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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2022-18-20-24</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-2759</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Возможности искусственного интеллекта в оценке эффективности немедикаментозного лечения ожирения у детей</article-title><trans-title-group xml:lang="en"><trans-title>Artifcial intelligence capabilities in evaluating effectiveness of non-medicinal treatment of obesity in children</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1352-7026</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чубаров</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Chubarov</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p> Чубаров Тимофей Валерьевич, к.м.н., гл. врач Воронежской детской клинической больницы, директор эндокринологического центра.</p><p> г. Воронеж </p></bio><bio xml:lang="en"><p> Chubarov Timofei V., PhD Med, chief physician of Voronezh Children's Clinical Hospital, director of Endocrinological Centre </p><p>Voronezh </p></bio><email xlink:type="simple">chubarov25@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3917-0395</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жданова</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhdanova</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>  Жданова Ольга Александровна, д.м.н., доцент кафедры клинической фармакологии</p><p>г. Воронеж </p></bio><bio xml:lang="en"><p> Zhdanova Olga A., DM Sciences (habil.), associate professor at Dept of Clinical Pharmacology </p><p> Voronezh </p></bio><email xlink:type="simple">olga.vr9@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0412-7853</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шаршова</surname><given-names>О. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Sharshova</surname><given-names>O. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p> Шаршова Ольга Геннадьевна, зав. отделением эндокринологии Воронежской детской клинической больницы</p><p>г. Воронеж </p></bio><bio xml:lang="en"><p> Sharshova Olga G., head of Dept of Endocrinology of Voronezh Children's Clinical Hospital </p><p>Voronezh </p></bio><email xlink:type="simple">genvgma@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2891-0906</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Галда</surname><given-names>О. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Galda</surname><given-names>O. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p> Галда Ольга Геннадьевна, студентка VI курса</p><p> г. Воронеж </p></bio><bio xml:lang="en"><p> Galda Olga G., 6th year student </p><p> Voronezh </p></bio><email xlink:type="simple">galda.ol@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4498-0130</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Патрицкая</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Patritskaya</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p> Патрицкая Мария Валерьевна, врач ультразвуковой диагностики Воронежской детской клинической больницы</p><p> г. Воронеж </p></bio><bio xml:lang="en"><p> Patritskaya Maria V., doctor of ultrasound diagnostics of Voronezh Children's Clinical Hospital </p><p> Voronezh </p></bio><email xlink:type="simple">doctorpatrikUZD@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6996-4188</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нифталиев</surname><given-names>К. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Niftaliev</surname><given-names>K. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>  Нифталиев Кенан Сабухиевич, студент V курса</p><p>г. Воронеж </p></bio><bio xml:lang="en"><p> Niftaliev Kenan S., 5th year student </p><p> Voronezh </p></bio><email xlink:type="simple">niftaliev.s@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБОУ ВО «Воронежский государственный медицинский университет имени Н.