<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2022-25-19-25</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-2853</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Особенности метаболических нарушений у долгожителей</article-title><trans-title-group xml:lang="en"><trans-title>Features of metabolic disorders in centenarians</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4131-8432</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тополянская</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Topolyanskaya</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тополянская Светлана Викторовна, кандидат медицинских наук, доцент кафедры госпитальной терапии № 2, ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Министерства здравоохранения РФ (Сеченовский университет), врач-терапевт, ГБУЗ «Госпиталь для ветеранов войн № 3»</p><p>Москва</p></bio><bio xml:lang="en"><p>Topolyanskaya Svetlana V., PhD Me, associate professor, hospital therapy department № 2, I.M. Sechenov First Moscow State Medical University (Sechenov University)</p><p>Moscow</p></bio><email xlink:type="simple">sshekshina@yahoo.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6921-0589</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Елисеева</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Eliseeva</surname><given-names>T. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Елисеева Татьяна Алексеевна, врач 6-го гериатрического отделения</p><p>Москва</p></bio><bio xml:lang="en"><p>Eliseeva Tatyana A., physician of 6 geriatric department</p><p>Moscow</p></bio><email xlink:type="simple">eliseet@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2933-7550</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Турна</surname><given-names>О. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Turna</surname><given-names>O. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Турна Ольга Игоревна, врач 6-го гериатрического отделения</p><p>Москва</p></bio><bio xml:lang="en"><p>Turna Olga I., physician of 6 geriatric department</p><p>Moscow</p></bio><email xlink:type="simple">olga1414@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4139-5075</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вакуленко</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Vakulenko</surname><given-names>O. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Вакуленко Ольга Николаевна, заведующая 6-м гериатрическим отделением</p><p>Москва</p></bio><bio xml:lang="en"><p>Vakulenko Olga N., head of 6 geriatric department</p><p>Moscow</p></bio><email xlink:type="simple">onv.62@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5351-1996</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Романова</surname><given-names>М. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Romanova</surname><given-names>M. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Романова Маргарита Анатольевна, заведующая 13-м гериатрическим отделением</p><p>Москва</p></bio><bio xml:lang="en"><p>Romanova Margarita A., head of 13 geriatric department</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3186-0102</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дворецкий</surname><given-names>Л. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Dvoretski</surname><given-names>L. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дворецкий Леонид Иванович, доктор медицинских наук, профессор, профессор кафедры госпитальной терапии</p><p>Москва</p></bio><bio xml:lang="en"><p>Dvoretski Leonid I., DM Sci (habil.), professor of hospital therapy department № 2</p><p>Moscow</p></bio><email xlink:type="simple">dvoretski@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3329-7846</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рачина</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Rachina</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Рачина Светлана Александровна, доктор медицинских наук, профессор, заведующая кафедрой госпитальной терапии № 2</p><p>Москва </p></bio><bio xml:lang="en"><p>Rathcina Svetlana A., DM Sci (habil.), head of hospital therapy department № 2</p><p>Moscow</p></bio><email xlink:type="simple">svetlana.ratchina@antibiotic.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9647-7492</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лыткина</surname><given-names>К. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Lytkina</surname><given-names>K. