<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2022-27-41-44</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-2865</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>В ПОМОЩЬ ПРАКТИЧЕСКОМУ ВРАЧУ</subject></subj-group></article-categories><title-group><article-title>Периоральный дерматит: современные методы терапии</article-title><trans-title-group xml:lang="en"><trans-title>Perioral dermatitis: Modern methods of therapy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5044-5265</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Круглова</surname><given-names>Л. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kruglova</surname><given-names>L. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Круглова Лариса Сергеевна, д.м.н., проф., зав. кафедройдерматовенерологии и косметологии</p><p> Москва </p></bio><bio xml:lang="en"><p>Kruglova Larisa S., DM Sci (habil.), professor, head of Dept of Dermatovenereology and Cosmetology </p><p> Moscow </p></bio><email xlink:type="simple">kruglovals@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рубцова</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rubtsova</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рубцова Любовь А., ординатор кафедры дерматовенерологии и косметологии</p><p> Москва </p></bio><bio xml:lang="en"><p>Rubtsova L.A., resident at Dept of Dermatovenereology and Cosmetology </p><p> Moscow </p></bio><email xlink:type="simple">lubovrubtz@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central State Medical Academy</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>29</day><month>11</month><year>2022</year></pub-date><volume>1</volume><issue>27</issue><issue-title>Дерматология (2)</issue-title><fpage>41</fpage><lpage>44</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Круглова Л.С., Рубцова Л.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Круглова Л.С., Рубцова Л.А.</copyright-holder><copyright-holder xml:lang="en">Kruglova L.S., Rubtsova L.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/2865">https://www.med-alphabet.com/jour/article/view/2865</self-uri><abstract><p>Одной из наиболее частых причин развития периорального дерматита (ПД) является использование глюкокортикостероидов (местно, интраназально, ингаляционно, системно). Если ПД вызван топическими ГКС, их необходимо отменить (по мнению авторов, без использования щадящей методики снижения: уменьшение кратности нанесения ГКС и силы активности ГКС). При выраженном синдроме отмены целесообразно лечение начинать с нулевой терапии: или полный отказ от применения наружных средств, или примочки с ромашкой (по 5–10 минут 2 раза в день) с последующим использованием дерматолово-ихтиоловой пасты (экспозиция по нарастающей с 10 до 40 минут) на протяжении 7–10 дней, а также орошение гипохлоридной термальной водой (5–6 раз в сутки). При легкой степени тяжести перорального дерматита возможно назначение монотопической терапии, в том числе кремом с активированным цинком пиритионом и ингибиторами кальциневрина. Длительность терапии определяется индивидуально и в среднем составляет 1,0–1,5 месяца. При среднетяжелом и тяжелом течении к топической терапии следует добавить системные препараты –антибиотики тетрациклинового ряда (7–10 дней) или изотретиноин в низких дозах (2–4 месяца). Длительность терапии определяется индивидуально и в среднем составляет 2 месяца.</p></abstract><trans-abstract xml:lang="en"><p>One of the most common causes of perioral dermatitis (PD) is the use of glucocorticosteroids (topically, intranasally, inhaled, systemically). If PD is caused by topical corticosteroids, they must be canceled (according to the authors, without using a sparing reduction technique: a decrease in the frequency of application of corticosteroids and the strength of corticosteroid activity). With a pronounced withdrawal syndrome, it is advisable to start treatment with ‘zero’ therapy: either a complete rejection of the use of external agents, or a lotion with chamomile (5–10 minutes 2 times a day) followed by the use of dermatolichthyol paste (exposure in increasing from 10 minutes to 40 minutes) for 7–10 days, as well as irrigation with hypochlorite thermal water (5–6 times a day). With mild severity of oral dermatitis, monotopic therapy may be prescribed, including cream with activated zinc pyrithione and calcineurin inhibitors. The duration of therapy is determined individually and averages 1.0–1.5 months. In moderate to severe cases, topical therapy should be supplemented with systemic drugs: tetracycline antibiotics (7–10 days) or low-dose isotretinoin (2–4 months). The duration of therapy is determined individually and averages 2 months.