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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2022-27-37-40</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-2864</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>В ПОМОЩЬ ПРАКТИЧЕСКОМУ ВРАЧУ</subject></subj-group></article-categories><title-group><article-title>Новые подходы в терапии розацеа с сочетанными фенотипами</article-title><trans-title-group xml:lang="en"><trans-title>Current issues in treatment of patients with combination of rosacea subtypes</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5995-6689</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Матушевская</surname><given-names>Ю. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Matushevskaya</surname><given-names>Yu. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Матушевская Юлия Игоревна, к.м.н., гл. врач</p><p>Люберцы </p></bio><bio xml:lang="en"><p>Matushevskaya Yuliya I., PhD Med, chief physician</p><p>Lyubertsy </p></bio><email xlink:type="simple">yuliya-matushevskaya@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ МО «Люберецкий кожно-венерологический диспансер», г. Люберцы</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Lyubertsy Dermatovenerologic Dispensary</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>28</day><month>11</month><year>2022</year></pub-date><volume>1</volume><issue>27</issue><issue-title>Дерматология (2)</issue-title><fpage>37</fpage><lpage>40</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Матушевская Ю.И., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Матушевская Ю.И.</copyright-holder><copyright-holder xml:lang="en">Matushevskaya Y.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/2864">https://www.med-alphabet.com/jour/article/view/2864</self-uri><abstract><p>Актуальность. Розацеа – хронический кожный синдром, охватывающий различные комбинации потенциальных признаков и симптомов. Глобальные эпидемиологические исследования установили, что розацеа страдают 5,46% взрослого населения. Комбинированные методы (лекарственные средства и аппаратные методы, в том числе лазеры) в лечении розацеа имеют высокий потенциал. Актуальным является исследование эффективности ивермектина и лазерных технологий у пациентов с сочетанием подтипов розацеа.Материал и методы. Под наблюдением находилось 36 пациентов с сочетанием подтипов розацеа. В зависимости от терапии пациенты были распределены на две группы: I группа (18 пациентов) – пациенты получили процедуры неодимового лазера и топическую терапию ивермектином; II группа (16 пациентов) – топическую терапию с применением ивермектина. Оценка эффективности проводилась с использованием визиосканирования, с учетом дерматологического индекса GSS (Global Severity Sсore), дерматологического индекса шкалы симптомов (ДИШС).Результаты исследования. По данным суммарного индекса ДИШС, через 2 месяца наибольшая эффективность в купировании и воспаления, и сосудистого компонента наблюдалась в I группе (75,2%) несколько ниже – во II группе (49,5%). В дальнейшем отмечалось усиление эффекта: через 3 месяца суммарный индекс ДИШС в I группе снизился на 85,1%, в то время как во II группе – на 58,5%, через 6 месяцев суммарный индекс ДИШС в I группе снизился на 91,5%, в то время как во II группе – на 65,6%.Выводы. Комбинированное применение неодимового лазера и ивермектина является высокоэффективным и безопасным методом терапии у пациентов с сочетанием эритемато-телеангиэктатического и папуло-пустулезного подтипов розацеа.</p></abstract><trans-abstract xml:lang="en"><p>Relevance. Rosacea is a chronic skin syndrome that encompasses various combinations of potential signs and symptoms. Global epidemiological studies have found that 5.46% of the adult population suffers from rosacea. Combined methods (drugs and hardware methods, including lasers) in the treatment of rosacea have a high potential. Relevant is the study of the effectiveness of ivermectin and laser technologies in patients with a combination of subtypes of rosacea.Material and methods. 36 patients with a combination of rosacea subtypes were under observation. Depending on the therapy, the patients were divided into two groups: group 1 (18 patients) – patients received neodymium laser procedures and topical therapy with ivermectin, group 2 (16 patients) – topical therapy using ivermectin. Efficiency was assessed using visioscanning, taking into account the dermatological index GSS (Global Severity Score), the dermatological index of the scale of symptoms (DISHS).Research results. According to the total index of DISH after 2 months, the highest efficiency in stopping both inflammation and the vascular component was observed in group 1 (75.2%), somewhat lower – in group 2 (49.5%). month, the total DISH index in group 1 decreased by 85.1%, while in group 2 – by 58.5%, after 6 months the total DISH index in group 1 decreased by 91.5%, while in group 2 group – by 65.6%.Conclusions. The combined use of neodymium laser and ivermectin is a highly effective and safe method of therapy in patients with a combination of erythematotelangiectatic and papulopustular rosacea subtypes.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>розацеа</kwd><kwd>папуло-пустулезный подтип</kwd><kwd>эритемато-телеангиэктатический подтип</kwd><kwd>сочетание подтипов</kwd><kwd>ивермектин</kwd><kwd>неодимовый лазер</kwd></kwd-group><kwd-group xml:lang="en"><kwd>rosacea</kwd><kwd>papulo-pustular subtype</kwd><kwd>erythematotelangiectatic subtype</kwd><kwd>combination of subtypes</kwd><kwd>ivermectin</kwd><kwd>neodymium laser</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Акне и розацеа. Под редакцией Кругловой Л.С. ГЭОТАР-Медиа. 2021. 207 с.</mixed-citation><mixed-citation xml:lang="en">Acne and rosacea. Edited by Kruglova L.S. 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