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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medalphabet-275</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>Применение клопидогрела и ацетилсалициловой кислоты в комплексе лечения сердечно-сосудистых заболеваний</article-title><trans-title-group xml:lang="en"><trans-title>Use of clopidogrel and acetylsalicylic acid in complex treatment of cardiovascular diseases</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Журавлева</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhuravlyova</surname><given-names>M. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Прокофьев</surname><given-names>А. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Prokofyev</surname><given-names>A. B.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сереброва</surname><given-names>С. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Serebrova</surname><given-names>S. Yu.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пономаренко</surname><given-names>Т. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Ponomarenko</surname><given-names>T. M.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белков</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Belkov</surname><given-names>S. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Крысанова</surname><given-names>В. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Krysanova</surname><given-names>V. S.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский университет)» Минздрава России; ФГБУ «Научный центр экспертизы средств медицинского применения» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>First Moscow State Medical University n.a. I.M. Sechenov; Scientific Centre for Expertise of Medical Application Products</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГАОУ ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский университет)» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>First Moscow State Medical University n.a. I.M. Sechenov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>07</day><month>10</month><year>2017</year></pub-date><volume>2</volume><issue>31</issue><issue-title>Кардиология</issue-title><fpage>5</fpage><lpage>9</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Журавлева М.В., Прокофьев А.Б., Сереброва С.Ю., Пономаренко Т.М., Белков С.А., Крысанова В.С., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Журавлева М.В., Прокофьев А.Б., Сереброва С.Ю., Пономаренко Т.М., Белков С.А., Крысанова В.С.</copyright-holder><copyright-holder xml:lang="en">Zhuravlyova M.V., Prokofyev A.B., Serebrova S.Y., Ponomarenko T.M., Belkov S.A., Krysanova V.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/275">https://www.med-alphabet.com/jour/article/view/275</self-uri><abstract><p>В статье дается краткий обзор рекомендаций по назначению ацетилсалициловой кислоты и клопидогрела у пациентов с сердечно-сосудистой патологией, делается акцент на возможные преимущества применения двойной антитромбоцитарной терапии: сочетании ацетилсалициловой кислоты и клопидогрела как наиболее изученного из PY-ингибиторов.</p></abstract><trans-abstract xml:lang="en"><p>The article gives a brief overview of the recommendations for the prescription of acetylsalicylic acid and clopidogrel in patients with cardiovascular pathology, focusing on the possible benefits of using double antiplatelet therapy: acetylsalicylic acid and clopidogrel, as the most considerable PY-inhibitor.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ацетилсалициловая кислота</kwd><kwd>клопидогрел</kwd><kwd>двойная антитромбоцитарная терапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acetylsalicylic acid</kwd><kwd>clopidogrel</kwd><kwd>double antiplatelet therapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">WHO GlobalInfoBase (http: www.infobase.who.int).</mixed-citation><mixed-citation xml:lang="en">WHO GlobalInfoBase (http: www.infobase.who.int).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Национальные рекомендации: кардиоваскулярная профилактика. Всероссийское научное общество кардиологов, Москва, 2011.</mixed-citation><mixed-citation xml:lang="en">Национальные рекомендации: кардиоваскулярная профилактика. Всероссийское научное общество кардиологов, Москва, 2011.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Global status report on noncommunicable diseases, 2014.</mixed-citation><mixed-citation xml:lang="en">Global status report on noncommunicable diseases, 2014.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Graham I, Atar D, Borch-Johnsen K, et al. European Atherosclerosis Society (EAS).Europe-an guidelines on cardiovascular disease prevention in clinical practice. Eur J Cardiovasc Prev Rehabil. 2007 Sep; 14 Suppl 2: S 1-113.</mixed-citation><mixed-citation xml:lang="en">Graham I, Atar D, Borch-Johnsen K, et al. European Atherosclerosis Society (EAS).Europe-an guidelines on cardiovascular disease prevention in clinical practice. Eur J Cardiovasc Prev Rehabil. 2007 Sep; 14 Suppl 2: S 1-113.