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лыткина Каринэ Арнольдовна, заместитель главного врача по терапии</p><p>Москва</p></bio><bio xml:lang="en"><p>Lytkina Karina A., deputy head physician</p><p>Moscow</p></bio><email xlink:type="simple">lytkina.k@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4021-5044</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мелконян</surname><given-names>Г. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Melkonyan</surname><given-names>G. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мелконян Георгий Геннадьевич, доктор медицинских наук, главный врач</p><p>Москва</p></bio><bio xml:lang="en"><p>Melkonyan Georgiy G., DM Sci (habil.), head physician</p><p>Moscow</p></bio><email xlink:type="simple">gvv3@zdrav.mos.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Министерства здравоохранения РФ (Сеченовский университет);&#13;
ГБУЗ «Госпиталь для ветеранов войн № 3»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov, First Moscow State Medical University (Sechenov University), RF Health Ministry;&#13;
War Veterans Hospital № 3</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ «Госпиталь для ветеранов войн № 3»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>War Veterans Hospital № 3</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Министерства здравоохранения РФ (Сеченовский университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov, First Moscow State Medical University (Sechenov University), RF Health Ministry</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>25</day><month>11</month><year>2022</year></pub-date><volume>0</volume><issue>25</issue><issue-title>Современная поликлиника (2)</issue-title><fpage>19</fpage><lpage>25</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Тополянская С.В., Елисеева Т.А., Турна О.И., Вакуленко О.Н., Романова М.А., Дворецкий Л.И., Рачина С.А., Лыткина К.А., Мелконян Г.Г., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Тополянская С.В., Елисеева Т.А., Турна О.И., Вакуленко О.Н., Романова М.А., Дворецкий Л.И., Рачина С.А., Лыткина К.А., Мелконян Г.Г.</copyright-holder><copyright-holder xml:lang="en">Topolyanskaya S.V., Eliseeva T.A., Turna O.I., Vakulenko O.N., Romanova M.A., Dvoretski L.I., Rachina S.A., Lytkina K.A., Melkonyan G.G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/2853">https://www.med-alphabet.com/jour/article/view/2853</self-uri><abstract><p>Основная цель исследования – изучение особенностей пуринового, липидного и углеводного обмена у больных ишемической болезнью сердца (ИБС) старше 90 лет (долгожителей).</p><sec><title>Материал и методы</title><p>Материал и методы. В исследование были включены 225 пациентов старше 90 лет, госпитализированных с диагнозом ИБС. Большинство пациентов (67,6%) составляли женщины. Средний возраст пациентов достигал 92,5±2,2 года (от 90 до 106 лет). Определялись уровни мочевой кислоты, липидов, глюкозы в крови и индекс массы тела.</p></sec><sec><title>Результаты</title><p>Результаты. Ожирение зарегистрировано у 31,5% пациентов, ожирение III степени – у 1 пациента. Избыточный вес выявлен у 39,1% пациентов, нормальный индекс массы тела (ИМТ) у 28,9%. Повышение концентрации триглицеридов в крови отмечено у 11,2% пациентов. Снижение уровня холестерина липопротеидов высокой плотности (ЛПВП) зарегистрировано у 12,7% пациентов. Концентрация холестерина липопротеидов низкой плотности (ЛПНП)менее 2,0 ммоль/л в крови наблюдалась в 23,3% случаев. Дислипидемия выявлялась чаще у женщин (р=0,02). Гиперурикемия обнаружена у 37,3% пациентов – у 41,4% женщин и 28,8% мужчин (р=0,04). Повышение уровня глюкозы в крови натощак было зарегистрировано у 23,1% пациентов, но только у 0,9% пациентов уровень глюкозы был выше 14 ммоль/л.</p></sec><sec><title>Выводы</title><p>Выводы. Результаты исследования указывают на некоторые особенности метаболических нарушений у долгожителей с ишемической болезнью сердца. Выявлена высокая доля пациентов с избыточной массой тела или ожирением. Регистрировалась частая гиперурикемия, но относительно низкие уровни атерогенных липидов и глюкозы.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim: to study the features of purine, lipid and carbohydrate metabolic disorders in patients with coronary artery disease over 90 years old (centenarians).</p></sec><sec><title>Materials and methods</title><p>Materials and methods. The study enrolled 225 patients over 90 years, hospitalized with coronary artery disease. The majority of patients (67.6%) were women. The mean age of the patients reached 92.5+2.2 years (from 90 to 106 years).The blood levels of uric acid, lipids, glucose and body mass index were determined.