Н. Бурденко» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Voronezh State Medical University n.a. N.N. Burdenko</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>24</day><month>09</month><year>2022</year></pub-date><volume>1</volume><issue>18</issue><issue-title>Практическая гастроэнтерология (2)</issue-title><fpage>20</fpage><lpage>24</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Чубаров Т.В., Жданова О.А., Шаршова О.Г., Галда О.Г., Патрицкая М.В., Нифталиев К.С., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Чубаров Т.В., Жданова О.А., Шаршова О.Г., Галда О.Г., Патрицкая М.В., Нифталиев К.С.</copyright-holder><copyright-holder xml:lang="en">Chubarov T.V., Zhdanova O.A., Sharshova O.G., Galda O.G., Patritskaya M.V., Niftaliev K.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/2759">https://www.med-alphabet.com/jour/article/view/2759</self-uri><abstract><sec><title>Введение</title><p>Введение. Немедикаментозная терапия ожирения не всегда может гарантировать положительный результат, что заставляет врачей и ученых со всего мира искать новые методы анализа эффективности лечения, в том числе с применением искусственного интеллекта. Его активное внедрение может значительно повысить качество диагностики и прогнозирования заболевания.</p></sec><sec><title>Цель исследования</title><p>Цель исследования. Оценить возможности использования системы искусственного интеллекта в прогнозировании эффективности немедикаментозной терапии ожирения у детей.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Осуществлялось построение искусственной нейронной сети (ИНС) с помощью пакета программ Statistica Neural Networks на основании данных пациентов, находившихся на стационарном лечении в Воронежской детской клинической больницеВГМУ имени Н.Н. Бурденко.</p></sec><sec><title>Результаты</title><p>Результаты. В исследуемую группу входило 60 детей (30 мальчиков и 30 девочек), возраст от 8 до 16 лет. Были отобраны параметры, оказывающие, на наш взгляд, наиболее значительное влияние на эффект немедикаментозного лечения ожирения: наличие и частота стационарного лечения; осложнения ожирения; соблюдение режима физической активности и диетических рекомендаций; динамика массы тела в период немедикаментозного лечения. После обучения выбрана нейронная сеть MLP 5-5-1 с коэффициентами детерминации 0,925231; 0,981940; 0,936712 для обучающей, тестовой и контрольной выборок. Ошибка обучения – 0,105782, алгоритм обучения – BFGS. Функция активации скрытых нейронов – гиперболическая, а выходных – тождественная.</p></sec><sec><title>Заключение</title><p>Заключение. Результаты исследования показывают, что искусственная нейронная сеть может применяться для оценки эффективности немедикаментозного лечения с минимальной погрешностью.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Non-drug therapy for obesity cannot always guarantee a positive result, which forces doctors and scientists from all over the world to look for new methods for analyzing the effectiveness of treatment, including using artifcial intelligence. Its active implementation can significantly improve the quality of diagnosis and prognosis of the disease. Purpose of the study. To evaluate the possibilities of using the artifcial intelligence system in predicting the effectiveness of non-drug therapy for obesity in children.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. An artifcial neural network was built using the Statistica Neural Networks software package based on data from patients who were hospitalized at the Voronezh Children's Clinical Hospital of the VSMU n.a. N.N. Burdenko.</p></sec><sec><title>Results</title><p>Results. The study group included 60 children (30 boys and 30 girls), aged 8 to 16 years. We selected the parameters that, in our opinion, have the most signifcant impact on the effect of non-drug treatment of obesity: the presence and frequency of inpatient treatment; obesity complications; compliance with the regime of physical activity and dietary recommendations; dynamics of body weight during non-drug treatment. After training, the neural network MLP 5-5-1 was selected with determination coeffcients of 0.925231; 0.981940; 0.936712 for training, test and control samples. The learning error is 0.105782, the learning algorithm is BFGS. The activation function of hidden neurons is hyperbolic, and the output function is identical.