medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2022-27-30-36medalphabet-2863Research ArticleВ ПОМОЩЬ ПРАКТИЧЕСКОМУ ВРАЧУЛечение пустулезного псориаза с применением ингибитора ИЛ-17A секукинумабаPustular psoriasis treated with IL-17a antibody secukinumabhttps://orcid.org/0000-0002-0621-5518РудневаН. С.RudnevaN. S.

Руднева Наталья Сергеевна, к.м.н., главный врач1, доцент кафедры пропедевтики внутренних болезней (курс дерматовенерологии); главный внештатный специалист – дерматовенеролог, косметолог Министерства здравоохранения Тульской области

 Тула 

Rudneva Natalya S., PhD Med, chief physician1, associate professor at Deptof Propaedeutics of Internal Diseases (Course of Dermatovenereology); chieffreelance specialist – dermatovenereologist, cosmetologist of the Ministry of Health of the Tula Region 

 Tula

natalya.rudneva@tularegion.ruhttps://orcid.org/0000-0001-6803-5646НатароваЭ. В.NatarovaE. V.

Натарова Элла Валерьевна, зам. главного врача по лечебной работе

 Тула 

Natarova Ella V., deputy chief physician for medical work 

 Tula 

natarova_ella@list.ruhttps://orcid.org/0000-0002-5044-5265КругловаЛ. С.KruglovaL. S.

Круглова Лариса Сергеевна, д.м.н., проф., зав. кафедройдерматовенерологии и косметологии

Москва 

Kruglova Larisa S., DM Sci (habil.), professor, head of Dept of Dermatovenereology and Cosmetology 

Moscow 

kruglovals@mail.ruГУЗ «Тульский областной клинический кожно-венерологический диспансер» Минздрава Тульской области; Медицинский институт ФГБОУ «Тульский государственный университет»РоссияTula Regional Clinical Dermatovenerologic Dispensary; Tula State UniversityRussian FederationГУЗ «Тульский областной клинический кожно-венерологический диспансер» Минздрава Тульской областиРоссияTula Regional Clinical Dermatovenerologic DispensaryRussian FederationФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента Российской ФедерацииРоссияCentral State Medical Academy of the Administrative Department of the President of Russian FederationRussian Federation202228112022127Дерматология (2)3036Copyright © Руднева Н.С., Натарова Э.В., Круглова Л.С., 20222022Руднева Н.С., Натарова Э.В., Круглова Л.С.Rudneva N.S., Natarova E.V., Kruglova L.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/2863

В статье представлены клинические случаи лечения острого генерализованного пустулезного псориаза (ГПП) с применением ингибитора интерлейкина ИЛ-17A секукинумаба, которое показало замечательный ответ с  почти полным исчезновением пустул после первой инъекции. Насколько нам известно, в литературе данные по  оценке эффективности терапии генно-инженерными  препаратами в лечении ГПП ограничены. 

 The article presents clinical cases of treatment of acute generalized pustular psoriasis (GPP) with the use of an interleukin IL-17A inhibitor, secukinumab, which showed a remarkable response with almost complete disappearance of pustules after the first injection. To the best of our knowledge, there are limited data in the literature on evaluating the effectiveness of therapy with genetically engineered drugs in the treatment of GPP. 

