ohkusa T, Fujiki K, Takashimizu I et al. Improvement in atrophic gastritis and intestinal metaplasia in patients in whom Helicobacter pylori was eradicated. Ann Intern Med. 2001; 134 (5): 380–386. DOI: 10.7326/0003–4819–134–5–200103060–00010.Ohkusa T, Fujiki K, Takashimizu I et al. Improvement in atrophic gastritis and intestinal metaplasia in patients in whom Helicobacter pylori was eradicated. Ann Intern Med. 2001; 134 (5): 380–386. DOI: 10.7326/0003–4819–134–5–200103060–00010.Matysiak-Budnik T, Camargo MC, Piazuelo MB, Leja M. Recent Guidelines on the Management of Patients with Gastric Atrophy: Common Points and Controversies. Dig Dis Sci. 2020; 65 (7): 1899–1903. DOI: 10.1007/s10620–020–06272–9.Matysiak-Budnik T, Camargo MC, Piazuelo MB, Leja M. Recent Guidelines on the Management of Patients with Gastric Atrophy: Common Points and Controversies. Dig Dis Sci. 2020; 65 (7): 1899–1903. DOI: 10.1007/s10620–020–06272–9.Ливзан М.А., Гаус О.В., Мозговой С.И. Хронический атрофический гастрит: тактика курации пациента. РМЖ. Медицинское обозрение. 2021; 5 (6): 427–432. DOI: 10.32364/2587–6821–2021–5–6–427–432. Livzan M.A., GausO.V., Mozgovoy S.I. Chronic atrophic gastritis: tactics of patient management. breast cancer. Medical review. 2021; 5(6):427–432. DOI: 10.32364/2587–6821–2021–5–6–427–432.Ливзан М.А., Гаус О.В., Мозговой С.И. Хронический атрофический гастрит: тактика курации пациента. РМЖ. Медицинское обозрение. 2021; 5 (6): 427–432. DOI: 10.32364/2587–6821–2021–5–6–427–432. Livzan M.A., GausO.V., Mozgovoy S.I. Chronic atrophic gastritis: tactics of patient management. breast cancer. Medical review. 2021; 5(6):427–432. DOI: 10.32364/2587–6821–2021–5–6–427–432.Zhou P, Hao X, Liu Y et al. Determination of the protective effects of Hua-Zhuo-Jie-Du in chronic atrophic gastritis by regulating intestinal microbiota and metabolites: combination of liquid chromatograph mass spectrometer metabolic profiling and 16S rRNA gene sequencing. Y. Chin Med. 2021; 16 (1): 37. DOI: 10.1186/s13020–021–00445-y.Zhou P, Hao X, Liu Y et al. Determination of the protective effects of Hua-Zhuo-Jie-Du in chronic atrophic gastritis by regulating intestinal microbiota and metabolites: combination of liquid chromatograph mass spectrometer metabolic profiling and 16S rRNA gene sequencing. Y. Chin Med. 2021; 16 (1): 37. DOI: 10.1186/s13020–021–00445-y.Park CH, Lee AR, Lee YR et al. Evaluation of gastric microbiome and metagenomic function in patients with intestinal metaplasia using 16S rRNA gene sequencing. Helicobacter. 2019; 24 (1): e12547. DOI: 10.1111/hel.12547.Park CH, Lee AR, Lee YR et al. Evaluation of gastric microbiome and metagenomic function in patients with intestinal metaplasia using 16S rRNA gene sequencing. Helicobacter. 2019; 24 (1): e12547. DOI: 10.1111/hel.12547.Oliphant K, Allen-Vercoe E. Macronutrient metabolism by the human gut microbiome: major fermentation by-products and their impact on host health. Microbiome. 2019; 7 (1): 91. DOI: 10.1186/s40168–019–0704–8.Oliphant K, Allen-Vercoe E. Macronutrient metabolism by the human gut microbiome: major fermentation by-products and their impact on host health. Microbiome. 2019; 7 (1): 91. DOI: 10.1186/s40168–019–0704–8.Zeng J, Yan R, Pan H, et al. Weipixiao attenuate early angiogenesis in rats with gastric precancerous lesions. BMC Complement Altern Med. 2018; 18 (1): 250. DOI: 10.1186/s12906–018–2309–3.Zeng J, Yan R, Pan H, et al. Weipixiao attenuate early angiogenesis in rats with gastric precancerous lesions. BMC Complement Altern Med. 2018; 18 (1): 250. DOI: 10.1186/s12906–018–2309–3.Huazano-García A, Silva-Adame MB, Vázquez-Martínez J et al. Highly branched neo-fructans (Agavins) attenuate metabolic endotoxemia and low-grade inflammation in association with gut microbiota modulation on high-fat diet-fed mice. Foods. 2020; 9: 12. DOI: 10.3390/foods9121792.Huazano-García A, Silva-Adame MB, Vázquez-Martínez J et al. Highly branched neo-fructans (Agavins) attenuate metabolic endotoxemia and low-grade inflammation in association with gut microbiota modulation on high-fat diet-fed mice. Foods. 