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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medalphabet</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский алфавит</journal-title><trans-title-group xml:lang="en"><trans-title>Medical alphabet</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2078-5631</issn><issn pub-type="epub">2949-2807</issn><publisher><publisher-name>ООО «Альфмед»</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.33667/2078-5631-2022-3-23-28</article-id><article-id custom-type="elpub" pub-id-type="custom">medalphabet-2541</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group></article-categories><title-group><article-title>COVID-19 в структуре факторов риска когнитивных нару шений, способы коррекции</article-title><trans-title-group xml:lang="en"><trans-title>COVID-19 in structure of risk factors for cognitive impairment, methods of correction</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6747-3476</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Камчатнов</surname><given-names>П. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Kamchatnov</surname><given-names>P. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Камчатнов Павел Рудольфович, д.м.н., проф. кафедры неврологии, нейрохирургии и медицинской генетики лечебного факультета</p><p>Москва</p></bio><bio xml:lang="en"><p>Kamchatnov Pavel R., DM Sci (habil.), professor at Dept of Neurology, Neurosurgery and Medical Genetics, Faculty of Medicine</p><p>Moscow</p></bio><email xlink:type="simple">pavkam7@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6018-6327</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Черемин</surname><given-names>Р. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Cheremin</surname><given-names>R. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Черемин Роман Авенирович, к.м.н., гл. врач</p><p>Москва</p></bio><bio xml:lang="en"><p>Cheremin Roman A., PhD Med, chief physician</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6019-4981</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Скипетрова</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Skipetrova</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Скипетрова Людмила Александровна, зам. гл. врача</p><p>Москва</p></bio><bio xml:lang="en"><p>Skipetrova Lyudmila A., deputy chief physician</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5221-0478</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Никонова</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Nikonova</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Никонова Анастасия Алексеевна, к.м.н., ассистент кафедры неврологии, нейрохирургии и медицинской генетики лечебного факультета</p><p>Москва</p></bio><bio xml:lang="en"><p>Nikonova Anastasia A., PhD Med, assistant at Dept of Neurology, Neurosurgery and Medical Genetics, Faculty of Medicine</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6418-8063</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пышкина</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Pyshkina</surname><given-names>L. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Пышкина Людмила Ильинична, д.м.н., проф. кафедры неврологии, нейрохирургии и медицинской генетики лечебного факультета</p><p>Москва</p></bio><bio xml:lang="en"><p>Pyshkina Lyudmila I., DM Sci (habil.), professor at Dept of Neurology, Neurosurgery and Medical Genetics, Faculty of Medicine</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФБГОУ ВО «Российский национальный исследовательский медицинский университет имени Н. И. Пирогова» Минздрава России</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian National Research Medical University n.a. N. I. Pirogov</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ «Центр патологии речи и нейрореабилитации Департамента здравоохранения Москвы»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Centre of Speech Pathology and Neurorehabilitation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>15</day><month>04</month><year>2022</year></pub-date><volume>0</volume><issue>3</issue><issue-title>Современная поликлиника (1)</issue-title><fpage>23</fpage><lpage>28</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Камчатнов П.Р., Черемин Р.А., Скипетрова Л.А., Никонова А.А., Пышкина Л.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Камчатнов П.Р., Черемин Р.А., Скипетрова Л.А., Никонова А.А., Пышкина Л.А.</copyright-holder><copyright-holder xml:lang="en">Kamchatnov P.R., Cheremin R.A., Skipetrova L.A., Nikonova A.A., Pyshkina L.