пустулезный псориазгенно-инженерная биологическая терапиясекукинумабpustular psoriasisbiological therapysecukinumabReferencesФедеральные клинические рекомендации «Псориаз» РОДВК 2020; https://cr.minzdrav.gov.ru. Дата посещения сайта: 27.08.2021.Federal clinical guidelines ‘Psoriasis’ RODVK 2020. https://cr.minzdrav.gov.ru. Date of visit to the site: 27.08.21.Shah M, Al Aboud DM, Crane JS, et al. Pustular Psoriasis [updated 2021 Aug 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537002Shah M, Al Aboud DM, Crane JS, et al. Pustular Psoriasis [updated 2021 Aug 11]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK537002Jeffrey J. Crowley, David M. Pariser & Paul S. Yamauchi (2021) A brief guide to pustular psoriasis for primary care providers, Postgraduate Medicine, 133: 3, 330–344, https://doi.org/10.1080/00325481.2020.1831315Jeffrey J. Crowley, David M. Pariser & Paul S. Yamauchi (2021) A brief guide to pustular psoriasis for primary care providers, Postgraduate Medicine, 133: 3, 330–344, https://doi.org/10.1080/00325481.2020.1831315Kubota K, Kamijima Y, Sato T, et al. Epidemiology of psoriasis and palmoplantar pustulosis: A nationwide study using the Japanese national claims database. BMJ Open. 2015; 5 (1): e006450. https://doi.org/10.1136/bmjopen-2014–006450Kubota K, Kamijima Y, Sato T, et al. Epidemiology of psoriasis and palmoplantar pustulosis: A nationwide study using the Japanese national claims database. BMJ Open. 2015; 5 (1): e006450. https://doi.org/10.1136/bmjopen-2014–006450Menter A, Van Voorhees AS, Hsu S. Pustular Psoriasis: A Narrative Review of Recent Developments in Pathophysiology and Therapeutic Options. Dermatol Ther (Heidelb). 2021 Dec; 11 (6): 1917–1929. https://doi.org/10.1007/s13555–021–00612-xMenter A, Van Voorhees AS, Hsu S. Pustular Psoriasis: A Narrative Review of Recent Developments in Pathophysiology and Therapeutic Options. Dermatol Ther (Heidelb). 2021 Dec; 11 (6): 1917–1929. https://doi.org/10.1007/s13555–021–00612-xМатушевская Е. В., Коновалова М. В., Владимирова Е. В., Свирщевская Е. В. Патогенез и терапия псориаза и псориатического артрита. Клиническая дерматология и венерология. 2019; 18 (5): 634–643. https://doi.org/10.17116/klinderma201918051634Matushevskaia EV, Konovalova MV, Vladimirova EV, Svirshchevskaia EV. Pathogenesis and therapy of psoriasis and psoriatic arthritis. Clinical Dermatology and Venereology. 2019; 18 (5): 634–643. (In Russ.) https://doi.org/10.17116/klinderma201918051634Sawabe Y, Hayashi K, Kamata M, Nagata M, Fukaya S, Fukuyasu A, Tanaka T, Ishikawa T, Ohnishi T, Komatsu H, Tanaka M, Sugiura K, Tada Y Case of generalized pustular psoriasis with coexisting mutations in IL36RN and CARD14.J Dermatol. 2019 Oct; 46 (10): e368–e370. https://doi.org/ 10.1111/1346–8138.14909Sawabe Y, Hayashi K, Kamata M, Nagata M, Fukaya S, Fukuyasu A, Tanaka T, Ishikawa T, Ohnishi T, Komatsu H, Tanaka M, Sugiura K, Tada Y Case of generalized pustular psoriasis with coexisting mutations in IL36RN and CARD14.J Dermatol. 2019 Oct; 46 (10): e368–e370. https://doi.org/ 10.1111/1346–8138.14909Gooderham MJ, Van Voorhees AS, Lebwohl MG. An update on generalized pustular psoriasis. Expert Rev Clin Immunol. 2019; 15: 907–19.Gooderham MJ, Van Voorhees AS, Lebwohl MG. An update on generalized pustular psoriasis. Expert Rev Clin Immunol. 2019; 15: 907–19.Ciccarelli F, De Martinis M, Sirufo MM, Ginaldi L. Psoriasis induced by anti-tumor necrosis factor alpha agents: a comprehensive review of the literature. Acta Dermatovenerol Croat. 2016; 24: 169–74. PMID: 27663916.Ciccarelli F, De Martinis M, Sirufo MM, Ginaldi L. Psoriasis induced by anti-tumor necrosis factor alpha agents: a comprehensive review of the literature. Acta Dermatovenerol Croat. 