</p></sec><sec><title>Conclusion</title><p>Conclusion. The results of the study show that an artifcial neural network can be used to evaluate the effectiveness of non-drug treatment with a minimum error.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>детское ожирение</kwd><kwd>немедикаментозное лечение</kwd><kwd>искусственная нейронная сеть</kwd><kwd>осложнения</kwd></kwd-group><kwd-group xml:lang="en"><kwd>childhood obesity</kwd><kwd>non-medicinal treatment</kwd><kwd>artifcial neural network</kwd><kwd>complications</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">WHO European Regional Obesity Report 2022. Copenhagen: WHO Regional Offce for Europe; 2022. Licence: CC BY-NC-SA 3.0 IGO</mixed-citation><mixed-citation xml:lang="en">WHO European Regional Obesity Report 2022. Copenhagen: WHO Regional Offce for Europe; 2022. Licence: CC BY-NC-SA 3.0 IGO</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Güngör N.K. Overweight and obesity in children and adolescents. Journal of clinical research in pediatric endocrinoljgy. 2014; 6(3): 129–43. https://doi.org/10.4274/Jcrpe.1471.</mixed-citation><mixed-citation xml:lang="en">Güngör N.K. Overweight and obesity in children and adolescents. Journal of clinical research in pediatric endocrinoljgy. 2014; 6(3): 129–43. https://doi.org/10.4274/Jcrpe.1471.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Чубаров Т. В., Петеркова В. А., Батищева Г.А., Жданова О.А., Шаршова О. Г., Артющенко А. И., Бессонова А. В. Характеристика уровня артериального давления у детей с различной массой тела. Ожирение и метаболизм. 2022; 19(1): 27–34. https://doi.org/10.14341/omet12721</mixed-citation><mixed-citation xml:lang="en">Chubarov T.V., Peterkova V.A., Batischeva G.A., Zhdanova O.A., Sharshova O.G., Artyushchenko A.I., Bessonova A.V. Characteristics of blood pressure level in children with different body weight. Obesity and metabolism. 2022;19(1):27–34. https://doi.org/10.14341/omet12721</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Sinaiko A.R., Steinberger J., Moran A., Hong C.P., Prineas R.J., Jacobs D.R. Jr. Inﬂuence of insulin resistance and body mass index at age 13 on systolic blood pressure, triglycerides, and high-density lipoprotein cholesterol at age 19. Hypertension. 2006; 48(4): 730–6. https://doi.org/10.1161/01.HYP.0000237863.24000.50</mixed-citation><mixed-citation xml:lang="en">Sinaiko A.R., Steinberger J., Moran A., Hong C.P., Prineas R.J., Jacobs D.R. Jr. Inﬂuence of insulin resistance and body mass index at age 13 on systolic blood pressure, triglycerides, and high-density lipoprotein cholesterol at age 19. Hypertension. 2006; 48(4): 730–6. https://doi.org/10.1161/01.HYP.0000237863.24000.50</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Asma Deeb, Salima Attia, Samia Mahmoud, Ghada Elhaj, Abubaker Elfatih. Dyslipidemia and Fatty Liver Disease in Overweight and Obese Children. Journal of Obesity. 2018; 8: 1–6. https://doi.org/10.1155/2018/8626818</mixed-citation><mixed-citation xml:lang="en">Asma Deeb, Salima Attia, Samia Mahmoud, Ghada Elhaj, Abubaker Elfatih. Dyslipidemia and Fatty Liver Disease in Overweight and Obese Children. Journal of Obesity. 2018; 8: 1–6. https://doi.org/10.1155/2018/8626818</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Korsten-Reck U., Kromeyer-Hauschild K., Korsten K., Baumstark M.W., Dickhuth H., Berg A. Frequency of secondary dyslipidemia in obese children. Vascular Health and Risk Management. 2008; 4(5): 1089–1094. https://doi.org/10.2147/VHRM.S2928</mixed-citation><mixed-citation xml:lang="en">Korsten-Reck U., Kromeyer-Hauschild K., Korsten K., Baumstark M.W., Dickhuth H., Berg A. Frequency of secondary dyslipidemia in obese children. Vascular Health  and Risk Management. 