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.med-alphabet.com/jour/article/view/2541">https://www.med-alphabet.com/jour/article/view/2541</self-uri><abstract><p>Цереброваскулярные расстройства – одна из основных причин формирования когнитивных нарушений. Понимание причины сосудистого поражения головного мозга, установление имеющихся факторов риска позволяют выбрать оптимальную тактику лечения и замедление прогрессирования когнитивных нарушений. В статье рассматриваются сведения о факторах риска развития когнитивных нарушений: возраст, уровень образования, социальная изоляция и отсутствие физической активности, избыточное потребление алкоголя, курение, пребывание в условиях загрязненного воздуха, артериальная гипертензия, утрата слуха, черепно-мозговая травма, сахарный диабет, депрессия, цереброваскулярные заболевания, болезнь Альцгеймера, генетическая предрасположенность. Приведены сведения о возможном влиянии COVID-19 на развитие и прогрессирование когнитивных нарушений. Рассмотрены возможности нейрометаболических препаратов в лечении когнитивных нарушений. Приведены результаты анализа опыта применения препарата цитиколин (Нооцил) при лечении больных с когнитивными нарушениями, отмечены возможные преимущества назначения Нооцила в виде раствора дли перорального применения.</p></abstract><trans-abstract xml:lang="en"><p>Cerebrovascular disorders are one of the main causes of cognitive impairment. Understanding the cause of vascular brain damage, establishing the existing risk factors allow choosing the optimal treatment strategy and slowing the progression of cognitive impairment. The article discusses information about risk factors for cognitive impairment: age, level of education, social isolation and lack of physical activity, excessive alcohol consumption, smoking, exposure to polluted air, hypertension, hearing loss, traumatic brain injury, diabetes mellitus, depression, cerebrovascular diseases, Alzheimer’s disease, genetic predisposition. Information is provided on the possible impact of COVID-19 on the development and progression of cognitive impairment. The possibilities of neurometabolic drugs in the treatment of cognitive disorders are considered. The results of the analysis of the experience of using the drug citicoline (Noocil) in the treatment of patients with cognitive impairment are presented, the possible advantages of prescribing Noocil in the form of a solution for oral administration are noted.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>когнитивные нарушения</kwd><kwd>факторы риска</kwd><kwd>COVID-19</kwd><kwd>постковидный синдром</kwd><kwd>лечение</kwd><kwd>приверженность</kwd><kwd>цитиколин</kwd><kwd>Нооцил</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cognitive impairment</kwd><kwd>risk factors</kwd><kwd>COVID-19</kwd><kwd>postcovid syndrome</kwd><kwd>treatment</kwd><kwd>adherence</kwd><kwd>citicoline</kwd><kwd>Noocil</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">World Health Organization (WHO) and Alzheimer disease international. Dementia: A Public Health Priority; 2012.</mixed-citation><mixed-citation xml:lang="en">World Health Organization (WHO) and Alzheimer disease international. Dementia: A Public Health Priority; 2012.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Brookmeyer R., Evans D.A., Hebert L., et al. National estimates of the prevalence of Alzheimer’s disease in the United States. Alzheimers Dement. 2011; 7 (1): 61–73. DOI: 10.1016/j.jalz.2010.11.00.</mixed-citation><mixed-citation xml:lang="en">Brookmeyer R., Evans D.A., Hebert L., et al. National estimates of the prevalence of Alzheimer’s disease in the United States. Alzheimers Dement. 2011; 7 (1): 61–73. DOI: 10.1016/j.jalz.2010.11.00.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Prince M, Knapp M, Guerchet M, et al. Dementia UK: update. Alzheimer’s. Society. 2014</mixed-citation><mixed-citation xml:lang="en">Prince M, Knapp M, Guerchet M, et al. Dementia UK: update. Alzheimer’s. Society. 2014</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Wittenberg R, Knapp M, Hu B, et al. The costs of dementia in England. Int J Geriatr Psychiatry. 2019; 34 (7): 1095–1103. DOI: 10.1002/gps.5113.</mixed-citation><mixed-citation xml:lang="en">Wittenberg R, Knapp M, Hu B, et al. The costs of dementia in England. Int J Geriatr Psychiatry. 2019; 34 (7): 1095–1103. DOI: 10.1002/gps.5113.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Alzheimer’s Society. Dementia UK Update. 2014.</mixed-citation><mixed-citation xml:lang="en">Alzheimer’s Society. Dementia UK Update. 2014.