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>периоральный дерматит</kwd><kwd>стероидная розацеа</kwd><kwd>этиология</kwd><kwd>патогенез</kwd><kwd>терапия</kwd><kwd>активированный цинк пиритион</kwd></kwd-group><kwd-group xml:lang="en"><kwd>perioral dermatitis</kwd><kwd>steroid rosacea</kwd><kwd>etiology</kwd><kwd>pathogenesis</kwd><kwd>therapy</kwd><kwd>activated zinc pyrithione</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Клинические рекомендации. Периоральный дерматит. М.: РОДВК. 2020.</mixed-citation><mixed-citation xml:lang="en">Clinical guidelines. Perioral dermatitis. Moscow: RODVK. 2020. In Russian.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Hoepfner A. et al. Rosacea and perioral dermatitis: A single-center retrospective analysis of the clinical presentation of 1032 patients. JDDG: Journal der Deutschen Dermatologischen Gesellschaft. 2020. V. 18. No. 6. P. 561–570. https://doi.org/10.1111/ddg.14120</mixed-citation><mixed-citation xml:lang="en">Hoepfner A. et al. Rosacea and perioral dermatitis: A single-center retrospective analysis of the clinical presentation of 1032 patients. JDDG: Journal der Deutschen Dermatologischen Gesellschaft. 2020. V. 18. No. 6. P. 561–570. https://doi.org/10.1111/ddg.14120</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Tolaymat L., Hall M.R. Perioral Dermatitis. 2022 May 27. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan. PMID: 30247843.</mixed-citation><mixed-citation xml:lang="en">Tolaymat L., Hall M.R. Perioral Dermatitis. 2022 May 27. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan. PMID: 30247843.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Searle T., Ali F.R., Al-Niaimi F. Perioral dermatitis: Diagnosis, proposed etiologies, and management. Journal of Cosmetic Dermatology. 2021. V. 20. No. 12. P. 3839–3848. https://doi.org/10.1111/jocd.14060</mixed-citation><mixed-citation xml:lang="en">Searle T., Ali F.R., Al-Niaimi F. Perioral dermatitis: Diagnosis, proposed etiologies, and management. Journal of Cosmetic Dermatology. 2021. V. 20. No. 12. P. 3839–3848. https://doi.org/10.1111/jocd.14060</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Kang S. et al. Fitzpatrick’s Dermatology 9th Edition. Vol. 2. 2 vols. 2019.</mixed-citation><mixed-citation xml:lang="en">Kang S. et al. Fitzpatrick’s Dermatology 9th Edition. Vol. 2. 2 vols. 2019.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Gray N.A. et al. Pharmacological interventions for periorificial (perioral) dermatitis in children and adults: A systematic review. Journal of the European Academy of Dermatology and Venereology. 2022. V. 36. No. 3. P. 380–390. https://doi.org/10.1111/jdv.17817</mixed-citation><mixed-citation xml:lang="en">Gray N.A. et al. Pharmacological interventions for periorificial (perioral) dermatitis in children and adults: A systematic review. Journal of the European Academy of Dermatology and Venereology. 2022. V. 36. No. 3. P. 380–390. https://doi.org/10.1111/jdv.17817</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Charnowski S., Wollenberg A., Reinholz M. Perioral dermatitis successfully treated with topical ivermectin. Annals of Dermatology. 2019. V. 31. No. Suppl. P. S27–S28. https://doi.org/10.5021/ad.2019.31.S.S27</mixed-citation><mixed-citation xml:lang="en">Charnowski S., Wollenberg A., Reinholz M. Perioral dermatitis successfully treated with topical ivermectin. Annals of Dermatology. 2019. V. 31. No. Suppl. P. S27–S28. https://doi.org/10.5021/ad.2019.31.S.S27</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Акне и розацеа. Под редакцией Кругловой Л.С. ГЭОТАР-Медиа. 2021. 207 с.</mixed-citation><mixed-citation xml:lang="en">Acne and rosacea. Edited by Kruglova L.S. GEOTAR-Media. 2021. 207 p. In Russian.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Круглова Л.С., Котенко К.В., Корчажкина Н.Б., Турбовская С.Н. Физиотерапия в дерматологии. Москва. ГЭОТАР. 2016. 304 с.</mixed-citation><mixed-citation xml:lang="en">Kruglova L.S., Kotenko K.V., Korchazhkina N.B., Turbovskaya S.N. Physiotherapy in dermatology. Moscow. GEOTAR. 2016. 304 p. In Russian.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
