medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2022-5-29-37medalphabet-2588Research ArticleСтатьиВитамин D и рак поджелудочной железы: влияние на онкогенез, перспективы использования в диагностике и леченииVitamin D and pancreatic cancer: Impact on oncogenesis, prospects for use in diagnosis and treatmenthttps://orcid.org/0000-0002-5058-8821МоисеенкоВ. Е.MoiseenkoV. E.

Моисеенко Владислав Евгеньевич, к. м. н., врач-хирург, онколог отделения хирургии № 2

Санкт-Петербург

Moiseenko Vladislav E., PhD Med, surgeon, oncologist of Dept of Surgery No. 2

Saint Petersburg

tmpr@inbox.ruhttps://orcid.org/0000-0003-3994-1329ПавловскийА. В.PavlovskyA. V.

Павловский Александр Васильевич, д. м. н., г. н. с.

Санкт-Петербург

Pavlovsky Alexander V., DM Sci (habil.), chief researcher

Saint Petersburg

prof.pavlovskiy@mail.ruhttps://orcid.org/0000-0004-5158-8895ПоповС. А.PopovS. A.

Попов Сергей Александрович, к. м. н., врач-хирург, онколог отделения хирургии № 2

Санкт-Петербург

Popov Sergey A., PhD Med, surgeon, oncologist of Dept of Surgery No. 2

Saint Petersburg

spsergey@inbox.ruКовенкоА. Е.KovenkoA. E.

Ковенко Альбина Евгеньевна, аспирант кафедры радиологии, хирургии и онкологии

Санкт-Петербург

Kovenko Albina E., post-graduate student of Dept of Radiology, Surgery and Oncology

Saint Petersburg

https://orcid.org/0000-0002-7435-8326СоловьеваЛ. А.SolovyovaL. A.

Соловьева Людмила Александровна, клинический ординатор кафедры радиологии, хирургии и онкологии

Санкт-Петербург

Solovyova Lyudmila A., resident of Dept of Radiology, Surgery and Oncology

Saint Petersburg

https://orcid.org/0000-0003-2239-2044СеменовК. Н.SemenovK. N.

Семенов Константин Николаевич, д. х. н., проф., зав. кафедрой общей и биоорганической химии

Санкт-Петербург

Semenov Konstantin N., Doctor of Chem Sci (habil.), professor, head of Dept of General and Bioorganic Chemistry

Saint Petersburg

knsemenov@gmail.comhttps://orcid.org/0000-0002-3717-0471ШаройкоВ. В.SharoikoV. V.

Шаройко Владимир Владимирович, д. б. н., проф., проф. кафедры общей и биоорганической химии

Санкт-Петербург

Sharoiko Vladimir V., Doctor of Bio Sci (habil.), professor, professor at Dept of General and Bioorganic Chemistry

Saint Petersburg

https://orcid.org/0000-0002-8746-8452ГрановД. А.GranovD. A.

Гранов Дмитрий Анатольевич, д. м. н., проф., акад. РАН, научный руководитель

Санкт-Петербург

Granov Dmitry A., DM Sci (habil.), professor, academician of RAS, scientific adviser

Saint Petersburg

D.granov@gmail.ruФГБУ «Российский научный центр радиологии и хирургических технологий имени академика А. М. Гранова» Минздрава РоссииРоссияRussian Scientific Centre of Radiology and Surgical Technologies n. a. academician A. M. GranovRussian FederationФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет имени академика И. П. Павлова» Минздрава РоссииРоссияFirst Saint Petersburg State Medical University n. a. academician I. P. PavlovRussian Federation20220505202215Диагностика и онкотерапия (1)2937Copyright © Моисеенко В.Е., Павловский А.В., Попов С.А., Ковенко А.Е., Соловьева Л.А., Семенов К.Н., Шаройко В.В., Гранов Д.А., 20222022Моисеенко В.Е., Павловский А.В., Попов С.А., Ковенко А.Е., Соловьева Л.А., Семенов К.Н., Шаройко В.В., Гранов Д.А.Moiseenko V.E., Pavlovsky A.V., Popov S.A., Kovenko A.E., Solovyova L.A., Semenov K.N., Sharoiko V.V., Granov D.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/2588

По данным Международного фонда изучения рака, злокачественные новообразования поджелудочной железы занимают четвертое место по причине смерти среди всех онкологических нозологий. За последние несколько лет отмечается тенденция в виде увеличения числа впервые выявленных случаев заболевания. Неутешительные данные статистики рака поджелудочной железы диктуют условия для более интенсивного изучения природы, поиску новых возможных методов раннего выявления и лечения рака поджелудочной железы. Одним из перспективных направлений является изучение влияния витамина D и его дериватов на канцерогенез и профилактику рака поджелудочной железы. Витамин D и его дериваты обладают способностью регулировать рост, дифференцировку, апоптоз и ангиогенез клеток, таким образом, концентрация данного вещества в плазме крови у пациентов групп риска развития рака поджелудочной железы может быть использовано в комплексе мер по раннему выявлению этой патологии. Одной из морфологических особенностей рака поджелудочной железы, обуславливающей резистентность к химиотерапевтическим агентам, является наличие десмопластической стромы. Витамин D способен оказывать влияние на функционирование элементов десмопластической стромы рака поджелудочной железы, что может способствовоать улучшенному воздействию цитотоксической химиотерапии и формированию иммуногенного ответа на лечение. Один из плейотропных эффектов витамина D заключается в регулировании иммунной системы: он может играть роль в повышении чувствительности опухолей к другим иммунотерапевтическим средствам. Данные направления считаются перспективными в лечении рака поджелудочной железы. Цель данного литературного обзора – осветить влияние витамина D на канцерогенез, раннее выявление и лечение рака поджелудочной железы.

According to the International Foundation for Research on Cancer, malignant neoplasms of the pancreas are the fourth leading cause of death among all oncological nosologies. Over the past few years, there has been a trend in the form of an increase in the number of newly diagnosed cases of the disease. The disappointing data of pancreatic cancer statistics dictate the conditions for a more intensive study of nature, the search for new possible methods for the early detection and treatment of pancreatic cancer. One of the promising areas is to study the effect of vitamin D and its derivatives on carcinogenesis and prevention of pancreatic cancer. Vitamin D and its derivatives have the ability to regulate growth, differentiation, apoptosis and angiogenesis of cells, thus, the concentration of this substance in blood plasma in patients at risk of developing pancreatic cancer can be used in a set of measures for the early detection of this pathology. One of the morphological features of pancreatic cancer, which determines resistance to chemotherapeutic agents, is the presence of a desmoplastic stroma. Vitamin D is able to influence the functioning of the elements of the desmoplastic stroma of pancreatic cancer, which may contribute to an improved effect of cytotoxic chemotherapy and the formation of an immunogenic response to treatment. One of the pleiotropic effects of vitamin D is in the regulation of the immune system: it may play a role in increasing the sensitivity of tumors to other immunotherapies. These areas are considered promising in the treatment of pancreatic cancer. The purpose of this literature review is to highlight the effect of vitamin D on carcinogenesis, early detection and treatment of pancreatic cancer.

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The authors declare that there are no conflicts of interest present.