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">McGilton K.S., Davis A.M., Naglie G., et al. Evaluation of patient-centered rehabilitation model targeting older persons with a hip fracture, including those with cognitive impairment. BMC Geriatr. 2013; 13 (1): 1–8. DOI: 10.1186/1471–2318–13–136.</mixed-citation><mixed-citation xml:lang="en">McGilton K.S., Davis A.M., Naglie G., et al. Evaluation of patient-centered rehabilitation model targeting older persons with a hip fracture, including those with cognitive impairment. BMC Geriatr. 2013; 13 (1): 1–8. DOI: 10.1186/1471–2318–13–136.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Draper B. Understanding Alzheimer’s disease and other dementias: Jessica Kingsley Publishers; 2013.</mixed-citation><mixed-citation xml:lang="en">Draper B. Understanding Alzheimer’s disease and other dementias: Jessica Kingsley Publishers; 2013.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Altomare D., Molinuevo J.L, Ritchie C., et al. Brain Health Services: Organization, structure and challenges for implementation. A user manual for Brain Health Services – Part 1 of 6. Alzheimers Res Ther. 2021.</mixed-citation><mixed-citation xml:lang="en">Altomare D., Molinuevo J.L, Ritchie C., et al. Brain Health Services: Organization, structure and challenges for implementation. A user manual for Brain Health Services – Part 1 of 6. Alzheimers Res Ther. 2021.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Livingston G., Sommerlad A., Orgeta V., et al. Dementia prevention, intervention, and care. Lancet. 2017; 390 (10113): 2673–2734. DOI: 10.1016/S0140–6736(17)31363–6.</mixed-citation><mixed-citation xml:lang="en">Livingston G., Sommerlad A., Orgeta V., et al. Dementia prevention, intervention, and care. Lancet. 2017; 390 (10113): 2673–2734. DOI: 10.1016/S0140–6736(17)31363–6.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Livingston G., Huntley J., Sommerlad A., et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020; 396 (10248): 413–446. DOI: 10.1016/S0140–6736(20)30367–6.</mixed-citation><mixed-citation xml:lang="en">Livingston G., Huntley J., Sommerlad A., et al. Dementia prevention, intervention, and care: 2020 report of the Lancet Commission. Lancet. 2020; 396 (10248): 413–446. DOI: 10.1016/S0140–6736(20)30367–6.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Камчатнов П.Р. Когнитивный резерв, когнитивные нарушения и возможность их медикаментозной коррекции. Журн. неврол. и психиат. им. С.С. Корсакова. 2014; 4: 52–56.</mixed-citation><mixed-citation xml:lang="en">Kamchatnov P.R. Cognitive reserve, cognitive disorders and the possibility of their drug correction. S.S. Korsakov Journal of Neurology and Psychiatry = Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2014; 4: 52–56. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Arenaza-Urquijo E.M., Wirth M., Chételat G. Cognitive reserve and lifestyle: moving towards preclinical Alzheimer’s disease. Front Aging Neurosci. 2015; 7: т134. DOI: 10.3389/fnagi.2015.00134.</mixed-citation><mixed-citation xml:lang="en">Arenaza-Urquijo E.M., Wirth M., Chételat G. Cognitive reserve and lifestyle: moving towards preclinical Alzheimer’s disease. Front Aging Neurosci. 2015; 7: т134. DOI: 10.3389/fnagi.2015.00134.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Peelle J.E., Troiani V., Grossman M., Wingﬁeld A. Hearing loss in older adults affects neural systems supporting speech comprehension. J Neurosci. 2011; 31т(35): 12638–12643. DOI: 10.1523/jneurosci.2559–11.2011.</mixed-citation><mixed-citation xml:lang="en">Peelle J.E., Troiani V., Grossman M., Wingﬁeld A. Hearing loss in older adults affects neural systems supporting speech comprehension. J Neurosci. 2011; 31т(35): 12638–12643. DOI: 10.1523/jneurosci.2559–11.2011.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Hughes T. F., Ganguli M. Modifiable midlife risk factors for late-life cognitive impairment and dementia. Curr Psychiatry Rev. 2009; 5 (2): 73–92. DOI: 10.2174/157340009788167347.</mixed-citation><mixed-citation xml:lang="en">Hughes T. F., Ganguli M. Modifiable midlife risk factors for late-life cognitive impairment and dementia. Curr Psychiatry Rev. 2009; 5 (2): 73–92. DOI: 10.2174/157340009788167347.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Leon B.M., Maddox T.M. Diabetes and cardiovascular disease: Epidemiology, biological mechanisms, treatment recommendations and future research. World J Diabetes. 2015; 6: 1246–1258. DOI: 10.4239/wjd.v6.i13.1246.