medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2022-5-54-59medalphabet-2592Research ArticleСтатьиИксабепилон в терапии метастатического рака молочной железы: обзор литературы и клиническое наблюдениеRole of ixabepilone in metastatic breast cancer treatment: Review and clinical casehttps://orcid.org/0000-0002-0105-9376ГаньшинаИ. П.GanshinaI P.

Ганьшина Инна Петровна, к. м. н., в. н. с. отделения химиотерапии № 1

Москва

Ganshina Inna P., PhD Med, leading researcher of Dept of Chemotherapy No. 1

Moscow

ganshinainna77@mail.ruhttps://orcid.org/0000-0002-8266-0218ГордееваО. О.GordeevaO. O.

Гордеева Ольга Олеговна, к. м. н., врач-онколог отделения химиотерапии № 4

Москва

Gordeeva Olga O., PhD Med, oncologist of Dept of Chemotherapy No. 4

Moscow

helga.stolz@yandex.ruhttps://orcid.org/0000-0001-7728-9533АртамоноваЕ. В.ArtamonovaE. V.

Артамонова Елена Владимировна, д. м. н., зав. химиотерапевтическим отделением № 1, проф. кафедры, зав. кафедрой онкологии и торакальной хирургии

Москва

Artamonova Elena V., DM Sci (habil.), head of Dept of Chemotherapy No. 1,professor at Dept, head of Dept of Oncology and Thoracic Surgery

Moscow

artamonovae@mail.ruФГБУ «Национальный медицинский исследовательский центр онкологии имени Н. Н. Блохина» Минздрава РоссииРоссияNational Medical Research Centre of Oncology n. a. N. N. BlokhinRussian FederationФГБУ «Национальный медицинский исследовательский центр онкологии имени Н. Н. Блохина» Минздрава России; ФГАОУ ВО «Российский национальный исследовательский медицинский университет имени Н. И. Пирогова» Минздрава России; ГБУЗ МО «Московский областной научно-исследовательский клинический институт имени М. Ф. Владимирского»РоссияNational Medical Research Centre of Oncology n. a. N. N. Blokhin; Russian National Research Medical University n. a. N. I. Pirogov; Moscow Regional Research Clinical Institute named after M. F. VladimirskyRussian Federation20220505202215Диагностика и онкотерапия (1)5459Copyright © Ганьшина И.П., Гордеева О.О., Артамонова Е.В., 20222022Ганьшина И.П., Гордеева О.О., Артамонова Е.В.Ganshina I.P., Gordeeva O.O., Artamonova E.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/2592

В статье рассмотрены основные аспекты применения препарата иксабепилон – от механизма действия и результатов рандомизированных исследований до клинических рекомендаций, утверждающих место препарата в современной терапии метастатического рака молочной железы. Также представлен собственный клинический опыт применения иксабепилона у интенсивно предлеченной пациентки, демонстрирующий возможность стабилизации процесса после прогрессирования на фоне семи предшествующих линий терапии. Использование всех имеющихся на сегодняшний день доступных препаратов позволяет существенно расширить возможности терапии, и, таким образом, продлить жизнь пациенток с метастатическим раком молочной железы.

This article reviews different aspects of usage of ixabepilone: from mechanism of action and data of clinical trials to clinical recommendations. We also present our own experience with this drug, which illustrates additional opportunities for extending survival in patient with metastatic breast cancer after seven lines of therapy. Rational usage of all available drugs helps to expand our treatment horizons and prolong lifetime of our patients.

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The authors declare that there are no conflicts of interest present.