2008; 4(5): 1089–1094. https://doi.org/10.2147/VHRM.S2928</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Vos M.B., Abrams S.H., Barlow S.E. NASPGHAN Clinical Practice Guideline for the Diagnosis and Treatment of Nonalcoholic Fatty Liver Disease in Children: Recommendations from the Expert Committee on NAFLD (ECON) and the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN). Journal of Pediatric Gastroenterology and Nutrition. 2017; 64(2): 319–334. https://doi.org/10.1097/MPG.0000000000001482</mixed-citation><mixed-citation xml:lang="en">Vos M.B., Abrams S.H., Barlow S.E. NASPGHAN Clinical Practice Guideline for the Diagnosis and Treatment of Nonalcoholic Fatty Liver Disease in Children: Recommendations from the Expert Committee on NAFLD (ECON) and the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN). Journal of Pediatric Gastroenterology and Nutrition. 2017; 64(2): 319–334. https://doi.org/10.1097/MPG.0000000000001482</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Звягин А.А., Фатеева Н.Ю., Чубаров Т.В., и др., Стеатогепатоз и стеатогепатит у детей с ожирением: терапевтические подходы. РМЖ. 2022; 3: 9–12</mixed-citation><mixed-citation xml:lang="en">Zvyagin A.A., Fateeva N. Yu., Chubarov T.V., Zhdanova O.A. Steatohepatosis and steatohepatitis in overweight children: therapeutic methods. RMJ. 2022; 3: 9–12.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Петеркова В.А., Безлепкина О.Б., Болотова Н.В., Богова Е.А., Васюкова О.В., Гирш Я.В., Кияев А.В., Кострова И.Б., Малиевский О.А., Михайлова Е.Г., Окороков П. Л., Петряйкина Е. Е., Таранушенко Т. Е., Храмова Е. Б. Клинические рекомендации «Ожирение у детей». Проблемы Эндокринологии. 2021; 67(5): 67–83. https://doi.org/10.14341/probl12802</mixed-citation><mixed-citation xml:lang="en">Peterkova V. A., Bezlepkina O. B., Bolotova N. V., Bogova E. A., Vasyukova O. V., Girsh Y.V., Kiyaev A.V., Kostrova I.B., Malievskiy O.A., Mikhailova E.G., Okorokov P.L., Petryaykina E.E., Taranushenko T.E., Khramova E.B. Clinical guidelines «Obesity in children». Problems of Endocrinology. 2021; 67(5): 67–83. (In Russ.) https://doi.org/10.14341/probl12802</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Алимова И. Л. Перспективы применения в педиатрической практике Федеральных клинических рекомендаций «Диагностика и лечение ожирения у детей и подростков». Российский вестник перинатологии и педиатрии. 2015; 60(1): 66–70.</mixed-citation><mixed-citation xml:lang="en">Alimova I.L. Prospects of application in pediatric practice of the Federal clinical recommendations «Diagnosis and treatment of obesity in children and adolescents». Russian Bulletin of Perinatology and Pediatrics. 2015; 60(1): 66–70</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Larentzakis A., Lygeros N. Artificial intelligence (AI) in medicine as a strategic valuable tool. Pan African Medical Journal. 2021; 38: 184. https://doi.org/10.11604/pamj.2021.38.184.28197.</mixed-citation><mixed-citation xml:lang="en">Larentzakis A., Lygeros N. Artificial intelligence (AI) in medicine as a strategic valuable tool. Pan African Medical Journal. 2021; 38: 184. https://doi.org/10.11604/pamj.2021.38.184.28197.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">González G., Ash S.Y., Vegas-Sánchez-Ferrero G., Onieva Onieva J., Rahaghi F.N., Ross J.C., Díaz A., San José Estépar R., Washko G.R.. Disease Staging and Prognosis in Smokers Using Deep Learning in Chest Computed Tomography. American Journal of Respiratory Critical Care Medicine. 2018; 197(2): 193–203. https://doi.org/10.1164/rccm.201705–0860OC</mixed-citation><mixed-citation xml:lang="en">González G., Ash S.Y., Vegas-Sánchez-Ferrero G., Onieva Onieva J., Rahaghi F.N., Ross J.C., Díaz A., San José Estépar R., Washko G.R.. Disease Staging and Prognosis in Smokers Using Deep Learning in Chest Computed Tomography. American Journal of Respiratory Critical Care Medicine. 