medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2022-13-7-13medalphabet-2696Research ArticleСтатьиПрименение пероральной формы винорелбина при метастатическом раке молочной железы – выбор в пользу качества жизниUse of peroral form of vinorelbine in metastatic breast cancer – choice in favor of quality of lifehttps://orcid.org/0000-0001-5289-7866ЛубенниковаЕ. В.LubennikovaE. V.

Лубенникова Елена Владимировна, к. м. н., с. н. с. химиотерапевтического отделения № 11

Москва

Lubennikova Elena V., PhD Med, senior researcher at Chemotherapy Dept No. 1

lubennikova@yandex.ruhttps://orcid.org/0000-0002-3770-5173ХорошиловМ. В.KhoroshilovM. V.

Хорошилов Максим Викторович, врач-онколог химиотерапевтического отделения № 11

Москва

Khoroshilov Maxim V., oncologist at Chemotherapy Dept No. 11

maximkhoroshilov@gmail.comhttps://orcid.org/0000-0001-6566-8085ДроботН. Ц.DrobotN. C.-D.

Дробот Наталья Цырен-Дондоковна, к. м. н., врач-рентгенологрентгенодиагностического отделения

Москва

Drobot Natalya C.-D., PhD Med, radiologist of Radiodiagnostic Dept

natsym@yandex.ruhttps://orcid.org/0000-0001-7728-9533АртамоноваЕ. В.ArtamonovaE. V.

Артамонова Елена Владимировна, д. м. н., зав. химиотерапевтическим отделением № 11, ФГБУ «Российский онкологический научный центр имени Н. Н. Блохина» Минздрава России; проф. кафедры онкологии и лучевой терапии, ФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н. И. Пирогова» Минздрава России; зав. кафедрой онкологии и торакальной хирургии, ФУВ ГБУЗ МО «Московский областной научно-исследовательский клинический институт имени М. Ф. Владимирского»

Москва

Artamonova Elena V., DM Sci (habil.), head of Chemotherapy Dept No. 1, Russian Oncological Scientific Centre n. a. N. N. Blokhin; professor at Dept of Oncology and Radiation Therapy, Russian National Research Medical University n. a. N. I. Pirogov; head of Dept of Oncology and Thoracic Surgery, Moscow Regional Research Clinical Institute n. a. M. F. Vladimirsky

Moscow

artamonovae@mail.ruФГБУ «Российский онкологический научный центр имени Н. Н. Блохина» Минздрава РоссииРоссияRussian Oncological Scientific Centre n. a. N. N. BlokhinRussian FederationФГБУ «Российский онкологический научный центр имени Н. Н. Блохина» Минздрава России; ФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н. И. Пирогова» Минздрава России; ФУВ ГБУЗ МО «Московский областной научно-исследовательский клинический институт имени М. Ф. Владимирского»РоссияRussian Oncological Scientific Centre n. a. N. N. Blokhin; Russian National Research Medical University n. a. N. I. Pirogov; Moscow Regional Research Clinical Institute n. a. M. F. VladimirskyRussian Federation202226072022013Диагностика и онкотерапия (2)713Copyright © Лубенникова Е.В., Хорошилов М.В., Дробот Н.Ц., Артамонова Е.В., 20222022Лубенникова Е.В., Хорошилов М.В., Дробот Н.Ц., Артамонова Е.В.Lubennikova E.V., Khoroshilov M.V., Drobot N.C., Artamonova E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/2696

Метастатический рак молочной железы (мРМЖ) на сегодняшний день является неизлечимой болезнью, основными целями лечения являются продление жизни, сохранение и повышение ее качества и контроль над симптомами. Современный арсенал противоопухолевых средств при выборе оптимального режима лечения позволяет руководствоваться не только показателями эффективности и безопасности, но и учитывать удобство применения препаратов. Так, пероральная форма винорелбина демонстрирует высокую противоопухолевую эффективность вне зависимости от подтипа мРМЖ и линии лечения, а также позволяет пациенту избежать серьезной токсичности и сохранять привычный образ жизни. В данном обзоре представлены результаты основных клинических исследований винорелбина, особое внимание уделено комбинациям для лечения HER2-положительного метастатического рака молочной железы. Представлен случай успешного лечения редкой патологии – метастатического HER2-позитивного рака молочной железы у мужчины.

Metastatic breast cancer (MBC) is an incurable disease by now. The main goals of treatment are prolongation of life, control of symptoms and preservation/improvement of quality of life. The modern arsenal of antitumor agents when choosing the optimal treatment regimen allows to be guided not only by efficiency and safety values, but also to take into account the ease of using drugs. Thus, the oral form of vinorelbine demonstrates high antitumor efficacy regardless of the subtype of breast cancer and the line of treatment, and also allows the patient to avoid serious toxicity and lead a regular lifestyle. This overview presents the results of the main clinical studies of vinorelbin, with special attention to combinations for the treatment of HER2-positive metastatic breast cancer. A case of successful treatment of a rare pathology – metastatic HER2-positive breast cancer in a man is presented.

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The authors declare that there are no conflicts of interest present.