medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2021-9-7-11medalphabet-2594Research ArticleОБЗОР ЛИТЕРАТУРЫАкне и зуд: патогенетические основы нейрогенного воспаленияAcne and itch: Pathogenic role of neurogenic inflammationhttps://orcid.org/0000-0002-9954-2920СидоренкоЕ. Е.SidorenkoЕ. Е.

 Сидоренко Елизавета Евгеньевна, врач-дерматовенеролог терапевтического отделения; старший лаборант кафедры кожных и венерических болезней

 Sidorenko Elizaveta E., dermatovenerologist, center of internal diseases; chief laboratory assistant at Dept of Skin and Venereal Diseases 

okt@rostgmu.ruhttps://orcid.org/0000-0002-3875-4030ЛьвовА. Н.LvovА. N.

 Львов Андрей Николаевич, д.м.н., проф., рук. отдела аспирантуры и ординатуры, проф. кафедры дерматовенерологии и косметологии, г.н.с..

 Lvov Andrey N., DM Sci (habil.), professor, head of Dept of Postgraduate Studies and Residency, professor at Dermatovenerology and Cosmetology Dept, chief researcher 

https://orcid.org/0000-0002-2985-5729МиченкоА. В.MichenkoА. V.

 Миченко Анна Валентиновна, к.м.н., доцент кафедры дерматовенерологии и косметологии, врач-дерматовенеролог

 Michenko Anna V., PhD Med, assistant professor at Dermatovenerology and Cosmetology Dept, dermatovenerologist 

amichenko@mail.ruhttps://orcid.org/0000-0002-7387-2497СидоренкоО. А.SidorenkoО. А.

 Сидоренко Ольга Анатольевна, д.м.н., проф., зав. кафедрой кожных и венерических болезней

 Sidorenko Olga A., DM Sci (habil.), professor, head of Dept of Skin and Venereal Diseases 

okt@rostgmu.ruhttps://orcid.org/0000-0002-9090-8287КоленькоН. Г.KolenkoN. G.

 Коленько Наталья Геннадьевна, к.м.н., ст. преподаватель кафедры управления сестринской деятельностью медицинского института4, врач-косметолог, дерматовенеролог

 Kolenko Natalia G., PhD Med, senior lecturer at Dept of Nursing Management in Medical Institute, cosmetologist, dermatovenereologist 

nkolenko@mail.ruФГБОУ ВО «Ростовский государственный медицинский университет» Минздрава РоссииРоссияRostov State Medical UniversityRussian FederationФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента Российской Федерации; Медицинский научно-образовательный центр ФГБОУ ВО «Московский государственный университет имени М.В. Ломоносова»РоссияCentral State Medical Academy, Moscow; Medical Scientifc and Educational Centre at Moscow State University n.a. M.V. LomonosovRussian FederationФГАОУ ВО «Российский университет дружбы народов»; Клинико-диагностический центр «МЕДСИ на Красной Пресне»РоссияPeoples’ Friendship University of Russia; Clinical and Diagnostic Centre ‘MEDSI on Krasnaya Presnya’Russian Federation20221705202208Дерматология (1)711Copyright © Сидоренко Е.Е., Львов А.Н., Миченко А.В., Сидоренко О.А., Коленько Н.Г., 20222022Сидоренко Е.Е., Львов А.Н., Миченко А.В., Сидоренко О.А., Коленько Н.Г.Sidorenko Е.Е., Lvov А.N., Michenko А.V., Sidorenko О.А., Kolenko N.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/2594

По современным представлениям, в основе патогенеза акне лежат не столько морфофункциональные изменения и гиперколонизация C. acnes в зоне сально-волосяного фолликула, сколько перманентное воспаление, ранее считавшееся вторичной патофизиологической реакцией. В последнее время большое внимание уделяется кожному зуду, который может сопутствовать высыпным элементам акне.

В обзоре проанализированы данные, касающиеся патогенетической роли факторов нейрогенного воспаления при акне; подчеркивается клиническая значимость зуда в общей картине болезни, его влияние на психосоматические корреляции.

According to the current concepts, pathogenesis of acne includes signifcant morphological and functional changes and hypercolonization of C. acnes of the sebaceous hair follicle. But most important input into pathogenesis of acne gives permanent inflammation, previously considered as a secondary pathophysiological reaction. Recently, much attention has been given to pruritus associated with acne lesions. This literature review analyzes the data concerning the pathogenetic role of neurogenic inflammation in acne; the clinical importance of itch in the overall presentation of the disease is underlined, and its influence on psychosomatic correlations is presented.

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The authors declare that there are no conflicts of interest present.