</mixed-citation><mixed-citation xml:lang="en">Leon B.M., Maddox T.M. Diabetes and cardiovascular disease: Epidemiology, biological mechanisms, treatment recommendations and future research. World J Diabetes. 2015; 6: 1246–1258. DOI: 10.4239/wjd.v6.i13.1246.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Kivimäki M., Singh-Manoux A., Pentti J., et al. Physical inactivity, cardiometabolic disease, and risk of dementia: an individual-participant meta-analysis. BMJ. 2019; 365: 1495. DOI: 10.1136/bmj.l1495.</mixed-citation><mixed-citation xml:lang="en">Kivimäki M., Singh-Manoux A., Pentti J., et al. Physical inactivity, cardiometabolic disease, and risk of dementia: an individual-participant meta-analysis. BMJ. 2019; 365: 1495. DOI: 10.1136/bmj.l1495.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Shalev D., Arbuckle M.R. Metabolism and memory: obesity, diabetes, and dementia. Biol Psychiatry. 2017; 82 (11): e81–e83. DOI: 10.1016/j.biopsych.2017.09.025.</mixed-citation><mixed-citation xml:lang="en">Shalev D., Arbuckle M.R. Metabolism and memory: obesity, diabetes, and dementia. Biol Psychiatry. 2017; 82 (11): e81–e83. DOI: 10.1016/j.biopsych.2017.09.025.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Чукаева И.И., Орлова Н.В., Алешкин В.А., и др. Воспалительные реакции у больных ишемической болезнью сердца с сопутствующими ожирением и сахарным диабетом 2-го типа. Клиническая медицина. 2008. Т. 86. № 1. С. 27–30</mixed-citation><mixed-citation xml:lang="en">Chukaeva I.I., Orlova N.V., Aleshkin V.A., i dr. Vospalitel’nye reakcii u bol’nyh ishemicheskoj bolezn’yu serdca s soputstvuyushchimi ozhireniem i saharnym diabetom 2-go tipa. Klinicheskaya medicina. 2008. T. 86. No. 1. P. 27–30.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Чукаева И.И., Орлова Н.В., Хавка Н.Н., Клепикова М.В. Изучение факторов воспаления у больных с метаболическим синдромом. Лечебное дело. 2010. № 4. С. 50–56</mixed-citation><mixed-citation xml:lang="en">Chukaeva I.I., Orlova N.V., Havka N.N., Klepikova M.V. Izuchenie faktorov vospaleniya u bol’nyh s metabolicheskim sindromom. Lechebnoe delo. 2010. No. 4. P. 50–56.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Peters R., Ee N., Peters J., et al. Air pollution and dementia: a systematic review. J Alzheimers Dis. 2019; 70 (s1): P. 145–163. DOI: 10.3233/JAD-180631.</mixed-citation><mixed-citation xml:lang="en">Peters R., Ee N., Peters J., et al. Air pollution and dementia: a systematic review. J Alzheimers Dis. 2019; 70 (s1): P. 145–163. DOI: 10.3233/JAD-180631.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Cacioppo J.T., Hawkley L.C., Norman G.J., Berntson G.G. Social isolation. Ann NY Acad Sci. 2011; 1231 (1): 17–22. DOI: 10.1111/j.1749–6632.2011.06028.x</mixed-citation><mixed-citation xml:lang="en">Cacioppo J.T., Hawkley L.C., Norman G.J., Berntson G.G. Social isolation. Ann NY Acad Sci. 2011; 1231 (1): 17–22. DOI: 10.1111/j.1749–6632.2011.06028.x</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Kobayashi L.C., Steptoe A. Social isolation, loneliness, and health behaviors at older ages: longitudinal cohort study. Ann Behav Med. 2018; 52 (7): 582–593. DOI: 10.1093/abm/kax033.</mixed-citation><mixed-citation xml:lang="en">Kobayashi L.C., Steptoe A. Social isolation, loneliness, and health behaviors at older ages: longitudinal cohort study. Ann Behav Med. 2018; 52 (7): 582–593. DOI: 10.1093/abm/kax033.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Kunkle B.W., Grenier-Boley B., Sims R., et al. Genetic meta-analysis of diagnosed Alzheimer’s disease identiﬁes new risk loci and implicates Aβ, tau, immunity and lipid processing. Nat Genet. 2019; 51 (3): 414–430. DOI: 10.1038/s41588–019–0358–2.</mixed-citation><mixed-citation xml:lang="en">Kunkle B.W., Grenier-Boley B., Sims R., et al. Genetic meta-analysis of diagnosed Alzheimer’s disease identiﬁes new risk loci and implicates Aβ, tau, immunity and lipid processing. Nat Genet. 2019; 51 (3): 414–430. DOI: 10.1038/s41588–019–0358–2.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">van der Lee S.J., Wolters F.J., Ikram M.K., et al. The effect of APOE and other common genetic variants on the onset of Alzheimer’s disease and dementia: a community-based cohort study. Lancet Neurol. 2018; 17: 434–444. DOI: 10.1016/S1474–4422(18)30053-X.</mixed-citation><mixed-citation xml:lang="en">van der Lee S.J., Wolters F.J., Ikram M.K., et al. The effect of APOE and other common genetic variants on the onset of Alzheimer’s disease and dementia: a community-based cohort study. Lancet Neurol. 2018; 17: 434–444. DOI: 10.1016/S1474–4422(18)30053-X.