2018; 197(2): 193–203. https://doi.org/10.1164/rccm.201705–0860OC</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Weng S.F., Reps J., Kai J., Garibaldi J.M., Qureshi N. Can machine-learning improve cardiovascular risk prediction using routine clinical data? PLoS One. 2017; 12(4): e0174944. https://doi.org/10.1371/journal.pone.0174944.</mixed-citation><mixed-citation xml:lang="en">Weng S.F., Reps J., Kai J., Garibaldi J.M., Qureshi N. Can machine-learning improve cardiovascular risk prediction using routine clinical data? PLoS One. 2017; 12(4): e0174944. https://doi.org/10.1371/journal.pone.0174944.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Ells L.J., Rees K., Brown T. Interventions for treating children and adolescents with overweight and obesity: an overview of Cochrane reviews. International Journal Of Obesity. 2018; 42(11): 1823–1833. https://doi.org/10.1038/s41366–018–0230-y.</mixed-citation><mixed-citation xml:lang="en">Ells L.J., Rees K., Brown T. Interventions for treating children and adolescents with overweight and obesity: an overview of Cochrane reviews. International Journal Of Obesity. 2018; 42(11): 1823–1833. https://doi.org/10.1038/s41366–018–0230-y.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Pan L., Li X., Feng Y., Hong L. Psychological assessment of children and adolescents with obesity. Journal of International Medical Research. 2018; 46(1): 89–97. https://doi.org/10.1177/0300060517718733</mixed-citation><mixed-citation xml:lang="en">Pan L., Li X., Feng Y., Hong L. Psychological assessment of children and adolescents with obesity. Journal of International Medical Research. 2018; 46(1): 89–97. https://doi.org/10.1177/0300060517718733</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Tsiros M.D., Sinn N., Coates A.M. Treatment of adolescent overweight and obesity.European Journal of Pediatrics. 2008; 167(1): 9–16. doi: 10.1007/s00431–007–0575-z</mixed-citation><mixed-citation xml:lang="en">Tsiros M.D., Sinn N., Coates A.M. Treatment of adolescent overweight and obesity.European Journal of Pediatrics. 2008; 167(1): 9–16. doi: 10.1007/s00431–007–0575-z</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Wickham E. P. 3rd, DeBoer M. D. Evaluation and Treatment of Severe Obesity in Childhood. Clinical Pediatrics. 2015; 54(10): 929–40. https://doi.org/10.1177/0009922814565886</mixed-citation><mixed-citation xml:lang="en">Wickham E. P. 3rd, DeBoer M. D. Evaluation and Treatment of Severe Obesity in Childhood. Clinical Pediatrics. 2015; 54(10): 929–40. https://doi.org/10.1177/0009922814565886</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Kumar S., Kelly, A.S. Review of Childhood Obesity: From Epidemiology, Etiology, and Comorbidities to Clinical Assessment and Treatment. Mayo Clinic proceedings. 2017; 92(2): 251–265. https://doi.org/10.1016/j.mayocp.2016.09.01</mixed-citation><mixed-citation xml:lang="en">Kumar S., Kelly, A.S. Review of Childhood Obesity: From Epidemiology, Etiology, and Comorbidities to Clinical Assessment and Treatment. Mayo Clinic proceedings. 2017; 92(2): 251–265. https://doi.org/10.1016/j.mayocp.2016.09.01</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Malhotra S., Czepiel K.S., Akam E.Y., Shaw A.Y., Sivasubramanian R., Seetharaman S., Stanford F.C. Bariatric surgery in the treatment of adolescent obesity: current perspectives in the United States. Expert Review of Endocrinology and Metabolism. 2021; 16(3): 123–134. https://doi.org/10.1080/17446651.2021.1914585</mixed-citation><mixed-citation xml:lang="en">Malhotra S., Czepiel K.S., Akam E.Y., Shaw A.Y., Sivasubramanian R., Seetharaman S., Stanford F.C. Bariatric surgery in the treatment of adolescent obesity: current perspectives in the United States. Expert Review of Endocrinology and Metabolism. 2021; 16(3): 123–134. https://doi.org/10.1080/17446651.2021.1914585</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