</p></sec><sec><title>Results</title><p>Results. Obesity was registered in 31.5% of patients, grade III obesity – in 1 patient. Overweight was observed in 39.1% of patients, normal body mass index (BMI) – in 28.9%. An increase in the blood concentration of triglycerides was determined in 11.2% of patients. A decrease in the level of high-density lipoprotein (HDL) cholesterol was registered in 12.7% of patients. The blood concentration of low-density lipoprotein cholesterol (LDL) less than 2.0 mmol/l was observed in 23.3% of cases. Dyslipidemia was registered more often in women (p=0.02). Hyperuricemia was found in 37.3% of patients – in 41.4% of women and 28.8% of men (p=0.04). Elevated fasting blood glucose levels were determined in 23.1% of patients, but only 0.9% of patients had glucose levels above 14 mmol/l.</p></sec><sec><title>Conclusion</title><p>Conclusion. The study results indicate some features of metabolic disorders in centenarians with coronary artery disease. Most of the patients were obese or overweight. Frequent hyperuricemia was registered, but relatively low levels of atherogenic lipids and glucose.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>ожирение</kwd><kwd>липиды</kwd><kwd>мочевая кислота</kwd><kwd>глюкоза</kwd><kwd>ишемическая болезнь сердца</kwd><kwd>долгожители</kwd></kwd-group><kwd-group xml:lang="en"><kwd>obesity</kwd><kwd>lipids</kwd><kwd>uric acid</kwd><kwd>glucose</kwd><kwd>coronary artery disease</kwd><kwd>centenarians</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ahmadi S.– F.F., Streja E., Zahmatkesh G. et al. Reverse Epidemiology of Traditional Cardiovascular Risk Factors in the Geriatric Population. Journal of the American Medical Directors Association. 2015; 11(16):933–939. DOI: 10.1016/j.jamda.2015.07.014.</mixed-citation><mixed-citation xml:lang="en">Ahmadi S.– F.F., Streja E., Zahmatkesh G. et al. Reverse Epidemiology of Traditional Cardiovascular Risk Factors in the Geriatric Population. Journal of the American Medical Directors Association. 2015; 11(16):933–939. DOI: 10.1016/j.jamda.2015.07.014.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Baden M., Vreeswijk R., Keijzers M. et al. Paradoxes in the old age – reverse epidemiology. European Geriatric Medicine. 2012; 3S:10–11.</mixed-citation><mixed-citation xml:lang="en">Baden M., Vreeswijk R., Keijzers M. et al. Paradoxes in the old age – reverse epidemiology. European Geriatric Medicine. 2012; 3S:10–11.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Pereira da Silva A., Matos A., Valente A. et al. Body composition assessment and nutritional status evaluation in men and women Portuguese centenarians. Journal of Nutrition, Health and Aging. 2016; 20:256–266. DOI: 10.1007/s12603–015–0566–0</mixed-citation><mixed-citation xml:lang="en">Pereira da Silva A., Matos A., Valente A. et al. Body composition assessment and nutritional status evaluation in men and women Portuguese centenarians. Journal of Nutrition, Health and Aging. 2016; 20:256–266. DOI: 10.1007/s12603–015–0566–0</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Duarte M.G., Duarte P.O., Pelichek A. et al. Comparison of body composition analysis methods among centenary women: Seeking simpler methods. SAGE Open Medicine. 2019; 7:1–7. DOI: 10.1177/2050312119865126</mixed-citation><mixed-citation xml:lang="en">Duarte M.G., Duarte P.O., Pelichek A. et al. Comparison of body composition analysis methods among centenary women: Seeking simpler methods. SAGE Open Medicine. 2019; 7:1–7. DOI: 10.1177/2050312119865126</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Silva A. P. Da., Valente A., Chaves C. et al. Characterization of Portuguese centenarian eating habits, nutritional biomarkers, and cardiovascular risk: A case control study. Oxidative Medicine and Cellular Longevity. 2018; 2018: 5296168. DOI: 10.1155/2018/5296168</mixed-citation><mixed-citation xml:lang="en">Silva A. P. Da., Valente A., Chaves C. et al. Characterization of Portuguese centenarian eating habits, nutritional biomarkers, and cardiovascular risk: A case control study. Oxidative Medicine and Cellular Longevity. 2018; 2018: 5296168. DOI: 10.1155/2018/5296168</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Chang S.H., Beason T. S., Hunleth J. M., Colditz G. A. A systematic review of body fat distribution and mortality in older people. Maturitas. 