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Reiman E. M., Arboleda-Velasquez J.F., Quiroz Y. T., et al. Exceptionally low likelihood of Alzheimer’s dementia in APOE 2 homozygotes from a 5,000-person neuropathological study. Nat Commun. 2020; 11 (1): 667. DOI: 10.1038/s41467–019–14279–8.</mixed-citation><mixed-citation xml:lang="en">Reiman E. M., Arboleda-Velasquez J.F., Quiroz Y. T., et al. Exceptionally low likelihood of Alzheimer’s dementia in APOE 2 homozygotes from a 5,000-person neuropathological study. Nat Commun. 2020; 11 (1): 667. DOI: 10.1038/s41467–019–14279–8.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Genin E., Hannequin D., Wallon D., et al. APOE and Alzheimer disease: a major gene with semi-dominant inheritance. Mol Psychiatry. 2011; 16 (9): 903–907. DOI: 10.1038/mp.2011.52.</mixed-citation><mixed-citation xml:lang="en">Genin E., Hannequin D., Wallon D., et al. APOE and Alzheimer disease: a major gene with semi-dominant inheritance. Mol Psychiatry. 2011; 16 (9): 903–907. DOI: 10.1038/mp.2011.52.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Myers R.H., Schaefer E.J., Wilson P.W., et al. Apolipoprotein E epsilon4 association with dementia in a population-based study: The Framingham study. Neurology. 1996; 46 (3): 673–677. DOI: 10.1212/WNL.46.3.673.</mixed-citation><mixed-citation xml:lang="en">Myers R.H., Schaefer E.J., Wilson P.W., et al. Apolipoprotein E epsilon4 association with dementia in a population-based study: The Framingham study. Neurology. 1996; 46 (3): 673–677. DOI: 10.1212/WNL.46.3.673.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Slooter A.J., Cruts M., Kalmijn S., et al. Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study. Arch Neurol. 1998; 55 (7): 964–968. DOI: 10.1001/archneur.55.7.964</mixed-citation><mixed-citation xml:lang="en">Slooter A.J., Cruts M., Kalmijn S., et al. Risk estimates of dementia by apolipoprotein E genotypes from a population-based incidence study: the Rotterdam Study. Arch Neurol. 1998; 55 (7): 964–968. DOI: 10.1001/archneur.55.7.964</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Bateman R.J., Aisen P.S., De Strooper B., et al. Autosomal-dominant Alzheimer’s disease: a review and proposal for the prevention of Alzheimer’s disease. Alzheimers Res Ther. 2011; 3 (1): 1–1. DOI: 10.1186/alzrt59</mixed-citation><mixed-citation xml:lang="en">Bateman R.J., Aisen P.S., De Strooper B., et al. Autosomal-dominant Alzheimer’s disease: a review and proposal for the prevention of Alzheimer’s disease. Alzheimers Res Ther. 2011; 3 (1): 1–1. DOI: 10.1186/alzrt59</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Rossor M.N., Fox N.C., Mummery C.J., et al. The diagnosis of young-onset dementia. Lancet Neurol. 2010; 9 (8): 793–806. DOI: 10.1016/S1474–4422(10)70159–9.</mixed-citation><mixed-citation xml:lang="en">Rossor M.N., Fox N.C., Mummery C.J., et al. The diagnosis of young-onset dementia. Lancet Neurol. 2010; 9 (8): 793–806. DOI: 10.1016/S1474–4422(10)70159–9.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Ryman D.C., Acosta-Baena N., Aisen P.S., et al. And the Dominantly Inherited Alzheimer Network Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis. Neurology. 2014; 83 (3): 253–260. DOI: 10.1212/WNL.0000000000000596.</mixed-citation><mixed-citation xml:lang="en">Ryman D.C., Acosta-Baena N., Aisen P.S., et al. And the Dominantly Inherited Alzheimer Network Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis. Neurology. 2014; 83 (3): 253–260. DOI: 10.1212/WNL.0000000000000596.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Pérez-Rodríguez P., Ganz F., Torralba R., et al. Impact of Social Isolation Due to COVID-19 on Health in Older People: Mental and Physical Effects and Recommendations. J. Nutr. Health Aging. 2020; 24: 938–947. DOI: 10.1007/s12603–020–1469–2.</mixed-citation><mixed-citation xml:lang="en">Pérez-Rodríguez P., Ganz F., Torralba R., et al. Impact of Social Isolation Due to COVID-19 on Health in Older People: Mental and Physical Effects and Recommendations. J. Nutr. Health Aging. 2020; 24: 938–947. DOI: 10.1007/s12603–020–1469–2.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Méndez-Giménez A. COVID-19, Psychological Well-being and Physical Activity Levels in Older Adults During the Nationwide Lockdown in Spain. Am.J. Geriatr. Psychiatry. 2020; 28: 1146–1155. DOI: 10.1016/j.jagp.2020.08.007.</mixed-citation><mixed-citation xml:lang="en">Méndez-Giménez A. COVID-19, Psychological Well-being and Physical Activity Levels in Older Adults During the Nationwide Lockdown in Spain. Am.J. Geriatr. Psychiatry. 