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">ESC guidelines on the management of stable coronary artery disease The Task Force on the management of stable coronary artery disease of the European Society of Cardiology European Heart Journal (2013) 34, 2949-3003.</mixed-citation><mixed-citation xml:lang="en">ESC guidelines on the management of stable coronary artery disease The Task Force on the management of stable coronary artery disease of the European Society of Cardiology European Heart Journal (2013) 34, 2949-3003.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Roffi M et al. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC) European Heart Journal, Volume 37, Issue 3, 14 January 2016, Pages 267-315.</mixed-citation><mixed-citation xml:lang="en">Roffi M et al. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC) European Heart Journal, Volume 37, Issue 3, 14 January 2016, Pages 267-315.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation European Heart Journal (2017) 00, 1-66.</mixed-citation><mixed-citation xml:lang="en">The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation European Heart Journal (2017) 00, 1-66.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Аверков ОВ, Аспирин и клопидогрел у больных инфарктом миокарда, подвергнутых реперфузионной терапии, Трудный пациент, ноябрь, 2006.</mixed-citation><mixed-citation xml:lang="en">Аверков ОВ, Аспирин и клопидогрел у больных инфарктом миокарда, подвергнутых реперфузионной терапии, Трудный пациент, ноябрь, 2006.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Krasopoulos G, Brister SJ, Beattie WS, et al. Aspirin “resistance” and risk of cardiovascular morbidity: systematic review and meta-analysis. BMJ 2008; 336 (7637): 195-8.</mixed-citation><mixed-citation xml:lang="en">Krasopoulos G, Brister SJ, Beattie WS, et al. Aspirin “resistance” and risk of cardiovascular morbidity: systematic review and meta-analysis. BMJ 2008; 336 (7637): 195-8.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet. 1996 Nov 16.</mixed-citation><mixed-citation xml:lang="en">CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet. 1996 Nov 16.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Tan S et al. Clopidogrel and Aspirin versus Aspirin Alone for Stroke Prevention: A Meta-Analysis. PLoS One. 2015 Aug 13; 10 (8).</mixed-citation><mixed-citation xml:lang="en">Tan S et al. Clopidogrel and Aspirin versus Aspirin Alone for Stroke Prevention: A Meta-Analysis. PLoS One. 2015 Aug 13; 10 (8).</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Valgimigli M et al, 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS, European Heart Journal (2017) 0,1-48.</mixed-citation><mixed-citation xml:lang="en">Valgimigli M et al, 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS, European Heart Journal (2017) 0,1-48.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Mauri L et al. Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents. N Engl J Med2014; 371: 2155-2166.</mixed-citation><mixed-citation xml:lang="en">Mauri L et al. Twelve or 30 months of dual antiplatelet therapy after drug-eluting stents. N Engl J Med2014; 371: 2155-2166.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Hao PP, Zhang MX, et al. Clopidogrel 150 vs. 75 mg day (-1) in patients undergoing percutaneous coronary intervention: a meta-analysis. Journal of Thrombosis and Haemostasis, 4 Apr 2011 (9); 4: 627-637.</mixed-citation><mixed-citation xml:lang="en">Hao PP, Zhang MX, et al. Clopidogrel 150 vs. 75 mg day (-1) in patients undergoing percutaneous coronary intervention: a meta-analysis. Journal of Thrombosis and Haemostasis, 4 Apr 2011 (9); 4: 627-637.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Zhao-Ke WU, Jing-Jing Wang JJ, Wang T, et al. Clopidogrel resistance response in patients with coronary artery disease and metabolic syndrome: the role of hyperglycemia and obesity. Journal of Geriatric Cardiology 2015; 12: 378-82.</mixed-citation><mixed-citation xml:lang="en">Zhao-Ke WU, Jing-Jing Wang JJ, Wang T, et al. Clopidogrel resistance response in patients with coronary artery disease and metabolic syndrome: the role of hyperglycemia and obesity. Journal of Geriatric Cardiology 2015; 12: 378-82.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Рекомендации по диагностике и лечению ИМ с подъемом ST. Кардиологический вестник, 2014; 4: 2-60,</mixed-citation><mixed-citation xml:lang="en">Рекомендации по диагностике и лечению ИМ с подъемом ST. Кардиологический вестник, 2014; 4: 2-60,</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Шишкова В. Н. Механизмы развития сердечно-сосудистых заболеваний при ожирении и инсулинорезистентности: фокус на атеротромботические осложнения, Российский кардиологический журнал № 9 (137), 2016.</mixed-citation><mixed-citation xml:lang="en">Шишкова В. Н. Механизмы развития сердечно-сосудистых заболеваний при ожирении и инсулинорезистентности: фокус на атеротромботические осложнения, Российский кардиологический журнал № 9 (137), 2016.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
