medalphabetМедицинский алфавитMedical alphabet2078-56312949-2807ООО «Альфмед»10.33667/2078-5631-2022-6-47-52medalphabet-2564Research ArticleСтатьиБиомаркеры неспецифического воспаления и атеросклероза сонных артерий при синдроме обструктивного апноэ снаBiomarkers of non-specific inflammation and atherosclerosis of carotid arteries in obstructive sleep apnea syndromehttps://orcid.org/0000-0002-0574-8064ПолонскийЕ. Л.PolonskiyE. L.

Полонский Евгений Львович, врач невролог отделения клинической неврологии отдела клинической неврологии и медицины сна

Санкт-Петербург

Polonsky Evgeniy L., neurologist of Dept of Clinical Neurology, Dept of Clinical Neurology and Sleep Medicine

Saint Petersburg

limbuss1@rambler.ruhttps://orcid.org/0000-0002-5422-2878ЗыбинаН. Н.ZybinaN. N.

Зыбина Наталья Николаевна, д.б.н., проф., зав. отделом лабораторной диагностики

Санкт-Петербург

Zybina Natalia N., Dr Bio Sci, professor, head of Dept of Clinical Laboratory Diagnostics

Saint Petersburg

zybinan@inbox.ruhttps://orcid.org/0000-0003-4722-0900ТихомироваО. В.TikhomirovaO. V.

Тихомирова Ольга Викторовна, д.м.н., доцент, зав. отделом клинической неврологии и медицины сна

Санкт-Петербург

Tikhomirova Olga V., DM Sci (habil.), associate professor, head of Dept of Clinical Neurology and Sleep Medicine

Saint Petersburg

Olvitikhomirova@gmail.comhttps://orcid.org/0000-0001-6411-1402ЛомоваИ. П.LomovaI. P.

Ломова Ирина Павловна, к.м.н., с.н.с. НИЛ цереброваскулярной патологии научноисследовательского центра

Санкт-Петербург

Lomova Irina P., PhD Med, senior research of Cerebrovascular Disease Laboratory

Saint Petersburg

irpalo@mail.ruФГБУ «Всероссийский центр экстренной и радиационной медицины имени А.М. Никифорова» МЧС РоссииРоссияAll-Russian Centre for Emergency and Radiation Medicine n.a. A.M. NikiforovRussian Federation20222204202216Современная лаборатория (1)4752Copyright © Полонский Е.Л., Зыбина Н.Н., Тихомирова О.В., Ломова И.П., 20222022Полонский Е.Л., Зыбина Н.Н., Тихомирова О.В., Ломова И.П.Polonskiy E.L., Zybina N.N., Tikhomirova O.V., Lomova I.P.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.med-alphabet.com/jour/article/view/2564Цель исследования

Цель исследования. Выявление значимых лабораторных маркеров развития атеросклероза (АС) сонных артерий (СА) у пациентов с синдромом обструктивного апноэ (СОАС).

Материалы и методы

Материалы и методы. Обследовано 152 пациента мужского пола, у 84 из которых, по данным полисомнографии (ПСГ), диагностирован СОАС. Диагностику АС СА проводили методом триплексного сканирования (ТС). Комплекс лабораторных исследований включал оценку показателей липидного обмена, концентрации высокочувствительного С-реактивного белка (вчСРБ), интерлейкина‑1β (ИЛ‑1β), интерлейкина‑6 (ИЛ‑6) и интерлейкина‑10 (ИЛ‑10) в сыворотке крови.

Результаты

Результаты. У пациентов с СОАС обнаружено статистически значимое увеличение комплекса проатерогенных факторов: вчСРБ, провоспалительных цитокинов, соотношения апобелков и коэффициента атерогенности по сравнению с пациентами без СОАС не смотря на отсутствие различий по выраженности атеросклеротического поражения сонных артерий в этих группах.

Заключение

Заключение. Развитие СОАС ассоциировано с выраженными нарушениями липидного обмена и активацией неспецифического воспаления, что определяет повышенный риск развития атеросклероза в данной группке пациентов.

Purpose of study

Purpose of study. Identification of significant laboratory markers for the development of atherosclerosis (AS) of the carotid arteries (CA) in patients with obstructive sleep apnea syndrome (OSAS).

Materials and methods

Materials and methods. 152 male patients were examined, 84 of whom, according to polysomnography (PSG), were diagnosed with OSAS. Diagnosis of AS CA was performed by triplex scanning. The complex of laboratory studies included the assessment of lipid metabolism, the concentration of highly sensitive C-reactive protein (hsCRP), interleukin‑1β (IL‑1β), interleukin‑6 (IL‑6) and interleukin‑10 (IL‑10) in blood serum.

Results

Results. In patients with OSAS, a statistically significant increase in the complex of proatherogenic factors was found: hsCRP, pro-inflammatory cytokines, ratio of apoproteins and atherogenic coefficient compared with patients without OSAS despite the absence of differences in the severity of atherosclerotic lesions of the carotid arteries in these groups

Conclusion

Conclusion. The development of OSAS is associated with severe lipid metabolism disorders and activation of nonspecific inflammation, which determines an increased risk of atherosclerosis in this group of patients.

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The authors declare that there are no conflicts of interest present.