2020; 28: 1146–1155. DOI: 10.1016/j.jagp.2020.08.007.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Hardan L., Filtchev D., Kassem R., et al. COVID-19 and Alzheimer’s Disease: A Literature Review. Medicina (Kaunas). 2021 Oct 25; 57 (11): 1159. DOI: 10.3390/medicina57111159.</mixed-citation><mixed-citation xml:lang="en">Hardan L., Filtchev D., Kassem R., et al. COVID-19 and Alzheimer’s Disease: A Literature Review. Medicina (Kaunas). 2021 Oct 25; 57 (11): 1159. DOI: 10.3390/medicina57111159.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Mok V.C., Pendlebury S., Wong A, et al. Tackling challenges in care of Alzheimer’s disease and other dementias amid the COVID-19 pandemic, now and in the future. Alzheimers Dement. 2020; 16: 1571–1581. DOI: 10.1002/alz.12143.</mixed-citation><mixed-citation xml:lang="en">Mok V.C., Pendlebury S., Wong A, et al. Tackling challenges in care of Alzheimer’s disease and other dementias amid the COVID-19 pandemic, now and in the future. Alzheimers Dement. 2020; 16: 1571–1581. DOI: 10.1002/alz.12143.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Zhou F., Yu T., Du R., et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet. 2020; 28: 1054–1062. DOI: 10.1016/S0140–6736(20)30566–3.</mixed-citation><mixed-citation xml:lang="en">Zhou F., Yu T., Du R., et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study. Lancet. 2020; 28: 1054–1062. DOI: 10.1016/S0140–6736(20)30566–3.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Yang X., Yu Y., Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: A single-centered, retrospective, observational study. Lancet Respir. Med. 2020; 8: 475–481. DOI: 10.1016/S2213–2600(20)30079–5.</mixed-citation><mixed-citation xml:lang="en">Yang X., Yu Y., Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: A single-centered, retrospective, observational study. Lancet Respir. Med. 2020; 8: 475–481. DOI: 10.1016/S2213–2600(20)30079–5.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Ye Q., Wang B., Mao J. The pathogenesis and treatment of the ‘Cytokine Storm’ in COVID-19. J. Infect. 2020; 80: 607–613. DOI: 10.1016/j.jinf.2020.03.037.</mixed-citation><mixed-citation xml:lang="en">Ye Q., Wang B., Mao J. The pathogenesis and treatment of the ‘Cytokine Storm’ in COVID-19. J. Infect. 2020; 80: 607–613. DOI: 10.1016/j.jinf.2020.03.037.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Numbers K., Brodaty H. The effects of the COVID-19 pandemic on people with dementia. Nat. Rev. Neurol. 2021; 17: 69–70. DOI: 10.1038/s41582–020–00450-z.</mixed-citation><mixed-citation xml:lang="en">Numbers K., Brodaty H. The effects of the COVID-19 pandemic on people with dementia. Nat. Rev. Neurol. 2021; 17: 69–70. DOI: 10.1038/s41582–020–00450-z.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Wang H., Li T., Barbarino P, et al. Dementia care during COVID-19. Lancet. 2020; 395: 1190–1191. DOI: 10.1016/S0140–6736(20)30755–8.</mixed-citation><mixed-citation xml:lang="en">Wang H., Li T., Barbarino P, et al. Dementia care during COVID-19. Lancet. 2020; 395: 1190–1191. DOI: 10.1016/S0140–6736(20)30755–8.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Palmer K., Monaco A., Kivipelto M, et al. The potential long-term impact of the COVID-19 outbreak on patients with non-communicable diseases in Europe: Consequences for healthy ageing. Aging Clin. Exp. Res. 2020; 32: 1189–1194. DOI: 10.1007/s40520–020–01601–4.</mixed-citation><mixed-citation xml:lang="en">Palmer K., Monaco A., Kivipelto M, et al. The potential long-term impact of the COVID-19 outbreak on patients with non-communicable diseases in Europe: Consequences for healthy ageing. Aging Clin. Exp. Res. 2020; 32: 1189–1194. DOI: 10.1007/s40520–020–01601–4.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Palmieri L., Vanacore N., Donfrancesco C, et al. Clinical characteristics of hospitalized individuals dying with COVID-19 by age Group in Italy. J. Gerontol. A Biol. Sci. Med. Sci. 2020; 75: 1796–1800. DOI: 10.1093/gerona/glaa146.</mixed-citation><mixed-citation xml:lang="en">Palmieri L., Vanacore N., Donfrancesco C, et al. Clinical characteristics of hospitalized individuals dying with COVID-19 by age Group in Italy. J. Gerontol. A Biol. Sci. Med. Sci. 2020; 75: 1796–1800. DOI: 10.1093/gerona/glaa146.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Boutoleau-Bretonnière C., Pouclet-Courtemanche H., Gillet A., et al. The Effects of Conﬁnement on Neuropsychiatric Symptoms in Alzheimer’s Disease During the COVID-19 Crisis. J. Alzheimers Dis. 2020; 76: 41–47. DOI: 10.3233/JAD-200604.