2012; 72(3):175– 191. DOI: 10.1016/j.maturitas.2012.04.004</mixed-citation><mixed-citation xml:lang="en">Chang S.H., Beason T. S., Hunleth J. M., Colditz G. A. A systematic review of body fat distribution and mortality in older people. Maturitas. 2012; 72(3):175– 191. DOI: 10.1016/j.maturitas.2012.04.004</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Rong W., Zhe T., Fei S., Lijun D. Prevalence of hyperuricemia in the elderly in 7 areas of China. Chinese Journal of Endemiology. 2018; 39(3):286–288.</mixed-citation><mixed-citation xml:lang="en">Rong W., Zhe T., Fei S., Lijun D. Prevalence of hyperuricemia in the elderly in 7 areas of China. Chinese Journal of Endemiology. 2018; 39(3):286–288.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Qiu L., Cheng X.Q., Wu J. et al. Prevalence of hyperuricemia and its related risk factors in healthy adults from Northern and Northeastern Chinese provinces. BMC Public Health. 2013; 13:664.</mixed-citation><mixed-citation xml:lang="en">Qiu L., Cheng X.Q., Wu J. et al. Prevalence of hyperuricemia and its related risk factors in healthy adults from Northern and Northeastern Chinese provinces. BMC Public Health. 2013; 13:664.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Wu J., Qiu L., Cheng X.Q. et al. Hyperuricemia and clustering of cardiovascular risk factors in the Chinese adult population. Scientific Reports. 2017; 7(1):5456. DOI: 10.1038/s41598–017–05751-w</mixed-citation><mixed-citation xml:lang="en">Wu J., Qiu L., Cheng X.Q. et al. Hyperuricemia and clustering of cardiovascular risk factors in the Chinese adult population. Scientific Reports. 2017; 7(1):5456. DOI: 10.1038/s41598–017–05751-w</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Villegas R., Xiang Y. B., Elasy T. et al. Purine–rich foods, protein intake, and the prevalence of hyperuricemia: The Shanghai Men’s Health Study. Nutrition, Metabolism and Cardiovascular Diseases. 2012; 22(5):409–416. DOI: 10.1016/j.numecd.2010.07.012</mixed-citation><mixed-citation xml:lang="en">Villegas R., Xiang Y. B., Elasy T. et al. Purine–rich foods, protein intake, and the prevalence of hyperuricemia: The Shanghai Men’s Health Study. Nutrition, Metabolism and Cardiovascular Diseases. 2012; 22(5):409–416. DOI: 10.1016/j.numecd.2010.07.012</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Wallace K. L., Riedel A. A., Joseph-Ridge N., Wortmann R. Increasing prevalence of gout and hyperuricemia over 10 years among older adults in a managed care population. Journal of Rheumatology. 2004; 31(8):1582–1587.</mixed-citation><mixed-citation xml:lang="en">Wallace K. L., Riedel A. A., Joseph-Ridge N., Wortmann R. Increasing prevalence of gout and hyperuricemia over 10 years among older adults in a managed care population. Journal of Rheumatology. 2004; 31(8):1582–1587.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Taha T., Rahman A., Abdel Rahman T. T. Prevalence of Hyperuricemia among Hospitalized Elderly Patients and Its Association with Metabolic Syndrome. Advances in Aging Research. 2014; 03(04):329–337. DOI: 10.4236/aar.2014.34043</mixed-citation><mixed-citation xml:lang="en">Taha T., Rahman A., Abdel Rahman T. T. Prevalence of Hyperuricemia among Hospitalized Elderly Patients and Its Association with Metabolic Syndrome. Advances in Aging Research. 2014; 03(04):329–337. DOI: 10.4236/aar.2014.34043</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Tseng W. C., Chen Y.H. C. T., Ou S.M. et al. U–shaped association between serum uric acid levels with cardiovascular and all–cause mortality in the elderly: The role of malnourishment. Journal of the American Heart Association. 2018; 7(4):2018–2019. DOI: 10.1161/JAHA.117.007523</mixed-citation><mixed-citation xml:lang="en">Tseng W. C., Chen Y.H. C. T., Ou S.M. et al. U–shaped association between serum uric acid levels with cardiovascular and all–cause mortality in the elderly: The role of malnourishment. Journal of the American Heart Association. 2018; 7(4):2018–2019. DOI: 10.1161/JAHA.117.007523</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Félix–Redondo F.J., Grau M., Fernández–BergésD. Cholesterol and cardiovascular disease in the elderly. Facts and gaps. Aging and Disease. 2013; 4(3):154–169.</mixed-citation><mixed-citation xml:lang="en">Félix–Redondo F.J., Grau M., Fernández–BergésD. Cholesterol and cardiovascular disease in the elderly. Facts and gaps. Aging and Disease. 