2016; 24: 169–74. PMID: 27663916.Bachelez H. Pustular psoriasis and related pustular skin diseases. Br J Dermatol. 2018; 178: 614–8.Bachelez H. Pustular psoriasis and related pustular skin diseases. Br J Dermatol. 2018; 178: 614–8.Melinda J. Gooderham, Abby S. van Voorhees & Mark G. Lebwohl (2019) An update on generalized pustular psoriasis, Expert Review of Clinical Immunology, 15: 9, 907–919, https://doi.org/10.1080/1744666X.2019.1648209Melinda J. Gooderham, Abby S. van Voorhees & Mark G. Lebwohl (2019) An update on generalized pustular psoriasis, Expert Review of Clinical Immunology, 15: 9, 907–919, https://doi.org/10.1080/1744666X.2019.1648209Fujita H, Terui T, Hayama K, et al. Japanese guidelines for the management and treatment of generalized pustular psoriasis: the new pathogenesis and treatment of GPP. J Dermatol. 2018 Nov; 45 (11): 1235–1270.Fujita H, Terui T, Hayama K, et al. Japanese guidelines for the management and treatment of generalized pustular psoriasis: the new pathogenesis and treatment of GPP. J Dermatol. 2018 Nov; 45 (11): 1235–1270.MorphoSys. MorphoSys announces approval of Tremfya® (guselkumab) for the treatment of moderate to severe forms of psoriasis and psoriatic arthritis in Japan. 2018 Apr 6 [cited 2018 Nov 12]. Available from: https://www.morphosys.com/media-investors/media-center/morphosys-announces-approval-of-tremfyar-guselkumab-for-the-treatmentMorphoSys. MorphoSys announces approval of Tremfya® (guselkumab) for the treatment of moderate to severe forms of psoriasis and psoriatic arthritis in Japan. 2018 Apr 6 [cited 2018 Nov 12]. Available from: https://www.morphosys.com/media-investors/media-center/morphosys-announces-approval-of-tremfyar-guselkumab-for-the-treatmentLópez-Sánchez C, Falla LM, Roé-Crespo E, Arostegui JI, Mozos A, Bernal S, Iznardo H, Baselga-Torres E Excellent response to secukinumab in an infant with severe generalized pustular psoriasis. J Dermatol. 2021 Jun; 48 (6): 907–910. https://doi.org/ 10.1111/1346–8138.15673López-Sánchez C, Falla LM, Roé-Crespo E, Arostegui JI, Mozos A, Bernal S, Iznardo H, Baselga-Torres E Excellent response to secukinumab in an infant with severe generalized pustular psoriasis. J Dermatol. 2021 Jun; 48 (6): 907–910. https://doi.org/ 10.1111/1346–8138.15673Zhou J, Luo Q, Cheng Y, Wen X, Liu J. Int An update on genetic basis of generalized pustular psoriasis (Review). J Mol Med. 2021 Jun; 47 (6): 118. https://doi.org/10.3892/ijmm.2021.4951Zhou J, Luo Q, Cheng Y, Wen X, Liu J. Int An update on genetic basis of generalized pustular psoriasis (Review). J Mol Med. 2021 Jun; 47 (6): 118. https://doi.org/10.3892/ijmm.2021.4951Komine M, Morita A. Generalized pustular psoriasis: current management status and unmet medical needs in Japan. Expert Rev Clin Immunol. 2021 Sep; 17 (9): 1015–1027. https://doi.org/10.1080/1744666X.2021.1961580Komine M, Morita A. Generalized pustular psoriasis: current management status and unmet medical needs in Japan. Expert Rev Clin Immunol. 2021 Sep; 17 (9): 1015–1027. https://doi.org/10.1080/1744666X.2021.1961580Wilsmann-Theis D, Schnell LM, Ralser-Isselstein V, Bieber T, Schön MP, Hüffmeier U, Mössner R.J Successful treatment with interleukin-17A antagonists of generalized pustular psoriasis in patients without IL36RN mutations. Dermatol. 2018 Jul; 45 (7): 850–854. https://doi.org/10.1111/1346–8138.14318Wilsmann-Theis D, Schnell LM, Ralser-Isselstein V, Bieber T, Schön MP, Hüffmeier U, Mössner R.J Successful treatment with interleukin-17A antagonists of generalized pustular psoriasis in patients without IL36RN mutations. Dermatol. 2018 Jul; 45 (7): 850–854. https://doi.org/10.1111/1346–8138.14318

The authors declare that there are no conflicts of interest present.