</mixed-citation><mixed-citation xml:lang="en">Boutoleau-Bretonnière C., Pouclet-Courtemanche H., Gillet A., et al. The Effects of Conﬁnement on Neuropsychiatric Symptoms in Alzheimer’s Disease During the COVID-19 Crisis. J. Alzheimers Dis. 2020; 76: 41–47. DOI: 10.3233/JAD-200604.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Chiao C.-Y., Wu H.-S., Hsiao C.-Y. Caregiver burden for informal caregivers of patients with dementia: A systematic review. Int. Nurs. Rev. 2015; 62: 340–350. DOI: 10.1111/inr.12194.</mixed-citation><mixed-citation xml:lang="en">Chiao C.-Y., Wu H.-S., Hsiao C.-Y. Caregiver burden for informal caregivers of patients with dementia: A systematic review. Int. Nurs. Rev. 2015; 62: 340–350. DOI: 10.1111/inr.12194.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Захаров В. В. Постковидный синдром глазами невролога. Поведенческая неврология. 2021; 2: 14–22.</mixed-citation><mixed-citation xml:lang="en">Zakharov VV. Postcovid syndrome through the eyes of a neurologist. Behavioral neurology. 2021; 2: 14–22. (In Russ.). https://doi.org/10.46393/2712–9675_2021_2_14_22</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Камчатнов П.Р., Соловьева Э.Ю., Хасанова Д.Р., Фатеева В.В. Астенические и когнитивные нарушения у пациентов, перенесших COVID-19. РМЖ. Медицинское обозрение. 2021; 5 (10): 636–641. https://doi.org/10.32364/2587–6821–2021–5–10–636–641</mixed-citation><mixed-citation xml:lang="en">Kamchatnov P.R., Solov’eva E. Yu., Khasanova D.R., Fateeva V.V. Asthenic and cognitive disorders after the COVID-19 infection. Russian Medical Inquiry. 2021; 5 (10): 636–641 (in Russ.). https://doi.org/10.32364/2587–6821–2021–5–10–636–641</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Helms J., Kremer S., Merdji H, et al. Neurologic features in severe SARS-CoV-2 infection. N. Engl. J. Med. 2020; 382: 2268–2270. DOI: 10.1056/NEJMc2008597.</mixed-citation><mixed-citation xml:lang="en">Helms J., Kremer S., Merdji H, et al. Neurologic features in severe SARS-CoV-2 infection. N. Engl. J. Med. 2020; 382: 2268–2270. DOI: 10.1056/NEJMc2008597.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Иванова Г.Е., Мельникова Е.В., Левин О.С. и др. Резолюция Совета экспертов. Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски. 2020; 120 (8–2): 81–87. https://doi.org/10.17116/jnevro202012008281</mixed-citation><mixed-citation xml:lang="en">Ivanova G.E., Melnikova E.V., Levin O.S., et al. Current issues in the rehabilitation of stroke patients against the background of a new coronavirus infection (COVID-19). Resolution of the Council of Experts. S.S. Korsakov Journal of Neurology and Psychiatry = Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2020; 120 (8–2): 81–87. (In Russ.). https://doi.org/10.17116/jnevro202012008281</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Стариков П. В., Камчатнов П. Р., Леушин Е. К. Открытое сравнительное исследование применения препарата Эврин при тревожных и когнитивных нарушениях у стационарных больных COVID-19. Эффективная фармакотерапия. 2021; 17; 29: 6–13. https://doi.org/10.33978/2307–3586–2021–17–29–6–13</mixed-citation><mixed-citation xml:lang="en">Starikov P.V., Kamchatnov P.R., Leushin E.K. An open comparative study of the use of the drug Evrin in anxiety and cognitive disorders in inpatient patients with COVID-19. Effective pharmacotherapy. 2021; 17; 29: 6–13. (In Russ.). https://doi.org/10.33978/2307–3586–2021–17–29–6–13</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Adibhalta R. M. Citicoline: neuroprotective mechanisms in cerebral ischemia. J. Neurochem. 2002; 80: 12–23.</mixed-citation><mixed-citation xml:lang="en">Adibhalta R. M. Citicoline: neuroprotective mechanisms in cerebral ischemia. J. Neurochem. 2002; 80: 12–23.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Одинак М.М., Вознюк И.А. Роль экзогенного холина в защите и восстановлении мозгового вещества при инсульте. Качество жизни. Медицина. 2007; 4 (21): 2–9.</mixed-citation><mixed-citation xml:lang="en">Odinak M.M., Voznyuk I.A. The role of exogenous choline in the protection and restoration of brain matter in stroke. Quality of life. Medicine. 2007; 4 (21): 2–9. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Adibhatla R.M., Hatcher J.F. Cytidine 5’diphosphocholine (CDP-choline) in stroke and other CNS disorders. Neurochem Res. 2005; 30: 15–23.</mixed-citation><mixed-citation xml:lang="en">Adibhatla R.M., Hatcher J.F. Cytidine 5’diphosphocholine (CDP-choline) in stroke and other CNS disorders. Neurochem Res. 2005; 30: 15–23.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Гусев Е.