2020; 9: 12. DOI: 10.3390/foods9121792.Huang R, Li T, Ni J, et al. Different sex-based responses of gut microbiota during the development of hepatocellular carcinoma in liver-specific Tsc1-knockout mice. Front Microbiol. 2018; 9: 1008. DOI: 10.3389/fmicb.2018.01008.Huang R, Li T, Ni J, et al. Different sex-based responses of gut microbiota during the development of hepatocellular carcinoma in liver-specific Tsc1-knockout mice. Front Microbiol. 2018; 9: 1008. DOI: 10.3389/fmicb.2018.01008.Liu Z, Zhu Z, Zhang H et al. Qualitative and quantitative analysis of Fructus Corni using ultrasound assisted microwave extraction and high-performance liquid chromatography coupled with diode array UV detection and time-of-flight mass spectrometry. J Pharm Biomed Anal 2011; 55: 557–562. DOI: 10.1016/j.jpba.2011.02.007.Liu Z, Zhu Z, Zhang H et al. Qualitative and quantitative analysis of Fructus Corni using ultrasound assisted microwave extraction and high-performance liquid chromatography coupled with diode array UV detection and time-of-flight mass spectrometry. J Pharm Biomed Anal 2011; 55: 557–562. DOI: 10.1016/j.jpba.2011.02.007.Zhang L, Liu Y, You P, Feng G. Occurrence of gastric cancer in patients with atrophic gastritis during long-term follow-up. Scand J Gastroenterol 2018; 53: 843–848. DOI: 10.1080/00365521.2018.1477987.Zhang L, Liu Y, You P, Feng G. Occurrence of gastric cancer in patients with atrophic gastritis during long-term follow-up. Scand J Gastroenterol 2018; 53: 843–848. DOI: 10.1080/00365521.2018.1477987.Zhang J, Wang H. Morroniside protects against chronic atrophic gastritis in rat via inhibiting inflammation and apoptosis. Am J Transl Res. 2019 Sep 15; 11 (9): 6016–6023.Zhang J, Wang H. Morroniside protects against chronic atrophic gastritis in rat via inhibiting inflammation and apoptosis. Am J Transl Res. 2019 Sep 15; 11 (9): 6016–6023.Youcheng HE, Xiaoling Y, Sihan LI, et al. Therapeutic effect of Qinghuayin against chronic atrophic gastritis through the inhibition of toll or interleukin-1 receptor domain-ontaining adaptor inducing interferon-β signaling pathway. J Tradit Chin Med. 2022 Apr; 42 (2): 221–226. DOI: 10.19852/j.cnki.jtcm.2022.02.004.Youcheng HE, Xiaoling Y, Sihan LI, et al. Therapeutic effect of Qinghuayin against chronic atrophic gastritis through the inhibition of toll or interleukin-1 receptor domain-ontaining adaptor inducing interferon-β signaling pathway. J Tradit Chin Med. 2022 Apr; 42 (2): 221–226. DOI: 10.19852/j.cnki.jtcm.2022.02.004.Wen J, Wu S, Ma X. et al. Zuojin Pill attenuates Helicobacter pylori-induced chronic atrophic gastritis in rats and improves gastric epithelial cells function in GES-1 cells. J Ethnopharmacol. 2022; 285: 114855. DOI: 10.1016/j.jep.2021.114855.Wen J, Wu S, Ma X. et al. Zuojin Pill attenuates Helicobacter pylori-induced chronic atrophic gastritis in rats and improves gastric epithelial cells function in GES-1 cells. J Ethnopharmacol. 2022; 285: 114855. DOI: 10.1016/j.jep.2021.114855.Jiang JY, Liu DJ, Liu MX. The protective effect of NF-κB signaling pathway inhibitor PDTC on mice with chronic atrophic gastritis. Scand J Gastroenterol. 2021; 56 (10): 1131–1139. DOI: 10.1080/00365521.2021.1953130.Jiang JY, Liu DJ, Liu MX. The protective effect of NF-κB signaling pathway inhibitor PDTC on mice with chronic atrophic gastritis. Scand J Gastroenterol. 2021; 56 (10): 1131–1139. DOI: 10.1080/00365521.2021.1953130.Tong Y, Zhao X, Wang R, et al. Therapeutic effect of berberine on chronic atrophic gastritis based on plasma and urine metabolisms. Eur J Pharmacol. 2021 Oct 5; 908: 174335. DOI: 10.1016/j.ejphar.2021.174335.Tong Y, Zhao X, Wang R, et al. Therapeutic effect of berberine on chronic atrophic gastritis based on plasma and urine metabolisms. Eur J Pharmacol. 2021 Oct 5; 908: 174335. DOI: 10.1016/j.ejphar.2021.174335.Tong Y, Wang R, Liu X. Et al. Zuojin Pill ameliorates chronic atrophic gastritis induced by MNNG through TGF-β1/PI3K/Akt axis. J Ethnopharmacol. 