2013; 4(3):154–169.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Guallar–Castillón P., Gil-Montero M., León-Muñoz L.M., et al. Magnitude and management of hypercholesterolemia in the adult population of Spain, 2008–2010: The ENRICA study. Revista Espanola de Cardiologia. 2012; 65(6): 551–558. DOI: 10.1016/j.recesp.2012.02.005</mixed-citation><mixed-citation xml:lang="en">Guallar–Castillón P., Gil-Montero M., León-Muñoz L.M., et al. Magnitude and management of hypercholesterolemia in the adult population of Spain, 2008–2010: The ENRICA study. Revista Espanola de Cardiologia. 2012; 65(6): 551–558. DOI: 10.1016/j.recesp.2012.02.005</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Тополянская С. В., Вакуленко О. Н., Елисеева Т. А., Балясникова Н. А., Калинин Г.А., Купина Л.М., Стрижова Н. В. Особенности липидного состава крови у больных ишемической болезнью сердца старческого возраста. Кардиология. 2018; 58(3):28–36.</mixed-citation><mixed-citation xml:lang="en">Topolyanskaya S. V., Vakulenko O. N., Eliseeva T. A., Balyasnikova N. A., Kalinin G. A., Kupina L. M., Strizhova N. V. Features of blood lipid profile in old patients with coronary artery disease. Kardiologia. 2018; 58(3):28–36.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Liu Y., Hao Z., Xiao C., Liu L., Liao H. Association of serum total cholesterol and left ventricular ejection fraction in patients with heart failure caused by coronary heart disease. Archives of Medical Science. 2018; 14(5): 988–994. DOI:10.5114/aoms.2017.70660.</mixed-citation><mixed-citation xml:lang="en">Liu Y., Hao Z., Xiao C., Liu L., Liao H. Association of serum total cholesterol and left ventricular ejection fraction in patients with heart failure caused by coronary heart disease. Archives of Medical Science. 2018; 14(5): 988–994. DOI:10.5114/aoms.2017.70660.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Chen Y., He X.M., Meng H. et. al. Relationship between lipids levels and right ventricular volume overload in congestive heart failure. Journal of Geriatric Cardiology. 2014; 11(3):192–199. DOI:10.11909/j.issn.1671–5411.2014.03.011</mixed-citation><mixed-citation xml:lang="en">Chen Y., He X.M., Meng H. et. al. Relationship between lipids levels and right ventricular volume overload in congestive heart failure. Journal of Geriatric Cardiology. 2014; 11(3):192–199. DOI:10.11909/j.issn.1671–5411.2014.03.011</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Alzahrani S.H., Baig M., Aashi M.M. et al. Association between glycated hemoglobin (HbA1c) and the lipid profile in patients with type 2 diabetes mellitus at a tertiary care hospital: A retrospective study. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2019; 12:1639–1644. DOI: 10.2147/DMSO.S222271</mixed-citation><mixed-citation xml:lang="en">Alzahrani S.H., Baig M., Aashi M.M. et al. Association between glycated hemoglobin (HbA1c) and the lipid profile in patients with type 2 diabetes mellitus at a tertiary care hospital: A retrospective study. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2019; 12:1639–1644. DOI: 10.2147/DMSO.S222271</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Ghari Arab A., Zahedi M., Kazemi Nejad V., Sanagoo A., AzimiM. Correlation between Hemoglobin A1c and Serum Lipid Profile in Type 2 Diabetic Patients Referred to the Diabetes Clinic in Gorgan, Iran. Journal of Clinical and Basic Research. 2018; 2(1):26–31.</mixed-citation><mixed-citation xml:lang="en">Ghari Arab A., Zahedi M., Kazemi Nejad V., Sanagoo A., AzimiM. Correlation between Hemoglobin A1c and Serum Lipid Profile in Type 2 Diabetic Patients Referred to the Diabetes Clinic in Gorgan, Iran. Journal of Clinical and Basic Research. 2018; 2(1):26–31.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Hussain A., Ali I., Ijaz M., RahimA. Correlation between hemoglobin A1c and serum lipid profile in Afghani patients with type 2 diabetes: hemoglobin A1c prognosticates dyslipidemia. Therapeutic Advances in Endocrinology and Metabolism. 2017; 8(4):51–57. DOI: 10.1177/2042018817692296</mixed-citation><mixed-citation xml:lang="en">Hussain A., Ali I., Ijaz M., RahimA. Correlation between hemoglobin A1c and serum lipid profile in Afghani patients with type 2 diabetes: hemoglobin A1c prognosticates dyslipidemia. Therapeutic Advances in Endocrinology and Metabolism. 2017; 8(4):51–57. DOI: 10.1177/2042018817692296</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