И., Батышева Т.Т., Бойко А.Н. и др. Результаты применения цераксона (цитиколин) у больных с острым инсультом. Медицина критических состояний. 2010; 1: 45–51.</mixed-citation><mixed-citation xml:lang="en">Gusev E. I., Batysheva T. T., Boyko A. N. et al. Results of the use of ceraxone (citicoline) in patients with acute stroke. Critical Condition Medicine. 2010; 1: 45–51. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Murphy E.J., Horrocks L.A. CDP-choline, CDP-ethanolamine, lipid metabolism and disorders of the central nervous system. Phopspholipids and Signal Transmission. Berlin: Spriger-Verlag. 1993: 353–72.</mixed-citation><mixed-citation xml:lang="en">Murphy E.J., Horrocks L.A. CDP-choline, CDP-ethanolamine, lipid metabolism and disorders of the central nervous system. Phopspholipids and Signal Transmission. Berlin: Spriger-Verlag. 1993: 353–72.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Gareri P., Castagna A., Cotroneo A.M., et al. The role of citicoline in cognitive impairment: pharmacological characteristics, possible advantages, and doubts for an old drug with new perspectives. Clin Interv Aging. 2015 Sep 3; 10: 1421–9. DOI: 10.2147/CIA.S87886.</mixed-citation><mixed-citation xml:lang="en">Gareri P., Castagna A., Cotroneo A.M., et al. The role of citicoline in cognitive impairment: pharmacological characteristics, possible advantages, and doubts for an old drug with new perspectives. Clin Interv Aging. 2015 Sep 3; 10: 1421–9. DOI: 10.2147/CIA.S87886.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Spiers P.A., Myers D., Hochanadel G. et al. Citicoline improves verbal memory in aging. Arch Neurol 1996; 53: 441–48.</mixed-citation><mixed-citation xml:lang="en">Spiers P.A., Myers D., Hochanadel G. et al. Citicoline improves verbal memory in aging. Arch Neurol 1996; 53: 441–48.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Белова Д.А., Машин В.В., Дудиков К.М. и др. Наблюдательная программа по оценке эффективности комплексной терапии препаратами кортексин и рекогнан (цитиколин) когнитивных нарушений у пациентов с хронической цереброваскулярной патологией. Журнал неврологии и психиатрии им. С.С. Корсакова. 2019; 119 (2): 35–38. https://doi.org/10.17116/jnevro201911902135</mixed-citation><mixed-citation xml:lang="en">Belova L.A., Mashin V.V., Dudikov E.M., et al. A multicenter observation study of the efﬁcacy of cortexin and recognan (citicoline) in the treatment of cognitive impairments in chronic cerebrovascular pathology. S. S. Korsakov Journal of Neurology and Psychiatry = Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2019; 119 (2): 35–38. (In Russ.). https://doi.org/10.17116/jnevro201911902135</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Wu S., Kutlubaev M.A., Chun H.Y., et al. Interventions for post-stroke fatigue. Cochrane Database Syst Rev. 2015 Jul 2; 2015 (7): CD007030. DOI: 10.1002/14651858.CD007030.pub3</mixed-citation><mixed-citation xml:lang="en">Wu S., Kutlubaev M.A., Chun H.Y., et al. Interventions for post-stroke fatigue. Cochrane Database Syst Rev. 2015 Jul 2; 2015 (7): CD007030. DOI: 10.1002/14651858.CD007030.pub3</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Немкова С.А., Семенов Д.А., Логинова Е.М. и др. Когнитивные и психоэмоциональные нарушения у учащихся и преподавателей вузов: возможности коррекции с помощью препарата рекогнан (цитиколин). Журнал неврологии и психиатрии им. С.С. Корсакова. 2018; 118 (12): 11–18. https://doi.org/10.17116/jnevro201811812111</mixed-citation><mixed-citation xml:lang="en">Nemkova S. A., Semenov D. V., Petrova E. A., et al. Cognitive and emotional disorders in university students and teachers: the possibility of treatment with recognan (citicoline). S.S. Korsakov Journal of Neurology and Psychiatry = Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2018; 118 (12): 11–18. (In Russ.). https://doi.org/10.17116/jnevro201811812111</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Ивонина Н.А., Петров К.Б. Применение нейротропной терапии у молодых пациентов с постковидным синдромом. Журнал неврологии и психиатрии им. С.С. Корсакова. 2022; 122 (3): 1–5. https://doi.org/10.17116/jnevro20221220311</mixed-citation><mixed-citation xml:lang="en">Ivonina N.A., Petrov K.B. The use of neurotropic therapy in young patients with postcovid syndrome. S.S. Korsakov Journal of Neurology and Psychiatry = Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2022; 122 (3): 1–5. (In Russ.). https://doi.org/10.17116/jnevro20221220311</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