2021 May 10; 271: 113893. DOI: 10.1016/j.jep.2021.113893.Tong Y, Wang R, Liu X. Et al. Zuojin Pill ameliorates chronic atrophic gastritis induced by MNNG through TGF-β1/PI3K/Akt axis. J Ethnopharmacol. 2021 May 10; 271: 113893. DOI: 10.1016/j.jep.2021.113893.Cao Y, Zheng Y, Niu J, et al. Efficacy of Banxia Xiexin decoction for chronic atrophic gastritis: A systematic review and meta-analysis. PLoS One. 2020 Oct 27; 15 (10): e0241202. DOI: 10.1371/journal.pone.0241202.Cao Y, Zheng Y, Niu J, et al. Efficacy of Banxia Xiexin decoction for chronic atrophic gastritis: A systematic review and meta-analysis. PLoS One. 2020 Oct 27; 15 (10): e0241202. DOI: 10.1371/journal.pone.0241202.Ben-Gang Z, Yu-Zhou M, Xue-Liang Y, et al. Systematic review and Meta-analysis of efficacy and safety of Yangwei Granules for chronic gastritis. Zhongguo Zhong Yao Za Zhi. 2020 Oct; 45 (20): 5008–5016. DOI: 10.19540/j.cnki.cjcmm.20200314.503.Ben-Gang Z, Yu-Zhou M, Xue-Liang Y, et al. Systematic review and Meta-analysis of efficacy and safety of Yangwei Granules for chronic gastritis. Zhongguo Zhong Yao Za Zhi. 2020 Oct; 45 (20): 5008–5016. DOI: 10.19540/j.cnki.cjcmm.20200314.503.Zhang ZD, Liu H, Lyu J. et al. Systematic review and Meta-analysis of efficacy and safety of Xiangsha Yangwei Pills in treatment of chronic gastritis. Zhongguo Zhong Yao Za Zhi. 2020 Jun; 45 (11): 2668–2676. DOI: 10.19540/j.cnki.cjcmm.20200102.502.Zhang ZD, Liu H, Lyu J. et al. Systematic review and Meta-analysis of efficacy and safety of Xiangsha Yangwei Pills in treatment of chronic gastritis. Zhongguo Zhong Yao Za Zhi. 2020 Jun; 45 (11): 2668–2676. DOI: 10.19540/j.cnki.cjcmm.20200102.502.Chen X, Wang R, Bao C. et al. Palmatine ameliorates Helicobacter pylori-induced chronic atrophic gastritis by inhibiting MMP-10 through ADAM17/EGFR. Eur J Pharmacol. 2020 Sep 5; 882: 173267. DOI: 10.1016/j.ejphar.2020.173267.Chen X, Wang R, Bao C. et al. Palmatine ameliorates Helicobacter pylori-induced chronic atrophic gastritis by inhibiting MMP-10 through ADAM17/EGFR. Eur J Pharmacol. 2020 Sep 5; 882: 173267. DOI: 10.1016/j.ejphar.2020.173267.Liu XQ, Wang L. Effect of modified Zhengqi Powder in treating chronic gastritis and on patients' life quality and inflammatory factors. Zhongguo Zhong Yao Za Zhi. 2019 Jan; 44 (1): 181–185. DOI: 10.19540/j.cnki.cjcmm.2019.0004.Liu XQ, Wang L. Effect of modified Zhengqi Powder in treating chronic gastritis and on patients' life quality and inflammatory factors. Zhongguo Zhong Yao Za Zhi. 2019 Jan; 44 (1): 181–185. DOI: 10.19540/j.cnki.cjcmm.2019.0004.Li X, Feng M, Yuan G. Clinical efficacy of Weisu granule combined with Weifuchun tablet in the treatment of chronic atrophic gastritis and its effect on serum G-17, PG I and PG II levels. Am J Transl Res. 2022; 14 (1): 275–284.Li X, Feng M, Yuan G. Clinical efficacy of Weisu granule combined with Weifuchun tablet in the treatment of chronic atrophic gastritis and its effect on serum G-17, PG I and PG II levels. Am J Transl Res. 2022; 14 (1): 275–284.Li S, Huang M, Chen Q. et al. Confirming the Effects of Qinghuayin against Chronic Atrophic Gastritis and a Preliminary Observation of the Involved Inflammatory Signaling Pathways: An In Vivo Study. Evid Based Complement Alternat Med. 2018; 2018: 4905089. DOI: 10.1155/2018/4905089.Li S, Huang M, Chen Q. et al. Confirming the Effects of Qinghuayin against Chronic Atrophic Gastritis and a Preliminary Observation of the Involved Inflammatory Signaling Pathways: An In Vivo Study. Evid Based Complement Alternat Med. 2018; 2018: 4905089. DOI: 10.1155/2018/4905089.Luo C, Sun Z, Li Z. et al. Notoginsenoside R1 (NGR1) Attenuates Chronic Atrophic Gastritis in Rats. Med Sci Monit. 2019; 25: 1177–1186. DOI: 10.12659/MSM.911512.Luo C, Sun Z, Li Z. et al. Notoginsenoside R1 (NGR1) Attenuates Chronic Atrophic Gastritis in Rats. Med Sci Monit. 2019; 25: 1177–1186. DOI: 10.12659/MSM.911512.

The authors declare that there are no conflicts of interest present.